In Week 1 against the Los Angeles Chargers, Isiah Pacheco is set to lead the Chiefs' backfield, benefiting from head coach Andy Reid's confidence in his role as the primary back. The Chargers' defense, often deploying Cover 1 and Cover 2 schemes, has struggled against the run, ranking in the bottom third for yards per carry allowed last season. Pacheco's historical 3.85 yards per carry against LAC aligns with his season average, and his projected 42% rush share could exploit LAC's 45.4% rush percentage vulnerability. Despite Kansas City's offensive line challenges, the Chiefs' heavy formations (10% usage) should create advantageous rushing lanes. Projected for 10.03 fantasy points (RB24), Pacheco is an RB2 with moderate confidence, offering solid upside in this average matchup.