| 1 | Trayveon WilliamsCleveland Browns·#38 | 4 | 4 | 26 | 6.50 | 0 | 21 | 3 | 0 | 5 | 4 | -2 | 0 | 80.0% | -0.40 | -0.50 | 16 | 2 | 2 | 0 | 0 | 25 |
| 2 | De'Von AchaneMiami Dolphins·#28 | 16 | 107 | 681 | 6.36 | 7 | 411 | 31 | 5 | 37 | 29 | 235 | 4 | 78.4% | 6.35 | 8.10 | 251 | 11 | 7 | 3 | 0 | 275 |
| 3 | J.K. DobbinsDenver Broncos·#27 | 10 | 65 | 333 | 5.12 | 4 | 183 | 17 | 7 | 7 | 4 | 25 | 0 | 57.1% | 3.57 | 6.25 | 22 | 0 | 0 | 0 | 0 | 124 |
| 4 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 81 | 407 | 5.02 | 2 | 223 | 22 | 2 | 23 | 17 | 101 | 2 | 73.9% | 4.39 | 5.94 | 100 | 5 | 4 | 2 | 2 | 227 |
| 5 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 17 | 85 | 5.00 | 1 | 23 | 4 | 1 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 29 |
| 6 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 133 | 651 | 4.89 | 10 | 367 | 44 | 18 | 24 | 19 | 156 | 3 | 79.2% | 6.50 | 8.21 | 73 | 10 | 8 | 3 | 5 | 376 |
| 7 | Blake CorumLos Angeles Rams·#22 | 17 | 85 | 414 | 4.87 | 6 | 178 | 26 | 13 | 3 | 1 | -6 | 0 | 33.3% | -2.00 | -6.00 | 1 | 1 | 0 | 0 | 1 | 167 |
| 8 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 100 | 481 | 4.81 | 6 | 308 | 27 | 14 | 20 | 18 | 151 | 2 | 90.0% | 7.55 | 8.39 | 197 | 5 | 4 | 1 | 3 | 218 |
| 9 | James CookBuffalo Bills·#4 | 16 | 155 | 744 | 4.80 | 11 | 477 | 34 | 16 | 14 | 11 | 96 | 2 | 78.6% | 6.86 | 8.73 | 92 | 3 | 3 | 1 | 3 | 284 |
| 10 | Jeremy McNicholsWashington Commanders·#26 | 17 | 22 | 105 | 4.77 | 0 | 99 | 9 | 2 | 16 | 13 | 95 | 0 | 81.3% | 5.94 | 7.31 | 113 | 3 | 2 | 0 | 2 | 151 |
| 11 | Ray DavisBuffalo Bills·#22 | 16 | 30 | 140 | 4.67 | 0 | 85 | 9 | 2 | 11 | 7 | 39 | 2 | 63.6% | 3.55 | 5.57 | 54 | 5 | 4 | 2 | 0 | 78 |
| 12 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 17 | 11 | 51 | 4.64 | 0 | 29 | 4 | 1 | 6 | 5 | 23 | 0 | 83.3% | 3.83 | 4.60 | 29 | 2 | 2 | 0 | 1 | 111 |
| 13 | Javonte WilliamsDallas Cowboys·#33 | 16 | 122 | 565 | 4.63 | 11 | 355 | 42 | 20 | 21 | 13 | 55 | 2 | 61.9% | 2.62 | 4.23 | 84 | 12 | 8 | 2 | 2 | 333 |
| 14 | Kendre MillerNew Orleans Saints·#5 | 7 | 24 | 110 | 4.58 | 1 | 92 | 7 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 51 |
| 15 | Malik DavisDallas Cowboys·#43 | 9 | 26 | 118 | 4.54 | 2 | 41 | 7 | 2 | 5 | 2 | 16 | 0 | 40.0% | 3.20 | 8.00 | 6 | 0 | 0 | 0 | 0 | 65 |
| 16 | Derrick HenryBaltimore Ravens·#22 | 17 | 151 | 686 | 4.54 | 16 | 357 | 40 | 27 | 12 | 9 | 81 | 0 | 75.0% | 6.75 | 9.00 | 63 | 2 | 2 | 0 | 1 | 256 |
| 17 | David MontgomeryDetroit Lions·#5 | 17 | 98 | 445 | 4.54 | 8 | 238 | 33 | 17 | 14 | 12 | 99 | 0 | 85.7% | 7.07 | 8.25 | 94 | 2 | 1 | 0 | 2 | 224 |
| 18 | Trey BensonArizona Cardinals·#33 | 4 | 19 | 86 | 4.53 | 0 | 70 | 2 | 1 | 11 | 8 | 39 | 0 | 72.7% | 3.55 | 4.88 | 37 | 2 | 1 | 0 | 0 | 59 |
| 19 | Tank BigsbyPhiladelphia Eagles·#37 | 10 | 32 | 144 | 4.50 | 1 | 124 | 9 | 6 | 2 | 2 | 33 | 0 | 100.0% | 16.50 | 16.50 | 33 | 1 | 1 | 0 | 0 | 65 |
| 20 | Audric EstiméNew Orleans Saints·#30 | 5 | 17 | 76 | 4.47 | 1 | 58 | 4 | 3 | 3 | 2 | 16 | 0 | 66.7% | 5.33 | 8.00 | 19 | 0 | 0 | 0 | 1 | 72 |
| 21 | Jordan MasonMinnesota Vikings·#27 | 16 | 63 | 281 | 4.46 | 6 | 163 | 20 | 7 | 4 | 4 | 12 | 0 | 100.0% | 3.00 | 3.00 | 22 | 1 | 1 | 0 | 2 | 172 |
| 22 | D'Andre SwiftChicago Bears·#4 | 16 | 117 | 520 | 4.44 | 9 | 341 | 38 | 14 | 19 | 15 | 107 | 0 | 79.0% | 5.63 | 7.13 | 160 | 1 | 1 | 0 | 2 | 303 |
| 23 | Rhamondre StevensonNew England Patriots·#38 | 14 | 65 | 284 | 4.37 | 7 | 170 | 17 | 12 | 18 | 14 | 105 | 2 | 77.8% | 5.83 | 7.50 | 66 | 6 | 5 | 1 | 3 | 234 |
| 24 | Nick ChubbHouston Texans·#21 | 14 | 52 | 226 | 4.35 | 3 | 127 | 8 | 6 | 9 | 6 | 30 | 0 | 66.7% | 3.33 | 5.00 | 20 | 2 | 1 | 0 | 1 | 116 |
| 25 | Tony PollardTennessee Titans·#20 | 17 | 92 | 400 | 4.35 | 4 | 220 | 23 | 4 | 13 | 10 | 41 | 0 | 76.9% | 3.15 | 4.10 | 56 | 1 | 1 | 0 | 3 | 236 |
| 26 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 47 | 203 | 4.32 | 7 | 98 | 15 | 11 | 6 | 4 | 24 | 1 | 66.7% | 4.00 | 6.00 | 34 | 3 | 1 | 0 | 0 | 85 |
| 27 | Tyjae SpearsTennessee Titans·#2 | 13 | 42 | 180 | 4.29 | 2 | 100 | 12 | 2 | 19 | 18 | 90 | 0 | 94.7% | 4.74 | 5.00 | 112 | 7 | 7 | 0 | 0 | 155 |
| 28 | Brian RobinsonSan Francisco 49ers·#3 | 16 | 68 | 289 | 4.25 | 2 | 169 | 16 | 2 | 9 | 5 | 13 | 0 | 55.6% | 1.44 | 2.60 | 23 | 4 | 3 | 0 | 0 | 120 |
| 29 | Ty JohnsonBuffalo Bills·#26 | 17 | 39 | 164 | 4.21 | 3 | 105 | 12 | 6 | 18 | 12 | 108 | 1 | 66.7% | 6.00 | 9.00 | 110 | 4 | 2 | 1 | 0 | 160 |
| 30 | Devin NealNew Orleans Saints·#24 | 9 | 32 | 134 | 4.19 | 2 | 66 | 10 | 2 | 12 | 11 | 68 | 0 | 91.7% | 5.67 | 6.18 | 85 | 1 | 1 | 0 | 0 | 117 |
| 31 | Travis EtienneJacksonville Jaguars·#1 | 17 | 134 | 562 | 4.19 | 7 | 358 | 30 | 12 | 24 | 20 | 178 | 6 | 83.3% | 7.42 | 8.90 | 193 | 10 | 8 | 5 | 1 | 315 |
| 32 | Keaton MitchellBaltimore Ravens·#34 | 13 | 33 | 138 | 4.18 | 1 | 66 | 7 | 0 | 6 | 4 | 24 | 0 | 66.7% | 4.00 | 6.00 | 40 | 0 | 0 | 0 | 1 | 62 |
| 33 | Jaydon BlueDallas Cowboys·#23 | 5 | 17 | 70 | 4.12 | 1 | 27 | 4 | 1 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 10 | 0 | 0 | 0 | 0 | 33 |
| 34 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 176 | 723 | 4.11 | 16 | 386 | 49 | 24 | 22 | 17 | 163 | 2 | 77.3% | 7.41 | 9.59 | 183 | 5 | 4 | 2 | 2 | 404 |
| 35 | Brashard SmithKansas City Chiefs·#24 | 17 | 21 | 86 | 4.10 | 0 | 76 | 4 | 1 | 22 | 17 | 123 | 1 | 77.3% | 5.59 | 7.24 | 147 | 7 | 6 | 1 | 1 | 88 |
| 36 | Emari DemercadoArizona Cardinals·#31 | 11 | 23 | 94 | 4.09 | 0 | 44 | 5 | 0 | 12 | 7 | 34 | 1 | 58.3% | 2.83 | 4.86 | 34 | 4 | 3 | 1 | 0 | 83 |
| 37 | Devin SingletaryNew York Giants·#26 | 15 | 71 | 290 | 4.08 | 5 | 157 | 23 | 10 | 9 | 9 | 70 | 0 | 100.0% | 7.78 | 7.78 | 60 | 2 | 2 | 0 | 1 | 164 |
| 38 | Isaiah DavisNew York Jets·#32 | 16 | 29 | 117 | 4.03 | 1 | 67 | 6 | 0 | 12 | 8 | 73 | 0 | 66.7% | 6.08 | 9.12 | 52 | 2 | 1 | 0 | 1 | 128 |
| 39 | Julius ChestnutTennessee Titans·#36 | 8 | 8 | 32 | 4.00 | 0 | 13 | 3 | 2 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 25 |
| 40 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 71 | 282 | 3.97 | 3 | 188 | 20 | 4 | 7 | 4 | 8 | 0 | 57.1% | 1.14 | 2.00 | 23 | 3 | 1 | 0 | 0 | 168 |
| 41 | Aaron JonesMinnesota Vikings·#33 | 12 | 53 | 210 | 3.96 | 2 | 130 | 15 | 3 | 16 | 12 | 81 | 1 | 75.0% | 5.06 | 6.75 | 75 | 5 | 3 | 0 | 1 | 149 |
| 42 | Jaret PattersonLos Angeles Chargers·#32 | 5 | 22 | 87 | 3.95 | 1 | 65 | 4 | 2 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 3 | 0 | 0 | 0 | 0 | 48 |
| 43 | Rico DowdleCarolina Panthers·#5 | 17 | 106 | 419 | 3.95 | 6 | 211 | 24 | 9 | 21 | 18 | 139 | 1 | 85.7% | 6.62 | 7.72 | 137 | 5 | 3 | 0 | 3 | 247 |
| 44 | Josh JacobsGreen Bay Packers·#8 | 15 | 136 | 536 | 3.94 | 13 | 382 | 36 | 20 | 17 | 15 | 135 | 1 | 88.2% | 7.94 | 9.00 | 139 | 6 | 5 | 1 | 3 | 255 |
| 45 | Woody MarksHouston Texans·#27 | 16 | 105 | 406 | 3.87 | 2 | 293 | 28 | 9 | 19 | 12 | 62 | 3 | 63.2% | 3.26 | 5.17 | 75 | 8 | 5 | 3 | 0 | 269 |
| 46 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 125 | 480 | 3.84 | 5 | 373 | 24 | 11 | 47 | 36 | 323 | 4 | 76.6% | 6.87 | 8.97 | 365 | 13 | 9 | 3 | 3 | 349 |
| 47 | RJ HarveyDenver Broncos·#12 | 17 | 71 | 272 | 3.83 | 7 | 135 | 16 | 10 | 24 | 20 | 154 | 5 | 83.3% | 6.42 | 7.70 | 128 | 11 | 9 | 4 | 1 | 216 |
| 48 | Jahmyr GibbsDetroit Lions·#0 | 17 | 127 | 484 | 3.81 | 11 | 313 | 32 | 10 | 46 | 40 | 293 | 5 | 87.0% | 6.37 | 7.32 | 277 | 15 | 12 | 5 | 2 | 338 |
| 49 | Samaje PerineCincinnati Bengals·#34 | 15 | 48 | 183 | 3.81 | 3 | 130 | 17 | 4 | 11 | 10 | 38 | 0 | 90.9% | 3.45 | 3.80 | 44 | 1 | 1 | 0 | 1 | 150 |
| 50 | Chase BrownCincinnati Bengals·#30 | 17 | 106 | 404 | 3.81 | 6 | 293 | 29 | 13 | 43 | 32 | 184 | 5 | 74.4% | 4.28 | 5.75 | 157 | 11 | 8 | 5 | 1 | 323 |