| 1 | Audric EstiméNew Orleans Saints·#30 | 4 | 7 | 20 | 2.86 | 0 | 20 | 2 | 2 | 4 | 4 | 28 | 0 | 100.0% | 7.00 | 7.00 | 15 | 0 | 0 | 0 | 0 | 36 |
| 2 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 73 | 331 | 4.53 | 1 | 233 | 13 | 3 | 24 | 14 | 69 | 0 | 58.3% | 2.88 | 4.93 | 102 | 1 | 1 | 0 | 0 | 190 |
| 3 | Bam KnightArizona Cardinals·#20 | 9 | 21 | 56 | 2.67 | 2 | 43 | 7 | 5 | 8 | 6 | 37 | 0 | 75.0% | 4.62 | 6.17 | 41 | 0 | 0 | 0 | 0 | 69 |
| 4 | Chris Rodriguez Jr.Washington Commanders·#36 | 10 | 26 | 111 | 4.27 | 3 | 43 | 13 | 4 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 58 |
| 5 | Cam SkatteboNew York Giants·#44 | 8 | 25 | 107 | 4.28 | 2 | 79 | 6 | 3 | 8 | 5 | 60 | 1 | 62.5% | 7.50 | 12.00 | 65 | 1 | 1 | 1 | 0 | 59 |
| 6 | Chris BrooksGreen Bay Packers·#30 | 14 | 6 | 17 | 2.83 | 0 | 18 | 1 | 0 | 8 | 7 | 45 | 0 | 87.5% | 5.62 | 6.43 | 57 | 1 | 0 | 0 | 0 | 51 |
| 7 | Brian RobinsonSan Francisco 49ers·#3 | 13 | 17 | 54 | 3.18 | 0 | 26 | 1 | 0 | 4 | 3 | 10 | 0 | 75.0% | 2.50 | 3.33 | 12 | 1 | 1 | 0 | 0 | 34 |
| 8 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 38 | 98 | 2.58 | 0 | 57 | 4 | 0 | 8 | 6 | 23 | 0 | 75.0% | 2.88 | 3.83 | 38 | 1 | 1 | 0 | 0 | 98 |
| 9 | Dylan SampsonCleveland Browns·#22 | 15 | 14 | 27 | 1.93 | 0 | 50 | 2 | 0 | 4 | 4 | 28 | 0 | 100.0% | 7.00 | 7.00 | 33 | 1 | 1 | 0 | 0 | 55 |
| 10 | Emanuel WilsonGreen Bay Packers·#23 | 15 | 29 | 102 | 3.52 | 1 | 71 | 6 | 0 | 3 | 2 | -6 | 0 | 66.7% | -2.00 | -3.00 | 6 | 0 | 0 | 0 | 0 | 68 |
| 11 | Isiah PachecoKansas City Chiefs·#10 | 13 | 29 | 127 | 4.38 | 0 | 87 | 7 | 0 | 6 | 4 | 11 | 1 | 66.7% | 1.83 | 2.75 | 18 | 1 | 1 | 1 | 0 | 117 |
| 12 | Devin NealNew Orleans Saints·#24 | 9 | 15 | 63 | 4.20 | 1 | 30 | 5 | 1 | 4 | 3 | 12 | 0 | 75.0% | 3.00 | 4.00 | 16 | 0 | 0 | 0 | 0 | 57 |
| 13 | David MontgomeryDetroit Lions·#5 | 17 | 54 | 207 | 3.83 | 4 | 123 | 17 | 13 | 10 | 9 | 70 | 0 | 90.0% | 7.00 | 7.78 | 69 | 0 | 0 | 0 | 0 | 124 |
| 14 | Derrick HenryBaltimore Ravens·#22 | 16 | 67 | 357 | 5.33 | 5 | 209 | 20 | 11 | 4 | 2 | 15 | 0 | 50.0% | 3.75 | 7.50 | 16 | 1 | 1 | 0 | 0 | 118 |
| 15 | Dare OgunbowaleHouston Texans·#33 | 14 | 2 | 6 | 3.00 | 0 | 6 | 0 | 0 | 2 | 2 | 26 | 0 | 100.0% | 13.00 | 13.00 | 29 | 0 | 0 | 0 | 0 | 40 |
| 16 | Chuba HubbardCarolina Panthers·#30 | 15 | 38 | 136 | 3.58 | 0 | 94 | 3 | 0 | 11 | 8 | 55 | 0 | 72.7% | 5.00 | 6.88 | 81 | 2 | 1 | 0 | 0 | 110 |
| 17 | Kendre MillerNew Orleans Saints·#5 | 6 | 12 | 37 | 3.08 | 0 | 35 | 3 | 0 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 9 | 0 | 0 | 0 | 0 | 32 |
| 18 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 27 | 173 | 6.41 | 1 | 125 | 11 | 1 | 31 | 28 | 211 | 1 | 90.3% | 6.81 | 7.54 | 207 | 7 | 6 | 0 | 0 | 147 |
| 19 | Kyle MonangaiChicago Bears·#25 | 16 | 39 | 157 | 4.03 | 2 | 69 | 11 | 2 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 18 | 0 | 0 | 0 | 0 | 107 |
| 20 | Kimani VidalLos Angeles Chargers·#30 | 11 | 32 | 120 | 3.75 | 1 | 77 | 11 | 3 | 5 | 4 | 27 | 0 | 80.0% | 5.40 | 6.75 | 47 | 1 | 0 | 0 | 0 | 133 |
| 21 | Kyren WilliamsLos Angeles Rams·#23 | 16 | 60 | 276 | 4.60 | 3 | 179 | 18 | 8 | 13 | 10 | 73 | 1 | 76.9% | 5.62 | 7.30 | 41 | 2 | 1 | 1 | 0 | 193 |
| 22 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 15 | 4 | 16 | 4.00 | 0 | 11 | 1 | 1 | 6 | 5 | 28 | 0 | 83.3% | 4.67 | 5.60 | 29 | 1 | 1 | 0 | 0 | 79 |
| 23 | Michael CarterArizona Cardinals·#22 | 11 | 19 | 54 | 2.84 | 0 | 54 | 4 | 2 | 13 | 10 | 79 | 0 | 76.9% | 6.08 | 7.90 | 69 | 3 | 3 | 0 | 0 | 84 |
| 24 | Jordan MasonMinnesota Vikings·#27 | 15 | 42 | 160 | 3.81 | 2 | 91 | 10 | 2 | 6 | 6 | 15 | 0 | 100.0% | 2.50 | 2.50 | 37 | 1 | 1 | 0 | 0 | 103 |
| 25 | Jeremy McNicholsWashington Commanders·#26 | 15 | 10 | 99 | 9.90 | 1 | 89 | 3 | 0 | 9 | 9 | 83 | 0 | 100.0% | 9.22 | 9.22 | 94 | 1 | 1 | 0 | 0 | 82 |
| 26 | Jerome FordCleveland Browns·#34 | 12 | 7 | 24 | 3.43 | 0 | 18 | 2 | 2 | 7 | 6 | 38 | 0 | 85.7% | 5.43 | 6.33 | 55 | 2 | 2 | 0 | 0 | 63 |
| 27 | Kareem HuntKansas City Chiefs·#29 | 17 | 43 | 200 | 4.65 | 1 | 126 | 18 | 2 | 10 | 10 | 79 | 0 | 100.0% | 7.90 | 7.90 | 89 | 0 | 0 | 0 | 0 | 139 |
| 28 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 54 | 200 | 3.70 | 3 | 123 | 13 | 7 | 8 | 8 | 66 | 0 | 100.0% | 8.25 | 8.25 | 76 | 1 | 1 | 0 | 0 | 121 |
| 29 | Jawhar JordanHouston Texans·#26 | 4 | 16 | 70 | 4.38 | 0 | 24 | 3 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 28 |
| 30 | Jaydon BlueDallas Cowboys·#23 | 5 | 14 | 53 | 3.79 | 0 | 33 | 2 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 26 |
| 31 | James ConnerArizona Cardinals·#6 | 3 | 6 | 20 | 3.33 | 0 | 26 | 2 | 1 | 5 | 4 | 20 | 1 | 80.0% | 4.00 | 5.00 | 33 | 1 | 1 | 1 | 0 | 25 |
| 32 | Jacory Croskey-MerrittWashington Commanders·#22 | 14 | 41 | 194 | 4.73 | 5 | 94 | 14 | 4 | 3 | 2 | 12 | 0 | 66.7% | 4.00 | 6.00 | 11 | 0 | 0 | 0 | 0 | 94 |
| 33 | RJ HarveyDenver Broncos·#12 | 17 | 33 | 84 | 2.55 | 1 | 49 | 3 | 3 | 12 | 9 | 57 | 0 | 75.0% | 4.75 | 6.33 | 67 | 1 | 1 | 0 | 0 | 106 |
| 34 | Ollie Gordon IIMiami Dolphins·#31 | 15 | 16 | 42 | 2.62 | 0 | 20 | 5 | 1 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 45 |
| 35 | Nick ChubbHouston Texans·#21 | 14 | 25 | 95 | 3.80 | 1 | 63 | 4 | 3 | 8 | 3 | -3 | 0 | 37.5% | -0.38 | -1.00 | 8 | 2 | 1 | 0 | 0 | 79 |
| 36 | Malik DavisDallas Cowboys·#43 | 7 | 14 | 78 | 5.57 | 2 | 20 | 2 | 1 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 36 |
| 37 | Tyrone Tracy Jr.New York Giants·#29 | 14 | 37 | 138 | 3.73 | 1 | 127 | 6 | 0 | 11 | 8 | 97 | 0 | 72.7% | 8.82 | 12.12 | 112 | 2 | 1 | 0 | 0 | 135 |
| 38 | Will ShipleyPhiladelphia Eagles·#28 | 13 | 5 | 8 | 1.60 | 0 | 3 | 0 | 0 | 5 | 4 | 25 | 0 | 80.0% | 5.00 | 6.25 | 18 | 1 | 0 | 0 | 0 | 45 |
| 39 | Woody MarksHouston Texans·#27 | 15 | 52 | 231 | 4.44 | 1 | 144 | 19 | 4 | 17 | 11 | 30 | 1 | 64.7% | 1.76 | 2.73 | 42 | 3 | 2 | 1 | 0 | 172 |
| 40 | Tyler BadieDenver Broncos·#28 | 16 | 0 | 0 | — | 0 | 9 | 0 | 0 | 16 | 10 | 70 | 0 | 62.5% | 4.38 | 7.00 | 97 | 2 | 1 | 0 | 0 | 74 |
| 41 | Travis EtienneJacksonville Jaguars·#1 | 17 | 50 | 356 | 7.12 | 3 | 214 | 14 | 1 | 12 | 8 | 40 | 1 | 66.7% | 3.33 | 5.00 | 34 | 3 | 3 | 1 | 0 | 139 |
| 42 | Trey BensonArizona Cardinals·#33 | 4 | 7 | 32 | 4.57 | 0 | 28 | 0 | 0 | 9 | 8 | 38 | 0 | 88.9% | 4.22 | 4.75 | 41 | 0 | 0 | 0 | 0 | 34 |
| 43 | Tyler AllgeierAtlanta Falcons·#25 | 15 | 28 | 92 | 3.29 | 2 | 47 | 10 | 2 | 6 | 6 | 31 | 0 | 100.0% | 5.17 | 5.17 | 33 | 1 | 1 | 0 | 0 | 62 |
| 44 | Ty JohnsonBuffalo Bills·#26 | 17 | 13 | 48 | 3.69 | 3 | 35 | 5 | 2 | 9 | 6 | 113 | 1 | 66.7% | 12.56 | 18.83 | 99 | 1 | 1 | 0 | 0 | 88 |
| 45 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 72 | 260 | 3.61 | 2 | 152 | 12 | 4 | 18 | 12 | 70 | 1 | 66.7% | 3.89 | 5.83 | 86 | 5 | 3 | 1 | 0 | 186 |
| 46 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 22 | 105 | 4.77 | 2 | 56 | 4 | 3 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 6 | 0 | 0 | 0 | 0 | 43 |
| 47 | Tank BigsbyPhiladelphia Eagles·#37 | 7 | 13 | 67 | 5.15 | 0 | 52 | 2 | 0 | 3 | 2 | 33 | 0 | 66.7% | 11.00 | 16.50 | 33 | 1 | 1 | 0 | 0 | 30 |
| 48 | Raheem MostertLas Vegas Raiders·#31 | 12 | 4 | 17 | 4.25 | 0 | 13 | 2 | 0 | 6 | 6 | 17 | 0 | 100.0% | 2.83 | 2.83 | 31 | 1 | 1 | 0 | 0 | 41 |
| 49 | Zavier ScottMinnesota Vikings·#36 | 5 | 8 | 27 | 3.38 | 0 | 13 | 1 | 0 | 6 | 5 | 20 | 0 | 83.3% | 3.33 | 4.00 | 19 | 1 | 1 | 0 | 0 | 28 |
| 50 | Quinshon JudkinsCleveland Browns·#10 | 14 | 56 | 184 | 3.29 | 2 | 119 | 13 | 5 | 6 | 5 | 44 | 0 | 83.3% | 7.33 | 8.80 | 48 | 1 | 1 | 0 | 1 | 107 |