The San Francisco 49ers' wide receiver room faces significant challenges heading into the 2025 season. Brandon Aiyuk is on the PUP list, recovering from ACL and MCL tears, with his Week 1 availability uncertain. This absence creates a void in the WR lineup.

Jauan Jennings, who had 77 receptions, 975 yards, and six touchdowns in 2024, is holding out for a new contract. His potential absence is critical, as he was the primary target in Aiyuk's absence last season, boasting a 25.1% target share and 2.23 yards per route run.

Ricky Pearsall, a first-round rookie, is expected to step up but is currently sidelined with a hamstring injury. His health and readiness for the season are in question, affecting the WR depth.

The 49ers are exploring options, having worked out several free agents, including Equanimeous St. Brown and Quintez Cephus. Demarcus Robinson could fill the X receiver role but faces a potential suspension.

With the WR room in flux, the 49ers may rely heavily on George Kittle and Christian McCaffrey for targets. Fantasy managers should monitor Jennings' contract situation and Aiyuk's recovery closely, as these factors will significantly impact the team's offensive dynamics and fantasy value in 2025.