| 1 | Justice HillBaltimore Ravens·#43 | 4 | 7 | 65 | 9.29 | 2 | 78 | 3 | 1 | 12 | 9 | 69 | 1 | 75.0% | 5.75 | 7.67 | 85 | 1 | 1 | 1 | 1 | 76 |
| 2 | Miles SandersDallas Cowboys·#24 | 2 | 13 | 94 | 7.23 | 0 | 51 | 4 | 0 | 4 | 4 | 9 | 0 | 100.0% | 2.25 | 2.25 | 4 | 1 | 1 | 0 | 1 | 34 |
| 3 | Emari DemercadoArizona Cardinals·#31 | 7 | 29 | 185 | 6.38 | 0 | 111 | 7 | 0 | 14 | 9 | 76 | 0 | 64.3% | 5.43 | 8.44 | 46 | 3 | 2 | 0 | 2 | 108 |
| 4 | Derrick HenryBaltimore Ravens·#22 | 8 | 150 | 950 | 6.33 | 7 | 572 | 43 | 9 | 11 | 9 | 59 | 0 | 81.8% | 5.36 | 6.56 | 51 | 0 | 0 | 0 | 1 | 251 |
| 5 | James CookBuffalo Bills·#4 | 8 | 156 | 963 | 6.17 | 9 | 565 | 41 | 7 | 17 | 15 | 94 | 1 | 88.2% | 5.53 | 6.27 | 93 | 2 | 2 | 1 | 1 | 267 |
| 6 | Trey BensonArizona Cardinals·#33 | 2 | 18 | 111 | 6.17 | 0 | 126 | 3 | 1 | 5 | 4 | 15 | 0 | 80.0% | 3.00 | 3.75 | 18 | 0 | 0 | 0 | 0 | 57 |
| 7 | Blake CorumLos Angeles Rams·#22 | 9 | 82 | 488 | 5.95 | 5 | 227 | 29 | 8 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 11 | 0 | 0 | 0 | 0 | 166 |
| 8 | Isaiah DavisNew York Jets·#32 | 7 | 27 | 159 | 5.89 | 1 | 120 | 7 | 0 | 14 | 12 | 123 | 0 | 85.7% | 8.79 | 10.25 | 118 | 2 | 1 | 0 | 2 | 131 |
| 9 | Omarion HamptonLos Angeles Chargers·#8 | 4 | 50 | 288 | 5.76 | 2 | 151 | 15 | 5 | 10 | 8 | 52 | 0 | 80.0% | 5.20 | 6.50 | 59 | 0 | 0 | 0 | 1 | 134 |
| 10 | Braelon AllenNew York Jets·#0 | 2 | 10 | 56 | 5.60 | 0 | 29 | 3 | 0 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 9 | 1 | 1 | 0 | 1 | 26 |
| 11 | De'Von AchaneMiami Dolphins·#28 | 7 | 79 | 434 | 5.49 | 1 | 275 | 15 | 1 | 39 | 31 | 192 | 3 | 79.5% | 4.92 | 6.19 | 218 | 4 | 3 | 3 | 1 | 252 |
| 12 | Tyjae SpearsTennessee Titans·#2 | 6 | 32 | 175 | 5.47 | 1 | 98 | 11 | 1 | 20 | 18 | 81 | 0 | 90.0% | 4.05 | 4.50 | 124 | 3 | 3 | 0 | 1 | 154 |
| 13 | Kenneth GainwellPittsburgh Steelers·#14 | 8 | 44 | 232 | 5.27 | 2 | 186 | 13 | 3 | 34 | 28 | 166 | 1 | 82.3% | 4.88 | 5.93 | 158 | 8 | 6 | 0 | 1 | 221 |
| 14 | Ameer AbdullahIndianapolis Colts·#26 | 6 | 8 | 42 | 5.25 | 0 | 22 | 1 | 0 | 12 | 11 | 71 | 0 | 91.7% | 5.92 | 6.45 | 74 | 1 | 1 | 0 | 0 | 48 |
| 15 | D'Andre SwiftChicago Bears·#4 | 8 | 112 | 586 | 5.23 | 6 | 296 | 34 | 9 | 24 | 17 | 169 | 1 | 70.8% | 7.04 | 9.94 | 188 | 1 | 1 | 0 | 1 | 304 |
| 16 | Keaton MitchellBaltimore Ravens·#34 | 6 | 33 | 172 | 5.21 | 0 | 84 | 9 | 0 | 7 | 5 | 37 | 0 | 71.4% | 5.29 | 7.40 | 53 | 0 | 0 | 0 | 0 | 60 |
| 17 | Kendre MillerNew Orleans Saints·#5 | 3 | 19 | 99 | 5.21 | 1 | 78 | 5 | 0 | 2 | 2 | 9 | 0 | 100.0% | 4.50 | 4.50 | 18 | 0 | 0 | 0 | 0 | 40 |
| 18 | Jaylen WarrenPittsburgh Steelers·#30 | 8 | 111 | 569 | 5.13 | 3 | 422 | 29 | 5 | 20 | 18 | 165 | 2 | 90.0% | 8.25 | 9.17 | 210 | 2 | 2 | 1 | 2 | 232 |
| 19 | Bijan RobinsonAtlanta Falcons·#7 | 9 | 150 | 762 | 5.08 | 2 | 513 | 38 | 5 | 62 | 46 | 432 | 2 | 74.2% | 6.97 | 9.39 | 465 | 8 | 6 | 2 | 4 | 448 |
| 20 | David MontgomeryDetroit Lions·#5 | 9 | 92 | 464 | 5.04 | 4 | 286 | 25 | 8 | 14 | 13 | 112 | 0 | 92.9% | 8.00 | 8.62 | 109 | 1 | 1 | 0 | 3 | 224 |
| 21 | Trayveon WilliamsCleveland Browns·#38 | 2 | 2 | 10 | 5.00 | 0 | 10 | 1 | 0 | 4 | 3 | 17 | 0 | 75.0% | 4.25 | 5.67 | 26 | 1 | 1 | 0 | 0 | 30 |
| 22 | Chris BrooksGreen Bay Packers·#30 | 9 | 17 | 83 | 4.88 | 0 | 53 | 3 | 0 | 6 | 4 | 16 | 0 | 66.7% | 2.67 | 4.00 | 16 | 1 | 0 | 0 | 0 | 89 |
| 23 | Kyle MonangaiChicago Bears·#25 | 9 | 105 | 511 | 4.87 | 2 | 264 | 26 | 7 | 17 | 10 | 78 | 0 | 58.8% | 4.59 | 7.80 | 98 | 2 | 1 | 0 | 0 | 261 |
| 24 | Tony PollardTennessee Titans·#20 | 8 | 120 | 582 | 4.85 | 4 | 346 | 23 | 1 | 16 | 14 | 99 | 0 | 87.5% | 6.19 | 7.07 | 109 | 1 | 1 | 0 | 5 | 282 |
| 25 | Chris Rodriguez Jr.Washington Commanders·#36 | 7 | 57 | 276 | 4.84 | 2 | 181 | 15 | 7 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 20 | 0 | 0 | 0 | 1 | 117 |
| 26 | TreVeyon HendersonNew England Patriots·#32 | 8 | 74 | 355 | 4.80 | 2 | 139 | 14 | 5 | 13 | 10 | 69 | 0 | 76.9% | 5.31 | 6.90 | 72 | 1 | 1 | 0 | 0 | 196 |
| 27 | Kyren WilliamsLos Angeles Rams·#23 | 9 | 137 | 654 | 4.77 | 5 | 390 | 39 | 9 | 25 | 18 | 157 | 1 | 72.0% | 6.28 | 8.72 | 81 | 3 | 3 | 1 | 2 | 378 |
| 28 | Kenneth Walker IIISeattle Seahawks·#9 | 9 | 119 | 565 | 4.75 | 2 | 289 | 30 | 4 | 22 | 18 | 179 | 0 | 81.8% | 8.14 | 9.94 | 207 | 2 | 1 | 0 | 1 | 249 |
| 29 | Tank BigsbyPhiladelphia Eagles·#37 | 6 | 11 | 52 | 4.73 | 0 | 27 | 2 | 0 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 9 | 1 | 1 | 0 | 0 | 31 |
| 30 | Isiah PachecoKansas City Chiefs·#10 | 5 | 33 | 156 | 4.73 | 0 | 95 | 9 | 0 | 16 | 14 | 84 | 0 | 87.5% | 5.25 | 6.00 | 94 | 1 | 0 | 0 | 0 | 149 |
| 31 | Dare OgunbowaleHouston Texans·#33 | 7 | 3 | 14 | 4.67 | 1 | 17 | 1 | 1 | 4 | 3 | 26 | 0 | 75.0% | 6.50 | 8.67 | 19 | 0 | 0 | 0 | 1 | 40 |
| 32 | Javonte WilliamsDallas Cowboys·#33 | 8 | 118 | 546 | 4.63 | 7 | 331 | 34 | 11 | 27 | 17 | 43 | 1 | 63.0% | 1.59 | 2.53 | 67 | 9 | 5 | 1 | 3 | 354 |
| 33 | Rachaad WhiteTampa Bay Buccaneers·#1 | 9 | 73 | 337 | 4.62 | 3 | 167 | 25 | 7 | 23 | 20 | 102 | 0 | 87.0% | 4.43 | 5.10 | 167 | 6 | 5 | 0 | 4 | 294 |
| 34 | J.K. DobbinsDenver Broncos·#27 | 5 | 74 | 339 | 4.58 | 3 | 168 | 18 | 4 | 7 | 4 | 12 | 0 | 57.1% | 1.71 | 3.00 | 23 | 0 | 0 | 0 | 0 | 150 |
| 35 | Malik DavisDallas Cowboys·#43 | 4 | 29 | 132 | 4.55 | 0 | 61 | 4 | 1 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 62 |
| 36 | Jacory Croskey-MerrittWashington Commanders·#22 | 9 | 93 | 418 | 4.49 | 3 | 257 | 25 | 5 | 9 | 6 | 53 | 0 | 66.7% | 5.89 | 8.83 | 63 | 1 | 1 | 0 | 2 | 198 |
| 37 | Tyler AllgeierAtlanta Falcons·#25 | 9 | 72 | 320 | 4.44 | 4 | 153 | 24 | 5 | 7 | 6 | 38 | 0 | 85.7% | 5.43 | 6.33 | 44 | 1 | 1 | 0 | 2 | 145 |
| 38 | Brashard SmithKansas City Chiefs·#24 | 8 | 18 | 80 | 4.44 | 0 | 67 | 4 | 0 | 13 | 8 | 52 | 0 | 61.5% | 4.00 | 6.50 | 71 | 3 | 2 | 0 | 1 | 77 |
| 39 | Audric EstiméNew Orleans Saints·#30 | 3 | 38 | 168 | 4.42 | 1 | 146 | 9 | 3 | 6 | 6 | 47 | 0 | 100.0% | 7.83 | 7.83 | 38 | 0 | 0 | 0 | 1 | 101 |
| 40 | Nick ChubbHouston Texans·#21 | 8 | 52 | 230 | 4.42 | 2 | 146 | 10 | 3 | 11 | 4 | -3 | 0 | 36.4% | -0.27 | -0.75 | 3 | 2 | 1 | 0 | 1 | 148 |
| 41 | Travis EtienneJacksonville Jaguars·#1 | 8 | 131 | 577 | 4.40 | 2 | 409 | 26 | 6 | 27 | 20 | 144 | 3 | 74.1% | 5.33 | 7.20 | 178 | 6 | 5 | 3 | 1 | 312 |
| 42 | Jaret PattersonLos Angeles Chargers·#32 | 2 | 17 | 73 | 4.29 | 0 | 47 | 2 | 0 | 4 | 3 | 8 | 0 | 75.0% | 2.00 | 2.67 | 8 | 0 | 0 | 0 | 1 | 64 |
| 43 | Jaleel McLaughlinDenver Broncos·#38 | 4 | 17 | 72 | 4.24 | 0 | 34 | 2 | 0 | 3 | 2 | 15 | 0 | 66.7% | 5.00 | 7.50 | 16 | 0 | 0 | 0 | 0 | 41 |
| 44 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 8 | 9 | 38 | 4.22 | 0 | 22 | 2 | 1 | 3 | 3 | 14 | 0 | 100.0% | 4.67 | 4.67 | 16 | 0 | 0 | 0 | 3 | 107 |
| 45 | Kareem HuntKansas City Chiefs·#29 | 8 | 68 | 281 | 4.13 | 5 | 152 | 18 | 10 | 15 | 10 | 80 | 0 | 66.7% | 5.33 | 8.00 | 89 | 1 | 0 | 0 | 0 | 240 |
| 46 | Emanuel WilsonGreen Bay Packers·#23 | 9 | 80 | 330 | 4.12 | 1 | 271 | 22 | 1 | 11 | 9 | 76 | 0 | 81.8% | 6.91 | 8.44 | 101 | 3 | 1 | 0 | 0 | 195 |
| 47 | Brian RobinsonSan Francisco 49ers·#3 | 9 | 46 | 188 | 4.09 | 1 | 110 | 11 | 1 | 8 | 5 | 11 | 0 | 62.5% | 1.38 | 2.20 | 20 | 2 | 1 | 0 | 0 | 86 |
| 48 | Jerome FordCleveland Browns·#34 | 6 | 11 | 45 | 4.09 | 0 | 36 | 3 | 0 | 17 | 12 | 39 | 0 | 70.6% | 2.29 | 3.25 | 54 | 2 | 1 | 0 | 2 | 115 |
| 49 | Kimani VidalLos Angeles Chargers·#30 | 7 | 55 | 223 | 4.05 | 0 | 135 | 10 | 1 | 9 | 7 | 26 | 1 | 77.8% | 2.89 | 3.71 | 52 | 3 | 2 | 1 | 0 | 183 |
| 50 | Breece HallNew York Jets·#20 | 7 | 98 | 397 | 4.05 | 2 | 269 | 21 | 1 | 26 | 21 | 179 | 0 | 80.8% | 6.88 | 8.52 | 178 | 4 | 0 | 0 | 2 | 253 |