| 1 | Kyren WilliamsLos Angeles Rams·#23 | 16 | 79 | 384 | 4.86 | 3 | 209 | 27 | 5 | 13 | 10 | 95 | 1 | 76.9% | 7.31 | 9.50 | 64 | 1 | 1 | 1 | 4 | 199 |
| 2 | D'Andre SwiftChicago Bears·#4 | 16 | 55 | 278 | 5.05 | 4 | 160 | 19 | 8 | 13 | 10 | 138 | 1 | 76.9% | 10.62 | 13.80 | 148 | 0 | 0 | 0 | 1 | 157 |
| 3 | Jonathan TaylorIndianapolis Colts·#28 | 15 | 66 | 416 | 6.30 | 4 | 360 | 19 | 5 | 9 | 8 | 55 | 1 | 88.9% | 6.11 | 6.88 | 70 | 2 | 1 | 1 | 1 | 157 |
| 4 | Josh JacobsGreen Bay Packers·#8 | 13 | 63 | 261 | 4.14 | 8 | 205 | 19 | 7 | 11 | 5 | 53 | 0 | 45.5% | 4.82 | 10.60 | 55 | 2 | 1 | 0 | 1 | 120 |
| 5 | Tony PollardTennessee Titans·#20 | 17 | 56 | 240 | 4.29 | 2 | 142 | 18 | 1 | 19 | 19 | 113 | 0 | 100.0% | 5.95 | 5.95 | 96 | 0 | 0 | 0 | 5 | 186 |
| 6 | De'Von AchaneMiami Dolphins·#28 | 15 | 64 | 348 | 5.44 | 3 | 255 | 18 | 3 | 17 | 16 | 153 | 1 | 94.1% | 9.00 | 9.56 | 145 | 3 | 3 | 1 | 0 | 182 |
| 7 | Derrick HenryBaltimore Ravens·#22 | 16 | 72 | 326 | 4.53 | 4 | 139 | 17 | 4 | 3 | 1 | 8 | 0 | 33.3% | 2.67 | 8.00 | 5 | 1 | 1 | 0 | 2 | 112 |
| 8 | Chase BrownCincinnati Bengals·#30 | 17 | 46 | 156 | 3.39 | 1 | 128 | 16 | 4 | 31 | 24 | 144 | 0 | 77.4% | 4.65 | 6.00 | 144 | 3 | 2 | 0 | 2 | 188 |
| 9 | Kareem HuntKansas City Chiefs·#29 | 16 | 48 | 171 | 3.56 | 5 | 90 | 15 | 9 | 5 | 2 | 7 | 0 | 40.0% | 1.40 | 3.50 | 12 | 1 | 0 | 0 | 1 | 146 |
| 10 | Travis EtienneJacksonville Jaguars·#1 | 17 | 80 | 287 | 3.59 | 2 | 180 | 15 | 5 | 8 | 6 | 71 | 1 | 75.0% | 8.88 | 11.83 | 79 | 1 | 1 | 0 | 0 | 162 |
| 11 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 62 | 220 | 3.55 | 3 | 146 | 14 | 7 | 6 | 4 | 45 | 0 | 66.7% | 7.50 | 11.25 | 60 | 0 | 0 | 0 | 1 | 106 |
| 12 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 71 | 217 | 3.06 | 3 | 183 | 14 | 4 | 33 | 29 | 348 | 1 | 87.9% | 10.55 | 12.00 | 250 | 6 | 5 | 1 | 2 | 211 |
| 13 | Breece HallNew York Jets·#20 | 16 | 50 | 272 | 5.44 | 3 | 131 | 13 | 2 | 16 | 11 | 155 | 1 | 68.8% | 9.69 | 14.09 | 156 | 4 | 1 | 0 | 2 | 176 |
| 14 | Jahmyr GibbsDetroit Lions·#0 | 17 | 53 | 252 | 4.75 | 5 | 176 | 13 | 1 | 29 | 21 | 135 | 1 | 72.4% | 4.66 | 6.43 | 95 | 5 | 5 | 1 | 1 | 200 |
| 15 | J.K. DobbinsDenver Broncos·#27 | 10 | 48 | 237 | 4.94 | 2 | 137 | 13 | 1 | 5 | 5 | 14 | 0 | 100.0% | 2.80 | 2.80 | 23 | 0 | 0 | 0 | 0 | 94 |
| 16 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 61 | 195 | 3.20 | 2 | 160 | 13 | 4 | 6 | 5 | 44 | 0 | 83.3% | 7.33 | 8.80 | 36 | 0 | 0 | 0 | 1 | 138 |
| 17 | Jacory Croskey-MerrittWashington Commanders·#22 | 15 | 49 | 212 | 4.33 | 0 | 122 | 12 | 4 | 2 | 1 | 3 | 0 | 50.0% | 1.50 | 3.00 | 1 | 0 | 0 | 0 | 1 | 87 |
| 18 | RJ HarveyDenver Broncos·#12 | 17 | 45 | 196 | 4.36 | 1 | 165 | 12 | 2 | 16 | 14 | 116 | 5 | 87.5% | 7.25 | 8.29 | 114 | 6 | 5 | 4 | 0 | 139 |
| 19 | Rico DowdleCarolina Panthers·#5 | 16 | 57 | 261 | 4.58 | 2 | 164 | 12 | 3 | 14 | 11 | 98 | 0 | 78.6% | 7.00 | 8.91 | 132 | 2 | 1 | 0 | 2 | 142 |
| 20 | Javonte WilliamsDallas Cowboys·#33 | 15 | 49 | 212 | 4.33 | 1 | 118 | 12 | 3 | 15 | 11 | 18 | 2 | 73.3% | 1.20 | 1.64 | 29 | 5 | 3 | 2 | 1 | 185 |
| 21 | Quinshon JudkinsCleveland Browns·#10 | 12 | 47 | 216 | 4.60 | 2 | 153 | 12 | 3 | 10 | 6 | 24 | 0 | 60.0% | 2.40 | 4.00 | 22 | 0 | 0 | 0 | 0 | 85 |
| 22 | Jaylen WarrenPittsburgh Steelers·#30 | 14 | 41 | 244 | 5.95 | 3 | 189 | 11 | 4 | 10 | 7 | 53 | 1 | 70.0% | 5.30 | 7.57 | 78 | 2 | 1 | 1 | 1 | 96 |
| 23 | Devin SingletaryNew York Giants·#26 | 15 | 38 | 159 | 4.18 | 2 | 104 | 11 | 4 | 5 | 5 | 87 | 0 | 100.0% | 17.40 | 17.40 | 94 | 0 | 0 | 0 | 0 | 109 |
| 24 | Tyrone Tracy Jr.New York Giants·#29 | 14 | 42 | 181 | 4.31 | 0 | 107 | 11 | 1 | 13 | 10 | 61 | 0 | 76.9% | 4.69 | 6.10 | 69 | 1 | 1 | 0 | 1 | 115 |
| 25 | Jordan MasonMinnesota Vikings·#27 | 14 | 43 | 246 | 5.72 | 1 | 173 | 10 | 2 | 2 | 1 | 2 | 0 | 50.0% | 1.00 | 2.00 | 7 | 0 | 0 | 0 | 2 | 121 |
| 26 | Blake CorumLos Angeles Rams·#22 | 14 | 37 | 242 | 6.54 | 2 | 90 | 10 | 3 | 1 | 1 | 14 | 0 | 100.0% | 14.00 | 14.00 | 16 | 0 | 0 | 0 | 0 | 59 |
| 27 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 62 | 184 | 2.97 | 1 | 191 | 10 | 5 | 27 | 21 | 192 | 0 | 77.8% | 7.11 | 9.14 | 192 | 2 | 1 | 0 | 0 | 196 |
| 28 | Kenneth Walker IIISeattle Seahawks·#9 | 16 | 44 | 219 | 4.98 | 2 | 115 | 10 | 1 | 9 | 8 | 55 | 0 | 88.9% | 6.11 | 6.88 | 55 | 1 | 1 | 0 | 2 | 93 |
| 29 | Woody MarksHouston Texans·#27 | 14 | 53 | 203 | 3.83 | 1 | 130 | 10 | 2 | 11 | 7 | 55 | 2 | 63.6% | 5.00 | 7.86 | 59 | 5 | 3 | 2 | 0 | 153 |
| 30 | Emanuel WilsonGreen Bay Packers·#23 | 14 | 38 | 152 | 4.00 | 0 | 112 | 10 | 0 | 8 | 6 | 42 | 0 | 75.0% | 5.25 | 7.00 | 52 | 2 | 0 | 0 | 0 | 97 |
| 31 | David MontgomeryDetroit Lions·#5 | 16 | 40 | 162 | 4.05 | 2 | 81 | 9 | 3 | 6 | 3 | 28 | 0 | 50.0% | 4.67 | 9.33 | 33 | 1 | 0 | 0 | 1 | 84 |
| 32 | TreVeyon HendersonNew England Patriots·#32 | 15 | 39 | 260 | 6.67 | 3 | 75 | 9 | 2 | 9 | 7 | 43 | 0 | 77.8% | 4.78 | 6.14 | 49 | 0 | 0 | 0 | 1 | 103 |
| 33 | Saquon BarkleyPhiladelphia Eagles·#26 | 15 | 66 | 228 | 3.45 | 2 | 172 | 9 | 3 | 16 | 10 | 85 | 0 | 62.5% | 5.31 | 8.50 | 94 | 2 | 1 | 0 | 1 | 175 |
| 34 | Kyle MonangaiChicago Bears·#25 | 17 | 45 | 203 | 4.51 | 2 | 110 | 8 | 3 | 9 | 5 | 33 | 0 | 55.6% | 3.67 | 6.60 | 27 | 2 | 1 | 0 | 0 | 130 |
| 35 | Kimani VidalLos Angeles Chargers·#30 | 12 | 38 | 132 | 3.47 | 1 | 55 | 8 | 3 | 5 | 3 | 0 | 0 | 60.0% | 0.00 | 0.00 | 6 | 1 | 0 | 0 | 0 | 108 |
| 36 | Jaylen WrightMiami Dolphins·#5 | 6 | 21 | 94 | 4.48 | 1 | 61 | 8 | 1 | 3 | 2 | 9 | 0 | 66.7% | 3.00 | 4.50 | 12 | 0 | 0 | 0 | 0 | 38 |
| 37 | James CookBuffalo Bills·#4 | 14 | 67 | 231 | 3.45 | 1 | 185 | 8 | 3 | 15 | 12 | 143 | 0 | 80.0% | 9.53 | 11.92 | 112 | 0 | 0 | 0 | 0 | 153 |
| 38 | Aaron JonesMinnesota Vikings·#33 | 10 | 30 | 120 | 4.00 | 0 | 75 | 8 | 0 | 7 | 4 | 43 | 1 | 57.1% | 6.14 | 10.75 | 25 | 1 | 1 | 0 | 1 | 76 |
| 39 | Cam SkatteboNew York Giants·#44 | 6 | 30 | 135 | 4.50 | 2 | 112 | 8 | 4 | 8 | 7 | 57 | 0 | 87.5% | 7.12 | 8.14 | 51 | 1 | 1 | 0 | 1 | 70 |
| 40 | Chris Rodriguez Jr.Washington Commanders·#36 | 10 | 36 | 120 | 3.33 | 2 | 91 | 8 | 5 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 23 | 0 | 0 | 0 | 0 | 63 |
| 41 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 28 | 101 | 3.61 | 1 | 109 | 8 | 3 | 26 | 23 | 170 | 1 | 88.5% | 6.54 | 7.39 | 190 | 5 | 4 | 1 | 2 | 141 |
| 42 | Michael CarterArizona Cardinals·#22 | 13 | 24 | 89 | 3.71 | 0 | 95 | 7 | 0 | 22 | 15 | 122 | 0 | 68.2% | 5.55 | 8.13 | 108 | 4 | 1 | 0 | 1 | 143 |
| 43 | Tank BigsbyPhiladelphia Eagles·#37 | 8 | 24 | 143 | 5.96 | 0 | 107 | 7 | 4 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 41 |
| 44 | Jeremy McNicholsWashington Commanders·#26 | 15 | 18 | 76 | 4.22 | 0 | 46 | 7 | 2 | 9 | 6 | 40 | 0 | 66.7% | 4.44 | 6.67 | 35 | 0 | 0 | 0 | 2 | 88 |
| 45 | Trevor EtienneCarolina Panthers·#23 | 5 | 16 | 83 | 5.19 | 0 | 43 | 7 | 1 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 3 | 0 | 0 | 0 | 0 | 25 |
| 46 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 22 | 71 | 3.23 | 1 | 61 | 6 | 1 | 15 | 12 | 62 | 0 | 80.0% | 4.13 | 5.17 | 96 | 2 | 1 | 0 | 2 | 150 |
| 47 | Ray DavisBuffalo Bills·#22 | 12 | 28 | 114 | 4.07 | 0 | 66 | 6 | 0 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 45 |
| 48 | Dylan SampsonCleveland Browns·#22 | 11 | 25 | 79 | 3.16 | 0 | 80 | 6 | 0 | 19 | 16 | 178 | 2 | 84.2% | 9.37 | 11.12 | 177 | 4 | 2 | 1 | 1 | 87 |
| 49 | Chuba HubbardCarolina Panthers·#30 | 13 | 22 | 74 | 3.36 | 1 | 74 | 6 | 2 | 9 | 7 | 67 | 2 | 77.8% | 7.44 | 9.57 | 54 | 2 | 2 | 1 | 1 | 109 |
| 50 | Brian RobinsonSan Francisco 49ers·#3 | 15 | 26 | 140 | 5.38 | 1 | 72 | 6 | 0 | 4 | 3 | 5 | 0 | 75.0% | 1.25 | 1.67 | 11 | 2 | 1 | 0 | 0 | 44 |