| 1 | Jeremy McNicholsWashington Commanders·#26 | 17 | 30 | 194 | 6.47 | 1 | 202 | 12 | 1 | 19 | 17 | 152 | 0 | 89.5% | 8.00 | 8.94 | 156 | 1 | 1 | 0 | 2 | 198 |
| 2 | Kenneth Walker IIISeattle Seahawks·#9 | 15 | 12 | 47 | 3.92 | 1 | 41 | 4 | 1 | 5 | 5 | 98 | 0 | 100.0% | 19.60 | 19.60 | 108 | 0 | 0 | 0 | 1 | 39 |
| 3 | Ashton JeantyLas Vegas Raiders·#2 | 14 | 9 | 75 | 8.33 | 1 | 65 | 2 | 0 | 14 | 13 | 118 | 1 | 92.9% | 8.43 | 9.08 | 95 | 1 | 1 | 0 | 0 | 53 |
| 4 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 11 | 52 | 4.73 | 0 | 33 | 5 | 0 | 13 | 13 | 78 | 0 | 100.0% | 6.00 | 6.00 | 85 | 0 | 0 | 0 | 1 | 68 |
| 5 | De'Von AchaneMiami Dolphins·#28 | 9 | 3 | 2 | 0.67 | 0 | 33 | 0 | 0 | 8 | 7 | 79 | 1 | 87.5% | 9.88 | 11.29 | 66 | 0 | 0 | 0 | 1 | 27 |
| 6 | Jacory Croskey-MerrittWashington Commanders·#22 | 16 | 85 | 344 | 4.05 | 3 | 178 | 22 | 5 | 9 | 6 | 52 | 0 | 66.7% | 5.78 | 8.67 | 64 | 1 | 1 | 0 | 2 | 215 |
| 7 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 46 | 161 | 3.50 | 0 | 85 | 9 | 4 | 14 | 8 | 88 | 1 | 57.1% | 6.29 | 11.00 | 63 | 1 | 0 | 0 | 1 | 139 |
| 8 | Christian McCaffreySan Francisco 49ers·#23 | 11 | 9 | 13 | 1.44 | 0 | 19 | 0 | 0 | 5 | 5 | 57 | 0 | 100.0% | 11.40 | 11.40 | 45 | 0 | 0 | 0 | 0 | 37 |
| 9 | Tyler AllgeierAtlanta Falcons·#25 | 12 | 6 | 19 | 3.17 | 1 | 20 | 3 | 2 | 6 | 5 | 38 | 0 | 83.3% | 6.33 | 7.60 | 38 | 1 | 1 | 0 | 0 | 27 |
| 10 | Michael CarterArizona Cardinals·#22 | 11 | 11 | 44 | 4.00 | 0 | 31 | 5 | 0 | 9 | 6 | 41 | 0 | 66.7% | 4.56 | 6.83 | 37 | 0 | 0 | 0 | 0 | 59 |
| 11 | Travis EtienneJacksonville Jaguars·#1 | 15 | 8 | 31 | 3.88 | 0 | 26 | 2 | 0 | 3 | 3 | 39 | 0 | 100.0% | 13.00 | 13.00 | 37 | 0 | 0 | 0 | 0 | 42 |
| 12 | Cam SkatteboNew York Giants·#44 | 6 | 25 | 98 | 3.92 | 0 | 67 | 10 | 1 | 5 | 4 | 45 | 1 | 80.0% | 9.00 | 11.25 | 32 | 1 | 1 | 1 | 1 | 51 |
| 13 | Devin SingletaryNew York Giants·#26 | 14 | 24 | 134 | 5.58 | 1 | 68 | 11 | 1 | 4 | 4 | 34 | 0 | 100.0% | 8.50 | 8.50 | 32 | 0 | 0 | 0 | 0 | 61 |
| 14 | Tyjae SpearsTennessee Titans·#2 | 12 | 4 | 11 | 2.75 | 0 | 13 | 1 | 0 | 6 | 5 | 26 | 0 | 83.3% | 4.33 | 5.20 | 31 | 1 | 1 | 0 | 0 | 37 |
| 15 | Tyrone Tracy Jr.New York Giants·#29 | 13 | 47 | 235 | 5.00 | 1 | 135 | 16 | 1 | 8 | 5 | 14 | 0 | 62.5% | 1.75 | 2.80 | 30 | 0 | 0 | 0 | 0 | 116 |
| 16 | Zach CharbonnetSeattle Seahawks·#26 | 14 | 9 | 46 | 5.11 | 0 | 24 | 5 | 1 | 4 | 4 | 36 | 0 | 100.0% | 9.00 | 9.00 | 28 | 1 | 1 | 0 | 0 | 31 |
| 17 | Audric EstiméNew Orleans Saints·#30 | 4 | 14 | 49 | 3.50 | 0 | 39 | 5 | 1 | 3 | 3 | 21 | 0 | 100.0% | 7.00 | 7.00 | 26 | 0 | 0 | 0 | 0 | 39 |
| 18 | Devin NealNew Orleans Saints·#24 | 8 | 17 | 72 | 4.24 | 0 | 36 | 4 | 0 | 4 | 4 | 33 | 0 | 100.0% | 8.25 | 8.25 | 24 | 0 | 0 | 0 | 0 | 58 |
| 19 | Tyler BadieDenver Broncos·#28 | 13 | 1 | 3 | 3.00 | 0 | 7 | 0 | 0 | 6 | 3 | 18 | 0 | 50.0% | 3.00 | 6.00 | 23 | 0 | 0 | 0 | 0 | 38 |
| 20 | Emanuel WilsonGreen Bay Packers·#23 | 11 | 10 | 42 | 4.20 | 0 | 34 | 2 | 0 | 3 | 3 | 26 | 0 | 100.0% | 8.67 | 8.67 | 21 | 0 | 0 | 0 | 0 | 33 |
| 21 | Jahmyr GibbsDetroit Lions·#0 | 17 | 12 | 46 | 3.83 | 2 | 27 | 6 | 3 | 8 | 7 | 31 | 1 | 87.5% | 3.88 | 4.43 | 19 | 1 | 1 | 1 | 0 | 53 |
| 22 | Josh JacobsGreen Bay Packers·#8 | 14 | 14 | 32 | 2.29 | 3 | 25 | 7 | 4 | 5 | 5 | 22 | 0 | 100.0% | 4.40 | 4.40 | 18 | 1 | 1 | 0 | 1 | 36 |
| 23 | RJ HarveyDenver Broncos·#12 | 13 | 15 | 39 | 2.60 | 0 | 23 | 2 | 0 | 6 | 4 | 25 | 1 | 66.7% | 4.17 | 6.25 | 17 | 3 | 2 | 1 | 0 | 52 |
| 24 | Alvin KamaraNew Orleans Saints·#41 | 11 | 34 | 107 | 3.15 | 1 | 89 | 8 | 0 | 5 | 4 | 16 | 0 | 80.0% | 3.20 | 4.00 | 14 | 0 | 0 | 0 | 2 | 100 |
| 25 | Kyren WilliamsLos Angeles Rams·#23 | 16 | 4 | 14 | 3.50 | 0 | 9 | 3 | 0 | 6 | 4 | 23 | 0 | 66.7% | 3.83 | 5.75 | 14 | 0 | 0 | 0 | 0 | 61 |
| 26 | Austin EkelerWashington Commanders·#30 | 2 | 10 | 31 | 3.10 | 0 | 23 | 2 | 0 | 4 | 2 | 16 | 0 | 50.0% | 4.00 | 8.00 | 13 | 0 | 0 | 0 | 0 | 44 |
| 27 | Chuba HubbardCarolina Panthers·#30 | 9 | 9 | 35 | 3.89 | 1 | 23 | 5 | 1 | 2 | 1 | 9 | 0 | 50.0% | 4.50 | 9.00 | 12 | 0 | 0 | 0 | 0 | 31 |
| 28 | Jordan MasonMinnesota Vikings·#27 | 8 | 4 | 26 | 6.50 | 0 | 23 | 1 | 1 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 0 | 28 |
| 29 | Jerome FordCleveland Browns·#34 | 10 | 2 | 3 | 1.50 | 0 | 4 | 1 | 1 | 6 | 5 | 19 | 0 | 83.3% | 3.17 | 3.80 | 10 | 2 | 1 | 0 | 0 | 28 |
| 30 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 15 | 21 | 1.40 | 0 | 15 | 7 | 0 | 2 | 1 | 3 | 0 | 50.0% | 1.50 | 3.00 | 9 | 0 | 0 | 0 | 0 | 31 |
| 31 | Aaron JonesMinnesota Vikings·#33 | 9 | 3 | 12 | 4.00 | 0 | 8 | 0 | 0 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 9 | 0 | 0 | 0 | 1 | 26 |
| 32 | Rico DowdleCarolina Panthers·#5 | 15 | 12 | 39 | 3.25 | 0 | 26 | 4 | 0 | 3 | 3 | 9 | 0 | 100.0% | 3.00 | 3.00 | 9 | 0 | 0 | 0 | 0 | 30 |
| 33 | Tony PollardTennessee Titans·#20 | 16 | 10 | 52 | 5.20 | 0 | 30 | 7 | 0 | 3 | 3 | 5 | 0 | 100.0% | 1.67 | 1.67 | 9 | 0 | 0 | 0 | 1 | 54 |
| 34 | D'Andre SwiftChicago Bears·#4 | 12 | 6 | 40 | 6.67 | 1 | 32 | 4 | 1 | 4 | 2 | 11 | 0 | 50.0% | 2.75 | 5.50 | 7 | 0 | 0 | 0 | 0 | 37 |
| 35 | Breece HallNew York Jets·#20 | 13 | 15 | 77 | 5.13 | 0 | 28 | 8 | 0 | 3 | 3 | 19 | 0 | 100.0% | 6.33 | 6.33 | 7 | 0 | 0 | 0 | 0 | 53 |
| 36 | Rachaad WhiteTampa Bay Buccaneers·#1 | 13 | 9 | 48 | 5.33 | 0 | 16 | 4 | 1 | 2 | 1 | 3 | 0 | 50.0% | 1.50 | 3.00 | 7 | 0 | 0 | 0 | 1 | 28 |
| 37 | J.K. DobbinsDenver Broncos·#27 | 9 | 5 | 19 | 3.80 | 0 | 13 | 1 | 1 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 5 | 0 | 0 | 0 | 0 | 26 |
| 38 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 25 | 96 | 3.84 | 2 | 55 | 12 | 3 | 8 | 7 | 26 | 0 | 87.5% | 3.25 | 3.71 | 3 | 1 | 1 | 0 | 0 | 92 |
| 39 | Chris Rodriguez Jr.Washington Commanders·#36 | 12 | 48 | 259 | 5.40 | 2 | 157 | 18 | 4 | 2 | 1 | 6 | 0 | 50.0% | 3.00 | 6.00 | 3 | 1 | 0 | 0 | 1 | 135 |
| 40 | Jaylen WarrenPittsburgh Steelers·#30 | 12 | 16 | 63 | 3.94 | 0 | 40 | 5 | 3 | 4 | 1 | 5 | 0 | 25.0% | 1.25 | 5.00 | 2 | 1 | 0 | 0 | 0 | 42 |
| 41 | Isaiah DavisNew York Jets·#32 | 10 | 4 | 9 | 2.25 | 0 | 6 | 0 | 0 | 3 | 2 | 12 | 0 | 66.7% | 4.00 | 6.00 | 1 | 0 | 0 | 0 | 0 | 26 |
| 42 | James CookBuffalo Bills·#4 | 9 | 16 | 80 | 5.00 | 1 | 30 | 5 | 3 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 0 | 0 | 0 | 0 | 1 | 27 |
| 43 | Quinshon JudkinsCleveland Browns·#10 | 9 | 14 | 66 | 4.71 | 0 | 34 | 7 | 0 | 1 | 1 | -4 | 0 | 100.0% | -4.00 | -4.00 | 0 | 0 | 0 | 0 | 0 | 31 |
| 44 | Javonte WilliamsDallas Cowboys·#33 | 13 | 11 | 78 | 7.09 | 0 | 44 | 3 | 1 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 62 |
| 45 | Ty JohnsonBuffalo Bills·#26 | 10 | 11 | 44 | 4.00 | 2 | 22 | 3 | 4 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 25 |
| 46 | Jonathan TaylorIndianapolis Colts·#28 | 14 | 14 | 42 | 3.00 | 1 | 24 | 4 | 1 | 3 | 2 | -2 | 0 | 66.7% | -0.67 | -1.00 | -2 | 0 | 0 | 0 | 1 | 44 |