The San Francisco 49ers face a challenging start to the 2025 season with wide receiver Jauan Jennings likely heading to injured reserve due to a calf injury and contract issues. This absence, alongside Brandon Aiyuk on the PUP list and Deebo Samuel traded, leaves the 49ers thin at WR.

Fantasy Impact: Jennings' absence significantly impacts the 49ers' passing game. Ricky Pearsall, a 2024 first-round pick, is projected to step up as a primary target. He could see 65-80 targets, translating to 700-800 yards and 4-5 TDs if he starts the first four games. Demarcus Robinson is expected to assume the No. 2 WR role, potentially garnering 115-130 targets and producing 900-1000 yards with 5-7 TDs.

Strategic Implications: Head Coach Kyle Shanahan will likely lean on a run-heavy scheme, utilizing George Kittle and Christian McCaffrey more in the passing game. The 49ers may also need to elevate practice squad WRs or sign a veteran to bolster depth.

Contract Context: Jennings is in the final year of his contract, earning a $1.71 million base salary with potential $3.5 million incentives. His IR placement could prevent him from achieving these incentives, impacting his future with the team.