| 1 | James CookBuffalo Bills·#4 | 16 | 44 | 258 | 5.86 | 1 | 160 | 11 | 4 | 6 | 3 | 12 | 1 | 50.0% | 2.00 | 4.00 | 20 | 2 | 2 | 1 | 0 | 109 |
| 2 | TreVeyon HendersonNew England Patriots·#32 | 17 | 30 | 93 | 3.10 | 1 | 52 | 9 | 3 | 5 | 5 | 14 | 1 | 100.0% | 2.80 | 2.80 | 17 | 3 | 3 | 1 | 0 | 70 |
| 3 | D'Andre SwiftChicago Bears·#4 | 16 | 41 | 226 | 5.51 | 0 | 97 | 17 | 3 | 3 | 3 | 19 | 0 | 100.0% | 6.33 | 6.33 | 20 | 0 | 0 | 0 | 1 | 71 |
| 4 | De'Von AchaneMiami Dolphins·#28 | 16 | 30 | 213 | 7.10 | 1 | 121 | 12 | 2 | 10 | 10 | 68 | 1 | 100.0% | 6.80 | 6.80 | 78 | 1 | 1 | 0 | 2 | 68 |
| 5 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 18 | 61 | 3.39 | 2 | 62 | 5 | 2 | 6 | 6 | 55 | 1 | 100.0% | 9.17 | 9.17 | 73 | 1 | 1 | 1 | 0 | 49 |
| 6 | Blake CorumLos Angeles Rams·#22 | 15 | 22 | 106 | 4.82 | 0 | 54 | 8 | 2 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 40 |
| 7 | Bhayshul TutenJacksonville Jaguars·#33 | 11 | 11 | 30 | 2.73 | 1 | 18 | 2 | 2 | 5 | 2 | 10 | 1 | 40.0% | 2.00 | 5.00 | 13 | 1 | 1 | 1 | 0 | 28 |
| 8 | Jacory Croskey-MerrittWashington Commanders·#22 | 16 | 21 | 86 | 4.10 | 2 | 39 | 6 | 2 | 2 | 1 | 5 | 0 | 50.0% | 2.50 | 5.00 | 9 | 0 | 0 | 0 | 0 | 58 |
| 9 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 29 | 130 | 4.48 | 3 | 124 | 13 | 2 | 3 | 3 | 41 | 0 | 100.0% | 13.67 | 13.67 | 33 | 0 | 0 | 0 | 0 | 45 |
| 10 | Tyler AllgeierAtlanta Falcons·#25 | 15 | 20 | 72 | 3.60 | 2 | 44 | 7 | 2 | 2 | 2 | 20 | 0 | 100.0% | 10.00 | 10.00 | 19 | 0 | 0 | 0 | 0 | 39 |
| 11 | Sean TuckerTampa Bay Buccaneers·#44 | 12 | 11 | 40 | 3.64 | 2 | 10 | 3 | 2 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 26 |
| 12 | Devin SingletaryNew York Giants·#26 | 14 | 20 | 103 | 5.15 | 2 | 57 | 7 | 1 | 1 | 1 | 16 | 0 | 100.0% | 16.00 | 16.00 | 16 | 0 | 0 | 0 | 0 | 33 |
| 13 | Saquon BarkleyPhiladelphia Eagles·#26 | 15 | 28 | 135 | 4.82 | 1 | 98 | 7 | 1 | 3 | 2 | 53 | 1 | 66.7% | 17.67 | 26.50 | 31 | 0 | 0 | 0 | 1 | 69 |
| 14 | RJ HarveyDenver Broncos·#12 | 16 | 23 | 66 | 2.87 | 1 | 46 | 4 | 1 | 4 | 3 | 36 | 0 | 75.0% | 9.00 | 12.00 | 40 | 1 | 1 | 0 | 0 | 63 |
| 15 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 34 | 162 | 4.76 | 0 | 83 | 12 | 1 | 8 | 3 | 23 | 0 | 37.5% | 2.88 | 7.67 | 18 | 2 | 0 | 0 | 0 | 87 |
| 16 | Jahmyr GibbsDetroit Lions·#0 | 17 | 35 | 200 | 5.71 | 4 | 130 | 10 | 1 | 6 | 6 | 115 | 0 | 100.0% | 19.17 | 19.17 | 127 | 0 | 0 | 0 | 1 | 72 |
| 17 | David MontgomeryDetroit Lions·#5 | 14 | 19 | 56 | 2.95 | 0 | 28 | 2 | 1 | 1 | 1 | 13 | 0 | 100.0% | 13.00 | 13.00 | 11 | 0 | 0 | 0 | 0 | 35 |
| 18 | Chris Rodriguez Jr.Washington Commanders·#36 | 10 | 14 | 118 | 8.43 | 0 | 79 | 6 | 1 | 2 | 1 | 6 | 0 | 50.0% | 3.00 | 6.00 | 6 | 1 | 0 | 0 | 0 | 31 |
| 19 | Josh JacobsGreen Bay Packers·#8 | 15 | 32 | 153 | 4.78 | 2 | 99 | 10 | 1 | 3 | 3 | 7 | 0 | 100.0% | 2.33 | 2.33 | 20 | 1 | 1 | 0 | 0 | 70 |
| 20 | Jaylen WarrenPittsburgh Steelers·#30 | 15 | 31 | 164 | 5.29 | 1 | 124 | 5 | 1 | 5 | 4 | 36 | 0 | 80.0% | 7.20 | 9.00 | 45 | 1 | 1 | 0 | 0 | 61 |
| 21 | Cam SkatteboNew York Giants·#44 | 8 | 15 | 30 | 2.00 | 1 | 26 | 3 | 1 | 3 | 2 | 12 | 0 | 66.7% | 4.00 | 6.00 | 14 | 0 | 0 | 0 | 1 | 29 |
| 22 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 36 | 142 | 3.94 | 0 | 102 | 6 | 1 | 12 | 9 | 106 | 1 | 75.0% | 8.83 | 11.78 | 106 | 2 | 1 | 0 | 0 | 85 |
| 23 | Aaron JonesMinnesota Vikings·#33 | 12 | 16 | 64 | 4.00 | 0 | 51 | 6 | 1 | 5 | 5 | 20 | 0 | 100.0% | 4.00 | 4.00 | 26 | 0 | 0 | 0 | 1 | 44 |
| 24 | Rico DowdleCarolina Panthers·#5 | 16 | 28 | 112 | 4.00 | 1 | 101 | 5 | 1 | 9 | 9 | 84 | 0 | 100.0% | 9.33 | 9.33 | 116 | 2 | 2 | 0 | 1 | 66 |
| 25 | Tyrone Tracy Jr.New York Giants·#29 | 13 | 29 | 154 | 5.31 | 1 | 71 | 11 | 1 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 1 | 52 |
| 26 | Quinshon JudkinsCleveland Browns·#10 | 14 | 28 | 87 | 3.11 | 1 | 65 | 6 | 1 | 3 | 3 | -10 | 0 | 100.0% | -3.33 | -3.33 | 7 | 0 | 0 | 0 | 0 | 50 |
| 27 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 14 | 47 | 3.36 | 0 | 50 | 5 | 1 | 7 | 6 | 16 | 1 | 85.7% | 2.29 | 2.67 | 36 | 5 | 4 | 1 | 0 | 40 |
| 28 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 24 | 92 | 3.83 | 0 | 83 | 5 | 1 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 26 | 1 | 1 | 0 | 1 | 49 |
| 29 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 51 | 297 | 5.82 | 4 | 167 | 20 | 1 | 3 | 3 | 2 | 0 | 100.0% | 0.67 | 0.67 | 12 | 0 | 0 | 0 | 1 | 95 |
| 30 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 26 | 88 | 3.38 | 1 | 60 | 5 | 0 | 5 | 4 | 79 | 1 | 80.0% | 15.80 | 19.75 | 72 | 0 | 0 | 0 | 1 | 48 |
| 31 | Derrick HenryBaltimore Ravens·#22 | 17 | 50 | 253 | 5.06 | 0 | 164 | 15 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 75 |
| 32 | Breece HallNew York Jets·#20 | 16 | 44 | 114 | 2.59 | 0 | 74 | 6 | 0 | 4 | 2 | 11 | 0 | 50.0% | 2.75 | 5.50 | 6 | 1 | 0 | 0 | 1 | 81 |
| 33 | Brian RobinsonSan Francisco 49ers·#3 | 14 | 13 | 53 | 4.08 | 0 | 37 | 3 | 0 | 2 | 2 | 8 | 0 | 100.0% | 4.00 | 4.00 | 12 | 2 | 2 | 0 | 0 | 27 |
| 34 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 32 | 157 | 4.91 | 1 | 154 | 9 | 0 | 5 | 3 | 22 | 1 | 60.0% | 4.40 | 7.33 | 34 | 1 | 1 | 1 | 0 | 85 |
| 35 | Bam KnightArizona Cardinals·#20 | 8 | 8 | 24 | 3.00 | 0 | 23 | 3 | 0 | 5 | 4 | 18 | 0 | 80.0% | 3.60 | 4.50 | 18 | 1 | 1 | 0 | 0 | 30 |
| 36 | Alvin KamaraNew Orleans Saints·#41 | 11 | 17 | 63 | 3.71 | 0 | 50 | 4 | 0 | 5 | 5 | 16 | 0 | 100.0% | 3.20 | 3.20 | 15 | 1 | 1 | 0 | 2 | 53 |
| 37 | Chase BrownCincinnati Bengals·#30 | 17 | 29 | 109 | 3.76 | 0 | 82 | 7 | 0 | 9 | 7 | 37 | 1 | 77.8% | 4.11 | 5.29 | 35 | 1 | 1 | 1 | 1 | 84 |
| 38 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 35 | 153 | 4.37 | 0 | 88 | 15 | 0 | 18 | 13 | 84 | 0 | 72.2% | 4.67 | 6.46 | 86 | 2 | 2 | 0 | 0 | 85 |
| 39 | Chuba HubbardCarolina Panthers·#30 | 14 | 17 | 50 | 2.94 | 0 | 39 | 4 | 0 | 5 | 4 | 44 | 0 | 80.0% | 8.80 | 11.00 | 57 | 1 | 0 | 0 | 0 | 46 |
| 40 | J.K. DobbinsDenver Broncos·#27 | 10 | 15 | 85 | 5.67 | 1 | 51 | 6 | 0 | 2 | 1 | 8 | 0 | 50.0% | 4.00 | 8.00 | 4 | 0 | 0 | 0 | 0 | 33 |
| 41 | Isiah PachecoKansas City Chiefs·#10 | 12 | 14 | 47 | 3.36 | 0 | 30 | 3 | 0 | 7 | 3 | 33 | 0 | 42.9% | 4.71 | 11.00 | 23 | 2 | 0 | 0 | 0 | 52 |
| 42 | Emanuel WilsonGreen Bay Packers·#23 | 14 | 20 | 95 | 4.75 | 0 | 63 | 7 | 0 | 4 | 4 | 18 | 0 | 100.0% | 4.50 | 4.50 | 28 | 0 | 0 | 0 | 0 | 46 |
| 43 | Kyle MonangaiChicago Bears·#25 | 15 | 17 | 71 | 4.18 | 0 | 47 | 5 | 0 | 4 | 4 | 21 | 0 | 100.0% | 5.25 | 5.25 | 13 | 0 | 0 | 0 | 0 | 34 |
| 44 | Kareem HuntKansas City Chiefs·#29 | 15 | 16 | 51 | 3.19 | 0 | 27 | 2 | 0 | 1 | 1 | 10 | 0 | 100.0% | 10.00 | 10.00 | 13 | 0 | 0 | 0 | 0 | 42 |
| 45 | Jordan MasonMinnesota Vikings·#27 | 15 | 19 | 70 | 3.68 | 0 | 53 | 6 | 0 | 3 | 3 | 4 | 0 | 100.0% | 1.33 | 1.33 | 15 | 0 | 0 | 0 | 1 | 40 |
| 46 | Javonte WilliamsDallas Cowboys·#33 | 16 | 27 | 129 | 4.78 | 0 | 63 | 12 | 0 | 7 | 4 | 15 | 0 | 57.1% | 2.14 | 3.75 | 26 | 3 | 2 | 0 | 0 | 81 |
| 47 | Kimani VidalLos Angeles Chargers·#30 | 12 | 15 | 39 | 2.60 | 0 | 29 | 5 | 0 | 3 | 3 | 17 | 0 | 100.0% | 5.67 | 5.67 | 23 | 1 | 1 | 0 | 0 | 49 |
| 48 | Nick ChubbHouston Texans·#21 | 11 | 7 | 34 | 4.86 | 0 | 21 | 2 | 0 | 4 | 2 | 9 | 0 | 50.0% | 2.25 | 4.50 | 0 | 0 | 0 | 0 | 0 | 29 |
| 49 | Michael CarterArizona Cardinals·#22 | 13 | 5 | 14 | 2.80 | 0 | 8 | 0 | 0 | 3 | 2 | 9 | 0 | 66.7% | 3.00 | 4.50 | 9 | 1 | 0 | 0 | 0 | 38 |
| 50 | Rhamondre StevensonNew England Patriots·#38 | 14 | 21 | 116 | 5.52 | 2 | 70 | 8 | 0 | 3 | 2 | 5 | 0 | 66.7% | 1.67 | 2.50 | 7 | 1 | 1 | 0 | 0 | 53 |