| 1 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 164 | 713 | 4.35 | 2 | 553 | 28 | 0 | 46 | 32 | 239 | 1 | 69.6% | 5.20 | 7.47 | 295 | 0 | 0 | 0 | 1 | 432 |
| 2 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 163 | 771 | 4.73 | 2 | 416 | 27 | 0 | 31 | 24 | 161 | 0 | 77.4% | 5.19 | 6.71 | 195 | 0 | 0 | 0 | 1 | 409 |
| 3 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 162 | 994 | 6.14 | 2 | 717 | 40 | 0 | 56 | 43 | 497 | 0 | 76.8% | 8.88 | 11.56 | 492 | 0 | 0 | 0 | 3 | 455 |
| 4 | Quinshon JudkinsCleveland Browns·#10 | 14 | 157 | 576 | 3.67 | 0 | 373 | 31 | 0 | 30 | 23 | 139 | 0 | 76.7% | 4.63 | 6.04 | 159 | 0 | 0 | 0 | 1 | 294 |
| 5 | Derrick HenryBaltimore Ravens·#22 | 17 | 156 | 909 | 5.83 | 0 | 559 | 40 | 0 | 8 | 6 | 69 | 0 | 75.0% | 8.62 | 11.50 | 72 | 0 | 0 | 0 | 3 | 272 |
| 6 | James CookBuffalo Bills·#4 | 17 | 153 | 868 | 5.67 | 1 | 543 | 35 | 0 | 26 | 22 | 195 | 0 | 84.6% | 7.50 | 8.86 | 180 | 0 | 0 | 0 | 2 | 310 |
| 7 | Tony PollardTennessee Titans·#20 | 17 | 149 | 679 | 4.56 | 1 | 428 | 25 | 0 | 28 | 23 | 165 | 0 | 82.1% | 5.89 | 7.17 | 147 | 0 | 0 | 0 | 6 | 379 |
| 8 | Breece HallNew York Jets·#20 | 16 | 148 | 691 | 4.67 | 1 | 310 | 34 | 0 | 26 | 22 | 203 | 0 | 84.6% | 7.81 | 9.23 | 177 | 0 | 0 | 0 | 1 | 355 |
| 9 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 145 | 857 | 5.91 | 2 | 561 | 36 | 0 | 34 | 29 | 215 | 0 | 85.3% | 6.32 | 7.41 | 251 | 0 | 0 | 0 | 3 | 419 |
| 10 | De'Von AchaneMiami Dolphins·#28 | 16 | 131 | 669 | 5.11 | 1 | 406 | 26 | 0 | 47 | 38 | 246 | 0 | 80.8% | 5.23 | 6.47 | 294 | 0 | 0 | 0 | 3 | 369 |
| 11 | Rico DowdleCarolina Panthers·#5 | 17 | 129 | 652 | 5.05 | 0 | 435 | 30 | 0 | 28 | 21 | 158 | 0 | 75.0% | 5.64 | 7.52 | 213 | 0 | 0 | 0 | 3 | 292 |
| 12 | Chase BrownCincinnati Bengals·#30 | 17 | 126 | 615 | 4.88 | 0 | 421 | 23 | 0 | 45 | 37 | 255 | 0 | 82.2% | 5.67 | 6.89 | 270 | 0 | 0 | 0 | 3 | 362 |
| 13 | Javonte WilliamsDallas Cowboys·#33 | 16 | 126 | 610 | 4.84 | 0 | 387 | 24 | 0 | 30 | 22 | 82 | 0 | 73.3% | 2.73 | 3.73 | 122 | 0 | 0 | 0 | 2 | 380 |
| 14 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 125 | 600 | 4.80 | 0 | 382 | 31 | 0 | 26 | 17 | 125 | 0 | 65.4% | 4.81 | 7.35 | 82 | 0 | 0 | 0 | 1 | 358 |
| 15 | Travis EtienneJacksonville Jaguars·#1 | 17 | 125 | 547 | 4.38 | 0 | 381 | 21 | 0 | 28 | 16 | 114 | 0 | 57.1% | 4.07 | 7.12 | 146 | 0 | 0 | 0 | 0 | 324 |
| 16 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 119 | 531 | 4.46 | 0 | 364 | 22 | 0 | 69 | 56 | 575 | 0 | 81.2% | 8.33 | 10.27 | 464 | 0 | 0 | 0 | 3 | 410 |
| 17 | Jahmyr GibbsDetroit Lions·#0 | 17 | 116 | 739 | 6.37 | 2 | 373 | 25 | 0 | 48 | 37 | 320 | 0 | 77.1% | 6.67 | 8.65 | 335 | 0 | 0 | 0 | 1 | 351 |
| 18 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 111 | 477 | 4.30 | 0 | 383 | 25 | 0 | 25 | 22 | 182 | 0 | 88.0% | 7.28 | 8.27 | 242 | 0 | 0 | 0 | 1 | 244 |
| 19 | D'Andre SwiftChicago Bears·#4 | 16 | 105 | 567 | 5.40 | 0 | 271 | 25 | 0 | 29 | 19 | 183 | 1 | 65.5% | 6.31 | 9.63 | 188 | 0 | 0 | 0 | 2 | 286 |
| 20 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 103 | 628 | 6.10 | 1 | 280 | 30 | 0 | 21 | 21 | 206 | 0 | 100.0% | 9.81 | 9.81 | 251 | 0 | 0 | 0 | 3 | 233 |
| 21 | Josh JacobsGreen Bay Packers·#8 | 15 | 98 | 393 | 4.01 | 0 | 276 | 20 | 0 | 27 | 21 | 147 | 0 | 77.8% | 5.44 | 7.00 | 165 | 0 | 0 | 0 | 2 | 257 |
| 22 | Jordan MasonMinnesota Vikings·#27 | 15 | 96 | 477 | 4.97 | 0 | 280 | 25 | 0 | 12 | 10 | 39 | 0 | 83.3% | 3.25 | 3.90 | 80 | 0 | 0 | 0 | 1 | 215 |
| 23 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 94 | 328 | 3.49 | 0 | 295 | 20 | 0 | 25 | 19 | 187 | 0 | 76.0% | 7.48 | 9.84 | 214 | 0 | 0 | 0 | 1 | 288 |
| 24 | TreVeyon HendersonNew England Patriots·#32 | 17 | 93 | 612 | 6.58 | 4 | 229 | 24 | 0 | 25 | 21 | 134 | 0 | 84.0% | 5.36 | 6.38 | 144 | 0 | 0 | 0 | 0 | 257 |
| 25 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 92 | 516 | 5.61 | 1 | 334 | 21 | 0 | 8 | 5 | 43 | 0 | 62.5% | 5.38 | 8.60 | 41 | 0 | 0 | 0 | 1 | 210 |
| 26 | Woody MarksHouston Texans·#27 | 16 | 91 | 297 | 3.26 | 0 | 182 | 13 | 0 | 17 | 12 | 146 | 0 | 70.6% | 8.59 | 12.17 | 148 | 0 | 0 | 0 | 0 | 259 |
| 27 | J.K. DobbinsDenver Broncos·#27 | 10 | 88 | 439 | 4.99 | 0 | 232 | 20 | 0 | 7 | 7 | 17 | 0 | 100.0% | 2.43 | 2.43 | 34 | 0 | 0 | 0 | 1 | 194 |
| 28 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 88 | 353 | 4.01 | 0 | 226 | 15 | 0 | 23 | 19 | 201 | 1 | 82.6% | 8.74 | 10.58 | 257 | 0 | 0 | 0 | 1 | 225 |
| 29 | Kareem HuntKansas City Chiefs·#29 | 17 | 80 | 362 | 4.53 | 0 | 220 | 21 | 0 | 12 | 10 | 78 | 0 | 83.3% | 6.50 | 7.80 | 89 | 0 | 0 | 0 | 0 | 249 |
| 30 | Aaron JonesMinnesota Vikings·#33 | 12 | 79 | 338 | 4.28 | 0 | 223 | 14 | 0 | 25 | 16 | 118 | 0 | 64.0% | 4.72 | 7.38 | 152 | 0 | 0 | 0 | 2 | 209 |
| 31 | Kimani VidalLos Angeles Chargers·#30 | 13 | 78 | 378 | 4.85 | 1 | 173 | 15 | 0 | 9 | 7 | 93 | 0 | 77.8% | 10.33 | 13.29 | 112 | 0 | 0 | 0 | 0 | 238 |
| 32 | RJ HarveyDenver Broncos·#12 | 17 | 76 | 268 | 3.53 | 0 | 260 | 14 | 0 | 34 | 27 | 202 | 0 | 79.4% | 5.94 | 7.48 | 232 | 0 | 0 | 0 | 0 | 232 |
| 33 | Kyle MonangaiChicago Bears·#25 | 17 | 75 | 453 | 6.04 | 0 | 252 | 23 | 0 | 13 | 8 | 115 | 0 | 61.5% | 8.85 | 14.38 | 114 | 0 | 0 | 0 | 0 | 212 |
| 34 | Alvin KamaraNew Orleans Saints·#41 | 11 | 74 | 277 | 3.74 | 0 | 188 | 10 | 0 | 17 | 15 | 130 | 0 | 88.2% | 7.65 | 8.67 | 127 | 0 | 0 | 0 | 3 | 218 |
| 35 | Chuba HubbardCarolina Panthers·#30 | 14 | 72 | 299 | 4.15 | 0 | 168 | 16 | 0 | 12 | 10 | 62 | 0 | 83.3% | 5.17 | 6.20 | 75 | 0 | 0 | 0 | 2 | 192 |
| 36 | Nick ChubbHouston Texans·#21 | 15 | 70 | 280 | 4.00 | 0 | 214 | 12 | 0 | 11 | 7 | 37 | 0 | 63.6% | 3.36 | 5.29 | 43 | 0 | 0 | 0 | 0 | 181 |
| 37 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 70 | 352 | 5.03 | 0 | 170 | 19 | 0 | 24 | 20 | 116 | 0 | 83.3% | 4.83 | 5.80 | 147 | 0 | 0 | 0 | 1 | 258 |
| 38 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 69 | 313 | 4.54 | 0 | 237 | 16 | 0 | 12 | 10 | 97 | 0 | 83.3% | 8.08 | 9.70 | 73 | 0 | 0 | 0 | 3 | 216 |
| 39 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 67 | 363 | 5.42 | 1 | 215 | 18 | 0 | 22 | 21 | 102 | 0 | 95.5% | 4.64 | 4.86 | 134 | 0 | 0 | 0 | 0 | 197 |
| 40 | Rhamondre StevensonNew England Patriots·#38 | 14 | 66 | 321 | 4.86 | 0 | 232 | 12 | 0 | 20 | 18 | 242 | 0 | 90.0% | 12.10 | 13.44 | 197 | 0 | 0 | 0 | 1 | 247 |
| 41 | Isiah PachecoKansas City Chiefs·#10 | 13 | 65 | 273 | 4.20 | 0 | 182 | 18 | 0 | 18 | 14 | 81 | 0 | 77.8% | 4.50 | 5.79 | 99 | 0 | 0 | 0 | 0 | 205 |
| 42 | David MontgomeryDetroit Lions·#5 | 17 | 61 | 273 | 4.48 | 0 | 196 | 9 | 0 | 15 | 12 | 93 | 0 | 80.0% | 6.20 | 7.75 | 105 | 0 | 0 | 0 | 3 | 164 |
| 43 | Blake CorumLos Angeles Rams·#22 | 17 | 60 | 332 | 5.53 | 0 | 168 | 19 | 0 | 11 | 7 | 42 | 0 | 63.6% | 3.82 | 6.00 | 36 | 0 | 0 | 0 | 0 | 141 |
| 44 | Cam SkatteboNew York Giants·#44 | 8 | 56 | 249 | 4.45 | 0 | 183 | 13 | 0 | 16 | 11 | 98 | 0 | 68.8% | 6.12 | 8.91 | 105 | 0 | 0 | 0 | 0 | 142 |
| 45 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 56 | 199 | 3.55 | 0 | 126 | 11 | 0 | 7 | 5 | 50 | 0 | 71.4% | 7.14 | 10.00 | 62 | 0 | 0 | 0 | 1 | 117 |
| 46 | Emanuel WilsonGreen Bay Packers·#23 | 15 | 54 | 214 | 3.96 | 0 | 209 | 12 | 0 | 11 | 11 | 93 | 0 | 100.0% | 8.45 | 8.45 | 110 | 0 | 0 | 0 | 0 | 132 |
| 47 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 51 | 350 | 6.86 | 0 | 200 | 16 | 0 | 38 | 35 | 192 | 0 | 92.1% | 5.05 | 5.49 | 214 | 0 | 0 | 0 | 1 | 240 |
| 48 | Michael CarterArizona Cardinals·#22 | 13 | 50 | 199 | 3.98 | 0 | 153 | 9 | 0 | 27 | 22 | 174 | 0 | 81.5% | 6.44 | 7.91 | 170 | 0 | 0 | 0 | 0 | 183 |
| 49 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 49 | 266 | 5.43 | 0 | 185 | 12 | 0 | 2 | 2 | 12 | 0 | 100.0% | 6.00 | 6.00 | 9 | 0 | 0 | 0 | 1 | 102 |
| 50 | Devin SingletaryNew York Giants·#26 | 16 | 48 | 147 | 3.06 | 0 | 117 | 5 | 0 | 10 | 9 | 81 | 0 | 90.0% | 8.10 | 9.00 | 102 | 0 | 0 | 0 | 0 | 115 |