The 2025 NFL Draft boasts an impressive depth of running back talent, with 13 prospects in the Top 100. Leading the pack is Boise State's Ashton Jeanty, whose explosive playmaking and vision make him a top-10 candidate despite size concerns. Ohio State's TreVeyon Henderson, a versatile three-down back, could be a steal if he falls due to injury worries. San Francisco, eyeing running back depth, might target Henderson at No. 43, addressing Christian McCaffrey's health concerns. Meanwhile, Arizona State's Cam Skattebo and Kansas' Devin Neal offer mid-round value with their hard-nosed running styles. Teams are expected to capitalize on this deep class, seeking immediate impact and future stars.