Omarion Hampton's 2025 outlook is shaped by a Chargers backfield in transition, highlighted by his first-round selection. Projected for 259.54 carries (RB13) and 1157.16 rushing yards (RB12), Hampton is poised to lead a run-heavy scheme under new OC Greg Roman, known for top-11 rushing attempts in 11 straight seasons. Despite Najee Harris’s competition, his eye injury could open early opportunities for Hampton, projected for a 57% rush share (RB10). With no NFL injuries and a solid college track record, Hampton's 260.92 projected PPR points (RB16) reflect both his potential and workload-sharing risks.