Christian McCaffrey's health is pivotal for the San Francisco 49ers' 2025 success. Head coach Kyle Shanahan has confirmed McCaffrey is "as healthy as can be," following a rigorous rehabilitation process. This is crucial as the 49ers aim for a projected 12-win season.

In fantasy football, McCaffrey is a high-risk, high-reward pick. His ADP is #11, but his injury history makes him a boom-or-bust option. The 49ers' offensive strategy, led by new offensive coordinator Klay Kubiak, will likely rely heavily on McCaffrey, especially with early-season absences at wide receiver.

Despite his 18th-ranked strength of schedule for running backs, McCaffrey's potential workload and explosiveness make him a valuable asset. However, fantasy managers should monitor his health closely, as his ability to stay on the field will directly impact his fantasy value and the 49ers' playoff aspirations.