| 1 | Ameer AbdullahIndianapolis Colts·#26 | 11 | 7 | 25 | 3.57 | 0 | 18 | 0 | 0 | 11 | 10 | 68 | 0 | 90.9% | 6.18 | 6.80 | 64 | 1 | 1 | 0 | 0 | 40 |
| 2 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 174 | 711 | 4.09 | 1 | 521 | 17 | 0 | 49 | 37 | 215 | 0 | 75.5% | 4.39 | 5.81 | 320 | 5 | 5 | 0 | 0 | 446 |
| 3 | Austin EkelerWashington Commanders·#30 | 2 | 8 | 30 | 3.75 | 0 | 26 | 0 | 0 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 36 | 0 | 0 | 0 | 0 | 37 |
| 4 | Braelon AllenNew York Jets·#0 | 4 | 7 | 28 | 4.00 | 0 | 12 | 0 | 0 | 1 | 1 | 12 | 0 | 100.0% | 12.00 | 12.00 | 9 | 0 | 0 | 0 | 0 | 25 |
| 5 | Brashard SmithKansas City Chiefs·#24 | 17 | 30 | 104 | 3.47 | 0 | 97 | 1 | 0 | 21 | 17 | 169 | 0 | 81.0% | 8.05 | 9.94 | 205 | 3 | 2 | 0 | 0 | 95 |
| 6 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 56 | 271 | 4.84 | 1 | 129 | 7 | 0 | 9 | 6 | 17 | 0 | 66.7% | 1.89 | 2.83 | 23 | 1 | 1 | 0 | 0 | 96 |
| 7 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 109 | 406 | 3.72 | 0 | 233 | 6 | 0 | 22 | 19 | 149 | 1 | 86.4% | 6.77 | 7.84 | 217 | 3 | 2 | 0 | 0 | 244 |
| 8 | Chris BrooksGreen Bay Packers·#30 | 16 | 17 | 75 | 4.41 | 0 | 51 | 2 | 0 | 10 | 9 | 72 | 0 | 90.0% | 7.20 | 8.00 | 94 | 0 | 0 | 0 | 0 | 97 |
| 9 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 70 | 284 | 4.06 | 1 | 221 | 8 | 0 | 11 | 10 | 85 | 0 | 90.9% | 7.73 | 8.50 | 104 | 1 | 1 | 0 | 0 | 163 |
| 10 | Devin NealNew Orleans Saints·#24 | 9 | 33 | 116 | 3.52 | 0 | 63 | 2 | 0 | 11 | 10 | 54 | 0 | 90.9% | 4.91 | 5.40 | 70 | 0 | 0 | 0 | 0 | 137 |
| 11 | Jaydon BlueDallas Cowboys·#23 | 5 | 30 | 91 | 3.03 | 1 | 35 | 4 | 0 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 10 | 0 | 0 | 0 | 0 | 52 |
| 12 | J.K. DobbinsDenver Broncos·#27 | 10 | 95 | 565 | 5.95 | 1 | 303 | 14 | 0 | 11 | 10 | 34 | 0 | 90.9% | 3.09 | 3.40 | 52 | 0 | 0 | 0 | 0 | 194 |
| 13 | Isiah PachecoKansas City Chiefs·#10 | 13 | 72 | 306 | 4.25 | 0 | 199 | 8 | 0 | 16 | 13 | 51 | 0 | 81.3% | 3.19 | 3.92 | 79 | 0 | 0 | 0 | 0 | 247 |
| 14 | Isaiah DavisNew York Jets·#32 | 16 | 25 | 163 | 6.52 | 0 | 131 | 3 | 0 | 20 | 15 | 144 | 0 | 75.0% | 7.20 | 9.60 | 139 | 1 | 1 | 0 | 0 | 145 |
| 15 | Hassan HaskinsLos Angeles Chargers·#28 | 9 | 11 | 32 | 2.91 | 0 | 17 | 1 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 7 | 0 | 0 | 0 | 0 | 41 |
| 16 | Evan HullNew Orleans Saints·#34 | 6 | 14 | 34 | 2.43 | 0 | 13 | 0 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 0 | 45 |
| 17 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 24 | 128 | 5.33 | 0 | 55 | 3 | 0 | 4 | 3 | 18 | 0 | 75.0% | 4.50 | 6.00 | 31 | 0 | 0 | 0 | 0 | 46 |
| 18 | James ConnerArizona Cardinals·#6 | 3 | 17 | 66 | 3.88 | 0 | 62 | 0 | 0 | 7 | 6 | 29 | 0 | 85.7% | 4.14 | 4.83 | 55 | 0 | 0 | 0 | 0 | 48 |
| 19 | Kimani VidalLos Angeles Chargers·#30 | 13 | 100 | 410 | 4.10 | 0 | 195 | 11 | 0 | 9 | 6 | 33 | 0 | 66.7% | 3.67 | 5.50 | 51 | 3 | 1 | 0 | 0 | 248 |
| 20 | Keaton MitchellBaltimore Ravens·#34 | 13 | 37 | 164 | 4.43 | 1 | 70 | 5 | 0 | 12 | 9 | 63 | 0 | 75.0% | 5.25 | 7.00 | 85 | 0 | 0 | 0 | 0 | 77 |
| 21 | Kaleb JohnsonPittsburgh Steelers·#20 | 10 | 20 | 53 | 2.65 | 0 | 35 | 1 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 14 | 0 | 0 | 0 | 0 | 30 |
| 22 | Kyle MonangaiChicago Bears·#25 | 17 | 101 | 541 | 5.36 | 0 | 273 | 13 | 0 | 20 | 12 | 112 | 0 | 60.0% | 5.60 | 9.33 | 113 | 2 | 1 | 0 | 0 | 272 |
| 23 | Jawhar JordanHouston Texans·#26 | 4 | 33 | 164 | 4.97 | 0 | 100 | 5 | 0 | 3 | 3 | 18 | 0 | 100.0% | 6.00 | 6.00 | 18 | 0 | 0 | 0 | 0 | 52 |
| 24 | Ty JohnsonBuffalo Bills·#26 | 17 | 24 | 106 | 4.42 | 0 | 83 | 0 | 0 | 15 | 9 | 64 | 0 | 60.0% | 4.27 | 7.11 | 72 | 3 | 1 | 0 | 0 | 132 |
| 25 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 36 | 246 | 6.83 | 0 | 152 | 9 | 0 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 9 | 1 | 1 | 0 | 0 | 68 |
| 26 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 48 | 232 | 4.83 | 1 | 125 | 6 | 0 | 7 | 5 | 3 | 0 | 71.4% | 0.43 | 0.60 | 24 | 2 | 1 | 0 | 0 | 91 |
| 27 | Ray DavisBuffalo Bills·#22 | 14 | 38 | 209 | 5.50 | 0 | 120 | 8 | 0 | 6 | 3 | 17 | 0 | 50.0% | 2.83 | 5.67 | 28 | 1 | 1 | 0 | 0 | 76 |
| 28 | Raheim SandersCleveland Browns·#35 | 3 | 11 | 55 | 5.00 | 0 | 47 | 1 | 0 | 4 | 3 | 21 | 0 | 75.0% | 5.25 | 7.00 | 14 | 0 | 0 | 0 | 0 | 29 |
| 29 | RJ HarveyDenver Broncos·#12 | 17 | 84 | 386 | 4.60 | 2 | 281 | 9 | 0 | 37 | 30 | 236 | 1 | 81.1% | 6.38 | 7.87 | 230 | 2 | 1 | 0 | 0 | 269 |
| 30 | Ollie Gordon IIMiami Dolphins·#31 | 17 | 33 | 128 | 3.88 | 0 | 53 | 3 | 0 | 7 | 6 | 29 | 1 | 85.7% | 4.14 | 4.83 | 50 | 1 | 1 | 1 | 0 | 106 |
| 31 | Nick ChubbHouston Texans·#21 | 15 | 86 | 366 | 4.26 | 1 | 238 | 4 | 0 | 13 | 8 | 35 | 0 | 61.5% | 2.69 | 4.38 | 51 | 2 | 1 | 0 | 0 | 194 |
| 32 | Michael CarterArizona Cardinals·#22 | 12 | 65 | 261 | 4.02 | 0 | 203 | 5 | 0 | 34 | 25 | 236 | 0 | 73.5% | 6.94 | 9.44 | 221 | 4 | 3 | 0 | 0 | 239 |
| 33 | Tyler BadieDenver Broncos·#28 | 16 | 4 | 14 | 3.50 | 0 | 35 | 0 | 0 | 20 | 13 | 113 | 0 | 65.0% | 5.65 | 8.69 | 150 | 3 | 3 | 0 | 0 | 88 |
| 34 | Zamir WhiteLas Vegas Raiders·#3 | 5 | 7 | 27 | 3.86 | 0 | 20 | 0 | 0 | 5 | 4 | 24 | 0 | 80.0% | 4.80 | 6.00 | 24 | 0 | 0 | 0 | 0 | 31 |
| 35 | Trayveon WilliamsCleveland Browns·#38 | 4 | 3 | 11 | 3.67 | 0 | 20 | 0 | 0 | 5 | 5 | 64 | 0 | 100.0% | 12.80 | 12.80 | 80 | 1 | 1 | 0 | 0 | 34 |
| 36 | Woody MarksHouston Texans·#27 | 16 | 123 | 446 | 3.63 | 1 | 315 | 9 | 0 | 26 | 18 | 95 | 1 | 69.2% | 3.65 | 5.28 | 111 | 5 | 3 | 1 | 0 | 319 |
| 37 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 75 | 321 | 4.28 | 1 | 199 | 10 | 0 | 13 | 11 | 75 | 0 | 84.6% | 5.77 | 6.82 | 100 | 1 | 1 | 0 | 0 | 153 |
| 38 | Will ShipleyPhiladelphia Eagles·#28 | 15 | 8 | 30 | 3.75 | 0 | 10 | 1 | 0 | 10 | 9 | 56 | 0 | 90.0% | 5.60 | 6.22 | 63 | 0 | 0 | 0 | 0 | 63 |
| 39 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 63 | 332 | 5.27 | 0 | 240 | 11 | 0 | 49 | 42 | 332 | 1 | 85.7% | 6.78 | 7.90 | 318 | 8 | 7 | 0 | 1 | 277 |
| 40 | Justice HillBaltimore Ravens·#43 | 10 | 9 | 73 | 8.11 | 1 | 90 | 1 | 0 | 17 | 14 | 138 | 1 | 82.3% | 8.12 | 9.86 | 139 | 1 | 1 | 1 | 1 | 89 |
| 41 | DJ GiddensIndianapolis Colts·#21 | 6 | 13 | 48 | 3.69 | 0 | 36 | 0 | 0 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 1 | 25 |
| 42 | Jaret PattersonLos Angeles Chargers·#32 | 6 | 27 | 92 | 3.41 | 0 | 52 | 1 | 0 | 3 | 2 | 4 | 0 | 66.7% | 1.33 | 2.00 | 5 | 0 | 0 | 0 | 1 | 67 |
| 43 | Emari DemercadoArizona Cardinals·#31 | 11 | 28 | 134 | 4.79 | 0 | 73 | 3 | 0 | 14 | 10 | 64 | 0 | 71.4% | 4.57 | 6.40 | 67 | 1 | 1 | 0 | 1 | 99 |
| 44 | Tyjae SpearsTennessee Titans·#2 | 13 | 36 | 131 | 3.64 | 0 | 159 | 1 | 0 | 32 | 29 | 185 | 0 | 90.6% | 5.78 | 6.38 | 228 | 4 | 4 | 0 | 1 | 173 |
| 45 | Samaje PerineCincinnati Bengals·#34 | 15 | 40 | 235 | 5.88 | 1 | 142 | 7 | 0 | 11 | 8 | 36 | 0 | 72.7% | 3.27 | 4.50 | 45 | 1 | 1 | 0 | 1 | 151 |
| 46 | Travis EtienneJacksonville Jaguars·#1 | 17 | 170 | 813 | 4.78 | 4 | 515 | 22 | 0 | 32 | 23 | 191 | 4 | 71.9% | 5.97 | 8.30 | 229 | 4 | 4 | 3 | 1 | 407 |
| 47 | TreVeyon HendersonNew England Patriots·#32 | 17 | 100 | 549 | 5.49 | 3 | 238 | 11 | 0 | 33 | 28 | 180 | 0 | 84.8% | 5.45 | 6.43 | 204 | 1 | 1 | 0 | 1 | 266 |
| 48 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 179 | 775 | 4.33 | 3 | 392 | 21 | 0 | 34 | 26 | 154 | 0 | 76.5% | 4.53 | 5.92 | 191 | 3 | 2 | 0 | 1 | 432 |
| 49 | Miles SandersDallas Cowboys·#24 | 4 | 14 | 95 | 6.79 | 0 | 58 | 2 | 0 | 7 | 7 | 27 | 0 | 100.0% | 3.86 | 3.86 | 43 | 1 | 1 | 0 | 1 | 41 |
| 50 | Kendre MillerNew Orleans Saints·#5 | 7 | 33 | 127 | 3.85 | 1 | 97 | 1 | 0 | 5 | 5 | 30 | 0 | 100.0% | 6.00 | 6.00 | 35 | 0 | 0 | 0 | 1 | 66 |