| 1 | Jonathan TaylorIndianapolis Colts·#28 | 16 | 38 | 188 | 4.95 | 5 | 129 | 25 | 8 | 1 | 1 | 1 | 0 | 100.0% | 1.00 | 1.00 | 2 | 0 | 0 | 0 | 1 | 51 |
| 2 | Jahmyr GibbsDetroit Lions·#0 | 14 | 21 | 172 | 8.19 | 3 | 115 | 17 | 3 | 5 | 4 | 23 | 1 | 80.0% | 4.60 | 5.75 | 16 | 1 | 1 | 1 | 0 | 35 |
| 3 | James CookBuffalo Bills·#4 | 16 | 25 | 156 | 6.24 | 5 | 107 | 19 | 5 | 1 | 1 | 23 | 0 | 100.0% | 23.00 | 23.00 | 23 | 0 | 0 | 0 | 1 | 41 |
| 4 | Bijan RobinsonAtlanta Falcons·#7 | 14 | 28 | 109 | 3.89 | 1 | 78 | 21 | 2 | 4 | 3 | 30 | 1 | 75.0% | 7.50 | 10.00 | 45 | 2 | 2 | 1 | 0 | 40 |
| 5 | Kyren WilliamsLos Angeles Rams·#23 | 16 | 27 | 124 | 4.59 | 1 | 75 | 18 | 2 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 50 |
| 6 | Javonte WilliamsDallas Cowboys·#33 | 15 | 26 | 86 | 3.31 | 3 | 70 | 15 | 3 | 6 | 3 | 10 | 1 | 50.0% | 1.67 | 3.33 | 9 | 2 | 1 | 1 | 1 | 47 |
| 7 | Christian McCaffreySan Francisco 49ers·#23 | 14 | 33 | 123 | 3.73 | 2 | 70 | 17 | 5 | 4 | 4 | 16 | 2 | 100.0% | 4.00 | 4.00 | 13 | 2 | 2 | 2 | 0 | 52 |
| 8 | Travis EtienneJacksonville Jaguars·#1 | 15 | 25 | 98 | 3.92 | 1 | 61 | 14 | 4 | 2 | 1 | 11 | 1 | 50.0% | 5.50 | 11.00 | 15 | 1 | 1 | 1 | 0 | 41 |
| 9 | Jaylen WarrenPittsburgh Steelers·#30 | 14 | 28 | 104 | 3.71 | 1 | 60 | 17 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 36 |
| 10 | Jacory Croskey-MerrittWashington Commanders·#22 | 13 | 23 | 110 | 4.78 | 2 | 57 | 17 | 2 | 1 | 1 | -1 | 0 | 100.0% | -1.00 | -1.00 | 6 | 0 | 0 | 0 | 1 | 28 |
| 11 | Chase BrownCincinnati Bengals·#30 | 16 | 20 | 79 | 3.95 | 2 | 54 | 13 | 4 | 3 | 2 | 21 | 0 | 66.7% | 7.00 | 10.50 | 32 | 0 | 0 | 0 | 0 | 38 |
| 12 | Derrick HenryBaltimore Ravens·#22 | 12 | 29 | 87 | 3.00 | 2 | 50 | 14 | 7 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 33 |
| 13 | Quinshon JudkinsCleveland Browns·#10 | 12 | 19 | 81 | 4.26 | 1 | 48 | 14 | 2 | 1 | 1 | 13 | 0 | 100.0% | 13.00 | 13.00 | 16 | 0 | 0 | 0 | 0 | 26 |
| 14 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 21 | 69 | 3.29 | 0 | 44 | 12 | 1 | 2 | 1 | 5 | 0 | 50.0% | 2.50 | 5.00 | 9 | 1 | 0 | 0 | 0 | 44 |
| 15 | Ashton JeantyLas Vegas Raiders·#2 | 13 | 17 | 66 | 3.88 | 0 | 43 | 7 | 2 | 4 | 3 | 13 | 0 | 75.0% | 3.25 | 4.33 | 14 | 1 | 0 | 0 | 0 | 33 |
| 16 | Josh JacobsGreen Bay Packers·#8 | 14 | 22 | 70 | 3.18 | 4 | 40 | 13 | 8 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 31 |
| 17 | Isiah PachecoKansas City Chiefs·#10 | 11 | 17 | 71 | 4.18 | 1 | 38 | 14 | 0 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 7 | 0 | 0 | 0 | 0 | 29 |
| 18 | De'Von AchaneMiami Dolphins·#28 | 13 | 18 | 55 | 3.06 | 0 | 38 | 12 | 0 | 2 | 2 | 7 | 1 | 100.0% | 3.50 | 3.50 | 4 | 1 | 1 | 1 | 0 | 32 |
| 19 | D'Andre SwiftChicago Bears·#4 | 13 | 14 | 45 | 3.21 | 0 | 36 | 8 | 2 | 2 | 1 | 8 | 0 | 50.0% | 4.00 | 8.00 | 13 | 0 | 0 | 0 | 0 | 33 |
| 20 | Kenneth Walker IIISeattle Seahawks·#9 | 15 | 21 | 81 | 3.86 | 2 | 36 | 13 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 28 |
| 21 | Jordan MasonMinnesota Vikings·#27 | 11 | 15 | 73 | 4.87 | 3 | 35 | 11 | 2 | 1 | 1 | 13 | 0 | 100.0% | 13.00 | 13.00 | 13 | 0 | 0 | 0 | 0 | 27 |
| 22 | Rico DowdleCarolina Panthers·#5 | 14 | 15 | 54 | 3.60 | 1 | 32 | 11 | 2 | 2 | 2 | 12 | 0 | 100.0% | 6.00 | 6.00 | 11 | 0 | 0 | 0 | 0 | 26 |
| 23 | J.K. DobbinsDenver Broncos·#27 | 10 | 22 | 78 | 3.55 | 1 | 30 | 11 | 2 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 33 |
| 24 | Kyle MonangaiChicago Bears·#25 | 14 | 15 | 46 | 3.07 | 1 | 29 | 10 | 4 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 29 |
| 25 | Breece HallNew York Jets·#20 | 14 | 20 | 47 | 2.35 | 0 | 28 | 13 | 1 | 2 | 2 | 13 | 0 | 100.0% | 6.50 | 6.50 | 5 | 0 | 0 | 0 | 0 | 28 |
| 26 | Kareem HuntKansas City Chiefs·#29 | 10 | 16 | 45 | 2.81 | 3 | 24 | 11 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 25 |
| 27 | Woody MarksHouston Texans·#27 | 12 | 18 | 46 | 2.56 | 1 | 24 | 9 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 27 |
| 28 | RJ HarveyDenver Broncos·#12 | 12 | 11 | 35 | 3.18 | 1 | 17 | 9 | 1 | 2 | 1 | 2 | 1 | 50.0% | 1.00 | 2.00 | 1 | 1 | 1 | 1 | 0 | 26 |