| 1 | Ameer AbdullahIndianapolis Colts·#26 | 11 | 8 | 29 | 3.62 | 0 | 12 | 0 | 0 | 4 | 3 | 13 | 0 | 75.0% | 3.25 | 4.33 | 23 | 0 | 0 | 0 | 0 | 25 |
| 2 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 142 | 523 | 3.68 | 2 | 403 | 14 | 5 | 36 | 28 | 159 | 0 | 77.8% | 4.42 | 5.68 | 232 | 3 | 3 | 0 | 0 | 316 |
| 3 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 50 | 242 | 4.84 | 1 | 122 | 7 | 1 | 7 | 4 | 14 | 0 | 57.1% | 2.00 | 3.50 | 18 | 0 | 0 | 0 | 0 | 80 |
| 4 | Brashard SmithKansas City Chiefs·#24 | 17 | 27 | 97 | 3.59 | 0 | 61 | 1 | 0 | 16 | 13 | 100 | 0 | 81.3% | 6.25 | 7.69 | 140 | 3 | 2 | 0 | 0 | 75 |
| 5 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 101 | 363 | 3.59 | 0 | 202 | 6 | 0 | 17 | 15 | 135 | 1 | 88.2% | 7.94 | 9.00 | 194 | 0 | 0 | 0 | 0 | 196 |
| 6 | Isaiah DavisNew York Jets·#32 | 15 | 16 | 104 | 6.50 | 0 | 92 | 3 | 0 | 13 | 8 | 66 | 0 | 61.5% | 5.08 | 8.25 | 49 | 1 | 1 | 0 | 0 | 69 |
| 7 | De'Von AchaneMiami Dolphins·#28 | 16 | 138 | 729 | 5.28 | 5 | 441 | 21 | 2 | 32 | 26 | 201 | 0 | 81.3% | 6.28 | 7.73 | 260 | 2 | 1 | 0 | 0 | 282 |
| 8 | Chris BrooksGreen Bay Packers·#30 | 14 | 14 | 67 | 4.79 | 0 | 44 | 2 | 0 | 6 | 5 | 39 | 0 | 83.3% | 6.50 | 7.80 | 47 | 0 | 0 | 0 | 0 | 50 |
| 9 | Devin NealNew Orleans Saints·#24 | 9 | 32 | 117 | 3.66 | 2 | 54 | 4 | 2 | 5 | 4 | 33 | 0 | 80.0% | 6.60 | 8.25 | 26 | 0 | 0 | 0 | 0 | 91 |
| 10 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 69 | 280 | 4.06 | 2 | 205 | 9 | 3 | 6 | 6 | 62 | 0 | 100.0% | 10.33 | 10.33 | 68 | 0 | 0 | 0 | 0 | 133 |
| 11 | Evan HullNew Orleans Saints·#34 | 6 | 14 | 34 | 2.43 | 0 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 36 |
| 12 | Emari DemercadoArizona Cardinals·#31 | 11 | 23 | 82 | 3.57 | 0 | 47 | 3 | 0 | 3 | 3 | 18 | 0 | 100.0% | 6.00 | 6.00 | 30 | 0 | 0 | 0 | 0 | 50 |
| 13 | Hassan HaskinsLos Angeles Chargers·#28 | 9 | 11 | 32 | 2.91 | 0 | 17 | 1 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 7 | 0 | 0 | 0 | 0 | 32 |
| 14 | James ConnerArizona Cardinals·#6 | 3 | 15 | 60 | 4.00 | 0 | 47 | 1 | 1 | 4 | 4 | 1 | 0 | 100.0% | 0.25 | 0.25 | 22 | 0 | 0 | 0 | 0 | 41 |
| 15 | J.K. DobbinsDenver Broncos·#27 | 10 | 93 | 556 | 5.98 | 2 | 297 | 15 | 5 | 9 | 9 | 34 | 0 | 100.0% | 3.78 | 3.78 | 46 | 0 | 0 | 0 | 0 | 176 |
| 16 | Isiah PachecoKansas City Chiefs·#10 | 13 | 72 | 294 | 4.08 | 0 | 194 | 8 | 0 | 12 | 9 | 35 | 1 | 75.0% | 2.92 | 3.89 | 56 | 1 | 1 | 1 | 0 | 198 |
| 17 | Jawhar JordanHouston Texans·#26 | 4 | 29 | 138 | 4.76 | 0 | 86 | 4 | 1 | 1 | 1 | 14 | 0 | 100.0% | 14.00 | 14.00 | 17 | 0 | 0 | 0 | 0 | 40 |
| 18 | Kaleb JohnsonPittsburgh Steelers·#20 | 10 | 18 | 47 | 2.61 | 0 | 34 | 1 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 14 | 0 | 0 | 0 | 0 | 27 |
| 19 | Keaton MitchellBaltimore Ravens·#34 | 12 | 32 | 134 | 4.19 | 1 | 59 | 5 | 0 | 6 | 5 | 20 | 0 | 83.3% | 3.33 | 4.00 | 35 | 0 | 0 | 0 | 0 | 59 |
| 20 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 61 | 311 | 5.10 | 3 | 183 | 14 | 4 | 18 | 17 | 104 | 0 | 94.4% | 5.78 | 6.12 | 120 | 3 | 3 | 0 | 0 | 167 |
| 21 | Kyle MonangaiChicago Bears·#25 | 17 | 88 | 426 | 4.84 | 3 | 214 | 12 | 3 | 10 | 7 | 72 | 0 | 70.0% | 7.20 | 10.29 | 80 | 0 | 0 | 0 | 0 | 198 |
| 22 | Michael CarterArizona Cardinals·#22 | 12 | 57 | 192 | 3.37 | 0 | 137 | 3 | 0 | 24 | 17 | 161 | 0 | 70.8% | 6.71 | 9.47 | 158 | 2 | 2 | 0 | 0 | 167 |
| 23 | Kimani VidalLos Angeles Chargers·#30 | 12 | 96 | 358 | 3.73 | 2 | 177 | 12 | 5 | 3 | 2 | 19 | 0 | 66.7% | 6.33 | 9.50 | 19 | 1 | 1 | 0 | 0 | 185 |
| 24 | Kareem HuntKansas City Chiefs·#29 | 17 | 81 | 352 | 4.35 | 2 | 220 | 8 | 6 | 9 | 7 | 60 | 0 | 77.8% | 6.67 | 8.57 | 77 | 2 | 1 | 0 | 0 | 181 |
| 25 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 20 | 106 | 5.30 | 0 | 48 | 3 | 0 | 2 | 1 | 17 | 0 | 50.0% | 8.50 | 17.00 | 22 | 0 | 0 | 0 | 0 | 38 |
| 26 | Jaydon BlueDallas Cowboys·#23 | 5 | 26 | 81 | 3.12 | 0 | 40 | 3 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 40 |
| 27 | Jerome FordCleveland Browns·#34 | 12 | 11 | 38 | 3.45 | 0 | 37 | 1 | 2 | 12 | 10 | 9 | 0 | 83.3% | 0.75 | 0.90 | 48 | 2 | 2 | 0 | 0 | 62 |
| 28 | Jeremy McNicholsWashington Commanders·#26 | 16 | 20 | 75 | 3.75 | 0 | 60 | 2 | 0 | 11 | 9 | 43 | 0 | 81.8% | 3.91 | 4.78 | 59 | 0 | 0 | 0 | 0 | 81 |
| 29 | RJ HarveyDenver Broncos·#12 | 17 | 80 | 321 | 4.01 | 3 | 241 | 8 | 5 | 21 | 16 | 138 | 1 | 76.2% | 6.57 | 8.62 | 114 | 2 | 1 | 0 | 0 | 198 |
| 30 | Ray DavisBuffalo Bills·#22 | 12 | 34 | 192 | 5.65 | 0 | 111 | 8 | 1 | 5 | 3 | 17 | 0 | 60.0% | 3.40 | 5.67 | 28 | 1 | 1 | 0 | 0 | 59 |
| 31 | Ollie Gordon IIMiami Dolphins·#31 | 17 | 35 | 107 | 3.06 | 1 | 52 | 2 | 1 | 4 | 3 | 2 | 0 | 75.0% | 0.50 | 0.67 | 9 | 0 | 0 | 0 | 0 | 92 |
| 32 | Nick ChubbHouston Texans·#21 | 15 | 79 | 300 | 3.80 | 2 | 197 | 5 | 5 | 10 | 6 | 6 | 0 | 60.0% | 0.60 | 1.00 | 15 | 2 | 1 | 0 | 0 | 163 |
| 33 | Trey BensonArizona Cardinals·#33 | 4 | 16 | 47 | 2.94 | 0 | 46 | 1 | 1 | 5 | 4 | 19 | 0 | 80.0% | 3.80 | 4.75 | 23 | 0 | 0 | 0 | 0 | 45 |
| 34 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 166 | 639 | 3.85 | 3 | 356 | 19 | 11 | 20 | 14 | 83 | 0 | 70.0% | 4.15 | 5.93 | 82 | 2 | 2 | 0 | 0 | 327 |
| 35 | Tyjae SpearsTennessee Titans·#2 | 13 | 31 | 95 | 3.06 | 1 | 102 | 2 | 1 | 14 | 14 | 63 | 0 | 100.0% | 4.50 | 4.50 | 82 | 3 | 3 | 0 | 0 | 101 |
| 36 | Ty JohnsonBuffalo Bills·#26 | 17 | 24 | 101 | 4.21 | 1 | 59 | 1 | 1 | 5 | 2 | 15 | 1 | 40.0% | 3.00 | 7.50 | 14 | 2 | 1 | 1 | 0 | 71 |
| 37 | Will ShipleyPhiladelphia Eagles·#28 | 12 | 4 | 17 | 4.25 | 0 | 5 | 1 | 0 | 3 | 3 | 14 | 0 | 100.0% | 4.67 | 4.67 | 23 | 0 | 0 | 0 | 0 | 25 |
| 38 | Tyler BadieDenver Broncos·#28 | 15 | 3 | 7 | 2.33 | 0 | 5 | 0 | 0 | 8 | 4 | 28 | 0 | 50.0% | 3.50 | 7.00 | 30 | 1 | 1 | 0 | 0 | 38 |
| 39 | Woody MarksHouston Texans·#27 | 16 | 111 | 359 | 3.23 | 1 | 262 | 8 | 5 | 14 | 11 | 51 | 1 | 78.6% | 3.64 | 4.64 | 57 | 4 | 2 | 1 | 0 | 216 |
| 40 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 74 | 285 | 3.85 | 3 | 191 | 10 | 3 | 9 | 9 | 65 | 0 | 100.0% | 7.22 | 7.22 | 90 | 1 | 1 | 0 | 0 | 130 |
| 41 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 30 | 162 | 5.40 | 0 | 105 | 4 | 1 | 1 | 1 | 2 | 0 | 100.0% | 2.00 | 2.00 | 3 | 1 | 1 | 0 | 0 | 54 |
| 42 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 48 | 214 | 4.46 | 3 | 115 | 7 | 4 | 4 | 2 | -2 | 0 | 50.0% | -0.50 | -1.00 | 11 | 2 | 1 | 0 | 0 | 80 |
| 43 | Malik DavisDallas Cowboys·#43 | 9 | 26 | 115 | 4.42 | 0 | 53 | 2 | 1 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 1 | 65 |
| 44 | Kendre MillerNew Orleans Saints·#5 | 7 | 32 | 125 | 3.91 | 1 | 91 | 2 | 0 | 2 | 2 | 16 | 0 | 100.0% | 8.00 | 8.00 | 17 | 0 | 0 | 0 | 1 | 56 |
| 45 | D'Andre SwiftChicago Bears·#4 | 16 | 109 | 553 | 5.07 | 4 | 295 | 16 | 2 | 23 | 15 | 76 | 0 | 65.2% | 3.30 | 5.07 | 87 | 0 | 0 | 0 | 1 | 255 |
| 46 | Dylan SampsonCleveland Browns·#22 | 15 | 37 | 101 | 2.73 | 0 | 101 | 2 | 0 | 16 | 11 | 54 | 1 | 68.8% | 3.38 | 4.91 | 68 | 3 | 1 | 1 | 1 | 94 |
| 47 | Chuba HubbardCarolina Panthers·#30 | 15 | 66 | 265 | 4.02 | 1 | 165 | 3 | 1 | 12 | 7 | 63 | 1 | 58.3% | 5.25 | 9.00 | 76 | 1 | 0 | 0 | 1 | 150 |
| 48 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 113 | 565 | 5.00 | 2 | 400 | 14 | 7 | 21 | 19 | 180 | 1 | 90.5% | 8.57 | 9.47 | 244 | 3 | 2 | 1 | 1 | 229 |
| 49 | Miles SandersDallas Cowboys·#24 | 4 | 11 | 38 | 3.45 | 0 | 39 | 1 | 0 | 6 | 6 | 24 | 0 | 100.0% | 4.00 | 4.00 | 35 | 1 | 1 | 0 | 1 | 32 |
| 50 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 15 | 9 | 21 | 2.33 | 0 | 19 | 0 | 1 | 3 | 3 | 12 | 0 | 100.0% | 4.00 | 4.00 | 9 | 1 | 1 | 0 | 1 | 49 |