| 1 | Trey McBrideArizona Cardinals·#85 | 17 | 103 | 79 | 808 | 3 | 76.7% | 7.84 | 10.23 | 387 | 643 | 1.6 | 11 | 7 | 3 | 54 | 259 | 73 | 11 | 30 | 4 | 434 |
| 2 | Tyler WarrenIndianapolis Colts·#84 | 17 | 66 | 48 | 520 | 2 | 72.7% | 7.88 | 10.83 | 312 | 341 | 1.1 | 8 | 5 | 2 | 40 | 208 | 52 | 12 | 19 | 4 | 317 |
| 3 | Colby ParkinsonLos Angeles Rams·#84 | 15 | 34 | 29 | 303 | 3 | 85.3% | 8.91 | 10.45 | 208 | 142 | 0.7 | 8 | 7 | 1 | 19 | 142 | 16 | 7 | 11 | 2 | 193 |
| 4 | Theo JohnsonNew York Giants·#84 | 15 | 45 | 28 | 354 | 2 | 62.2% | 7.87 | 12.64 | 131 | 373 | 1.4 | 7 | 2 | 1 | 27 | 178 | 31 | 7 | 13 | 3 | 290 |
| 5 | Evan EngramDenver Broncos·#1 | 16 | 55 | 41 | 391 | 1 | 74.5% | 7.11 | 9.54 | 273 | 142 | 0.9 | 7 | 5 | 1 | 25 | 162 | 24 | 5 | 11 | 0 | 218 |
| 6 | T.J. HockensonMinnesota Vikings·#87 | 15 | 39 | 32 | 298 | 0 | 82.0% | 7.64 | 9.31 | 152 | 189 | 0.8 | 6 | 4 | 0 | 28 | 146 | 22 | 8 | 11 | 2 | 247 |
| 7 | Juwan JohnsonNew Orleans Saints·#83 | 17 | 61 | 45 | 534 | 2 | 73.8% | 8.75 | 11.87 | 256 | 341 | 1.5 | 5 | 3 | 1 | 37 | 202 | 50 | 6 | 17 | 5 | 315 |
| 8 | Pat FreiermuthPittsburgh Steelers·#88 | 17 | 35 | 30 | 364 | 2 | 85.7% | 10.40 | 12.13 | 182 | 212 | 1.1 | 5 | 3 | 1 | 20 | 133 | 26 | 6 | 13 | 1 | 205 |
| 9 | Oronde Gadsden IILos Angeles Chargers·#86 | 15 | 33 | 25 | 363 | 1 | 75.8% | 11.00 | 14.52 | 102 | 328 | 1.7 | 5 | 2 | 1 | 24 | 125 | 28 | 2 | 12 | 2 | 213 |
| 10 | Brock BowersLas Vegas Raiders·#89 | 12 | 47 | 37 | 451 | 0 | 78.7% | 9.60 | 12.19 | 199 | 281 | 1.3 | 5 | 3 | 0 | 22 | 163 | 43 | 5 | 17 | 1 | 252 |
| 11 | Tucker KraftGreen Bay Packers·#85 | 8 | 20 | 16 | 213 | 2 | 80.0% | 10.65 | 13.31 | 175 | 72 | 0.6 | 5 | 3 | 2 | 7 | 89 | 16 | 2 | 8 | 1 | 128 |
| 12 | AJ BarnerSeattle Seahawks·#88 | 17 | 38 | 29 | 320 | 3 | 76.3% | 8.42 | 11.03 | 174 | 190 | 0.8 | 5 | 5 | 2 | 17 | 167 | 28 | 6 | 10 | 2 | 251 |
| 13 | Colston LovelandChicago Bears·#84 | 16 | 47 | 34 | 440 | 2 | 72.3% | 9.36 | 12.94 | 168 | 406 | 1.8 | 4 | 4 | 0 | 28 | 149 | 38 | 11 | 14 | 1 | 257 |
| 14 | Brenton StrangeJacksonville Jaguars·#85 | 12 | 36 | 27 | 345 | 1 | 75.0% | 9.58 | 12.78 | 153 | 234 | 1.2 | 4 | 2 | 0 | 25 | 122 | 26 | 4 | 15 | 0 | 199 |
| 15 | David NjokuCleveland Browns·#85 | 12 | 34 | 25 | 233 | 1 | 73.5% | 6.85 | 9.32 | 123 | 185 | 1.0 | 4 | 2 | 1 | 22 | 117 | 23 | 4 | 5 | 2 | 181 |
| 16 | Jake FergusonDallas Cowboys·#87 | 17 | 59 | 51 | 401 | 1 | 86.4% | 6.80 | 7.86 | 230 | 213 | 0.9 | 4 | 4 | 0 | 29 | 196 | 35 | 6 | 14 | 3 | 278 |
| 17 | Jonnu SmithPittsburgh Steelers·#81 | 17 | 34 | 22 | 131 | 0 | 64.7% | 3.85 | 5.95 | 124 | 84 | 0.6 | 4 | 2 | 0 | 17 | 136 | 19 | 7 | 3 | 2 | 217 |
| 18 | Kyle PittsAtlanta Falcons·#8 | 17 | 67 | 54 | 572 | 1 | 80.6% | 8.54 | 10.59 | 246 | 409 | 1.3 | 4 | 3 | 1 | 34 | 213 | 43 | 6 | 24 | 2 | 333 |
| 19 | Cole KmetChicago Bears·#85 | 16 | 32 | 22 | 246 | 1 | 68.8% | 7.69 | 11.18 | 99 | 205 | 1.1 | 4 | 3 | 1 | 20 | 153 | 24 | 11 | 11 | 0 | 254 |
| 20 | Harold Fannin Jr.Cleveland Browns·#44 | 16 | 70 | 50 | 513 | 2 | 71.4% | 7.33 | 10.26 | 288 | 345 | 1.2 | 3 | 3 | 2 | 38 | 173 | 45 | 5 | 18 | 2 | 289 |
| 21 | Gunnar HelmTennessee Titans·#84 | 16 | 36 | 32 | 262 | 1 | 88.9% | 7.28 | 8.19 | 134 | 145 | 1.0 | 3 | 2 | 0 | 17 | 96 | 20 | 4 | 8 | 0 | 156 |
| 22 | Hunter HenryNew England Patriots·#85 | 17 | 44 | 30 | 463 | 1 | 68.2% | 10.52 | 15.43 | 216 | 331 | 1.5 | 3 | 3 | 0 | 31 | 190 | 32 | 19 | 17 | 3 | 276 |
| 23 | Greg DulcichMiami Dolphins·#85 | 10 | 21 | 16 | 187 | 1 | 76.2% | 8.90 | 11.69 | 130 | 61 | 0.7 | 3 | 2 | 1 | 11 | 62 | 16 | 1 | 6 | 1 | 92 |
| 24 | Dalton SchultzHouston Texans·#86 | 17 | 64 | 52 | 530 | 0 | 81.3% | 8.28 | 10.19 | 274 | 323 | 1.2 | 3 | 1 | 0 | 29 | 197 | 50 | 6 | 15 | 1 | 309 |
| 25 | Dawson KnoxBuffalo Bills·#88 | 17 | 26 | 22 | 302 | 3 | 84.6% | 11.62 | 13.73 | 123 | 207 | 1.2 | 3 | 3 | 3 | 17 | 116 | 19 | 3 | 12 | 2 | 183 |
| 26 | Darnell WashingtonPittsburgh Steelers·#80 | 16 | 27 | 19 | 248 | 0 | 70.4% | 9.19 | 13.05 | 172 | 129 | 0.9 | 3 | 3 | 0 | 10 | 107 | 17 | 1 | 8 | 2 | 160 |
| 27 | Cade OttonTampa Bay Buccaneers·#88 | 16 | 42 | 32 | 353 | 1 | 76.2% | 8.40 | 11.03 | 185 | 241 | 0.9 | 3 | 2 | 1 | 22 | 197 | 30 | 7 | 13 | 3 | 303 |
| 28 | Mo Alie-CoxIndianapolis Colts·#81 | 17 | 12 | 8 | 75 | 0 | 66.7% | 6.25 | 9.38 | 55 | 26 | 0.3 | 3 | 2 | 0 | 17 | 90 | 6 | 7 | 2 | 0 | 133 |
| 29 | Travis KelceKansas City Chiefs·#87 | 17 | 62 | 42 | 507 | 1 | 67.7% | 8.18 | 12.07 | 273 | 392 | 1.3 | 3 | 3 | 0 | 19 | 183 | 49 | 2 | 21 | 0 | 338 |
| 30 | Tyler HigbeeLos Angeles Rams·#89 | 10 | 14 | 9 | 113 | 1 | 64.3% | 8.07 | 12.56 | 66 | -17 | -0.2 | 3 | 2 | 0 | 11 | 68 | 7 | 3 | 4 | 0 | 103 |
| 31 | Mason TaylorNew York Jets·#85 | 13 | 41 | 27 | 253 | 0 | 65.8% | 6.17 | 9.37 | 87 | 248 | 1.1 | 3 | 3 | 0 | 29 | 131 | 32 | 5 | 10 | 1 | 237 |
| 32 | Ja'Tavion SandersCarolina Panthers·#0 | 12 | 20 | 18 | 111 | 0 | 90.0% | 5.55 | 6.17 | 62 | 63 | 0.7 | 3 | 2 | 0 | 14 | 77 | 13 | 1 | 2 | 2 | 125 |
| 33 | Mark AndrewsBaltimore Ravens·#89 | 17 | 35 | 28 | 264 | 1 | 80.0% | 7.54 | 9.43 | 65 | 271 | 1.4 | 3 | 3 | 1 | 23 | 132 | 28 | 5 | 10 | 4 | 198 |
| 34 | Davis AllenLos Angeles Rams·#87 | 17 | 15 | 12 | 136 | 1 | 80.0% | 9.07 | 11.33 | 101 | 68 | 0.5 | 2 | 2 | 1 | 8 | 94 | 8 | 3 | 5 | 2 | 129 |
| 35 | Daniel BellingerNew York Giants·#82 | 16 | 15 | 11 | 199 | 2 | 73.3% | 13.27 | 18.09 | 80 | 169 | 1.1 | 2 | 2 | 0 | 20 | 89 | 14 | 5 | 8 | 2 | 148 |
| 36 | Darren WallerMiami Dolphins·#83 | 9 | 14 | 8 | 102 | 1 | 57.1% | 7.29 | 12.75 | 29 | 144 | 1.8 | 2 | 1 | 1 | 8 | 49 | 12 | 2 | 4 | 0 | 88 |
| 37 | Chig OkonkwoTennessee Titans·#85 | 17 | 52 | 40 | 368 | 0 | 76.9% | 7.08 | 9.20 | 251 | 178 | 0.8 | 2 | 1 | 0 | 27 | 152 | 28 | 5 | 13 | 5 | 247 |
| 38 | Charlie KolarBaltimore Ravens·#88 | 17 | 11 | 7 | 114 | 1 | 63.6% | 10.36 | 16.29 | 48 | 87 | 1.1 | 2 | 1 | 1 | 9 | 50 | 8 | 6 | 6 | 0 | 82 |
| 39 | Cade StoverHouston Texans·#87 | 9 | 10 | 8 | 48 | 0 | 80.0% | 4.80 | 6.00 | 26 | 22 | 0.5 | 2 | 2 | 0 | 8 | 38 | 8 | 1 | 1 | 0 | 51 |
| 40 | Dalton KincaidBuffalo Bills·#86 | 12 | 23 | 19 | 325 | 2 | 82.6% | 14.13 | 17.11 | 127 | 243 | 2.5 | 2 | 1 | 1 | 16 | 70 | 18 | 3 | 14 | 1 | 107 |
| 41 | Dallas GoedertPhiladelphia Eagles·#88 | 15 | 44 | 32 | 331 | 2 | 72.7% | 7.52 | 10.34 | 102 | 283 | 1.2 | 2 | 2 | 1 | 34 | 167 | 33 | 10 | 11 | 2 | 273 |
| 42 | Tanner HudsonCincinnati Bengals·#87 | 11 | 11 | 8 | 57 | 0 | 72.7% | 5.18 | 7.12 | 29 | 56 | 1.0 | 2 | 1 | 0 | 8 | 34 | 9 | 1 | 1 | 0 | 56 |
| 43 | Tanner ConnerMiami Dolphins·#48 | 9 | 10 | 7 | 49 | 0 | 70.0% | 4.90 | 7.00 | 25 | 68 | 1.0 | 2 | 1 | 0 | 4 | 44 | 7 | 4 | 1 | 0 | 68 |
| 44 | George KittleSan Francisco 49ers·#85 | 11 | 37 | 32 | 378 | 2 | 86.5% | 10.22 | 11.81 | 177 | 227 | 1.5 | 2 | 2 | 1 | 27 | 121 | 26 | 2 | 16 | 3 | 170 |
| 45 | Julian HillMiami Dolphins·#89 | 14 | 13 | 10 | 104 | 0 | 76.9% | 8.00 | 10.40 | 77 | 38 | 0.3 | 2 | 1 | 0 | 7 | 74 | 8 | 2 | 4 | 0 | 125 |
| 46 | Josh OliverMinnesota Vikings·#84 | 14 | 7 | 6 | 88 | 2 | 85.7% | 12.57 | 14.67 | 38 | 54 | 0.7 | 2 | 2 | 1 | 12 | 48 | 6 | 3 | 3 | 0 | 78 |
| 47 | Eric SaubertSeattle Seahawks·#81 | 10 | 4 | 1 | 9 | 0 | 25.0% | 2.25 | 9.00 | 5 | 17 | 0.3 | 1 | 0 | 0 | 4 | 43 | 3 | 4 | 0 | 0 | 57 |
| 48 | Elijah ArroyoSeattle Seahawks·#18 | 13 | 14 | 9 | 125 | 1 | 64.3% | 8.93 | 13.89 | 57 | 118 | 1.4 | 1 | 0 | 0 | 9 | 69 | 11 | 1 | 4 | 2 | 98 |
| 49 | Anthony FirkserDetroit Lions·#86 | 7 | 5 | 3 | 22 | 0 | 60.0% | 4.40 | 7.33 | 5 | 19 | 0.1 | 1 | 1 | 0 | 2 | 50 | 4 | 0 | 1 | 1 | 72 |
| 50 | Andrew OgletreeIndianapolis Colts·#85 | 15 | 4 | 3 | 23 | 0 | 75.0% | 5.75 | 7.67 | 9 | 14 | 0.5 | 1 | 1 | 0 | 8 | 44 | 3 | 3 | 1 | 0 | 67 |