Christian McCaffrey is likely to play in the San Francisco 49ers' Week 1 matchup against the Seattle Seahawks, despite being listed as questionable due to a calf injury. Multiple sources, including NFL Network insiders, express optimism about his availability.
Fantasy Football Implications: McCaffrey is projected to deliver RB1 fantasy value if active, with an expected output of 100-120 total yards and 1 touchdown. Fantasy managers should monitor his status up to the official inactives release, 90 minutes before kickoff.
Backup Plans: Consider Brian Robinson Jr. and Isaac Guerendo as contingency options. Robinson Jr. is expected to be the #2 RB, while Guerendo offers change-of-pace potential.
Team Strategy: The 49ers have bolstered their RB depth, but McCaffrey remains integral to their 2025 plans. His historical success against Seattle, averaging 109.7 rushing yards and a touchdown per game, underscores his potential impact.
