| 1 | Jahmyr GibbsDetroit Lions·#0 | 11 | 9 | 26 | 2.89 | 1 | 22 | 3 | 0 | 9 | 8 | 54 | 0 | 88.9% | 6.00 | 6.75 | 35 | 2 | 2 | 0 | 0 | 56 |
| 2 | Christian McCaffreySan Francisco 49ers·#23 | 12 | 9 | 37 | 4.11 | 1 | 33 | 2 | 1 | 7 | 7 | 91 | 0 | 100.0% | 13.00 | 13.00 | 62 | 1 | 1 | 0 | 1 | 42 |
| 3 | Chase BrownCincinnati Bengals·#30 | 10 | 13 | 19 | 1.46 | 0 | 17 | 5 | 2 | 9 | 6 | 40 | 0 | 66.7% | 4.44 | 6.67 | 34 | 0 | 0 | 0 | 0 | 56 |
| 4 | Bucky IrvingTampa Bay Buccaneers·#7 | 9 | 12 | 19 | 1.58 | 0 | 41 | 0 | 0 | 7 | 6 | 40 | 0 | 85.7% | 5.71 | 6.67 | 57 | 0 | 0 | 0 | 0 | 41 |
| 5 | Tony PollardTennessee Titans·#20 | 13 | 10 | 27 | 2.70 | 0 | 29 | 2 | 0 | 6 | 6 | 18 | 0 | 100.0% | 3.00 | 3.00 | 25 | 0 | 0 | 0 | 3 | 40 |
| 6 | Kenneth GainwellPittsburgh Steelers·#14 | 13 | 7 | 29 | 4.14 | 0 | 31 | 1 | 0 | 4 | 4 | 38 | 0 | 100.0% | 9.50 | 9.50 | 50 | 0 | 0 | 0 | 0 | 52 |
| 7 | Saquon BarkleyPhiladelphia Eagles·#26 | 11 | 17 | 22 | 1.29 | 0 | 23 | 1 | 1 | 4 | 4 | 20 | 0 | 100.0% | 5.00 | 5.00 | 12 | 1 | 1 | 0 | 0 | 44 |
| 8 | Rachaad WhiteTampa Bay Buccaneers·#1 | 12 | 6 | 23 | 3.83 | 1 | 20 | 2 | 1 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 29 | 0 | 0 | 0 | 1 | 44 |
| 9 | Woody MarksHouston Texans·#27 | 10 | 18 | 48 | 2.67 | 0 | 41 | 3 | 1 | 3 | 3 | 19 | 1 | 100.0% | 6.33 | 6.33 | 17 | 1 | 1 | 1 | 0 | 41 |
| 10 | RJ HarveyDenver Broncos·#12 | 9 | 10 | 43 | 4.30 | 0 | 17 | 3 | 1 | 3 | 3 | 5 | 1 | 100.0% | 1.67 | 1.67 | 13 | 1 | 1 | 1 | 0 | 26 |
| 11 | Michael CarterArizona Cardinals·#22 | 9 | 3 | 20 | 6.67 | 0 | 18 | 2 | 0 | 4 | 3 | 28 | 0 | 75.0% | 7.00 | 9.33 | 21 | 1 | 0 | 0 | 0 | 35 |
| 12 | De'Von AchaneMiami Dolphins·#28 | 8 | 11 | 40 | 3.64 | 0 | 29 | 1 | 2 | 3 | 3 | 46 | 0 | 100.0% | 15.33 | 15.33 | 39 | 0 | 0 | 0 | 0 | 40 |
| 13 | Tyrone Tracy Jr.New York Giants·#29 | 9 | 2 | 5 | 2.50 | 0 | 3 | 0 | 0 | 3 | 3 | 9 | 0 | 100.0% | 3.00 | 3.00 | 13 | 0 | 0 | 0 | 1 | 34 |
| 14 | Tyjae SpearsTennessee Titans·#2 | 7 | 2 | 1 | 0.50 | 1 | 6 | 1 | 1 | 4 | 3 | 13 | 0 | 75.0% | 3.25 | 4.33 | 29 | 1 | 1 | 0 | 0 | 27 |
| 15 | Kyren WilliamsLos Angeles Rams·#23 | 14 | 27 | 145 | 5.37 | 0 | 66 | 9 | 1 | 4 | 2 | 20 | 0 | 50.0% | 5.00 | 10.00 | 16 | 0 | 0 | 0 | 2 | 64 |
| 16 | Bijan RobinsonAtlanta Falcons·#7 | 9 | 8 | 20 | 2.50 | 0 | 24 | 1 | 1 | 4 | 2 | 17 | 0 | 50.0% | 4.25 | 8.50 | 13 | 0 | 0 | 0 | 0 | 52 |
| 17 | James CookBuffalo Bills·#4 | 12 | 21 | 51 | 2.43 | 0 | 34 | 0 | 1 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 14 | 0 | 0 | 0 | 0 | 37 |
| 18 | Devin NealNew Orleans Saints·#24 | 5 | 2 | -1 | -0.50 | 0 | 2 | 0 | 0 | 2 | 2 | 19 | 0 | 100.0% | 9.50 | 9.50 | 16 | 0 | 0 | 0 | 0 | 42 |
| 19 | Javonte WilliamsDallas Cowboys·#33 | 7 | 6 | 21 | 3.50 | 0 | 13 | 1 | 0 | 3 | 2 | 12 | 0 | 66.7% | 4.00 | 6.00 | 3 | 0 | 0 | 0 | 0 | 42 |
| 20 | D'Andre SwiftChicago Bears·#4 | 9 | 12 | 62 | 5.17 | 1 | 29 | 4 | 1 | 3 | 2 | 14 | 0 | 66.7% | 4.67 | 7.00 | 13 | 0 | 0 | 0 | 1 | 47 |
| 21 | Ty JohnsonBuffalo Bills·#26 | 10 | 5 | 18 | 3.60 | 0 | 12 | 2 | 0 | 3 | 2 | 8 | 0 | 66.7% | 2.67 | 4.00 | 12 | 0 | 0 | 0 | 0 | 32 |
| 22 | Travis EtienneJacksonville Jaguars·#1 | 8 | 13 | 48 | 3.69 | 1 | 36 | 3 | 0 | 2 | 2 | 19 | 0 | 100.0% | 9.50 | 9.50 | 17 | 0 | 0 | 0 | 0 | 26 |
| 23 | Rico DowdleCarolina Panthers·#5 | 10 | 12 | 44 | 3.67 | 0 | 31 | 1 | 0 | 4 | 2 | 31 | 0 | 50.0% | 7.75 | 15.50 | 34 | 1 | 0 | 0 | 1 | 33 |
| 24 | Samaje PerineCincinnati Bengals·#34 | 10 | 5 | 7 | 1.40 | 0 | 10 | 0 | 0 | 2 | 2 | 16 | 0 | 100.0% | 8.00 | 8.00 | 20 | 0 | 0 | 0 | 0 | 27 |
| 25 | Jeremy McNicholsWashington Commanders·#26 | 8 | 8 | 34 | 4.25 | 0 | 17 | 4 | 1 | 3 | 2 | 8 | 0 | 66.7% | 2.67 | 4.00 | 10 | 0 | 0 | 0 | 0 | 40 |
| 26 | Zach CharbonnetSeattle Seahawks·#26 | 10 | 12 | 15 | 1.25 | 1 | 31 | 2 | 1 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 11 | 0 | 0 | 0 | 0 | 36 |
| 27 | Jerome FordCleveland Browns·#34 | 9 | 2 | 13 | 6.50 | 0 | 13 | 1 | 0 | 1 | 1 | 1 | 0 | 100.0% | 1.00 | 1.00 | 7 | 1 | 1 | 0 | 0 | 33 |
| 28 | Isaiah DavisNew York Jets·#32 | 9 | 1 | 3 | 3.00 | 0 | 4 | 1 | 0 | 1 | 1 | 14 | 0 | 100.0% | 14.00 | 14.00 | 9 | 0 | 0 | 0 | 0 | 32 |
| 29 | Kyle MonangaiChicago Bears·#25 | 11 | 13 | 33 | 2.54 | 0 | 21 | 1 | 0 | 2 | 1 | 15 | 0 | 50.0% | 7.50 | 15.00 | 8 | 0 | 0 | 0 | 0 | 38 |
| 30 | Jonathan TaylorIndianapolis Colts·#28 | 8 | 13 | 59 | 4.54 | 0 | 93 | 2 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 10 | 0 | 0 | 0 | 0 | 34 |
| 31 | Jordan MasonMinnesota Vikings·#27 | 7 | 6 | 5 | 0.83 | 0 | 8 | 0 | 1 | 1 | 1 | 2 | 0 | 100.0% | 2.00 | 2.00 | 7 | 0 | 0 | 0 | 0 | 26 |
| 32 | Josh JacobsGreen Bay Packers·#8 | 8 | 19 | 55 | 2.89 | 2 | 54 | 5 | 2 | 2 | 1 | 25 | 0 | 50.0% | 12.50 | 25.00 | 25 | 0 | 0 | 0 | 1 | 35 |
| 33 | Breece HallNew York Jets·#20 | 9 | 8 | 14 | 1.75 | 0 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 39 |
| 34 | Chuba HubbardCarolina Panthers·#30 | 7 | 3 | 5 | 1.67 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 1 | 28 |
| 35 | Kareem HuntKansas City Chiefs·#29 | 9 | 12 | 40 | 3.33 | 1 | 27 | 4 | 4 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 38 |
| 36 | Rhamondre StevensonNew England Patriots·#38 | 9 | 7 | 44 | 6.29 | 1 | 37 | 2 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 29 |