| 1 | Audric EstiméNew Orleans Saints·#30 | 5 | 20 | 76 | 3.80 | 0 | 65 | 5 | 1 | 2 | 2 | 20 | 0 | 100.0% | 10.00 | 10.00 | 24 | 0 | 0 | 0 | 0 | 50 |
| 2 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 75 | 217 | 2.89 | 1 | 152 | 12 | 3 | 17 | 14 | 127 | 2 | 82.3% | 7.47 | 9.07 | 150 | 1 | 1 | 1 | 0 | 174 |
| 3 | Blake CorumLos Angeles Rams·#22 | 14 | 38 | 150 | 3.95 | 2 | 91 | 11 | 2 | 7 | 4 | 20 | 0 | 57.1% | 2.86 | 5.00 | 12 | 1 | 0 | 0 | 0 | 83 |
| 4 | Bhayshul TutenJacksonville Jaguars·#33 | 12 | 27 | 98 | 3.63 | 1 | 86 | 8 | 1 | 2 | 2 | 14 | 0 | 100.0% | 7.00 | 7.00 | 12 | 0 | 0 | 0 | 0 | 56 |
| 5 | Chase BrownCincinnati Bengals·#30 | 17 | 60 | 256 | 4.27 | 3 | 200 | 9 | 4 | 19 | 16 | 106 | 2 | 84.2% | 5.58 | 6.62 | 95 | 4 | 2 | 2 | 0 | 148 |
| 6 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 32 | 126 | 3.94 | 1 | 81 | 7 | 1 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 12 | 1 | 1 | 0 | 0 | 58 |
| 7 | Breece HallNew York Jets·#20 | 16 | 63 | 261 | 4.14 | 0 | 120 | 17 | 0 | 8 | 6 | 43 | 0 | 75.0% | 5.38 | 7.17 | 17 | 1 | 0 | 0 | 0 | 143 |
| 8 | Brashard SmithKansas City Chiefs·#24 | 13 | 10 | 46 | 4.60 | 0 | 37 | 2 | 0 | 7 | 6 | 43 | 0 | 85.7% | 6.14 | 7.17 | 64 | 1 | 1 | 0 | 0 | 36 |
| 9 | Chris BrooksGreen Bay Packers·#30 | 11 | 7 | 15 | 2.14 | 0 | 22 | 1 | 0 | 2 | 1 | 6 | 0 | 50.0% | 3.00 | 6.00 | 11 | 1 | 0 | 0 | 0 | 39 |
| 10 | Emanuel WilsonGreen Bay Packers·#23 | 13 | 33 | 154 | 4.67 | 1 | 127 | 9 | 3 | 2 | 2 | 25 | 0 | 100.0% | 12.50 | 12.50 | 22 | 0 | 0 | 0 | 0 | 66 |
| 11 | Emari DemercadoArizona Cardinals·#31 | 9 | 11 | 53 | 4.82 | 0 | 30 | 2 | 0 | 4 | 2 | 32 | 0 | 50.0% | 8.00 | 16.00 | 14 | 2 | 1 | 0 | 0 | 40 |
| 12 | Isaiah DavisNew York Jets·#32 | 15 | 10 | 86 | 8.60 | 0 | 75 | 3 | 0 | 4 | 4 | 52 | 0 | 100.0% | 13.00 | 13.00 | 62 | 0 | 0 | 0 | 0 | 55 |
| 13 | Isiah PachecoKansas City Chiefs·#10 | 13 | 36 | 161 | 4.47 | 1 | 83 | 11 | 0 | 10 | 6 | 60 | 0 | 60.0% | 6.00 | 10.00 | 53 | 1 | 0 | 0 | 0 | 110 |
| 14 | Devin NealNew Orleans Saints·#24 | 6 | 23 | 99 | 4.30 | 0 | 33 | 4 | 0 | 3 | 3 | 41 | 0 | 100.0% | 13.67 | 13.67 | 49 | 0 | 0 | 0 | 0 | 46 |
| 15 | Devin SingletaryNew York Giants·#26 | 15 | 23 | 69 | 3.00 | 0 | 59 | 4 | 0 | 5 | 5 | 40 | 0 | 100.0% | 8.00 | 8.00 | 28 | 2 | 2 | 0 | 0 | 54 |
| 16 | D'Andre SwiftChicago Bears·#4 | 16 | 57 | 273 | 4.79 | 2 | 154 | 15 | 5 | 9 | 5 | 36 | 0 | 55.6% | 4.00 | 7.20 | 47 | 0 | 0 | 0 | 0 | 136 |
| 17 | Jahmyr GibbsDetroit Lions·#0 | 17 | 62 | 276 | 4.45 | 1 | 145 | 12 | 2 | 19 | 17 | 187 | 1 | 89.5% | 9.84 | 11.00 | 227 | 1 | 1 | 1 | 0 | 138 |
| 18 | J.K. DobbinsDenver Broncos·#27 | 10 | 49 | 306 | 6.24 | 2 | 147 | 13 | 1 | 2 | 2 | 6 | 0 | 100.0% | 3.00 | 3.00 | 11 | 0 | 0 | 0 | 0 | 78 |
| 19 | Dylan SampsonCleveland Browns·#22 | 13 | 13 | 35 | 2.69 | 0 | 57 | 3 | 0 | 11 | 9 | 55 | 0 | 81.8% | 5.00 | 6.11 | 86 | 1 | 1 | 0 | 0 | 42 |
| 20 | Nick ChubbHouston Texans·#21 | 13 | 29 | 148 | 5.10 | 1 | 93 | 6 | 0 | 4 | 3 | 14 | 0 | 75.0% | 3.50 | 4.67 | 6 | 0 | 0 | 0 | 0 | 64 |
| 21 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 33 | 176 | 5.33 | 1 | 91 | 8 | 5 | 7 | 7 | 41 | 0 | 100.0% | 5.86 | 5.86 | 46 | 1 | 1 | 0 | 0 | 95 |
| 22 | Ollie Gordon IIMiami Dolphins·#31 | 13 | 19 | 80 | 4.21 | 0 | 43 | 5 | 1 | 2 | 2 | 4 | 0 | 100.0% | 2.00 | 2.00 | 12 | 0 | 0 | 0 | 0 | 41 |
| 23 | Kimani VidalLos Angeles Chargers·#30 | 11 | 45 | 244 | 5.42 | 1 | 94 | 6 | 0 | 6 | 4 | 26 | 1 | 66.7% | 4.33 | 6.50 | 28 | 4 | 3 | 1 | 0 | 117 |
| 24 | Kyle MonangaiChicago Bears·#25 | 17 | 43 | 213 | 4.95 | 0 | 138 | 12 | 3 | 10 | 8 | 98 | 0 | 80.0% | 9.80 | 12.25 | 111 | 1 | 1 | 0 | 0 | 108 |
| 25 | Kareem HuntKansas City Chiefs·#29 | 17 | 36 | 87 | 2.42 | 2 | 63 | 9 | 3 | 7 | 4 | 42 | 1 | 57.1% | 6.00 | 10.50 | 41 | 3 | 2 | 1 | 0 | 107 |
| 26 | Keaton MitchellBaltimore Ravens·#34 | 9 | 14 | 141 | 10.07 | 1 | 63 | 6 | 0 | 3 | 1 | 6 | 0 | 33.3% | 2.00 | 6.00 | 10 | 0 | 0 | 0 | 0 | 26 |
| 27 | Kendre MillerNew Orleans Saints·#5 | 6 | 14 | 51 | 3.64 | 0 | 44 | 2 | 0 | 1 | 1 | 8 | 0 | 100.0% | 8.00 | 8.00 | 9 | 0 | 0 | 0 | 0 | 26 |
| 28 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 30 | 173 | 5.77 | 1 | 105 | 9 | 2 | 12 | 8 | 43 | 0 | 66.7% | 3.58 | 5.38 | 34 | 2 | 1 | 0 | 0 | 92 |
| 29 | Jerome FordCleveland Browns·#34 | 13 | 9 | 25 | 2.78 | 0 | 22 | 2 | 0 | 5 | 2 | 5 | 0 | 40.0% | 1.00 | 2.50 | 6 | 0 | 0 | 0 | 0 | 50 |
| 30 | Jordan MasonMinnesota Vikings·#27 | 14 | 38 | 216 | 5.68 | 3 | 109 | 13 | 3 | 6 | 5 | 22 | 0 | 83.3% | 3.67 | 4.40 | 37 | 0 | 0 | 0 | 0 | 88 |
| 31 | Jeremy McNicholsWashington Commanders·#26 | 17 | 5 | 19 | 3.80 | 0 | 35 | 0 | 0 | 8 | 6 | 38 | 0 | 75.0% | 4.75 | 6.33 | 48 | 1 | 1 | 0 | 0 | 58 |
| 32 | Javonte WilliamsDallas Cowboys·#33 | 15 | 59 | 302 | 5.12 | 3 | 216 | 15 | 5 | 10 | 7 | 36 | 0 | 70.0% | 3.60 | 5.14 | 49 | 2 | 2 | 0 | 0 | 146 |
| 33 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 30 | 83 | 2.77 | 4 | 52 | 8 | 5 | 2 | 2 | 5 | 0 | 100.0% | 2.50 | 2.50 | 13 | 0 | 0 | 0 | 0 | 53 |
| 34 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 30 | 133 | 4.43 | 1 | 59 | 12 | 2 | 9 | 8 | 52 | 0 | 88.9% | 5.78 | 6.50 | 72 | 2 | 2 | 0 | 0 | 112 |
| 35 | Ray DavisBuffalo Bills·#22 | 12 | 13 | 66 | 5.08 | 0 | 61 | 4 | 2 | 5 | 5 | 44 | 1 | 100.0% | 8.80 | 8.80 | 48 | 2 | 2 | 1 | 0 | 40 |
| 36 | Samaje PerineCincinnati Bengals·#34 | 13 | 19 | 117 | 6.16 | 1 | 76 | 8 | 0 | 1 | 1 | 1 | 0 | 100.0% | 1.00 | 1.00 | 7 | 0 | 0 | 0 | 0 | 57 |
| 37 | Quinshon JudkinsCleveland Browns·#10 | 13 | 57 | 198 | 3.47 | 0 | 112 | 12 | 0 | 8 | 6 | 23 | 0 | 75.0% | 2.88 | 3.83 | 21 | 0 | 0 | 0 | 0 | 103 |
| 38 | RJ HarveyDenver Broncos·#12 | 17 | 30 | 91 | 3.03 | 3 | 105 | 5 | 4 | 19 | 14 | 129 | 0 | 73.7% | 6.79 | 9.21 | 110 | 3 | 2 | 0 | 0 | 96 |
| 39 | Malik DavisDallas Cowboys·#43 | 7 | 14 | 58 | 4.14 | 0 | 23 | 4 | 1 | 1 | 1 | 10 | 0 | 100.0% | 10.00 | 10.00 | 6 | 0 | 0 | 0 | 0 | 39 |
| 40 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 16 | 3 | 15 | 5.00 | 0 | 10 | 2 | 0 | 1 | 1 | 10 | 0 | 100.0% | 10.00 | 10.00 | 6 | 0 | 0 | 0 | 0 | 34 |
| 41 | Michael CarterArizona Cardinals·#22 | 10 | 24 | 73 | 3.04 | 0 | 45 | 5 | 0 | 7 | 6 | 56 | 0 | 85.7% | 8.00 | 9.33 | 72 | 0 | 0 | 0 | 0 | 75 |
| 42 | Tyler AllgeierAtlanta Falcons·#25 | 15 | 28 | 106 | 3.79 | 1 | 93 | 6 | 0 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 24 | 0 | 0 | 0 | 0 | 56 |
| 43 | Woody MarksHouston Texans·#27 | 14 | 44 | 109 | 2.48 | 0 | 74 | 4 | 1 | 2 | 1 | 9 | 0 | 50.0% | 4.50 | 9.00 | 5 | 0 | 0 | 0 | 0 | 98 |
| 44 | Tyler BadieDenver Broncos·#28 | 13 | 2 | 6 | 3.00 | 0 | 21 | 0 | 0 | 2 | 1 | 19 | 0 | 50.0% | 9.50 | 19.00 | 23 | 0 | 0 | 0 | 0 | 27 |
| 45 | Tyjae SpearsTennessee Titans·#2 | 13 | 7 | 9 | 1.29 | 0 | 26 | 0 | 0 | 6 | 6 | 22 | 0 | 100.0% | 3.67 | 3.67 | 55 | 2 | 2 | 0 | 0 | 48 |
| 46 | Travis EtienneJacksonville Jaguars·#1 | 17 | 61 | 224 | 3.67 | 1 | 174 | 10 | 1 | 18 | 14 | 122 | 3 | 77.8% | 6.78 | 8.71 | 155 | 4 | 3 | 3 | 0 | 164 |
| 47 | TreVeyon HendersonNew England Patriots·#32 | 16 | 44 | 221 | 5.02 | 1 | 114 | 10 | 0 | 10 | 7 | 23 | 1 | 70.0% | 2.30 | 3.29 | 35 | 3 | 3 | 1 | 0 | 109 |
| 48 | Chris Rodriguez Jr.Washington Commanders·#36 | 11 | 20 | 88 | 4.40 | 1 | 58 | 4 | 1 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 3 | 0 | 0 | 0 | 1 | 52 |
| 49 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 46 | 214 | 4.65 | 1 | 137 | 8 | 1 | 12 | 8 | 72 | 1 | 66.7% | 6.00 | 9.00 | 24 | 2 | 2 | 1 | 1 | 155 |
| 50 | Rhamondre StevensonNew England Patriots·#38 | 14 | 30 | 94 | 3.13 | 3 | 100 | 5 | 8 | 11 | 9 | 147 | 1 | 81.8% | 13.36 | 16.33 | 107 | 2 | 2 | 1 | 1 | 120 |