| 1 | Kareem HuntKansas City Chiefs·#29 | 17 | 61 | 177 | 2.90 | 7 | 98 | 46 | 13 | 4 | 3 | 30 | 1 | 75.0% | 7.50 | 10.00 | 28 | 2 | 1 | 1 | 0 | 111 |
| 2 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 70 | 304 | 4.34 | 10 | 180 | 45 | 18 | 3 | 3 | 50 | 0 | 100.0% | 16.67 | 16.67 | 52 | 0 | 0 | 0 | 1 | 118 |
| 3 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 64 | 238 | 3.72 | 7 | 180 | 39 | 13 | 6 | 4 | 56 | 0 | 66.7% | 9.33 | 14.00 | 14 | 1 | 1 | 0 | 1 | 140 |
| 4 | Derrick HenryBaltimore Ravens·#22 | 16 | 60 | 170 | 2.83 | 11 | 96 | 33 | 21 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 81 |
| 5 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 60 | 199 | 3.32 | 7 | 111 | 33 | 14 | 9 | 8 | 75 | 3 | 88.9% | 8.33 | 9.38 | 52 | 5 | 4 | 3 | 0 | 124 |
| 6 | Javonte WilliamsDallas Cowboys·#33 | 16 | 50 | 129 | 2.58 | 8 | 106 | 31 | 16 | 10 | 4 | 13 | 2 | 40.0% | 1.30 | 3.25 | 12 | 3 | 2 | 2 | 1 | 123 |
| 7 | Josh JacobsGreen Bay Packers·#8 | 15 | 55 | 173 | 3.15 | 9 | 128 | 31 | 15 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 2 | 0 | 0 | 0 | 1 | 87 |
| 8 | Quinshon JudkinsCleveland Browns·#10 | 13 | 46 | 146 | 3.17 | 5 | 88 | 31 | 8 | 1 | 1 | 13 | 0 | 100.0% | 13.00 | 13.00 | 16 | 0 | 0 | 0 | 0 | 62 |
| 9 | Jaylen WarrenPittsburgh Steelers·#30 | 15 | 49 | 145 | 2.96 | 4 | 77 | 31 | 10 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 0 | 0 | 0 | 0 | 1 | 68 |
| 10 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 47 | 155 | 3.30 | 2 | 117 | 29 | 6 | 10 | 9 | 96 | 1 | 90.0% | 9.60 | 10.67 | 96 | 3 | 3 | 1 | 1 | 89 |
| 11 | James CookBuffalo Bills·#4 | 16 | 43 | 228 | 5.30 | 9 | 205 | 28 | 12 | 3 | 3 | 61 | 0 | 100.0% | 20.33 | 20.33 | 61 | 0 | 0 | 0 | 2 | 74 |
| 12 | Rachaad WhiteTampa Bay Buccaneers·#1 | 14 | 33 | 126 | 3.82 | 3 | 56 | 27 | 7 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 19 | 0 | 0 | 0 | 1 | 65 |
| 13 | Breece HallNew York Jets·#20 | 16 | 39 | 111 | 2.85 | 2 | 71 | 27 | 3 | 4 | 3 | 15 | 0 | 75.0% | 3.75 | 5.00 | 5 | 0 | 0 | 0 | 0 | 67 |
| 14 | Jahmyr GibbsDetroit Lions·#0 | 17 | 40 | 222 | 5.55 | 4 | 137 | 27 | 5 | 9 | 6 | 30 | 2 | 66.7% | 3.33 | 5.00 | 24 | 3 | 2 | 2 | 0 | 79 |
| 15 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 39 | 128 | 3.28 | 7 | 77 | 26 | 11 | 2 | 2 | 13 | 0 | 100.0% | 6.50 | 6.50 | 11 | 1 | 1 | 0 | 0 | 68 |
| 16 | D'Andre SwiftChicago Bears·#4 | 16 | 35 | 117 | 3.34 | 5 | 84 | 24 | 10 | 5 | 2 | 15 | 0 | 40.0% | 3.00 | 7.50 | 17 | 0 | 0 | 0 | 1 | 77 |
| 17 | Rico DowdleCarolina Panthers·#5 | 15 | 32 | 110 | 3.44 | 4 | 53 | 24 | 5 | 4 | 3 | 10 | 0 | 75.0% | 2.50 | 3.33 | 11 | 0 | 0 | 0 | 0 | 67 |
| 18 | Samaje PerineCincinnati Bengals·#34 | 13 | 32 | 101 | 3.16 | 1 | 81 | 23 | 3 | 3 | 3 | 29 | 0 | 100.0% | 9.67 | 9.67 | 28 | 0 | 0 | 0 | 0 | 54 |
| 19 | Chase BrownCincinnati Bengals·#30 | 17 | 34 | 113 | 3.32 | 3 | 72 | 23 | 8 | 9 | 6 | 43 | 1 | 66.7% | 4.78 | 7.17 | 44 | 1 | 1 | 1 | 0 | 78 |
| 20 | David MontgomeryDetroit Lions·#5 | 17 | 32 | 81 | 2.53 | 5 | 58 | 22 | 13 | 2 | 2 | 13 | 0 | 100.0% | 6.50 | 6.50 | 8 | 0 | 0 | 0 | 1 | 67 |
| 21 | Chuba HubbardCarolina Panthers·#30 | 15 | 31 | 93 | 3.00 | 1 | 76 | 22 | 1 | 5 | 5 | 15 | 1 | 100.0% | 3.00 | 3.00 | 19 | 2 | 2 | 1 | 0 | 67 |
| 22 | Jacory Croskey-MerrittWashington Commanders·#22 | 14 | 31 | 119 | 3.84 | 3 | 65 | 21 | 7 | 1 | 1 | -1 | 0 | 100.0% | -1.00 | -1.00 | 6 | 0 | 0 | 0 | 1 | 39 |
| 23 | Travis EtienneJacksonville Jaguars·#1 | 17 | 41 | 130 | 3.17 | 2 | 89 | 21 | 9 | 3 | 1 | 11 | 1 | 33.3% | 3.67 | 11.00 | 15 | 1 | 1 | 1 | 0 | 80 |
| 24 | Tyler AllgeierAtlanta Falcons·#25 | 16 | 31 | 92 | 2.97 | 5 | 50 | 20 | 6 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 1 | 0 | 0 | 0 | 1 | 44 |
| 25 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 34 | 149 | 4.38 | 3 | 57 | 20 | 7 | 5 | 4 | 7 | 0 | 80.0% | 1.40 | 1.75 | 17 | 2 | 1 | 0 | 0 | 75 |
| 26 | Kyle MonangaiChicago Bears·#25 | 16 | 31 | 95 | 3.06 | 3 | 53 | 20 | 9 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 65 |
| 27 | Woody MarksHouston Texans·#27 | 15 | 36 | 87 | 2.42 | 1 | 55 | 19 | 7 | 3 | 1 | 6 | 0 | 33.3% | 2.00 | 6.00 | 10 | 1 | 0 | 0 | 0 | 70 |
| 28 | Blake CorumLos Angeles Rams·#22 | 15 | 27 | 94 | 3.48 | 4 | 44 | 19 | 9 | 1 | 1 | 13 | 0 | 100.0% | 13.00 | 13.00 | 7 | 0 | 0 | 0 | 0 | 51 |
| 29 | Jordan MasonMinnesota Vikings·#27 | 14 | 30 | 100 | 3.33 | 4 | 56 | 19 | 4 | 1 | 1 | 13 | 0 | 100.0% | 13.00 | 13.00 | 13 | 0 | 0 | 0 | 0 | 63 |
| 30 | Ashton JeantyLas Vegas Raiders·#2 | 16 | 42 | 101 | 2.40 | 2 | 92 | 18 | 8 | 8 | 6 | 13 | 1 | 75.0% | 1.62 | 2.17 | 15 | 2 | 1 | 1 | 1 | 93 |
| 31 | TreVeyon HendersonNew England Patriots·#32 | 15 | 26 | 93 | 3.58 | 1 | 30 | 17 | 4 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 47 |
| 32 | Chris Rodriguez Jr.Washington Commanders·#36 | 11 | 26 | 72 | 2.77 | 4 | 38 | 17 | 9 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 46 |
| 33 | RJ HarveyDenver Broncos·#12 | 16 | 24 | 63 | 2.62 | 3 | 44 | 16 | 5 | 8 | 7 | 40 | 2 | 87.5% | 5.00 | 5.71 | 40 | 3 | 3 | 2 | 1 | 61 |
| 34 | Tony PollardTennessee Titans·#20 | 16 | 26 | 65 | 2.50 | 2 | 40 | 16 | 4 | 2 | 1 | 9 | 0 | 50.0% | 4.50 | 9.00 | 7 | 0 | 0 | 0 | 1 | 59 |
| 35 | Isiah PachecoKansas City Chiefs·#10 | 11 | 20 | 78 | 3.90 | 1 | 42 | 16 | 0 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 7 | 0 | 0 | 0 | 0 | 40 |
| 36 | J.K. DobbinsDenver Broncos·#27 | 10 | 33 | 96 | 2.91 | 2 | 42 | 16 | 6 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 57 |
| 37 | Bhayshul TutenJacksonville Jaguars·#33 | 14 | 21 | 68 | 3.24 | 3 | 57 | 16 | 4 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 35 |
| 38 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 29 | 110 | 3.79 | 1 | 73 | 16 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 48 |
| 39 | Kimani VidalLos Angeles Chargers·#30 | 12 | 30 | 163 | 5.43 | 3 | 48 | 16 | 6 | 5 | 4 | 22 | 1 | 80.0% | 4.40 | 5.50 | 24 | 1 | 1 | 1 | 0 | 64 |
| 40 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 26 | 129 | 4.96 | 3 | 60 | 16 | 6 | 9 | 8 | 59 | 0 | 88.9% | 6.56 | 7.38 | 73 | 0 | 0 | 0 | 0 | 60 |
| 41 | Ollie Gordon IIMiami Dolphins·#31 | 14 | 25 | 63 | 2.52 | 2 | 46 | 16 | 5 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 38 |
| 42 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 25 | 63 | 2.52 | 0 | 66 | 15 | 0 | 5 | 4 | 24 | 0 | 80.0% | 4.80 | 6.00 | 33 | 0 | 0 | 0 | 0 | 56 |
| 43 | Cam SkatteboNew York Giants·#44 | 7 | 22 | 64 | 2.91 | 3 | 54 | 15 | 7 | 3 | 1 | 9 | 0 | 33.3% | 3.00 | 9.00 | 10 | 1 | 0 | 0 | 0 | 42 |
| 44 | Emanuel WilsonGreen Bay Packers·#23 | 13 | 24 | 71 | 2.96 | 2 | 73 | 15 | 3 | 1 | 1 | -4 | 0 | 100.0% | -4.00 | -4.00 | 1 | 0 | 0 | 0 | 0 | 41 |
| 45 | Devin SingletaryNew York Giants·#26 | 13 | 27 | 53 | 1.96 | 2 | 41 | 15 | 9 | 1 | 1 | 41 | 0 | 100.0% | 41.00 | 41.00 | 42 | 0 | 0 | 0 | 0 | 51 |
| 46 | Kenneth Walker IIISeattle Seahawks·#9 | 15 | 27 | 84 | 3.11 | 3 | 47 | 15 | 7 | 2 | 2 | 22 | 0 | 100.0% | 11.00 | 11.00 | 22 | 0 | 0 | 0 | 0 | 45 |
| 47 | Michael CarterArizona Cardinals·#22 | 12 | 18 | 49 | 2.72 | 1 | 37 | 14 | 3 | 4 | 3 | 19 | 0 | 75.0% | 4.75 | 6.33 | 20 | 0 | 0 | 0 | 0 | 46 |
| 48 | De'Von AchaneMiami Dolphins·#28 | 16 | 23 | 78 | 3.39 | 0 | 66 | 13 | 1 | 5 | 4 | 25 | 1 | 80.0% | 5.00 | 6.25 | 11 | 2 | 1 | 1 | 0 | 56 |
| 49 | Bam KnightArizona Cardinals·#20 | 9 | 21 | 57 | 2.71 | 3 | 42 | 13 | 6 | 4 | 3 | 28 | 1 | 75.0% | 7.00 | 9.33 | 19 | 3 | 2 | 1 | 0 | 39 |
| 50 | Alvin KamaraNew Orleans Saints·#41 | 10 | 21 | 88 | 4.19 | 1 | 57 | 13 | 2 | 2 | 1 | 2 | 0 | 50.0% | 1.00 | 2.00 | 1 | 0 | 0 | 0 | 0 | 53 |