After Week 1 of the 2025 NFL season, several key fantasy players are dealing with injuries that could impact their availability and performance in the coming weeks.

Xavier Worthy of the Kansas City Chiefs suffered a right shoulder dislocation. The timeline for his return is projected at 3–4+ weeks if surgery is not required, but it could be season-ending if surgery is necessary. Fantasy managers should prepare for a multi-week absence and monitor for potential IR placement.

Evan Engram, tight end for the Denver Broncos, is dealing with a right calf strain and is considered week-to-week. He is likely to miss at least 2 weeks. Fantasy managers should have a backup plan at tight end as his return by Week 2 is uncertain.

Jayden Reed of the Green Bay Packers is managing a suspected Jones fracture in his foot. Although he returned to practice, he is not fully healthy, and the risk of re-injury is elevated. Fantasy managers should consider him a risky flex option due to the potential for aggravation.

Josh Downs from the Indianapolis Colts has a hamstring injury and has not returned to full practice. His coach expects him back soon, but the risk of re-aggravation remains. If healthy, he projects as a WR3/flex, but managers should monitor his status closely.

Tyreek Hill of the Miami Dolphins is dealing with an oblique strain but is expected to play in Week 2. Despite the injury, he remains a locked-in WR1/WR2, though the risk of aggravation exists. Managers should keep an eye on his practice status.

Other notable mentions include Darnell Mooney of the Falcons, who is questionable with a shoulder injury and did not play in Week 1. Fantasy managers should continue monitoring practice reports and medical updates for these players to make informed decisions.