James Cook, the starting running back for the Buffalo Bills in 2025, is projected for 1,050 rushing yards and 9.5 rushing touchdowns. Despite his contract dispute, Cook remains a key fantasy asset, ranked as the 14th RB by ADP. His potential absence due to contract issues could open up opportunities for rookie Ray Davis, who has been receiving first-team reps in preseason.

Cook's involvement in warmups but not in the game highlights his "hold-in" strategy, aiming for a contract extension worth $11-$12.5 million annually. This situation is crucial for fantasy managers, as Cook's projected 196.1 fantasy points make him a valuable RB2 option. His absence could significantly impact the Bills' offensive dynamics and fantasy lineups.

With the Bills' offensive line expected to support a high-powered attack, Cook's role as a dual-threat back (projected 31.4 receptions and 258.5 receiving yards) is vital. Fantasy managers should monitor his contract negotiations closely, as his availability will influence draft strategies and early-season lineups.