| 1 | Adam TrautmanDenver Broncos·#82 | 17 | 18 | 16 | 153 | 0 | 88.9% | 8.50 | 9.56 | 78 | 81 | 0.5 | 0 | 0 | 0 | 14 | 112 | 13 | 2 | 7 | 0 | 178 |
| 2 | Andrew OgletreeIndianapolis Colts·#85 | 15 | 4 | 3 | 23 | 0 | 75.0% | 5.75 | 7.67 | 9 | 14 | 0.5 | 1 | 1 | 0 | 8 | 44 | 3 | 3 | 1 | 0 | 67 |
| 3 | Cade StoverHouston Texans·#87 | 9 | 10 | 8 | 48 | 0 | 80.0% | 4.80 | 6.00 | 26 | 22 | 0.5 | 2 | 2 | 0 | 8 | 38 | 8 | 1 | 1 | 0 | 51 |
| 4 | Brenton StrangeJacksonville Jaguars·#85 | 12 | 36 | 27 | 345 | 1 | 75.0% | 9.58 | 12.78 | 153 | 234 | 1.2 | 4 | 2 | 0 | 25 | 122 | 26 | 4 | 15 | 0 | 199 |
| 5 | Charlie KolarBaltimore Ravens·#88 | 17 | 11 | 7 | 114 | 1 | 63.6% | 10.36 | 16.29 | 48 | 87 | 1.1 | 2 | 1 | 1 | 9 | 50 | 8 | 6 | 6 | 0 | 82 |
| 6 | Durham SmytheChicago Bears·#81 | 16 | 5 | 4 | 25 | 0 | 80.0% | 5.00 | 6.25 | 15 | 15 | 0.2 | 0 | 0 | 0 | 6 | 55 | 3 | 4 | 1 | 0 | 77 |
| 7 | Cole KmetChicago Bears·#85 | 16 | 32 | 22 | 246 | 1 | 68.8% | 7.69 | 11.18 | 99 | 205 | 1.1 | 4 | 3 | 1 | 20 | 153 | 24 | 11 | 11 | 0 | 254 |
| 8 | Chris ManhertzNew York Giants·#85 | 12 | 2 | 1 | 7 | 0 | 50.0% | 3.50 | 7.00 | 6 | 1 | 0.3 | 1 | 0 | 0 | 5 | 23 | 2 | 2 | 0 | 0 | 37 |
| 9 | Darren WallerMiami Dolphins·#83 | 9 | 14 | 8 | 102 | 1 | 57.1% | 7.29 | 12.75 | 29 | 144 | 1.8 | 2 | 1 | 1 | 8 | 49 | 12 | 2 | 4 | 0 | 88 |
| 10 | Harrison BryantHouston Texans·#88 | 11 | 2 | 1 | 2 | 0 | 50.0% | 1.00 | 2.00 | 0 | 2 | 0.5 | 0 | 0 | 0 | 3 | 15 | 1 | 1 | 0 | 0 | 33 |
| 11 | Ian ThomasLas Vegas Raiders·#80 | 14 | 10 | 10 | 95 | 0 | 100.0% | 9.50 | 9.50 | 54 | 41 | 0.4 | 0 | 0 | 0 | 15 | 58 | 7 | 2 | 3 | 0 | 101 |
| 12 | Hunter LongJacksonville Jaguars·#84 | 8 | 9 | 6 | 40 | 0 | 66.7% | 4.44 | 6.67 | 19 | 29 | 0.3 | 0 | 0 | 0 | 10 | 56 | 4 | 1 | 0 | 0 | 86 |
| 13 | Foster MoreauNew Orleans Saints·#87 | 11 | 8 | 6 | 49 | 0 | 75.0% | 6.12 | 8.17 | 40 | 11 | 0.2 | 0 | 0 | 0 | 7 | 46 | 5 | 0 | 1 | 0 | 68 |
| 14 | Grant CalcaterraPhiladelphia Eagles·#81 | 15 | 9 | 6 | 46 | 0 | 66.7% | 5.11 | 7.67 | 23 | 57 | 0.7 | 1 | 1 | 0 | 10 | 52 | 8 | 3 | 1 | 0 | 86 |
| 15 | Eric SaubertSeattle Seahawks·#81 | 10 | 4 | 1 | 9 | 0 | 25.0% | 2.25 | 9.00 | 5 | 17 | 0.3 | 1 | 0 | 0 | 4 | 43 | 3 | 4 | 0 | 0 | 57 |
| 16 | Evan EngramDenver Broncos·#1 | 16 | 55 | 41 | 391 | 1 | 74.5% | 7.11 | 9.54 | 273 | 142 | 0.9 | 7 | 5 | 1 | 25 | 162 | 24 | 5 | 11 | 0 | 218 |
| 17 | Jack StollNew Orleans Saints·#88 | 14 | 7 | 5 | 42 | 1 | 71.4% | 6.00 | 8.40 | 17 | 23 | 0.3 | 1 | 1 | 1 | 3 | 26 | 4 | 1 | 1 | 0 | 44 |
| 18 | Jackson HawesBuffalo Bills·#85 | 17 | 8 | 6 | 111 | 1 | 75.0% | 13.88 | 18.50 | 47 | 80 | 1.1 | 0 | 0 | 0 | 5 | 48 | 4 | 1 | 5 | 0 | 70 |
| 19 | John FitzPatrickGreen Bay Packers·#86 | 15 | 9 | 7 | 50 | 0 | 77.8% | 5.56 | 7.14 | 43 | 10 | 0.1 | 1 | 0 | 0 | 14 | 56 | 4 | 3 | 2 | 0 | 90 |
| 20 | Kylen GransonPhiladelphia Eagles·#83 | 14 | 5 | 5 | 31 | 0 | 100.0% | 6.20 | 6.20 | 10 | 21 | 0.3 | 1 | 1 | 0 | 6 | 33 | 3 | 0 | 1 | 0 | 60 |
| 21 | Julian HillMiami Dolphins·#89 | 14 | 13 | 10 | 104 | 0 | 76.9% | 8.00 | 10.40 | 77 | 38 | 0.3 | 2 | 1 | 0 | 7 | 74 | 8 | 2 | 4 | 0 | 125 |
| 22 | Josiah DeguaraArizona Cardinals·#45 | 10 | 3 | 1 | 6 | 0 | 33.3% | 2.00 | 6.00 | 1 | 7 | 0.4 | 0 | 0 | 0 | 6 | 17 | 3 | 0 | 0 | 0 | 33 |
| 23 | Josh WhyleGreen Bay Packers·#81 | 8 | 4 | 3 | 13 | 0 | 75.0% | 3.25 | 4.33 | 12 | 9 | 0.2 | 0 | 0 | 0 | 4 | 33 | 1 | 1 | 0 | 0 | 55 |
| 24 | Josh OliverMinnesota Vikings·#84 | 14 | 7 | 6 | 88 | 2 | 85.7% | 12.57 | 14.67 | 38 | 54 | 0.7 | 2 | 2 | 1 | 12 | 48 | 6 | 3 | 3 | 0 | 78 |
| 25 | Gunnar HelmTennessee Titans·#84 | 16 | 36 | 32 | 262 | 1 | 88.9% | 7.28 | 8.19 | 134 | 145 | 1.0 | 3 | 2 | 0 | 17 | 96 | 20 | 4 | 8 | 0 | 156 |
| 26 | Tucker FiskLos Angeles Chargers·#42 | 10 | 1 | 1 | 7 | 0 | 100.0% | 7.00 | 7.00 | 9 | -2 | -0.1 | 0 | 0 | 0 | 3 | 23 | 0 | 0 | 0 | 0 | 43 |
| 27 | Shane ZylstraDetroit Lions·#84 | 5 | 3 | 2 | 16 | 0 | 66.7% | 5.33 | 8.00 | 0 | 32 | 0.5 | 0 | 0 | 0 | 2 | 43 | 3 | 0 | 0 | 0 | 65 |
| 28 | Payne DurhamTampa Bay Buccaneers·#87 | 15 | 3 | 1 | 11 | 0 | 33.3% | 3.67 | 11.00 | 11 | 11 | 0.2 | 1 | 0 | 0 | 8 | 38 | 3 | 7 | 1 | 0 | 64 |
| 29 | Mo Alie-CoxIndianapolis Colts·#81 | 17 | 12 | 8 | 75 | 0 | 66.7% | 6.25 | 9.38 | 55 | 26 | 0.3 | 3 | 2 | 0 | 17 | 90 | 6 | 7 | 2 | 0 | 133 |
| 30 | Nate AdkinsDenver Broncos·#45 | 9 | 6 | 4 | 26 | 1 | 66.7% | 4.33 | 6.50 | 10 | 15 | 0.5 | 1 | 1 | 1 | 3 | 26 | 5 | 0 | 1 | 0 | 39 |
| 31 | Noah GrayKansas City Chiefs·#83 | 16 | 20 | 11 | 110 | 0 | 55.0% | 5.50 | 10.00 | 59 | 124 | 0.8 | 0 | 0 | 0 | 6 | 93 | 17 | 1 | 4 | 0 | 174 |
| 32 | Michael MayerLas Vegas Raiders·#87 | 12 | 28 | 22 | 249 | 0 | 78.6% | 8.89 | 11.32 | 158 | 128 | 0.9 | 1 | 1 | 0 | 13 | 97 | 16 | 2 | 10 | 0 | 149 |
| 33 | Will DisslyLos Angeles Chargers·#89 | 9 | 14 | 9 | 89 | 0 | 64.3% | 6.36 | 9.89 | 57 | 73 | 1.1 | 1 | 1 | 0 | 11 | 39 | 10 | 0 | 4 | 0 | 64 |
| 34 | Sam LaPortaDetroit Lions·#87 | 9 | 22 | 20 | 239 | 0 | 90.9% | 10.86 | 11.95 | 150 | 98 | 0.7 | 1 | 0 | 0 | 13 | 102 | 15 | 2 | 8 | 0 | 141 |
| 35 | Robert TonyanKansas City Chiefs·#85 | 13 | 1 | 1 | 1 | 0 | 100.0% | 1.00 | 1.00 | 0 | 1 | 0.0 | 0 | 0 | 0 | 1 | 12 | 0 | 0 | 0 | 0 | 29 |
| 36 | Stone SmarttNew York Jets·#84 | 6 | 4 | 3 | 13 | 0 | 75.0% | 3.25 | 4.33 | 4 | 9 | 0.7 | 0 | 0 | 0 | 1 | 19 | 3 | 0 | 0 | 0 | 36 |
| 37 | Tanner ConnerMiami Dolphins·#48 | 9 | 10 | 7 | 49 | 0 | 70.0% | 4.90 | 7.00 | 25 | 68 | 1.0 | 2 | 1 | 0 | 4 | 44 | 7 | 4 | 1 | 0 | 68 |
| 38 | Tanner HudsonCincinnati Bengals·#87 | 11 | 11 | 8 | 57 | 0 | 72.7% | 5.18 | 7.12 | 29 | 56 | 1.0 | 2 | 1 | 0 | 8 | 34 | 9 | 1 | 1 | 0 | 56 |
| 39 | Tyler HigbeeLos Angeles Rams·#89 | 10 | 14 | 9 | 113 | 1 | 64.3% | 8.07 | 12.56 | 66 | -17 | -0.2 | 3 | 2 | 0 | 11 | 68 | 7 | 3 | 4 | 0 | 103 |
| 40 | Travis KelceKansas City Chiefs·#87 | 17 | 62 | 42 | 507 | 1 | 67.7% | 8.18 | 12.07 | 273 | 392 | 1.3 | 3 | 3 | 0 | 19 | 183 | 49 | 2 | 21 | 0 | 338 |
| 41 | Tyler ConklinLos Angeles Chargers·#83 | 8 | 6 | 6 | 80 | 0 | 100.0% | 13.33 | 13.33 | 42 | 38 | 0.7 | 0 | 0 | 0 | 11 | 33 | 5 | 0 | 2 | 0 | 52 |
| 42 | Dalton KincaidBuffalo Bills·#86 | 12 | 23 | 19 | 325 | 2 | 82.6% | 14.13 | 17.11 | 127 | 243 | 2.5 | 2 | 1 | 1 | 16 | 70 | 18 | 3 | 14 | 1 | 107 |
| 43 | Mitchell EvansCarolina Panthers·#84 | 17 | 14 | 11 | 114 | 0 | 78.6% | 8.14 | 10.36 | 84 | 43 | 0.6 | 1 | 0 | 0 | 4 | 49 | 7 | 0 | 4 | 1 | 74 |
| 44 | Mike GesickiCincinnati Bengals·#88 | 13 | 19 | 14 | 154 | 0 | 73.7% | 8.11 | 11.00 | 50 | 131 | 1.2 | 1 | 0 | 0 | 24 | 86 | 16 | 5 | 7 | 1 | 135 |
| 45 | Terrance FergusonLos Angeles Rams·#18 | 12 | 10 | 3 | 65 | 1 | 30.0% | 6.50 | 21.67 | 12 | 223 | 3.2 | 1 | 0 | 0 | 5 | 51 | 9 | 2 | 2 | 1 | 70 |
| 46 | Tucker KraftGreen Bay Packers·#85 | 8 | 20 | 16 | 213 | 2 | 80.0% | 10.65 | 13.31 | 175 | 72 | 0.6 | 5 | 3 | 2 | 7 | 89 | 16 | 2 | 8 | 1 | 128 |
| 47 | Mason TaylorNew York Jets·#85 | 13 | 41 | 27 | 253 | 0 | 65.8% | 6.17 | 9.37 | 87 | 248 | 1.1 | 3 | 3 | 0 | 29 | 131 | 32 | 5 | 10 | 1 | 237 |
| 48 | Luke SchoonmakerDallas Cowboys·#86 | 17 | 14 | 7 | 44 | 0 | 50.0% | 3.14 | 6.29 | 27 | 70 | 1.1 | 0 | 0 | 0 | 12 | 63 | 10 | 0 | 1 | 1 | 97 |
| 49 | Jake TongesSan Francisco 49ers·#88 | 12 | 26 | 18 | 163 | 1 | 69.2% | 6.27 | 9.06 | 102 | 102 | 0.7 | 0 | 0 | 0 | 17 | 106 | 14 | 2 | 7 | 1 | 146 |
| 50 | Johnny MundtJacksonville Jaguars·#86 | 15 | 13 | 7 | 86 | 0 | 53.9% | 6.62 | 12.29 | 61 | 47 | 0.4 | 1 | 0 | 0 | 14 | 75 | 9 | 2 | 4 | 1 | 100 |