For the 2025 fantasy football season, several running backs stand out due to their favorable schedules and projected roles. Derrick Henry of the Baltimore Ravens is a prime candidate, facing the Cincinnati Bengals, New England Patriots, and Green Bay Packers in Weeks 15-17. These defenses struggled against the run in 2024, with the Patriots allowing 2,237 rushing yards and 16 rushing touchdowns.

RJ Harvey of the Denver Broncos is another top option. As the projected workhorse back following Javonte Williams' departure, Harvey benefits from a soft AFC West schedule and a clear three-down role, making him a potential league-winner.

Jaylen Wright of the Miami Dolphins is a high-upside stash. His explosive speed and fit in Miami's outside-zone scheme could lead to increased touches if De'Von Achane faces durability issues, positioning Wright as a potential playoff game-changer.

Javonte Williams with the Dallas Cowboys is expected to thrive in a high-powered offense, with a favorable December schedule enhancing his late-season value.

Lastly, Bucky Irving of the Tampa Bay Buccaneers offers dual-threat capabilities and benefits from a strong offensive line, making him a solid playoff asset.

In summary, targeting these running backs or securing handcuffs like Wright and Harvey can provide a strategic edge for the 2025 fantasy playoffs.