| 1 | AJ DillonPhiladelphia Eagles·#29 | 7 | 12 | 60 | 5.00 | 0 | 42 | 4 | 0 | 3 | 3 | 21 | 0 | 100.0% | 7.00 | 7.00 | 9 | 1 | 1 | 0 | 1 | 37 |
| 2 | George HolaniSeattle Seahawks·#36 | 4 | 22 | 73 | 3.32 | 1 | 60 | 5 | 0 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 16 | 0 | 0 | 0 | 1 | 34 |
| 3 | Evan HullNew Orleans Saints·#34 | 6 | 18 | 47 | 2.61 | 0 | 19 | 2 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 1 | 66 |
| 4 | Hassan HaskinsLos Angeles Chargers·#28 | 9 | 17 | 47 | 2.76 | 0 | 33 | 4 | 0 | 4 | 4 | 13 | 0 | 100.0% | 3.25 | 3.25 | 16 | 0 | 0 | 0 | 2 | 76 |
| 5 | Miles SandersDallas Cowboys·#24 | 4 | 20 | 117 | 5.85 | 1 | 75 | 6 | 1 | 8 | 8 | 30 | 0 | 100.0% | 3.75 | 3.75 | 44 | 1 | 1 | 0 | 1 | 58 |
| 6 | Kendre MillerNew Orleans Saints·#5 | 7 | 47 | 193 | 4.11 | 1 | 156 | 9 | 0 | 5 | 5 | 30 | 0 | 100.0% | 6.00 | 6.00 | 35 | 0 | 0 | 0 | 1 | 102 |
| 7 | Jaydon BlueDallas Cowboys·#23 | 5 | 38 | 129 | 3.39 | 1 | 54 | 7 | 1 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 10 | 0 | 0 | 0 | 0 | 71 |
| 8 | Jawhar JordanHouston Texans·#26 | 4 | 43 | 193 | 4.49 | 0 | 129 | 8 | 1 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 40 | 0 | 0 | 0 | 0 | 74 |
| 9 | Raheem MostertLas Vegas Raiders·#31 | 12 | 21 | 100 | 4.76 | 0 | 84 | 5 | 0 | 12 | 12 | 70 | 0 | 100.0% | 5.83 | 5.83 | 86 | 1 | 1 | 0 | 1 | 119 |
| 10 | Terrell JenningsNew England Patriots·#26 | 5 | 23 | 73 | 3.17 | 1 | 36 | 8 | 2 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 7 | 0 | 0 | 0 | 0 | 30 |
| 11 | Trevor EtienneCarolina Panthers·#23 | 11 | 20 | 94 | 4.70 | 0 | 55 | 7 | 1 | 3 | 3 | 13 | 0 | 100.0% | 4.33 | 4.33 | 11 | 0 | 0 | 0 | 0 | 42 |
| 12 | Najee HarrisLos Angeles Chargers·#22 | 3 | 15 | 61 | 4.07 | 0 | 45 | 3 | 0 | 3 | 3 | 25 | 0 | 100.0% | 8.33 | 8.33 | 15 | 0 | 0 | 0 | 0 | 39 |
| 13 | Devin SingletaryNew York Giants·#26 | 17 | 119 | 437 | 3.67 | 5 | 274 | 28 | 10 | 19 | 18 | 151 | 0 | 94.7% | 7.95 | 8.39 | 162 | 2 | 2 | 0 | 1 | 279 |
| 14 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 13 | 60 | 4.62 | 1 | 32 | 3 | 1 | 17 | 16 | 99 | 0 | 94.1% | 5.82 | 6.19 | 105 | 1 | 1 | 0 | 0 | 77 |
| 15 | Zavier ScottMinnesota Vikings·#36 | 9 | 32 | 114 | 3.56 | 0 | 78 | 6 | 1 | 15 | 14 | 98 | 1 | 93.3% | 6.53 | 7.00 | 105 | 3 | 3 | 1 | 1 | 97 |
| 16 | Audric EstiméNew Orleans Saints·#30 | 5 | 46 | 198 | 4.30 | 1 | 182 | 12 | 3 | 13 | 12 | 103 | 0 | 92.3% | 7.92 | 8.58 | 108 | 0 | 0 | 0 | 1 | 163 |
| 17 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 123 | 535 | 4.35 | 4 | 356 | 30 | 8 | 35 | 32 | 192 | 1 | 91.4% | 5.49 | 6.00 | 245 | 2 | 2 | 1 | 2 | 348 |
| 18 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 17 | 23 | 94 | 4.09 | 0 | 67 | 5 | 1 | 11 | 10 | 54 | 0 | 90.9% | 4.91 | 5.40 | 61 | 2 | 2 | 0 | 4 | 225 |
| 19 | Tyjae SpearsTennessee Titans·#2 | 13 | 72 | 283 | 3.93 | 2 | 236 | 16 | 2 | 50 | 45 | 264 | 0 | 90.0% | 5.28 | 5.87 | 361 | 7 | 7 | 0 | 2 | 347 |
| 20 | Devin NealNew Orleans Saints·#24 | 9 | 57 | 206 | 3.61 | 2 | 103 | 11 | 2 | 19 | 17 | 104 | 0 | 89.5% | 5.47 | 6.12 | 138 | 1 | 1 | 0 | 0 | 239 |
| 21 | James ConnerArizona Cardinals·#6 | 3 | 32 | 95 | 2.97 | 1 | 98 | 7 | 3 | 9 | 8 | 38 | 1 | 88.9% | 4.22 | 4.75 | 68 | 1 | 1 | 1 | 0 | 85 |
| 22 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 133 | 572 | 4.30 | 4 | 327 | 40 | 9 | 45 | 40 | 218 | 0 | 88.9% | 4.84 | 5.45 | 329 | 10 | 9 | 0 | 4 | 519 |
| 23 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 211 | 958 | 4.54 | 6 | 691 | 52 | 14 | 45 | 40 | 333 | 2 | 88.9% | 7.40 | 8.32 | 439 | 5 | 4 | 1 | 4 | 462 |
| 24 | Jordan MasonMinnesota Vikings·#27 | 16 | 159 | 758 | 4.77 | 6 | 443 | 45 | 7 | 16 | 14 | 51 | 0 | 87.5% | 3.19 | 3.64 | 102 | 1 | 1 | 0 | 3 | 387 |
| 25 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 143 | 514 | 3.59 | 8 | 327 | 37 | 10 | 16 | 14 | 99 | 0 | 87.5% | 6.19 | 7.07 | 120 | 1 | 1 | 0 | 2 | 284 |
| 26 | Trayveon WilliamsCleveland Browns·#38 | 4 | 7 | 37 | 5.29 | 0 | 34 | 3 | 0 | 8 | 7 | 55 | 0 | 87.5% | 6.88 | 7.86 | 82 | 2 | 2 | 0 | 0 | 60 |
| 27 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 219 | 1,015 | 4.63 | 5 | 546 | 48 | 8 | 36 | 31 | 282 | 0 | 86.1% | 7.83 | 9.10 | 339 | 3 | 2 | 0 | 5 | 451 |
| 28 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 114 | 537 | 4.71 | 5 | 396 | 34 | 9 | 85 | 73 | 486 | 3 | 85.9% | 5.72 | 6.66 | 528 | 17 | 14 | 2 | 2 | 473 |
| 29 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 173 | 588 | 3.40 | 1 | 391 | 27 | 0 | 35 | 30 | 282 | 3 | 85.7% | 8.06 | 9.40 | 360 | 4 | 3 | 1 | 1 | 401 |
| 30 | Alvin KamaraNew Orleans Saints·#41 | 11 | 131 | 471 | 3.60 | 1 | 350 | 22 | 2 | 39 | 33 | 212 | 0 | 84.6% | 5.44 | 6.42 | 202 | 5 | 4 | 0 | 6 | 429 |
| 31 | Rhamondre StevensonNew England Patriots·#38 | 14 | 131 | 605 | 4.62 | 7 | 402 | 29 | 12 | 38 | 32 | 347 | 2 | 84.2% | 9.13 | 10.84 | 263 | 6 | 5 | 1 | 4 | 481 |
| 32 | TreVeyon HendersonNew England Patriots·#32 | 17 | 178 | 902 | 5.07 | 9 | 367 | 44 | 8 | 42 | 35 | 221 | 1 | 83.3% | 5.26 | 6.31 | 244 | 4 | 4 | 1 | 2 | 456 |
| 33 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 181 | 723 | 3.99 | 12 | 505 | 51 | 18 | 24 | 20 | 144 | 0 | 83.3% | 6.00 | 7.20 | 123 | 3 | 3 | 0 | 4 | 444 |
| 34 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 125 | 496 | 3.97 | 3 | 397 | 32 | 4 | 18 | 15 | 101 | 0 | 83.3% | 5.61 | 6.73 | 133 | 3 | 1 | 0 | 0 | 300 |
| 35 | David MontgomeryDetroit Lions·#5 | 17 | 159 | 718 | 4.52 | 8 | 434 | 42 | 17 | 29 | 24 | 192 | 0 | 82.8% | 6.62 | 8.00 | 199 | 2 | 1 | 0 | 5 | 388 |
| 36 | Dylan SampsonCleveland Browns·#22 | 15 | 65 | 175 | 2.69 | 0 | 233 | 12 | 0 | 40 | 33 | 271 | 2 | 82.5% | 6.78 | 8.21 | 318 | 6 | 4 | 1 | 2 | 224 |
| 37 | James CookBuffalo Bills·#4 | 17 | 308 | 1,612 | 5.23 | 12 | 1,020 | 69 | 16 | 40 | 33 | 291 | 2 | 82.5% | 7.28 | 8.82 | 272 | 3 | 3 | 1 | 5 | 594 |
| 38 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 321 | 1,580 | 4.92 | 18 | 947 | 85 | 24 | 56 | 46 | 378 | 2 | 82.1% | 6.75 | 8.22 | 434 | 5 | 4 | 2 | 5 | 823 |
| 39 | Jahmyr GibbsDetroit Lions·#0 | 17 | 243 | 1,223 | 5.03 | 13 | 686 | 57 | 10 | 94 | 77 | 613 | 5 | 81.9% | 6.52 | 7.96 | 612 | 15 | 12 | 5 | 3 | 689 |
| 40 | Rasheen AliBaltimore Ravens·#26 | 10 | 7 | 24 | 3.43 | 0 | 39 | 1 | 0 | 11 | 9 | 68 | 1 | 81.8% | 6.18 | 7.56 | 83 | 1 | 1 | 0 | 3 | 101 |
| 41 | Josh JacobsGreen Bay Packers·#8 | 15 | 234 | 929 | 3.97 | 13 | 658 | 56 | 20 | 44 | 36 | 282 | 1 | 81.8% | 6.41 | 7.83 | 304 | 6 | 5 | 1 | 5 | 512 |
| 42 | Jerome FordCleveland Browns·#34 | 13 | 24 | 73 | 3.04 | 0 | 73 | 5 | 3 | 32 | 26 | 103 | 0 | 81.3% | 3.22 | 3.96 | 154 | 6 | 5 | 0 | 2 | 245 |
| 43 | Trey BensonArizona Cardinals·#33 | 4 | 29 | 160 | 5.52 | 0 | 157 | 4 | 1 | 16 | 13 | 64 | 0 | 81.3% | 4.00 | 4.92 | 73 | 2 | 1 | 0 | 1 | 113 |
| 44 | RJ HarveyDenver Broncos·#12 | 17 | 147 | 540 | 3.67 | 7 | 395 | 30 | 10 | 58 | 47 | 356 | 5 | 81.0% | 6.14 | 7.57 | 360 | 11 | 9 | 4 | 1 | 448 |
| 45 | Samaje PerineCincinnati Bengals·#34 | 15 | 84 | 382 | 4.55 | 3 | 263 | 33 | 4 | 21 | 17 | 87 | 0 | 81.0% | 4.14 | 5.12 | 109 | 1 | 1 | 0 | 3 | 308 |
| 46 | Tony PollardTennessee Titans·#20 | 17 | 241 | 1,079 | 4.48 | 5 | 648 | 48 | 4 | 41 | 33 | 206 | 0 | 80.5% | 5.02 | 6.24 | 203 | 1 | 1 | 0 | 9 | 615 |
| 47 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 310 | 1,192 | 3.85 | 10 | 796 | 72 | 20 | 127 | 102 | 904 | 7 | 80.3% | 7.12 | 8.86 | 700 | 24 | 20 | 7 | 6 | 877 |
| 48 | De'Von AchaneMiami Dolphins·#28 | 16 | 238 | 1,350 | 5.67 | 8 | 817 | 57 | 5 | 84 | 67 | 481 | 4 | 79.8% | 5.73 | 7.18 | 545 | 11 | 7 | 3 | 3 | 644 |
| 49 | Rico DowdleCarolina Panthers·#5 | 17 | 235 | 1,071 | 4.56 | 6 | 646 | 54 | 9 | 49 | 39 | 297 | 1 | 79.6% | 6.06 | 7.62 | 350 | 5 | 3 | 0 | 6 | 539 |
| 50 | J.K. DobbinsDenver Broncos·#27 | 10 | 153 | 772 | 5.05 | 4 | 415 | 37 | 7 | 14 | 11 | 42 | 0 | 78.6% | 3.00 | 3.82 | 56 | 0 | 0 | 0 | 1 | 318 |