| 1 | AJ DillonPhiladelphia Eagles·#29 | 6 | 9 | 44 | 4.89 | 0 | 29 | 1 | 0 | 2 | 2 | 18 | 0 | 100.0% | 9.00 | 9.00 | 9 | 0 | 0 | 0 | 1 | 29 |
| 2 | Braelon AllenNew York Jets·#0 | 4 | 10 | 38 | 3.80 | 1 | 15 | 1 | 0 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 9 | 1 | 1 | 0 | 0 | 30 |
| 3 | George HolaniSeattle Seahawks·#36 | 4 | 15 | 56 | 3.73 | 1 | 37 | 1 | 0 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 16 | 0 | 0 | 0 | 1 | 27 |
| 4 | Hassan HaskinsLos Angeles Chargers·#28 | 9 | 12 | 34 | 2.83 | 0 | 21 | 1 | 0 | 3 | 3 | 11 | 0 | 100.0% | 3.67 | 3.67 | 11 | 0 | 0 | 0 | 2 | 51 |
| 5 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 67 | 344 | 5.13 | 1 | 226 | 9 | 0 | 3 | 3 | 30 | 0 | 100.0% | 10.00 | 10.00 | 26 | 0 | 0 | 0 | 1 | 157 |
| 6 | Evan HullNew Orleans Saints·#34 | 6 | 14 | 34 | 2.43 | 0 | 13 | 0 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 1 | 53 |
| 7 | Kendre MillerNew Orleans Saints·#5 | 7 | 36 | 145 | 4.03 | 1 | 110 | 2 | 0 | 5 | 5 | 30 | 0 | 100.0% | 6.00 | 6.00 | 35 | 0 | 0 | 0 | 1 | 80 |
| 8 | Najee HarrisLos Angeles Chargers·#22 | 3 | 10 | 53 | 5.30 | 0 | 37 | 0 | 0 | 3 | 3 | 25 | 0 | 100.0% | 8.33 | 8.33 | 15 | 0 | 0 | 0 | 0 | 25 |
| 9 | Jawhar JordanHouston Texans·#26 | 4 | 35 | 173 | 4.94 | 0 | 106 | 6 | 0 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 40 | 0 | 0 | 0 | 0 | 60 |
| 10 | Jaydon BlueDallas Cowboys·#23 | 5 | 34 | 112 | 3.29 | 1 | 39 | 6 | 0 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 10 | 0 | 0 | 0 | 0 | 60 |
| 11 | Raheem MostertLas Vegas Raiders·#31 | 12 | 14 | 54 | 3.86 | 0 | 39 | 2 | 0 | 9 | 9 | 50 | 0 | 100.0% | 5.56 | 5.56 | 65 | 1 | 1 | 0 | 1 | 81 |
| 12 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 38 | 258 | 6.79 | 0 | 158 | 10 | 0 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 9 | 1 | 1 | 0 | 0 | 77 |
| 13 | Tahj BrooksCincinnati Bengals·#25 | 6 | 12 | 36 | 3.00 | 0 | 25 | 0 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 11 | 0 | 0 | 0 | 0 | 31 |
| 14 | Miles SandersDallas Cowboys·#24 | 4 | 15 | 97 | 6.47 | 0 | 60 | 2 | 0 | 7 | 7 | 27 | 0 | 100.0% | 3.86 | 3.86 | 43 | 1 | 1 | 0 | 1 | 47 |
| 15 | Trevor EtienneCarolina Panthers·#23 | 11 | 17 | 89 | 5.24 | 0 | 49 | 5 | 0 | 2 | 2 | 6 | 0 | 100.0% | 3.00 | 3.00 | 8 | 0 | 0 | 0 | 0 | 29 |
| 16 | Trayveon WilliamsCleveland Browns·#38 | 4 | 3 | 11 | 3.67 | 0 | 20 | 0 | 0 | 5 | 5 | 64 | 0 | 100.0% | 12.80 | 12.80 | 80 | 1 | 1 | 0 | 0 | 40 |
| 17 | Devin NealNew Orleans Saints·#24 | 9 | 36 | 146 | 4.06 | 0 | 81 | 3 | 0 | 17 | 16 | 94 | 0 | 94.1% | 5.53 | 5.88 | 131 | 1 | 1 | 0 | 0 | 168 |
| 18 | Devin SingletaryNew York Giants·#26 | 17 | 70 | 247 | 3.53 | 0 | 167 | 4 | 0 | 14 | 13 | 85 | 0 | 92.9% | 6.07 | 6.54 | 90 | 0 | 0 | 0 | 1 | 176 |
| 19 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 9 | 33 | 3.67 | 0 | 22 | 0 | 0 | 14 | 13 | 89 | 0 | 92.9% | 6.36 | 6.85 | 87 | 1 | 1 | 0 | 0 | 55 |
| 20 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 81 | 330 | 4.07 | 1 | 267 | 9 | 0 | 13 | 12 | 97 | 0 | 92.3% | 7.46 | 8.08 | 122 | 1 | 1 | 0 | 0 | 212 |
| 21 | Audric EstiméNew Orleans Saints·#30 | 5 | 28 | 140 | 5.00 | 1 | 152 | 2 | 0 | 11 | 10 | 79 | 0 | 90.9% | 7.18 | 7.90 | 100 | 0 | 0 | 0 | 1 | 115 |
| 22 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 17 | 13 | 45 | 3.46 | 0 | 47 | 0 | 0 | 11 | 10 | 54 | 0 | 90.9% | 4.91 | 5.40 | 61 | 2 | 2 | 0 | 2 | 160 |
| 23 | Tyjae SpearsTennessee Titans·#2 | 13 | 41 | 132 | 3.22 | 0 | 171 | 1 | 0 | 41 | 37 | 241 | 0 | 90.2% | 5.88 | 6.51 | 303 | 6 | 6 | 0 | 2 | 235 |
| 24 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 74 | 378 | 5.11 | 1 | 219 | 9 | 0 | 30 | 27 | 130 | 0 | 90.0% | 4.33 | 4.81 | 172 | 1 | 1 | 0 | 2 | 237 |
| 25 | Rasheen AliBaltimore Ravens·#26 | 9 | 4 | 19 | 4.75 | 0 | 37 | 0 | 0 | 10 | 9 | 68 | 1 | 90.0% | 6.80 | 7.56 | 83 | 1 | 1 | 0 | 3 | 66 |
| 26 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 91 | 431 | 4.74 | 1 | 250 | 12 | 0 | 39 | 35 | 175 | 0 | 89.7% | 4.49 | 5.00 | 281 | 8 | 7 | 0 | 3 | 375 |
| 27 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 166 | 840 | 5.06 | 2 | 418 | 29 | 0 | 29 | 26 | 238 | 0 | 89.7% | 8.21 | 9.15 | 295 | 2 | 1 | 0 | 3 | 353 |
| 28 | Rhamondre StevensonNew England Patriots·#38 | 14 | 83 | 346 | 4.17 | 2 | 208 | 7 | 0 | 28 | 25 | 245 | 1 | 89.3% | 8.75 | 9.80 | 206 | 2 | 2 | 0 | 2 | 327 |
| 29 | Zavier ScottMinnesota Vikings·#36 | 9 | 24 | 75 | 3.12 | 0 | 51 | 1 | 0 | 9 | 8 | 35 | 0 | 88.9% | 3.89 | 4.38 | 46 | 1 | 1 | 0 | 1 | 75 |
| 30 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 136 | 702 | 5.16 | 1 | 511 | 17 | 0 | 36 | 32 | 259 | 0 | 88.9% | 7.19 | 8.09 | 368 | 4 | 3 | 0 | 3 | 330 |
| 31 | Ollie Gordon IIMiami Dolphins·#31 | 17 | 41 | 128 | 3.12 | 1 | 66 | 4 | 0 | 8 | 7 | 32 | 1 | 87.5% | 4.00 | 4.57 | 57 | 2 | 2 | 1 | 1 | 132 |
| 32 | Jeremy McNicholsWashington Commanders·#26 | 17 | 28 | 118 | 4.21 | 0 | 112 | 4 | 0 | 24 | 21 | 135 | 0 | 87.5% | 5.62 | 6.43 | 173 | 2 | 2 | 0 | 1 | 196 |
| 33 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 72 | 356 | 4.94 | 0 | 271 | 11 | 0 | 64 | 55 | 380 | 2 | 85.9% | 5.94 | 6.91 | 384 | 12 | 10 | 1 | 1 | 341 |
| 34 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 127 | 456 | 3.59 | 0 | 282 | 8 | 0 | 28 | 24 | 255 | 3 | 85.7% | 9.11 | 10.62 | 313 | 4 | 3 | 1 | 0 | 301 |
| 35 | Jordan MasonMinnesota Vikings·#27 | 16 | 110 | 586 | 5.33 | 0 | 340 | 18 | 0 | 14 | 12 | 36 | 0 | 85.7% | 2.57 | 3.00 | 82 | 1 | 1 | 0 | 1 | 269 |
| 36 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 92 | 361 | 3.92 | 1 | 239 | 10 | 0 | 14 | 12 | 80 | 0 | 85.7% | 5.71 | 6.67 | 104 | 1 | 1 | 0 | 1 | 194 |
| 37 | James ConnerArizona Cardinals·#6 | 3 | 19 | 70 | 3.68 | 0 | 65 | 0 | 0 | 7 | 6 | 29 | 0 | 85.7% | 4.14 | 4.83 | 55 | 0 | 0 | 0 | 0 | 61 |
| 38 | TreVeyon HendersonNew England Patriots·#32 | 17 | 124 | 720 | 5.81 | 6 | 288 | 18 | 0 | 34 | 29 | 192 | 0 | 85.3% | 5.65 | 6.62 | 218 | 1 | 1 | 0 | 2 | 343 |
| 39 | Alvin KamaraNew Orleans Saints·#41 | 11 | 91 | 320 | 3.52 | 0 | 247 | 5 | 0 | 33 | 28 | 180 | 0 | 84.8% | 5.45 | 6.43 | 181 | 5 | 4 | 0 | 4 | 311 |
| 40 | James CookBuffalo Bills·#4 | 17 | 224 | 1,145 | 5.11 | 2 | 623 | 31 | 0 | 33 | 28 | 174 | 1 | 84.8% | 5.27 | 6.21 | 153 | 2 | 2 | 0 | 3 | 431 |
| 41 | Chase BrownCincinnati Bengals·#30 | 17 | 168 | 794 | 4.73 | 1 | 560 | 21 | 0 | 66 | 56 | 343 | 3 | 84.8% | 5.20 | 6.12 | 340 | 7 | 6 | 3 | 3 | 515 |
| 42 | J.K. DobbinsDenver Broncos·#27 | 10 | 104 | 597 | 5.74 | 1 | 320 | 16 | 0 | 13 | 11 | 42 | 0 | 84.6% | 3.23 | 3.82 | 56 | 0 | 0 | 0 | 1 | 226 |
| 43 | Jerome FordCleveland Browns·#34 | 13 | 14 | 42 | 3.00 | 0 | 52 | 1 | 0 | 25 | 21 | 84 | 0 | 84.0% | 3.36 | 4.00 | 132 | 5 | 5 | 0 | 1 | 180 |
| 44 | Trey BensonArizona Cardinals·#33 | 4 | 24 | 149 | 6.21 | 0 | 134 | 3 | 0 | 12 | 10 | 41 | 0 | 83.3% | 3.42 | 4.10 | 53 | 1 | 1 | 0 | 1 | 91 |
| 45 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 111 | 433 | 3.90 | 0 | 318 | 9 | 0 | 18 | 15 | 99 | 0 | 83.3% | 5.50 | 6.60 | 88 | 2 | 2 | 0 | 4 | 308 |
| 46 | Dylan SampsonCleveland Browns·#22 | 15 | 50 | 142 | 2.84 | 0 | 185 | 3 | 0 | 34 | 28 | 214 | 2 | 82.3% | 6.29 | 7.64 | 256 | 6 | 4 | 1 | 2 | 186 |
| 47 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 201 | 1,025 | 5.10 | 4 | 610 | 22 | 0 | 50 | 41 | 318 | 2 | 82.0% | 6.36 | 7.76 | 362 | 4 | 4 | 2 | 2 | 585 |
| 48 | Jahmyr GibbsDetroit Lions·#0 | 17 | 167 | 785 | 4.70 | 5 | 413 | 19 | 0 | 77 | 63 | 483 | 2 | 81.8% | 6.27 | 7.67 | 480 | 10 | 8 | 2 | 2 | 500 |
| 49 | Will ShipleyPhiladelphia Eagles·#28 | 15 | 8 | 30 | 3.75 | 0 | 10 | 1 | 0 | 11 | 9 | 56 | 0 | 81.8% | 5.09 | 6.22 | 63 | 1 | 0 | 0 | 0 | 74 |
| 50 | Breece HallNew York Jets·#20 | 16 | 166 | 824 | 4.96 | 2 | 381 | 22 | 0 | 38 | 31 | 313 | 1 | 81.6% | 8.24 | 10.10 | 304 | 6 | 1 | 0 | 2 | 417 |