| 1 | James CookBuffalo Bills·#4 | 17 | 204 | 1,059 | 5.19 | 2 | 563 | 29 | 0 | 27 | 24 | 158 | 1 | 88.9% | 5.85 | 6.58 | 127 | 1 | 1 | 0 | 3 | 360 |
| 2 | Derrick HenryBaltimore Ravens·#22 | 17 | 166 | 1,069 | 6.44 | 5 | 593 | 27 | 0 | 17 | 13 | 142 | 0 | 76.5% | 8.35 | 10.92 | 132 | 2 | 2 | 0 | 3 | 318 |
| 3 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 154 | 801 | 5.20 | 2 | 388 | 26 | 0 | 23 | 20 | 206 | 0 | 87.0% | 8.96 | 10.30 | 243 | 1 | 0 | 0 | 2 | 302 |
| 4 | De'Von AchaneMiami Dolphins·#28 | 16 | 166 | 892 | 5.37 | 3 | 543 | 25 | 0 | 57 | 48 | 345 | 2 | 84.2% | 6.05 | 7.19 | 429 | 5 | 4 | 2 | 1 | 407 |
| 5 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 174 | 976 | 5.61 | 2 | 740 | 23 | 0 | 61 | 50 | 543 | 1 | 82.0% | 8.90 | 10.86 | 605 | 4 | 3 | 1 | 3 | 469 |
| 6 | Travis EtienneJacksonville Jaguars·#1 | 17 | 170 | 813 | 4.78 | 4 | 515 | 22 | 0 | 32 | 23 | 191 | 4 | 71.9% | 5.97 | 8.30 | 229 | 4 | 4 | 3 | 1 | 407 |
| 7 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 179 | 775 | 4.33 | 3 | 392 | 21 | 0 | 34 | 26 | 154 | 0 | 76.5% | 4.53 | 5.92 | 191 | 3 | 2 | 0 | 1 | 432 |
| 8 | Breece HallNew York Jets·#20 | 16 | 141 | 756 | 5.36 | 2 | 348 | 20 | 0 | 33 | 28 | 306 | 1 | 84.8% | 9.27 | 10.93 | 293 | 3 | 0 | 0 | 2 | 358 |
| 9 | Javonte WilliamsDallas Cowboys·#33 | 16 | 158 | 879 | 5.56 | 1 | 553 | 20 | 0 | 29 | 24 | 100 | 0 | 82.8% | 3.45 | 4.17 | 143 | 4 | 3 | 0 | 3 | 403 |
| 10 | Rico DowdleCarolina Panthers·#5 | 17 | 158 | 765 | 4.84 | 0 | 425 | 20 | 0 | 31 | 23 | 184 | 1 | 74.2% | 5.94 | 8.00 | 196 | 3 | 1 | 0 | 4 | 319 |
| 11 | Chase BrownCincinnati Bengals·#30 | 17 | 153 | 756 | 4.94 | 1 | 522 | 19 | 0 | 54 | 47 | 292 | 1 | 87.0% | 5.41 | 6.21 | 276 | 3 | 3 | 1 | 3 | 434 |
| 12 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 179 | 943 | 5.27 | 4 | 566 | 19 | 0 | 39 | 33 | 276 | 1 | 84.6% | 7.08 | 8.36 | 305 | 3 | 3 | 1 | 2 | 487 |
| 13 | Jordan MasonMinnesota Vikings·#27 | 16 | 103 | 563 | 5.47 | 0 | 321 | 18 | 0 | 9 | 7 | 24 | 0 | 77.8% | 2.67 | 3.43 | 52 | 1 | 1 | 0 | 1 | 226 |
| 14 | Blake CorumLos Angeles Rams·#22 | 17 | 89 | 521 | 5.85 | 2 | 242 | 18 | 0 | 11 | 6 | 22 | 0 | 54.5% | 2.00 | 3.67 | 29 | 1 | 0 | 0 | 1 | 178 |
| 15 | Tony PollardTennessee Titans·#20 | 17 | 165 | 778 | 4.72 | 1 | 456 | 18 | 0 | 23 | 20 | 133 | 0 | 87.0% | 5.78 | 6.65 | 147 | 1 | 1 | 0 | 5 | 385 |
| 16 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 180 | 746 | 4.14 | 0 | 498 | 17 | 0 | 69 | 58 | 551 | 0 | 84.1% | 7.99 | 9.50 | 420 | 5 | 3 | 0 | 6 | 497 |
| 17 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 174 | 711 | 4.09 | 1 | 521 | 17 | 0 | 49 | 37 | 215 | 0 | 75.5% | 4.39 | 5.81 | 320 | 5 | 5 | 0 | 0 | 446 |
| 18 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 137 | 741 | 5.41 | 0 | 435 | 17 | 0 | 29 | 24 | 177 | 2 | 82.8% | 6.10 | 7.38 | 117 | 3 | 3 | 2 | 5 | 397 |
| 19 | D'Andre SwiftChicago Bears·#4 | 16 | 126 | 652 | 5.17 | 3 | 347 | 16 | 0 | 32 | 23 | 128 | 0 | 71.9% | 4.00 | 5.57 | 167 | 0 | 0 | 0 | 2 | 350 |
| 20 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 121 | 626 | 5.17 | 1 | 462 | 16 | 0 | 31 | 27 | 222 | 0 | 87.1% | 7.16 | 8.22 | 321 | 1 | 0 | 0 | 2 | 285 |
| 21 | J.K. DobbinsDenver Broncos·#27 | 10 | 95 | 565 | 5.95 | 1 | 303 | 14 | 0 | 11 | 10 | 34 | 0 | 90.9% | 3.09 | 3.40 | 52 | 0 | 0 | 0 | 0 | 194 |
| 22 | Jahmyr GibbsDetroit Lions·#0 | 17 | 144 | 712 | 4.94 | 3 | 369 | 14 | 0 | 65 | 51 | 411 | 2 | 78.5% | 6.32 | 8.06 | 391 | 8 | 6 | 2 | 2 | 415 |
| 23 | Kyle MonangaiChicago Bears·#25 | 17 | 101 | 541 | 5.36 | 0 | 273 | 13 | 0 | 20 | 12 | 112 | 0 | 60.0% | 5.60 | 9.33 | 113 | 2 | 1 | 0 | 0 | 272 |
| 24 | David MontgomeryDetroit Lions·#5 | 17 | 87 | 508 | 5.84 | 2 | 310 | 13 | 0 | 24 | 20 | 153 | 0 | 83.3% | 6.38 | 7.65 | 164 | 2 | 1 | 0 | 3 | 213 |
| 25 | Quinshon JudkinsCleveland Browns·#10 | 14 | 141 | 557 | 3.95 | 1 | 364 | 13 | 0 | 27 | 17 | 132 | 0 | 63.0% | 4.89 | 7.76 | 139 | 1 | 1 | 0 | 1 | 271 |
| 26 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 112 | 540 | 4.82 | 2 | 358 | 12 | 0 | 7 | 5 | 55 | 0 | 71.4% | 7.86 | 11.00 | 50 | 1 | 1 | 0 | 2 | 236 |
| 27 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 109 | 418 | 3.83 | 1 | 324 | 12 | 0 | 29 | 21 | 188 | 1 | 72.4% | 6.48 | 8.95 | 203 | 2 | 1 | 1 | 2 | 331 |
| 28 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 63 | 332 | 5.27 | 0 | 240 | 11 | 0 | 49 | 42 | 332 | 1 | 85.7% | 6.78 | 7.90 | 318 | 8 | 7 | 0 | 1 | 277 |
| 29 | Kimani VidalLos Angeles Chargers·#30 | 13 | 100 | 410 | 4.10 | 0 | 195 | 11 | 0 | 9 | 6 | 33 | 0 | 66.7% | 3.67 | 5.50 | 51 | 3 | 1 | 0 | 0 | 248 |
| 30 | TreVeyon HendersonNew England Patriots·#32 | 17 | 100 | 549 | 5.49 | 3 | 238 | 11 | 0 | 33 | 28 | 180 | 0 | 84.8% | 5.45 | 6.43 | 204 | 1 | 1 | 0 | 1 | 266 |
| 31 | Josh JacobsGreen Bay Packers·#8 | 15 | 126 | 520 | 4.13 | 1 | 374 | 11 | 0 | 35 | 29 | 256 | 1 | 82.9% | 7.31 | 8.83 | 260 | 4 | 3 | 1 | 3 | 285 |
| 32 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 83 | 405 | 4.88 | 0 | 223 | 10 | 0 | 28 | 26 | 129 | 0 | 92.9% | 4.61 | 4.96 | 204 | 4 | 4 | 0 | 3 | 288 |
| 33 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 75 | 321 | 4.28 | 1 | 199 | 10 | 0 | 13 | 11 | 75 | 0 | 84.6% | 5.77 | 6.82 | 100 | 1 | 1 | 0 | 0 | 153 |
| 34 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 67 | 353 | 5.27 | 1 | 202 | 9 | 0 | 25 | 23 | 130 | 0 | 92.0% | 5.20 | 5.65 | 159 | 1 | 1 | 0 | 2 | 196 |
| 35 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 36 | 246 | 6.83 | 0 | 152 | 9 | 0 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 9 | 1 | 1 | 0 | 0 | 68 |
| 36 | RJ HarveyDenver Broncos·#12 | 17 | 84 | 386 | 4.60 | 2 | 281 | 9 | 0 | 37 | 30 | 236 | 1 | 81.1% | 6.38 | 7.87 | 230 | 2 | 1 | 0 | 0 | 269 |
| 37 | Woody MarksHouston Texans·#27 | 16 | 123 | 446 | 3.63 | 1 | 315 | 9 | 0 | 26 | 18 | 95 | 1 | 69.2% | 3.65 | 5.28 | 111 | 5 | 3 | 1 | 0 | 319 |
| 38 | Aaron JonesMinnesota Vikings·#33 | 12 | 90 | 380 | 4.22 | 0 | 236 | 8 | 0 | 25 | 16 | 141 | 1 | 64.0% | 5.64 | 8.81 | 152 | 2 | 1 | 0 | 2 | 212 |
| 39 | Ray DavisBuffalo Bills·#22 | 14 | 38 | 209 | 5.50 | 0 | 120 | 8 | 0 | 6 | 3 | 17 | 0 | 50.0% | 2.83 | 5.67 | 28 | 1 | 1 | 0 | 0 | 76 |
| 40 | Isiah PachecoKansas City Chiefs·#10 | 13 | 72 | 306 | 4.25 | 0 | 199 | 8 | 0 | 16 | 13 | 51 | 0 | 81.3% | 3.19 | 3.92 | 79 | 0 | 0 | 0 | 0 | 247 |
| 41 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 70 | 284 | 4.06 | 1 | 221 | 8 | 0 | 11 | 10 | 85 | 0 | 90.9% | 7.73 | 8.50 | 104 | 1 | 1 | 0 | 0 | 163 |
| 42 | Cam SkatteboNew York Giants·#44 | 8 | 53 | 276 | 5.21 | 1 | 206 | 8 | 0 | 21 | 17 | 158 | 2 | 81.0% | 7.52 | 9.29 | 162 | 3 | 3 | 2 | 1 | 137 |
| 43 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 56 | 271 | 4.84 | 1 | 129 | 7 | 0 | 9 | 6 | 17 | 0 | 66.7% | 1.89 | 2.83 | 23 | 1 | 1 | 0 | 0 | 96 |
| 44 | Samaje PerineCincinnati Bengals·#34 | 15 | 40 | 235 | 5.88 | 1 | 142 | 7 | 0 | 11 | 8 | 36 | 0 | 72.7% | 3.27 | 4.50 | 45 | 1 | 1 | 0 | 1 | 151 |
| 45 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 48 | 232 | 4.83 | 1 | 125 | 6 | 0 | 7 | 5 | 3 | 0 | 71.4% | 0.43 | 0.60 | 24 | 2 | 1 | 0 | 0 | 91 |
| 46 | Rhamondre StevensonNew England Patriots·#38 | 14 | 71 | 326 | 4.59 | 1 | 197 | 6 | 0 | 24 | 21 | 181 | 0 | 87.5% | 7.54 | 8.62 | 169 | 2 | 2 | 0 | 2 | 258 |
| 47 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 109 | 406 | 3.72 | 0 | 233 | 6 | 0 | 22 | 19 | 149 | 1 | 86.4% | 6.77 | 7.84 | 217 | 3 | 2 | 0 | 0 | 244 |
| 48 | Chris Rodriguez Jr.Washington Commanders·#36 | 12 | 60 | 257 | 4.28 | 0 | 164 | 6 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 3 | 0 | 0 | 0 | 1 | 129 |
| 49 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 94 | 355 | 3.78 | 0 | 281 | 6 | 0 | 16 | 13 | 77 | 0 | 81.3% | 4.81 | 5.92 | 70 | 2 | 2 | 0 | 2 | 246 |
| 50 | Kareem HuntKansas City Chiefs·#29 | 17 | 79 | 362 | 4.58 | 0 | 228 | 6 | 0 | 13 | 9 | 71 | 0 | 69.2% | 5.46 | 7.89 | 78 | 2 | 1 | 0 | 1 | 253 |