Week 1 of the 2025 NFL season features several exciting matchups that promise to set the tone for the year. Here are some of the most compelling games:

Buffalo Bills vs. Baltimore Ravens: This matchup features MVP finalists Josh Allen and Lamar Jackson. The Bills, bolstered by the addition of Joey Bosa, are projected as a top AFC team. This game is one of Buffalo’s toughest, with both teams boasting playoff-caliber rosters.

Dallas Cowboys at Philadelphia Eagles: Dak Prescott returns from injury to lead the Cowboys, with new acquisition George Pickens joining CeeDee Lamb. The Eagles, led by Jalen Hurts and Saquon Barkley, are defending their Super Bowl title and have the highest odds of beating Dallas in over a decade.

Houston Texans at Los Angeles Rams: C.J. Stroud aims to rebound from a sophomore slump as he leads the Texans against the Rams. Davante Adams makes his debut for Los Angeles, adding intrigue to this matchup.

Minnesota Vikings at Chicago Bears: J.J. McCarthy makes his NFL debut for the Vikings against Caleb Williams and the Bears. This Monday Night Football game is a significant test for both teams’ revamped offenses.

New Orleans Saints vs. Arizona Cardinals: Chris Olave and Marvin Harrison Jr. are key players to watch in this matchup, as both teams look to start the season strong.

These games highlight the dynamic storylines and player performances that will shape the 2025 NFL season from the outset.