In Week 1, Patrick Mahomes faces the Los Angeles Chargers, a team he has consistently excelled against, averaging 279.5 passing yards over six recent encounters. Despite an average matchup quality, Mahomes' historical success against the Chargers, highlighted by performances of 360 and 336 passing yards, underscores his ability to dissect their balanced coverage, especially their 25% usage of Cover 1. However, the Chargers' revamped defense under coordinator Jesse Minter poses new challenges, with Khalil Mack likely targeting rookie left tackle Josh Simmons. Mahomes must swiftly adapt to a restructured receiving corps, with Asante Samuel Jr. keying on Travis Kelce. With a projected 15.0 fantasy points (QB13), Mahomes is a streaming QB with moderate-confidence, relying on his offensive line's resilience against a dynamic pass rush.