| 1 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 30 | 138 | 4.60 | 3 | 98 | 17 | 4 | 27 | 22 | 244 | 3 | 81.5% | 9.04 | 11.09 | 125 | 8 | 6 | 3 | 1 | 191 |
| 2 | Rhamondre StevensonNew England Patriots·#38 | 14 | 15 | 53 | 3.53 | 0 | 68 | 5 | 1 | 13 | 12 | 191 | 2 | 92.3% | 14.69 | 15.92 | 120 | 2 | 2 | 1 | 1 | 126 |
| 3 | D'Andre SwiftChicago Bears·#4 | 16 | 30 | 113 | 3.77 | 4 | 89 | 16 | 7 | 11 | 9 | 144 | 1 | 81.8% | 13.09 | 16.00 | 169 | 1 | 1 | 0 | 1 | 118 |
| 4 | Kenneth GainwellPittsburgh Steelers·#14 | 16 | 11 | 27 | 2.45 | 1 | 66 | 6 | 1 | 32 | 24 | 144 | 0 | 75.0% | 4.50 | 6.00 | 156 | 6 | 4 | 0 | 0 | 141 |
| 5 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 21 | 72 | 3.43 | 1 | 62 | 8 | 1 | 22 | 15 | 128 | 1 | 68.2% | 5.82 | 8.53 | 117 | 5 | 2 | 1 | 2 | 164 |
| 6 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 11 | 44 | 4.00 | 1 | 95 | 4 | 0 | 16 | 14 | 123 | 1 | 87.5% | 7.69 | 8.79 | 131 | 3 | 3 | 1 | 0 | 103 |
| 7 | Jahmyr GibbsDetroit Lions·#0 | 17 | 21 | 88 | 4.19 | 0 | 90 | 11 | 2 | 21 | 16 | 118 | 1 | 76.2% | 5.62 | 7.38 | 141 | 4 | 3 | 1 | 0 | 136 |
| 8 | Ty JohnsonBuffalo Bills·#26 | 17 | 10 | 65 | 6.50 | 1 | 39 | 7 | 1 | 13 | 10 | 115 | 1 | 76.9% | 8.85 | 11.50 | 141 | 0 | 0 | 0 | 1 | 139 |
| 9 | Dylan SampsonCleveland Browns·#22 | 14 | 8 | 21 | 2.62 | 0 | 26 | 4 | 0 | 5 | 4 | 110 | 1 | 80.0% | 22.00 | 27.50 | 109 | 0 | 0 | 0 | 0 | 40 |
| 10 | Devin SingletaryNew York Giants·#26 | 14 | 13 | 56 | 4.31 | 1 | 40 | 6 | 1 | 9 | 9 | 103 | 0 | 100.0% | 11.44 | 11.44 | 100 | 2 | 2 | 0 | 0 | 57 |
| 11 | RJ HarveyDenver Broncos·#12 | 17 | 9 | 21 | 2.33 | 1 | 29 | 4 | 2 | 17 | 15 | 98 | 3 | 88.2% | 5.76 | 6.53 | 111 | 7 | 6 | 3 | 1 | 61 |
| 12 | Alvin KamaraNew Orleans Saints·#41 | 11 | 12 | 25 | 2.08 | 0 | 30 | 4 | 0 | 8 | 7 | 97 | 0 | 87.5% | 12.12 | 13.86 | 63 | 1 | 1 | 0 | 0 | 79 |
| 13 | Jeremy McNicholsWashington Commanders·#26 | 17 | 11 | 55 | 5.00 | 0 | 75 | 5 | 0 | 11 | 7 | 92 | 0 | 63.6% | 8.36 | 13.14 | 92 | 0 | 0 | 0 | 2 | 124 |
| 14 | De'Von AchaneMiami Dolphins·#28 | 16 | 13 | 80 | 6.15 | 1 | 42 | 3 | 1 | 19 | 11 | 91 | 1 | 57.9% | 4.79 | 8.27 | 73 | 3 | 1 | 1 | 1 | 117 |
| 15 | James CookBuffalo Bills·#4 | 14 | 16 | 73 | 4.56 | 2 | 142 | 7 | 3 | 3 | 3 | 89 | 0 | 100.0% | 29.67 | 29.67 | 92 | 0 | 0 | 0 | 0 | 31 |
| 16 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 21 | 65 | 3.10 | 1 | 49 | 9 | 2 | 12 | 7 | 85 | 1 | 58.3% | 7.08 | 12.14 | 69 | 1 | 1 | 0 | 0 | 136 |
| 17 | Kimani VidalLos Angeles Chargers·#30 | 12 | 15 | 146 | 9.73 | 1 | 66 | 9 | 0 | 7 | 5 | 85 | 1 | 71.4% | 12.14 | 17.00 | 89 | 2 | 1 | 1 | 0 | 110 |
| 18 | Justice HillBaltimore Ravens·#43 | 10 | 3 | 9 | 3.00 | 0 | 14 | 1 | 0 | 12 | 8 | 83 | 0 | 66.7% | 6.92 | 10.38 | 83 | 0 | 0 | 0 | 1 | 83 |
| 19 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 30 | 153 | 5.10 | 2 | 66 | 12 | 2 | 7 | 6 | 82 | 0 | 85.7% | 11.71 | 13.67 | 90 | 0 | 0 | 0 | 2 | 146 |
| 20 | Tyler BadieDenver Broncos·#28 | 16 | 3 | 10 | 3.33 | 0 | 34 | 0 | 1 | 13 | 7 | 73 | 0 | 53.9% | 5.62 | 10.43 | 105 | 1 | 0 | 0 | 0 | 95 |
| 21 | Isaiah DavisNew York Jets·#32 | 16 | 12 | 68 | 5.67 | 0 | 46 | 3 | 0 | 10 | 9 | 73 | 0 | 90.0% | 7.30 | 8.11 | 98 | 0 | 0 | 0 | 1 | 109 |
| 22 | Tyjae SpearsTennessee Titans·#2 | 13 | 17 | 122 | 7.18 | 0 | 78 | 9 | 0 | 15 | 14 | 70 | 0 | 93.3% | 4.67 | 5.00 | 130 | 2 | 2 | 0 | 2 | 136 |
| 23 | Chase BrownCincinnati Bengals·#30 | 16 | 12 | 35 | 2.92 | 1 | 27 | 9 | 1 | 11 | 5 | 62 | 1 | 45.5% | 5.64 | 12.40 | 39 | 2 | 1 | 1 | 0 | 82 |
| 24 | Chuba HubbardCarolina Panthers·#30 | 15 | 22 | 84 | 3.82 | 0 | 50 | 12 | 0 | 10 | 9 | 61 | 1 | 90.0% | 6.10 | 6.78 | 89 | 2 | 2 | 0 | 0 | 110 |
| 25 | Jaylen WarrenPittsburgh Steelers·#30 | 14 | 17 | 40 | 2.35 | 2 | 19 | 13 | 3 | 7 | 7 | 61 | 1 | 100.0% | 8.71 | 8.71 | 66 | 1 | 1 | 0 | 0 | 59 |
| 26 | Kareem HuntKansas City Chiefs·#29 | 17 | 31 | 108 | 3.48 | 1 | 59 | 22 | 4 | 10 | 7 | 61 | 0 | 70.0% | 6.10 | 8.71 | 51 | 1 | 0 | 0 | 0 | 157 |
| 27 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 16 | 69 | 4.31 | 0 | 53 | 11 | 1 | 11 | 9 | 60 | 0 | 81.8% | 5.45 | 6.67 | 86 | 5 | 4 | 0 | 1 | 167 |
| 28 | Rasheen AliBaltimore Ravens·#26 | 9 | 1 | 0 | 0.00 | 0 | 21 | 0 | 0 | 6 | 5 | 57 | 1 | 83.3% | 9.50 | 11.40 | 66 | 0 | 0 | 0 | 1 | 55 |
| 29 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 18 | 120 | 6.67 | 2 | 37 | 9 | 1 | 7 | 6 | 55 | 0 | 85.7% | 7.86 | 9.17 | 63 | 1 | 1 | 0 | 1 | 122 |
| 30 | Kenneth Walker IIISeattle Seahawks·#9 | 15 | 14 | 109 | 7.79 | 1 | 49 | 4 | 0 | 8 | 7 | 53 | 0 | 87.5% | 6.62 | 7.57 | 64 | 0 | 0 | 0 | 1 | 43 |
| 31 | Jerome FordCleveland Browns·#34 | 13 | 4 | 11 | 2.75 | 0 | 11 | 2 | 0 | 9 | 7 | 53 | 0 | 77.8% | 5.89 | 7.57 | 66 | 2 | 2 | 0 | 0 | 112 |
| 32 | Woody MarksHouston Texans·#27 | 14 | 19 | 72 | 3.79 | 0 | 43 | 11 | 1 | 9 | 6 | 52 | 2 | 66.7% | 5.78 | 8.67 | 49 | 2 | 2 | 2 | 0 | 100 |
| 33 | Tony PollardTennessee Titans·#20 | 16 | 16 | 36 | 2.25 | 0 | 35 | 6 | 1 | 6 | 3 | 49 | 0 | 50.0% | 8.17 | 16.33 | 46 | 0 | 0 | 0 | 1 | 83 |
| 34 | Emari DemercadoArizona Cardinals·#31 | 11 | 10 | 172 | 17.20 | 0 | 78 | 1 | 0 | 11 | 7 | 46 | 0 | 63.6% | 4.18 | 6.57 | 35 | 3 | 2 | 0 | 3 | 78 |
| 35 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 17 | 9 | 43 | 4.78 | 0 | 30 | 3 | 0 | 8 | 7 | 42 | 0 | 87.5% | 5.25 | 6.00 | 52 | 1 | 1 | 0 | 1 | 135 |
| 36 | Cam SkatteboNew York Giants·#44 | 7 | 7 | 13 | 1.86 | 0 | 12 | 3 | 1 | 7 | 5 | 41 | 1 | 71.4% | 5.86 | 8.20 | 40 | 1 | 1 | 1 | 0 | 54 |
| 37 | Will ShipleyPhiladelphia Eagles·#28 | 15 | 3 | 13 | 4.33 | 0 | 2 | 0 | 0 | 6 | 5 | 38 | 0 | 83.3% | 6.33 | 7.60 | 32 | 0 | 0 | 0 | 0 | 50 |
| 38 | Chris BrooksGreen Bay Packers·#30 | 16 | 2 | 6 | 3.00 | 0 | 9 | 1 | 0 | 5 | 4 | 36 | 0 | 80.0% | 7.20 | 9.00 | 41 | 0 | 0 | 0 | 0 | 62 |
| 39 | Dare OgunbowaleHouston Texans·#33 | 15 | 4 | 15 | 3.75 | 0 | 18 | 0 | 0 | 9 | 6 | 35 | 0 | 66.7% | 3.89 | 5.83 | 26 | 2 | 1 | 0 | 0 | 90 |
| 40 | Aaron JonesMinnesota Vikings·#33 | 12 | 11 | 33 | 3.00 | 1 | 26 | 7 | 1 | 10 | 5 | 34 | 0 | 50.0% | 3.40 | 6.80 | 39 | 3 | 1 | 0 | 1 | 65 |
| 41 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 16 | 101 | 6.31 | 0 | 60 | 10 | 1 | 5 | 5 | 34 | 0 | 100.0% | 6.80 | 6.80 | 28 | 0 | 0 | 0 | 0 | 76 |
| 42 | Devin NealNew Orleans Saints·#24 | 9 | 6 | 18 | 3.00 | 0 | 11 | 3 | 0 | 5 | 4 | 33 | 0 | 80.0% | 6.60 | 8.25 | 42 | 0 | 0 | 0 | 0 | 62 |
| 43 | TreVeyon HendersonNew England Patriots·#32 | 16 | 9 | 48 | 5.33 | 0 | 25 | 6 | 2 | 8 | 5 | 31 | 0 | 62.5% | 3.88 | 6.20 | 35 | 1 | 1 | 0 | 0 | 66 |
| 44 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 29 | 96 | 3.31 | 0 | 70 | 14 | 3 | 9 | 5 | 30 | 0 | 55.6% | 3.33 | 6.00 | 15 | 2 | 2 | 0 | 1 | 146 |
| 45 | Kyle MonangaiChicago Bears·#25 | 17 | 16 | 72 | 4.50 | 1 | 44 | 11 | 2 | 5 | 2 | 29 | 0 | 40.0% | 5.80 | 14.50 | 26 | 1 | 0 | 0 | 0 | 88 |
| 46 | Raheem MostertLas Vegas Raiders·#31 | 11 | 4 | 9 | 2.25 | 0 | 7 | 1 | 0 | 3 | 3 | 28 | 0 | 100.0% | 9.33 | 9.33 | 40 | 0 | 0 | 0 | 0 | 37 |
| 47 | Samaje PerineCincinnati Bengals·#34 | 14 | 24 | 65 | 2.71 | 0 | 52 | 13 | 1 | 10 | 6 | 28 | 0 | 60.0% | 2.80 | 4.67 | 27 | 0 | 0 | 0 | 1 | 127 |
| 48 | Audric EstiméNew Orleans Saints·#30 | 5 | 7 | 17 | 2.43 | 0 | 11 | 4 | 1 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 8 | 0 | 0 | 0 | 0 | 42 |
| 49 | David MontgomeryDetroit Lions·#5 | 17 | 17 | 47 | 2.76 | 1 | 34 | 6 | 3 | 6 | 4 | 24 | 0 | 66.7% | 4.00 | 6.00 | 19 | 1 | 1 | 0 | 3 | 82 |
| 50 | Brashard SmithKansas City Chiefs·#24 | 12 | 5 | 26 | 5.20 | 0 | 25 | 2 | 0 | 8 | 5 | 24 | 1 | 62.5% | 3.00 | 4.80 | 32 | 2 | 2 | 1 | 0 | 32 |