The Buffalo Bills' 2025 training camp has been eventful, particularly with the injury to wide receiver Khalil Shakir. Shakir's high ankle sprain is a significant concern as he is expected to miss 4-5 weeks, potentially sidelining him for the season opener against the Baltimore Ravens on September 7. His absence leaves a void, as he was projected to be a top target after leading the team with 76 receptions for 821 yards and four touchdowns last year.

In Shakir's absence, second year Keon Coleman is emerging as the likely WR1, receiving increased practice reps alongside Joshua Palmer. This shift could impact fantasy strategies, making Coleman a potential sleeper pick for early-season production. Meanwhile, the Bills' secondary is focusing on integrating rookie cornerback Maxwell Hairston and second-year safety Cole Bishop, who have shown promise in coverage and physicality under new defensive coordinator Bobby Babich.

Running back James Cook's status is also in question as he sat out practice on August 3, working on an exercise bike. Fantasy managers should monitor his situation closely. Additionally, tight end Dawson Knox is dealing with a non-football injury, which could elevate Dalton Kincaid's role in the offense.

Overall, the Bills' training camp is characterized by a competitive atmosphere, particularly among receivers and secondary personnel. The team's depth and adaptability will be tested as they navigate these early challenges in preparation for the 2025 season.