The Kansas City Chiefs and Los Angeles Chargers are set for a thrilling matchup to kick off the 2025 NFL season. Patrick Mahomes is projected for an over/under of 241.5 passing yards, with Xaiver Worthy looking to become the number 1 guy in Kansas City, look out for this connection being a key focus for the game.

For the Chargers, Justin Herbert remains a pivotal player, especially with the addition of Najee Harris and rookie Omarion Hampton in the backfield. This duo could provide a balanced attack, challenging the Chiefs' defense, which may struggle on the perimeter due to injuries.

Isiah Pacheco is projected for an over/under of 8.5 receiving yards, though he averages 11.9 receiving yards per game for his career. His performance could be vital in offsetting the Chiefs' injury woes.

The Chargers' defense will aim to capitalize on the Chiefs' weakened perimeter, leveraging their strong ATS record from 2024, where they went 12-5-0 and covered in three consecutive games against AFC opponents.