| 1 | Alvin KamaraNew Orleans Saints·#41 | 10 | 23 | 73 | 3.17 | 0 | 65 | 3 | 1 | 6 | 5 | 39 | 0 | 83.3% | 6.50 | 7.80 | 25 | 1 | 1 | 0 | 0 | 107 |
| 2 | Ameer AbdullahIndianapolis Colts·#26 | 8 | 1 | 2 | 2.00 | 0 | 1 | 0 | 0 | 4 | 4 | 17 | 0 | 100.0% | 4.25 | 4.25 | 23 | 0 | 0 | 0 | 0 | 27 |
| 3 | Ashton JeantyLas Vegas Raiders·#2 | 16 | 47 | 171 | 3.64 | 1 | 182 | 6 | 2 | 16 | 14 | 55 | 2 | 87.5% | 3.44 | 3.93 | 96 | 3 | 3 | 2 | 0 | 148 |
| 4 | Bam KnightArizona Cardinals·#20 | 7 | 14 | 26 | 1.86 | 0 | 25 | 3 | 1 | 5 | 5 | 17 | 0 | 100.0% | 3.40 | 3.40 | 23 | 1 | 1 | 0 | 0 | 46 |
| 5 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 62 | 184 | 2.97 | 1 | 191 | 10 | 5 | 27 | 21 | 192 | 0 | 77.8% | 7.11 | 9.14 | 192 | 2 | 1 | 0 | 0 | 196 |
| 6 | Bhayshul TutenJacksonville Jaguars·#33 | 12 | 18 | 43 | 2.39 | 2 | 25 | 3 | 3 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 31 |
| 7 | Brashard SmithKansas City Chiefs·#24 | 13 | 17 | 42 | 2.47 | 0 | 62 | 1 | 1 | 10 | 7 | 51 | 0 | 70.0% | 5.10 | 7.29 | 54 | 1 | 1 | 0 | 0 | 44 |
| 8 | Blake CorumLos Angeles Rams·#22 | 14 | 37 | 242 | 6.54 | 2 | 90 | 10 | 3 | 1 | 1 | 14 | 0 | 100.0% | 14.00 | 14.00 | 16 | 0 | 0 | 0 | 0 | 59 |
| 9 | Chris BrooksGreen Bay Packers·#30 | 11 | 9 | 46 | 5.11 | 0 | 29 | 2 | 0 | 3 | 1 | 8 | 0 | 33.3% | 2.67 | 8.00 | 8 | 0 | 0 | 0 | 0 | 38 |
| 10 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 39 | 139 | 3.56 | 0 | 108 | 5 | 0 | 12 | 10 | 58 | 0 | 83.3% | 4.83 | 5.80 | 94 | 0 | 0 | 0 | 0 | 106 |
| 11 | Brian RobinsonSan Francisco 49ers·#3 | 15 | 26 | 140 | 5.38 | 1 | 72 | 6 | 0 | 4 | 3 | 5 | 0 | 75.0% | 1.25 | 1.67 | 11 | 2 | 1 | 0 | 0 | 44 |
| 12 | Emanuel WilsonGreen Bay Packers·#23 | 14 | 38 | 152 | 4.00 | 0 | 112 | 10 | 0 | 8 | 6 | 42 | 0 | 75.0% | 5.25 | 7.00 | 52 | 2 | 0 | 0 | 0 | 97 |
| 13 | Isaiah DavisNew York Jets·#32 | 13 | 5 | 41 | 8.20 | 1 | 22 | 2 | 0 | 11 | 8 | 70 | 0 | 72.7% | 6.36 | 8.75 | 67 | 2 | 1 | 0 | 0 | 86 |
| 14 | De'Von AchaneMiami Dolphins·#28 | 15 | 64 | 348 | 5.44 | 3 | 255 | 18 | 3 | 17 | 16 | 153 | 1 | 94.1% | 9.00 | 9.56 | 145 | 3 | 3 | 1 | 0 | 182 |
| 15 | DJ GiddensIndianapolis Colts·#21 | 6 | 21 | 79 | 3.76 | 0 | 48 | 4 | 1 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 31 |
| 16 | Chris Rodriguez Jr.Washington Commanders·#36 | 10 | 36 | 120 | 3.33 | 2 | 91 | 8 | 5 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 23 | 0 | 0 | 0 | 0 | 63 |
| 17 | Devin SingletaryNew York Giants·#26 | 15 | 38 | 159 | 4.18 | 2 | 104 | 11 | 4 | 5 | 5 | 87 | 0 | 100.0% | 17.40 | 17.40 | 94 | 0 | 0 | 0 | 0 | 109 |
| 18 | Hassan HaskinsLos Angeles Chargers·#28 | 5 | 8 | 20 | 2.50 | 0 | 22 | 1 | 0 | 3 | 3 | 4 | 0 | 100.0% | 1.33 | 1.33 | 9 | 0 | 0 | 0 | 0 | 26 |
| 19 | Devin NealNew Orleans Saints·#24 | 7 | 10 | 18 | 1.80 | 0 | 17 | 0 | 0 | 9 | 8 | 37 | 0 | 88.9% | 4.11 | 4.62 | 64 | 1 | 1 | 0 | 0 | 96 |
| 20 | Justice HillBaltimore Ravens·#43 | 10 | 5 | 76 | 15.20 | 1 | 77 | 1 | 0 | 10 | 7 | 73 | 0 | 70.0% | 7.30 | 10.43 | 73 | 0 | 0 | 0 | 0 | 61 |
| 21 | RJ HarveyDenver Broncos·#12 | 17 | 45 | 196 | 4.36 | 1 | 165 | 12 | 2 | 16 | 14 | 116 | 5 | 87.5% | 7.25 | 8.29 | 114 | 6 | 5 | 4 | 0 | 139 |
| 22 | Ollie Gordon IIMiami Dolphins·#31 | 15 | 18 | 36 | 2.00 | 2 | 29 | 5 | 2 | 4 | 4 | 25 | 1 | 100.0% | 6.25 | 6.25 | 38 | 1 | 1 | 1 | 0 | 60 |
| 23 | Quinshon JudkinsCleveland Browns·#10 | 12 | 47 | 216 | 4.60 | 2 | 153 | 12 | 3 | 10 | 6 | 24 | 0 | 60.0% | 2.40 | 4.00 | 22 | 0 | 0 | 0 | 0 | 85 |
| 24 | Khalil HerbertNew York Jets·#31 | 3 | 7 | 21 | 3.00 | 0 | 9 | 2 | 0 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 28 |
| 25 | Keaton MitchellBaltimore Ravens·#34 | 10 | 17 | 72 | 4.24 | 0 | 36 | 3 | 0 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 26 | 0 | 0 | 0 | 0 | 26 |
| 26 | Kyle MonangaiChicago Bears·#25 | 17 | 45 | 203 | 4.51 | 2 | 110 | 8 | 3 | 9 | 5 | 33 | 0 | 55.6% | 3.67 | 6.60 | 27 | 2 | 1 | 0 | 0 | 130 |
| 27 | Kimani VidalLos Angeles Chargers·#30 | 12 | 38 | 132 | 3.47 | 1 | 55 | 8 | 3 | 5 | 3 | 0 | 0 | 60.0% | 0.00 | 0.00 | 6 | 1 | 0 | 0 | 0 | 108 |
| 28 | Isiah PachecoKansas City Chiefs·#10 | 13 | 21 | 72 | 3.43 | 0 | 44 | 3 | 0 | 5 | 5 | 20 | 0 | 100.0% | 4.00 | 4.00 | 24 | 1 | 1 | 0 | 0 | 81 |
| 29 | Jaylen WrightMiami Dolphins·#5 | 6 | 21 | 94 | 4.48 | 1 | 61 | 8 | 1 | 3 | 2 | 9 | 0 | 66.7% | 3.00 | 4.50 | 12 | 0 | 0 | 0 | 0 | 38 |
| 30 | James CookBuffalo Bills·#4 | 14 | 67 | 231 | 3.45 | 1 | 185 | 8 | 3 | 15 | 12 | 143 | 0 | 80.0% | 9.53 | 11.92 | 112 | 0 | 0 | 0 | 0 | 153 |
| 31 | J.K. DobbinsDenver Broncos·#27 | 10 | 48 | 237 | 4.94 | 2 | 137 | 13 | 1 | 5 | 5 | 14 | 0 | 100.0% | 2.80 | 2.80 | 23 | 0 | 0 | 0 | 0 | 94 |
| 32 | Ray DavisBuffalo Bills·#22 | 12 | 28 | 114 | 4.07 | 0 | 66 | 6 | 0 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 45 |
| 33 | Sean TuckerTampa Bay Buccaneers·#44 | 9 | 15 | 56 | 3.73 | 0 | 26 | 3 | 1 | 4 | 3 | 32 | 1 | 75.0% | 8.00 | 10.67 | 27 | 1 | 0 | 0 | 0 | 28 |
| 34 | Tank BigsbyPhiladelphia Eagles·#37 | 8 | 24 | 143 | 5.96 | 0 | 107 | 7 | 4 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 41 |
| 35 | Travis EtienneJacksonville Jaguars·#1 | 17 | 80 | 287 | 3.59 | 2 | 180 | 15 | 5 | 8 | 6 | 71 | 1 | 75.0% | 8.88 | 11.83 | 79 | 1 | 1 | 0 | 0 | 162 |
| 36 | Trayveon WilliamsCleveland Browns·#38 | 4 | 3 | 17 | 5.67 | 0 | 18 | 2 | 0 | 5 | 4 | 23 | 0 | 80.0% | 4.60 | 5.75 | 39 | 2 | 2 | 0 | 0 | 25 |
| 37 | Trey BensonArizona Cardinals·#33 | 4 | 11 | 24 | 2.18 | 0 | 31 | 1 | 1 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 31 |
| 38 | Ty JohnsonBuffalo Bills·#26 | 17 | 16 | 52 | 3.25 | 0 | 67 | 3 | 1 | 11 | 9 | 55 | 1 | 81.8% | 5.00 | 6.11 | 86 | 2 | 1 | 1 | 0 | 95 |
| 39 | Woody MarksHouston Texans·#27 | 14 | 53 | 203 | 3.83 | 1 | 130 | 10 | 2 | 11 | 7 | 55 | 2 | 63.6% | 5.00 | 7.86 | 59 | 5 | 3 | 2 | 0 | 153 |
| 40 | Tyler BadieDenver Broncos·#28 | 13 | 3 | 14 | 4.67 | 0 | 17 | 0 | 0 | 6 | 5 | 33 | 0 | 83.3% | 5.50 | 6.60 | 62 | 2 | 2 | 0 | 0 | 48 |
| 41 | Rhamondre StevensonNew England Patriots·#38 | 14 | 22 | 63 | 2.86 | 2 | 66 | 3 | 0 | 8 | 5 | 32 | 0 | 62.5% | 4.00 | 6.40 | 31 | 1 | 0 | 0 | 0 | 99 |
| 42 | Trevor EtienneCarolina Panthers·#23 | 5 | 16 | 83 | 5.19 | 0 | 43 | 7 | 1 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 3 | 0 | 0 | 0 | 0 | 25 |
| 43 | Michael CarterArizona Cardinals·#22 | 13 | 24 | 89 | 3.71 | 0 | 95 | 7 | 0 | 22 | 15 | 122 | 0 | 68.2% | 5.55 | 8.13 | 108 | 4 | 1 | 0 | 1 | 143 |
| 44 | Kareem HuntKansas City Chiefs·#29 | 16 | 48 | 171 | 3.56 | 5 | 90 | 15 | 9 | 5 | 2 | 7 | 0 | 40.0% | 1.40 | 3.50 | 12 | 1 | 0 | 0 | 1 | 146 |
| 45 | Dare OgunbowaleHouston Texans·#33 | 10 | 4 | 10 | 2.50 | 1 | 9 | 1 | 2 | 6 | 5 | 31 | 0 | 83.3% | 5.17 | 6.20 | 18 | 2 | 1 | 0 | 1 | 27 |
| 46 | Nick ChubbHouston Texans·#21 | 13 | 34 | 148 | 4.35 | 1 | 99 | 5 | 2 | 2 | 2 | 13 | 0 | 100.0% | 6.50 | 6.50 | 5 | 0 | 0 | 0 | 1 | 68 |
| 47 | Omarion HamptonLos Angeles Chargers·#8 | 8 | 24 | 100 | 4.17 | 2 | 55 | 5 | 2 | 10 | 9 | 63 | 0 | 90.0% | 6.30 | 7.00 | 69 | 0 | 0 | 0 | 1 | 69 |
| 48 | Jacory Croskey-MerrittWashington Commanders·#22 | 15 | 49 | 212 | 4.33 | 0 | 122 | 12 | 4 | 2 | 1 | 3 | 0 | 50.0% | 1.50 | 3.00 | 1 | 0 | 0 | 0 | 1 | 87 |
| 49 | Malik DavisDallas Cowboys·#43 | 6 | 13 | 45 | 3.46 | 0 | 25 | 2 | 0 | 2 | 1 | 6 | 0 | 50.0% | 3.00 | 6.00 | 0 | 0 | 0 | 0 | 1 | 39 |
| 50 | Josh JacobsGreen Bay Packers·#8 | 13 | 63 | 261 | 4.14 | 8 | 205 | 19 | 7 | 11 | 5 | 53 | 0 | 45.5% | 4.82 | 10.60 | 55 | 2 | 1 | 0 | 1 | 120 |