| 1 | Christian McCaffreySan Francisco 49ers·#23 | 9 | 164 | 617 | 3.76 | 5 | 447 | 41 | 11 | 64 | 53 | 464 | 6 | 82.8% | 7.25 | 8.75 | 370 | 17 | 15 | 6 | 2 | 472 |
| 2 | Chase BrownCincinnati Bengals·#30 | 8 | 107 | 394 | 3.68 | 3 | 271 | 19 | 6 | 37 | 31 | 183 | 3 | 83.8% | 4.95 | 5.90 | 184 | 7 | 5 | 3 | 2 | 302 |
| 3 | De'Von AchaneMiami Dolphins·#28 | 7 | 79 | 434 | 5.49 | 1 | 275 | 15 | 1 | 39 | 31 | 192 | 3 | 79.5% | 4.92 | 6.19 | 218 | 4 | 3 | 3 | 1 | 252 |
| 4 | Jahmyr GibbsDetroit Lions·#0 | 9 | 136 | 545 | 4.01 | 4 | 384 | 26 | 6 | 47 | 35 | 306 | 3 | 74.5% | 6.51 | 8.74 | 308 | 9 | 7 | 3 | 3 | 364 |
| 5 | Travis EtienneJacksonville Jaguars·#1 | 8 | 131 | 577 | 4.40 | 2 | 409 | 26 | 6 | 27 | 20 | 144 | 3 | 74.1% | 5.33 | 7.20 | 178 | 6 | 5 | 3 | 1 | 312 |
| 6 | Bijan RobinsonAtlanta Falcons·#7 | 9 | 150 | 762 | 5.08 | 2 | 513 | 38 | 5 | 62 | 46 | 432 | 2 | 74.2% | 6.97 | 9.39 | 465 | 8 | 6 | 2 | 4 | 448 |
| 7 | Chuba HubbardCarolina Panthers·#30 | 9 | 76 | 268 | 3.53 | 0 | 212 | 17 | 1 | 28 | 21 | 165 | 2 | 75.0% | 5.89 | 7.86 | 209 | 4 | 2 | 1 | 1 | 251 |
| 8 | Cam SkatteboNew York Giants·#44 | 5 | 47 | 173 | 3.68 | 1 | 145 | 10 | 2 | 20 | 14 | 123 | 2 | 70.0% | 6.15 | 8.79 | 120 | 4 | 3 | 2 | 2 | 132 |
| 9 | Jaylen WarrenPittsburgh Steelers·#30 | 8 | 111 | 569 | 5.13 | 3 | 422 | 29 | 5 | 20 | 18 | 165 | 2 | 90.0% | 8.25 | 9.17 | 210 | 2 | 2 | 1 | 2 | 232 |
| 10 | RJ HarveyDenver Broncos·#12 | 8 | 59 | 184 | 3.12 | 3 | 182 | 14 | 5 | 33 | 30 | 205 | 2 | 90.9% | 6.21 | 6.83 | 219 | 4 | 4 | 1 | 0 | 197 |
| 11 | Dylan SampsonCleveland Browns·#22 | 7 | 30 | 67 | 2.23 | 0 | 66 | 7 | 0 | 19 | 15 | 128 | 2 | 79.0% | 6.74 | 8.53 | 134 | 3 | 2 | 1 | 1 | 117 |
| 12 | Woody MarksHouston Texans·#27 | 8 | 108 | 316 | 2.93 | 0 | 205 | 16 | 4 | 15 | 9 | 51 | 2 | 60.0% | 3.40 | 5.67 | 57 | 4 | 3 | 2 | 0 | 281 |
| 13 | Bam KnightArizona Cardinals·#20 | 5 | 42 | 149 | 3.55 | 1 | 115 | 14 | 4 | 11 | 7 | 81 | 1 | 63.6% | 7.36 | 11.57 | 67 | 4 | 2 | 1 | 2 | 132 |
| 14 | Bucky IrvingTampa Bay Buccaneers·#7 | 4 | 59 | 198 | 3.36 | 0 | 154 | 9 | 0 | 16 | 15 | 77 | 1 | 93.8% | 4.81 | 5.13 | 108 | 1 | 1 | 1 | 0 | 167 |
| 15 | D'Andre SwiftChicago Bears·#4 | 8 | 112 | 586 | 5.23 | 6 | 296 | 34 | 9 | 24 | 17 | 169 | 1 | 70.8% | 7.04 | 9.94 | 188 | 1 | 1 | 0 | 1 | 304 |
| 16 | Aaron JonesMinnesota Vikings·#33 | 7 | 70 | 279 | 3.99 | 0 | 212 | 16 | 0 | 23 | 19 | 156 | 1 | 82.6% | 6.78 | 8.21 | 181 | 3 | 2 | 0 | 2 | 190 |
| 17 | Josh JacobsGreen Bay Packers·#8 | 8 | 112 | 436 | 3.89 | 6 | 296 | 23 | 13 | 24 | 18 | 169 | 1 | 75.0% | 7.04 | 9.39 | 182 | 3 | 2 | 1 | 2 | 250 |
| 18 | Justice HillBaltimore Ravens·#43 | 4 | 7 | 65 | 9.29 | 2 | 78 | 3 | 1 | 12 | 9 | 69 | 1 | 75.0% | 5.75 | 7.67 | 85 | 1 | 1 | 1 | 1 | 76 |
| 19 | Kimani VidalLos Angeles Chargers·#30 | 7 | 55 | 223 | 4.05 | 0 | 135 | 10 | 1 | 9 | 7 | 26 | 1 | 77.8% | 2.89 | 3.71 | 52 | 3 | 2 | 1 | 0 | 183 |
| 20 | Ollie Gordon IIMiami Dolphins·#31 | 8 | 45 | 123 | 2.73 | 2 | 86 | 16 | 3 | 5 | 4 | 23 | 1 | 80.0% | 4.60 | 5.75 | 38 | 1 | 1 | 1 | 0 | 113 |
| 21 | Sean TuckerTampa Bay Buccaneers·#44 | 9 | 54 | 210 | 3.89 | 4 | 114 | 11 | 7 | 9 | 7 | 36 | 1 | 77.8% | 4.00 | 5.14 | 47 | 3 | 1 | 0 | 0 | 103 |
| 22 | Rhamondre StevensonNew England Patriots·#38 | 7 | 72 | 279 | 3.88 | 5 | 178 | 16 | 8 | 21 | 17 | 190 | 1 | 81.0% | 9.05 | 11.18 | 130 | 2 | 1 | 0 | 2 | 253 |
| 23 | Kyren WilliamsLos Angeles Rams·#23 | 9 | 137 | 654 | 4.77 | 5 | 390 | 39 | 9 | 25 | 18 | 157 | 1 | 72.0% | 6.28 | 8.72 | 81 | 3 | 3 | 1 | 2 | 378 |
| 24 | Kenneth GainwellPittsburgh Steelers·#14 | 8 | 44 | 232 | 5.27 | 2 | 186 | 13 | 3 | 34 | 28 | 166 | 1 | 82.3% | 4.88 | 5.93 | 158 | 8 | 6 | 0 | 1 | 221 |
| 25 | Javonte WilliamsDallas Cowboys·#33 | 8 | 118 | 546 | 4.63 | 7 | 331 | 34 | 11 | 27 | 17 | 43 | 1 | 63.0% | 1.59 | 2.53 | 67 | 9 | 5 | 1 | 3 | 354 |
| 26 | James ConnerArizona Cardinals·#6 | 2 | 21 | 61 | 2.90 | 0 | 69 | 4 | 1 | 8 | 7 | 20 | 1 | 87.5% | 2.50 | 2.86 | 50 | 1 | 1 | 1 | 0 | 60 |
| 27 | James CookBuffalo Bills·#4 | 8 | 156 | 963 | 6.17 | 9 | 565 | 41 | 7 | 17 | 15 | 94 | 1 | 88.2% | 5.53 | 6.27 | 93 | 2 | 2 | 1 | 1 | 267 |
| 28 | Ashton JeantyLas Vegas Raiders·#2 | 8 | 124 | 443 | 3.57 | 3 | 310 | 16 | 5 | 31 | 22 | 157 | 1 | 71.0% | 5.06 | 7.14 | 176 | 2 | 1 | 0 | 0 | 310 |
| 29 | Bhayshul TutenJacksonville Jaguars·#33 | 6 | 40 | 124 | 3.10 | 2 | 103 | 8 | 4 | 8 | 6 | 44 | 1 | 75.0% | 5.50 | 7.33 | 55 | 1 | 1 | 1 | 0 | 88 |
| 30 | Zavier ScottMinnesota Vikings·#36 | 5 | 14 | 56 | 4.00 | 0 | 34 | 3 | 0 | 11 | 10 | 63 | 1 | 90.9% | 5.73 | 6.30 | 58 | 2 | 2 | 1 | 1 | 60 |
| 31 | Ray DavisBuffalo Bills·#22 | 8 | 32 | 114 | 3.56 | 0 | 83 | 7 | 2 | 8 | 6 | 52 | 1 | 75.0% | 6.50 | 8.67 | 52 | 2 | 2 | 1 | 0 | 65 |
| 32 | Rasheen AliBaltimore Ravens·#26 | 6 | 2 | 5 | 2.50 | 0 | 25 | 0 | 0 | 6 | 5 | 55 | 1 | 83.3% | 9.17 | 11.00 | 55 | 0 | 0 | 0 | 0 | 39 |
| 33 | Emari DemercadoArizona Cardinals·#31 | 7 | 29 | 185 | 6.38 | 0 | 111 | 7 | 0 | 14 | 9 | 76 | 0 | 64.3% | 5.43 | 8.44 | 46 | 3 | 2 | 0 | 2 | 108 |
| 34 | Emanuel WilsonGreen Bay Packers·#23 | 9 | 80 | 330 | 4.12 | 1 | 271 | 22 | 1 | 11 | 9 | 76 | 0 | 81.8% | 6.91 | 8.44 | 101 | 3 | 1 | 0 | 0 | 195 |
| 35 | Devin SingletaryNew York Giants·#26 | 9 | 56 | 215 | 3.84 | 2 | 138 | 12 | 4 | 14 | 13 | 140 | 0 | 92.9% | 10.00 | 10.77 | 143 | 0 | 0 | 0 | 1 | 134 |
| 36 | Devin NealNew Orleans Saints·#24 | 5 | 41 | 151 | 3.68 | 1 | 55 | 7 | 1 | 8 | 8 | 46 | 0 | 100.0% | 5.75 | 5.75 | 57 | 1 | 1 | 0 | 0 | 133 |
| 37 | David MontgomeryDetroit Lions·#5 | 9 | 92 | 464 | 5.04 | 4 | 286 | 25 | 8 | 14 | 13 | 112 | 0 | 92.9% | 8.00 | 8.62 | 109 | 1 | 1 | 0 | 3 | 224 |
| 38 | Derrick HenryBaltimore Ravens·#22 | 8 | 150 | 950 | 6.33 | 7 | 572 | 43 | 9 | 11 | 9 | 59 | 0 | 81.8% | 5.36 | 6.56 | 51 | 0 | 0 | 0 | 1 | 251 |
| 39 | DJ GiddensIndianapolis Colts·#21 | 3 | 9 | 33 | 3.67 | 0 | 24 | 2 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 26 |
| 40 | Dare OgunbowaleHouston Texans·#33 | 7 | 3 | 14 | 4.67 | 1 | 17 | 1 | 1 | 4 | 3 | 26 | 0 | 75.0% | 6.50 | 8.67 | 19 | 0 | 0 | 0 | 1 | 40 |
| 41 | Chris BrooksGreen Bay Packers·#30 | 9 | 17 | 83 | 4.88 | 0 | 53 | 3 | 0 | 6 | 4 | 16 | 0 | 66.7% | 2.67 | 4.00 | 16 | 1 | 0 | 0 | 0 | 89 |
| 42 | Chris Rodriguez Jr.Washington Commanders·#36 | 7 | 57 | 276 | 4.84 | 2 | 181 | 15 | 7 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 20 | 0 | 0 | 0 | 1 | 117 |
| 43 | Alvin KamaraNew Orleans Saints·#41 | 5 | 72 | 237 | 3.29 | 0 | 178 | 13 | 1 | 16 | 12 | 78 | 0 | 75.0% | 4.88 | 6.50 | 72 | 2 | 2 | 0 | 2 | 208 |
| 44 | Blake CorumLos Angeles Rams·#22 | 9 | 82 | 488 | 5.95 | 5 | 227 | 29 | 8 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 11 | 0 | 0 | 0 | 0 | 166 |
| 45 | Brashard SmithKansas City Chiefs·#24 | 8 | 18 | 80 | 4.44 | 0 | 67 | 4 | 0 | 13 | 8 | 52 | 0 | 61.5% | 4.00 | 6.50 | 71 | 3 | 2 | 0 | 1 | 77 |
| 46 | Braelon AllenNew York Jets·#0 | 2 | 10 | 56 | 5.60 | 0 | 29 | 3 | 0 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 9 | 1 | 1 | 0 | 1 | 26 |
| 47 | Brian RobinsonSan Francisco 49ers·#3 | 9 | 46 | 188 | 4.09 | 1 | 110 | 11 | 1 | 8 | 5 | 11 | 0 | 62.5% | 1.38 | 2.20 | 20 | 2 | 1 | 0 | 0 | 86 |
| 48 | Breece HallNew York Jets·#20 | 7 | 98 | 397 | 4.05 | 2 | 269 | 21 | 1 | 26 | 21 | 179 | 0 | 80.8% | 6.88 | 8.52 | 178 | 4 | 0 | 0 | 2 | 253 |
| 49 | Ameer AbdullahIndianapolis Colts·#26 | 6 | 8 | 42 | 5.25 | 0 | 22 | 1 | 0 | 12 | 11 | 71 | 0 | 91.7% | 5.92 | 6.45 | 74 | 1 | 1 | 0 | 0 | 48 |
| 50 | Audric EstiméNew Orleans Saints·#30 | 3 | 38 | 168 | 4.42 | 1 | 146 | 9 | 3 | 6 | 6 | 47 | 0 | 100.0% | 7.83 | 7.83 | 38 | 0 | 0 | 0 | 1 | 101 |