| 1 | Breece HallNew York Jets·#20 | 15 | 151 | 688 | 4.56 | 3 | 389 | 35 | 2 | 39 | 29 | 273 | 0 | 74.4% | 7.00 | 9.41 | 235 | 7 | 2 | 0 | 4 | 412 |
| 2 | Kareem HuntKansas City Chiefs·#29 | 14 | 98 | 336 | 3.43 | 6 | 197 | 34 | 11 | 14 | 9 | 80 | 0 | 64.3% | 5.71 | 8.89 | 87 | 2 | 0 | 0 | 1 | 304 |
| 3 | Javonte WilliamsDallas Cowboys·#33 | 15 | 122 | 527 | 4.32 | 5 | 341 | 32 | 10 | 32 | 24 | 117 | 1 | 75.0% | 3.66 | 4.88 | 157 | 8 | 4 | 1 | 2 | 421 |
| 4 | Jonathan TaylorIndianapolis Colts·#28 | 12 | 138 | 664 | 4.81 | 4 | 437 | 31 | 7 | 21 | 18 | 180 | 1 | 85.7% | 8.57 | 10.00 | 185 | 1 | 1 | 1 | 4 | 352 |
| 5 | Rico DowdleCarolina Panthers·#5 | 15 | 125 | 626 | 5.01 | 2 | 400 | 30 | 4 | 31 | 26 | 226 | 1 | 83.9% | 7.29 | 8.69 | 256 | 2 | 1 | 0 | 5 | 322 |
| 6 | Tony PollardTennessee Titans·#20 | 17 | 134 | 581 | 4.34 | 4 | 341 | 30 | 4 | 32 | 26 | 145 | 0 | 81.3% | 4.53 | 5.58 | 124 | 0 | 0 | 0 | 7 | 396 |
| 7 | Derrick HenryBaltimore Ravens·#22 | 14 | 115 | 521 | 4.53 | 7 | 344 | 29 | 13 | 12 | 8 | 86 | 0 | 66.7% | 7.17 | 10.75 | 75 | 2 | 2 | 0 | 2 | 225 |
| 8 | Quinshon JudkinsCleveland Browns·#10 | 12 | 121 | 459 | 3.79 | 1 | 296 | 28 | 5 | 23 | 20 | 155 | 0 | 87.0% | 6.74 | 7.75 | 170 | 1 | 1 | 0 | 0 | 232 |
| 9 | Ashton JeantyLas Vegas Raiders·#2 | 16 | 156 | 589 | 3.78 | 2 | 455 | 28 | 6 | 47 | 36 | 254 | 5 | 76.6% | 5.40 | 7.06 | 307 | 7 | 7 | 4 | 1 | 438 |
| 10 | D'Andre SwiftChicago Bears·#4 | 12 | 91 | 416 | 4.57 | 5 | 228 | 27 | 10 | 27 | 20 | 188 | 1 | 74.1% | 6.96 | 9.40 | 196 | 1 | 1 | 0 | 3 | 283 |
| 11 | James CookBuffalo Bills·#4 | 13 | 127 | 604 | 4.76 | 4 | 429 | 27 | 6 | 22 | 18 | 168 | 2 | 81.8% | 7.64 | 9.33 | 141 | 1 | 1 | 1 | 1 | 286 |
| 12 | Kyren WilliamsLos Angeles Rams·#23 | 12 | 76 | 397 | 5.22 | 4 | 215 | 26 | 5 | 20 | 17 | 142 | 2 | 85.0% | 7.10 | 8.35 | 86 | 5 | 5 | 2 | 4 | 257 |
| 13 | Chase BrownCincinnati Bengals·#30 | 16 | 111 | 505 | 4.55 | 0 | 305 | 26 | 7 | 60 | 44 | 260 | 0 | 73.3% | 4.33 | 5.91 | 255 | 3 | 1 | 0 | 4 | 401 |
| 14 | Chris Rodriguez Jr.Washington Commanders·#36 | 11 | 71 | 340 | 4.79 | 6 | 208 | 25 | 10 | 2 | 1 | 6 | 0 | 50.0% | 3.00 | 6.00 | 6 | 1 | 0 | 0 | 0 | 162 |
| 15 | Jaylen WarrenPittsburgh Steelers·#30 | 12 | 93 | 418 | 4.49 | 1 | 309 | 23 | 8 | 15 | 12 | 105 | 1 | 80.0% | 7.00 | 8.75 | 137 | 3 | 2 | 1 | 1 | 197 |
| 16 | Jordan MasonMinnesota Vikings·#27 | 11 | 81 | 375 | 4.63 | 3 | 237 | 23 | 4 | 12 | 10 | 37 | 0 | 83.3% | 3.08 | 3.70 | 72 | 0 | 0 | 0 | 1 | 224 |
| 17 | Tyrone Tracy Jr.New York Giants·#29 | 14 | 87 | 359 | 4.13 | 1 | 268 | 22 | 0 | 26 | 20 | 136 | 1 | 76.9% | 5.23 | 6.80 | 152 | 1 | 1 | 1 | 1 | 277 |
| 18 | Josh JacobsGreen Bay Packers·#8 | 8 | 77 | 314 | 4.08 | 7 | 205 | 22 | 9 | 16 | 12 | 89 | 1 | 75.0% | 5.56 | 7.42 | 80 | 5 | 4 | 1 | 1 | 172 |
| 19 | Bijan RobinsonAtlanta Falcons·#7 | 11 | 87 | 373 | 4.29 | 2 | 285 | 21 | 4 | 45 | 35 | 310 | 2 | 77.8% | 6.89 | 8.86 | 321 | 4 | 3 | 2 | 4 | 325 |
| 20 | Jacory Croskey-MerrittWashington Commanders·#22 | 14 | 108 | 472 | 4.37 | 4 | 289 | 21 | 8 | 9 | 6 | 24 | 0 | 66.7% | 2.67 | 4.00 | 29 | 0 | 0 | 0 | 2 | 238 |
| 21 | Christian McCaffreySan Francisco 49ers·#23 | 12 | 89 | 305 | 3.43 | 2 | 261 | 20 | 2 | 55 | 43 | 400 | 2 | 78.2% | 7.27 | 9.30 | 301 | 11 | 9 | 2 | 2 | 306 |
| 22 | Rachaad WhiteTampa Bay Buccaneers·#1 | 14 | 47 | 203 | 4.32 | 1 | 96 | 18 | 1 | 25 | 21 | 95 | 0 | 84.0% | 3.80 | 4.52 | 144 | 6 | 5 | 0 | 3 | 251 |
| 23 | Woody MarksHouston Texans·#27 | 10 | 59 | 225 | 3.81 | 1 | 161 | 18 | 7 | 11 | 7 | 54 | 1 | 63.6% | 4.91 | 7.71 | 62 | 3 | 1 | 1 | 0 | 190 |
| 24 | Travis EtienneJacksonville Jaguars·#1 | 12 | 55 | 300 | 5.45 | 1 | 207 | 17 | 2 | 19 | 15 | 98 | 0 | 79.0% | 5.16 | 6.53 | 110 | 1 | 1 | 0 | 1 | 177 |
| 25 | De'Von AchaneMiami Dolphins·#28 | 11 | 81 | 456 | 5.63 | 3 | 350 | 17 | 2 | 46 | 35 | 249 | 2 | 76.1% | 5.41 | 7.11 | 302 | 4 | 3 | 1 | 2 | 293 |
| 26 | Saquon BarkleyPhiladelphia Eagles·#26 | 8 | 73 | 332 | 4.55 | 2 | 124 | 17 | 6 | 18 | 10 | 40 | 0 | 55.6% | 2.22 | 4.00 | 40 | 5 | 2 | 0 | 1 | 237 |
| 27 | Blake CorumLos Angeles Rams·#22 | 11 | 48 | 275 | 5.73 | 2 | 146 | 16 | 5 | 5 | 2 | 4 | 0 | 40.0% | 0.80 | 2.00 | 8 | 1 | 0 | 0 | 1 | 107 |
| 28 | Chuba HubbardCarolina Panthers·#30 | 12 | 73 | 278 | 3.81 | 1 | 217 | 16 | 2 | 27 | 21 | 168 | 3 | 77.8% | 6.22 | 8.00 | 210 | 3 | 2 | 1 | 2 | 251 |
| 29 | Alvin KamaraNew Orleans Saints·#41 | 11 | 97 | 325 | 3.35 | 1 | 265 | 16 | 2 | 34 | 29 | 171 | 0 | 85.3% | 5.03 | 5.90 | 161 | 5 | 4 | 0 | 3 | 350 |
| 30 | Michael CarterArizona Cardinals·#22 | 12 | 56 | 226 | 4.04 | 0 | 172 | 16 | 2 | 34 | 24 | 212 | 0 | 70.6% | 6.24 | 8.83 | 207 | 6 | 3 | 0 | 1 | 283 |
| 31 | Kyle MonangaiChicago Bears·#25 | 13 | 71 | 301 | 4.24 | 1 | 158 | 16 | 6 | 15 | 10 | 109 | 0 | 66.7% | 7.27 | 10.90 | 115 | 0 | 0 | 0 | 0 | 206 |
| 32 | Jahmyr GibbsDetroit Lions·#0 | 11 | 97 | 373 | 3.85 | 2 | 334 | 16 | 3 | 53 | 42 | 281 | 2 | 79.3% | 5.30 | 6.69 | 283 | 8 | 7 | 2 | 2 | 331 |
| 33 | Devin SingletaryNew York Giants·#26 | 13 | 64 | 233 | 3.64 | 2 | 147 | 16 | 6 | 10 | 10 | 77 | 0 | 100.0% | 7.70 | 7.70 | 64 | 2 | 2 | 0 | 0 | 158 |
| 34 | David MontgomeryDetroit Lions·#5 | 10 | 54 | 188 | 3.48 | 3 | 136 | 15 | 8 | 19 | 16 | 125 | 0 | 84.2% | 6.58 | 7.81 | 133 | 2 | 1 | 0 | 2 | 157 |
| 35 | Samaje PerineCincinnati Bengals·#34 | 13 | 39 | 148 | 3.79 | 1 | 92 | 14 | 2 | 12 | 9 | 43 | 0 | 75.0% | 3.58 | 4.78 | 52 | 1 | 1 | 0 | 2 | 163 |
| 36 | Tyler AllgeierAtlanta Falcons·#25 | 11 | 38 | 163 | 4.29 | 4 | 63 | 13 | 6 | 5 | 4 | 31 | 0 | 80.0% | 6.20 | 7.75 | 29 | 0 | 0 | 0 | 0 | 103 |
| 37 | Zach CharbonnetSeattle Seahawks·#26 | 10 | 47 | 175 | 3.72 | 2 | 102 | 13 | 6 | 9 | 7 | 36 | 0 | 77.8% | 4.00 | 5.14 | 22 | 1 | 1 | 0 | 1 | 142 |
| 38 | J.K. DobbinsDenver Broncos·#27 | 10 | 57 | 293 | 5.14 | 2 | 174 | 13 | 3 | 4 | 3 | 8 | 0 | 75.0% | 2.00 | 2.67 | 12 | 0 | 0 | 0 | 0 | 138 |
| 39 | Kenneth Walker IIISeattle Seahawks·#9 | 10 | 52 | 323 | 6.21 | 2 | 157 | 13 | 2 | 9 | 7 | 64 | 0 | 77.8% | 7.11 | 9.14 | 61 | 2 | 1 | 0 | 1 | 123 |
| 40 | Bam KnightArizona Cardinals·#20 | 7 | 41 | 123 | 3.00 | 3 | 109 | 12 | 6 | 21 | 14 | 109 | 1 | 66.7% | 5.19 | 7.79 | 96 | 5 | 3 | 1 | 2 | 137 |
| 41 | Omarion HamptonLos Angeles Chargers·#8 | 7 | 52 | 268 | 5.15 | 2 | 150 | 12 | 3 | 20 | 20 | 131 | 0 | 100.0% | 6.55 | 6.55 | 166 | 1 | 1 | 0 | 0 | 165 |
| 42 | Tyjae SpearsTennessee Titans·#2 | 13 | 44 | 223 | 5.07 | 1 | 154 | 12 | 1 | 35 | 32 | 176 | 0 | 91.4% | 5.03 | 5.50 | 235 | 4 | 4 | 0 | 2 | 241 |
| 43 | Emanuel WilsonGreen Bay Packers·#23 | 10 | 50 | 165 | 3.30 | 2 | 169 | 11 | 1 | 9 | 9 | 54 | 0 | 100.0% | 6.00 | 6.00 | 68 | 1 | 1 | 0 | 0 | 137 |
| 44 | Kimani VidalLos Angeles Chargers·#30 | 11 | 50 | 216 | 4.32 | 0 | 110 | 11 | 2 | 14 | 10 | 29 | 0 | 71.4% | 2.07 | 2.90 | 51 | 4 | 2 | 0 | 0 | 198 |
| 45 | Sean TuckerTampa Bay Buccaneers·#44 | 12 | 38 | 191 | 5.03 | 5 | 71 | 11 | 3 | 6 | 5 | 38 | 1 | 83.3% | 6.33 | 7.60 | 41 | 1 | 0 | 0 | 0 | 72 |
| 46 | Devin NealNew Orleans Saints·#24 | 9 | 44 | 176 | 4.00 | 1 | 82 | 10 | 1 | 13 | 11 | 71 | 0 | 84.6% | 5.46 | 6.45 | 100 | 1 | 1 | 0 | 0 | 191 |
| 47 | Rhamondre StevensonNew England Patriots·#38 | 11 | 32 | 163 | 5.09 | 2 | 103 | 9 | 3 | 11 | 8 | 111 | 0 | 72.7% | 10.09 | 13.88 | 84 | 1 | 0 | 0 | 1 | 153 |
| 48 | Audric EstiméNew Orleans Saints·#30 | 5 | 37 | 149 | 4.03 | 0 | 105 | 9 | 3 | 7 | 6 | 55 | 0 | 85.7% | 7.86 | 9.17 | 45 | 0 | 0 | 0 | 1 | 107 |
| 49 | Bucky IrvingTampa Bay Buccaneers·#7 | 8 | 59 | 230 | 3.90 | 0 | 180 | 9 | 0 | 20 | 17 | 218 | 2 | 85.0% | 10.90 | 12.82 | 255 | 2 | 1 | 0 | 1 | 183 |
| 50 | Ollie Gordon IIMiami Dolphins·#31 | 12 | 30 | 81 | 2.70 | 1 | 66 | 9 | 3 | 7 | 6 | 12 | 0 | 85.7% | 1.71 | 2.00 | 35 | 1 | 1 | 0 | 0 | 92 |