Brandon Aiyuk's 2025 Outlook: Brandon Aiyuk is projected to start the 2025 season on the PUP list due to his recovery from a significant knee injury, potentially sidelining him for at least the first four games. His 2025 projections include 48.6 receptions, 745.2 receiving yards, and 3.2 touchdowns, translating to 93.7 fantasy points. The San Francisco 49ers are expected to exercise caution, likely delaying his return to ensure full recovery.

Fantasy Implications: Aiyuk's uncertain early-season availability makes him a risky draft pick in redraft leagues. His potential absence opens opportunities for rookie WR Ricky Pearsall and veteran Jauan Jennings to see increased targets. Fantasy managers should monitor his rehab progress closely and consider Aiyuk a mid-season stash with upside, particularly in leagues with IR spots.

Team Strategy: The 49ers will likely rely on Brock Purdy's connection with George Kittle and Christian McCaffrey in the passing game, especially in the early weeks. Aiyuk's return could significantly boost the offense, but his impact will depend on how quickly he regains his pre-injury form, which included a YPRR above 2.0.