| 1 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 91 | 380 | 4.18 | 1 | 259 | 31 | 3 | 39 | 28 | 320 | 2 | 71.8% | 8.21 | 11.43 | 303 | 5 | 4 | 1 | 1 | 270 |
| 2 | Jahmyr GibbsDetroit Lions·#0 | 17 | 86 | 473 | 5.50 | 7 | 303 | 29 | 4 | 40 | 34 | 319 | 3 | 85.0% | 7.98 | 9.38 | 313 | 5 | 4 | 3 | 1 | 237 |
| 3 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 94 | 343 | 3.65 | 2 | 260 | 33 | 5 | 51 | 40 | 301 | 3 | 78.4% | 5.90 | 7.52 | 269 | 10 | 10 | 3 | 1 | 269 |
| 4 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 38 | 135 | 3.55 | 1 | 130 | 12 | 3 | 34 | 31 | 229 | 3 | 91.2% | 6.74 | 7.39 | 245 | 8 | 7 | 2 | 1 | 150 |
| 5 | Travis EtienneJacksonville Jaguars·#1 | 17 | 87 | 338 | 3.89 | 2 | 246 | 26 | 4 | 28 | 19 | 175 | 4 | 67.9% | 6.25 | 9.21 | 188 | 7 | 5 | 3 | 0 | 254 |
| 6 | De'Von AchaneMiami Dolphins·#28 | 16 | 87 | 541 | 6.22 | 2 | 320 | 33 | 2 | 30 | 28 | 172 | 2 | 93.3% | 5.73 | 6.14 | 193 | 4 | 4 | 1 | 2 | 231 |
| 7 | Rico DowdleCarolina Panthers·#5 | 17 | 68 | 294 | 4.32 | 2 | 224 | 18 | 3 | 24 | 20 | 163 | 0 | 83.3% | 6.79 | 8.15 | 204 | 3 | 2 | 0 | 1 | 187 |
| 8 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 56 | 196 | 3.50 | 1 | 165 | 12 | 0 | 16 | 13 | 145 | 2 | 81.3% | 9.06 | 11.15 | 156 | 4 | 3 | 1 | 1 | 151 |
| 9 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 86 | 344 | 4.00 | 2 | 194 | 22 | 2 | 23 | 17 | 135 | 2 | 73.9% | 5.87 | 7.94 | 151 | 4 | 2 | 1 | 2 | 243 |
| 10 | Chase BrownCincinnati Bengals·#30 | 17 | 70 | 276 | 3.94 | 2 | 189 | 22 | 4 | 31 | 25 | 130 | 2 | 80.7% | 4.19 | 5.20 | 163 | 3 | 3 | 2 | 1 | 236 |
| 11 | RJ HarveyDenver Broncos·#12 | 17 | 54 | 196 | 3.63 | 3 | 124 | 16 | 2 | 20 | 16 | 120 | 1 | 80.0% | 6.00 | 7.50 | 135 | 2 | 2 | 1 | 0 | 180 |
| 12 | Josh JacobsGreen Bay Packers·#8 | 15 | 78 | 327 | 4.19 | 6 | 230 | 26 | 9 | 15 | 13 | 110 | 0 | 86.7% | 7.33 | 8.46 | 114 | 2 | 2 | 0 | 1 | 181 |
| 13 | Dylan SampsonCleveland Browns·#22 | 15 | 20 | 53 | 2.65 | 0 | 106 | 6 | 0 | 19 | 18 | 107 | 0 | 94.7% | 5.63 | 5.94 | 141 | 3 | 3 | 0 | 1 | 88 |
| 14 | Woody MarksHouston Texans·#27 | 16 | 63 | 266 | 4.22 | 1 | 160 | 20 | 3 | 12 | 7 | 105 | 0 | 58.3% | 8.75 | 15.00 | 117 | 2 | 1 | 0 | 0 | 199 |
| 15 | Tyjae SpearsTennessee Titans·#2 | 13 | 23 | 63 | 2.74 | 0 | 50 | 4 | 0 | 17 | 13 | 101 | 0 | 76.5% | 5.94 | 7.77 | 116 | 2 | 2 | 0 | 0 | 91 |
| 16 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 34 | 137 | 4.03 | 1 | 91 | 14 | 2 | 15 | 13 | 101 | 0 | 86.7% | 6.73 | 7.77 | 131 | 3 | 3 | 0 | 1 | 140 |
| 17 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 96 | 389 | 4.05 | 1 | 341 | 19 | 2 | 24 | 19 | 100 | 3 | 79.2% | 4.17 | 5.26 | 150 | 5 | 4 | 3 | 0 | 244 |
| 18 | TreVeyon HendersonNew England Patriots·#32 | 17 | 60 | 288 | 4.80 | 2 | 111 | 23 | 4 | 15 | 15 | 98 | 1 | 100.0% | 6.53 | 6.53 | 109 | 3 | 3 | 1 | 1 | 171 |
| 19 | Tony PollardTennessee Titans·#20 | 17 | 77 | 348 | 4.52 | 3 | 220 | 24 | 1 | 19 | 17 | 96 | 0 | 89.5% | 5.05 | 5.65 | 85 | 0 | 0 | 0 | 3 | 224 |
| 20 | Michael CarterArizona Cardinals·#22 | 13 | 24 | 92 | 3.83 | 1 | 83 | 8 | 3 | 17 | 14 | 94 | 0 | 82.3% | 5.53 | 6.71 | 82 | 3 | 1 | 0 | 0 | 129 |
| 21 | Chuba HubbardCarolina Panthers·#30 | 15 | 43 | 145 | 3.37 | 0 | 125 | 14 | 0 | 15 | 12 | 93 | 0 | 80.0% | 6.20 | 7.75 | 123 | 2 | 1 | 0 | 2 | 122 |
| 22 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 81 | 353 | 4.36 | 2 | 272 | 25 | 4 | 17 | 14 | 92 | 0 | 82.3% | 5.41 | 6.57 | 129 | 1 | 1 | 0 | 3 | 171 |
| 23 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 38 | 107 | 2.82 | 3 | 110 | 11 | 4 | 12 | 11 | 91 | 1 | 91.7% | 7.58 | 8.27 | 109 | 1 | 1 | 1 | 0 | 123 |
| 24 | Bam KnightArizona Cardinals·#20 | 9 | 22 | 84 | 3.82 | 1 | 66 | 9 | 1 | 15 | 12 | 85 | 1 | 80.0% | 5.67 | 7.08 | 63 | 2 | 2 | 1 | 1 | 97 |
| 25 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 104 | 532 | 5.12 | 9 | 332 | 46 | 9 | 18 | 16 | 82 | 0 | 88.9% | 4.56 | 5.12 | 101 | 1 | 1 | 0 | 2 | 269 |
| 26 | Breece HallNew York Jets·#20 | 16 | 94 | 270 | 2.87 | 0 | 142 | 20 | 1 | 14 | 10 | 81 | 1 | 71.4% | 5.79 | 8.10 | 78 | 2 | 0 | 0 | 1 | 208 |
| 27 | James CookBuffalo Bills·#4 | 16 | 85 | 491 | 5.78 | 6 | 331 | 32 | 9 | 18 | 13 | 81 | 1 | 72.2% | 4.50 | 6.23 | 89 | 2 | 2 | 1 | 1 | 232 |
| 28 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 80 | 276 | 3.45 | 2 | 192 | 21 | 4 | 12 | 11 | 79 | 0 | 91.7% | 6.58 | 7.18 | 113 | 2 | 2 | 0 | 3 | 164 |
| 29 | Ty JohnsonBuffalo Bills·#26 | 16 | 11 | 32 | 2.91 | 1 | 55 | 3 | 3 | 13 | 11 | 78 | 0 | 84.6% | 6.00 | 7.09 | 109 | 2 | 1 | 0 | 0 | 64 |
| 30 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 63 | 277 | 4.40 | 4 | 190 | 25 | 5 | 7 | 7 | 70 | 0 | 100.0% | 10.00 | 10.00 | 54 | 1 | 1 | 0 | 2 | 140 |
| 31 | Aaron JonesMinnesota Vikings·#33 | 12 | 44 | 198 | 4.50 | 0 | 121 | 13 | 1 | 15 | 13 | 69 | 0 | 86.7% | 4.60 | 5.31 | 96 | 2 | 2 | 0 | 1 | 121 |
| 32 | Ray DavisBuffalo Bills·#22 | 16 | 20 | 73 | 3.65 | 0 | 56 | 5 | 1 | 7 | 6 | 67 | 1 | 85.7% | 9.57 | 11.17 | 69 | 2 | 2 | 1 | 0 | 55 |
| 33 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 80 | 423 | 5.29 | 1 | 231 | 34 | 3 | 16 | 10 | 66 | 1 | 62.5% | 4.12 | 6.60 | 33 | 5 | 3 | 1 | 1 | 240 |
| 34 | Alvin KamaraNew Orleans Saints·#41 | 11 | 40 | 192 | 4.80 | 1 | 142 | 14 | 1 | 14 | 13 | 65 | 0 | 92.9% | 4.64 | 5.00 | 86 | 3 | 2 | 0 | 3 | 154 |
| 35 | D'Andre SwiftChicago Bears·#4 | 16 | 82 | 412 | 5.02 | 1 | 218 | 30 | 5 | 11 | 9 | 63 | 0 | 81.8% | 5.73 | 7.00 | 88 | 0 | 0 | 0 | 2 | 199 |
| 36 | Kyle MonangaiChicago Bears·#25 | 17 | 61 | 276 | 4.52 | 1 | 144 | 19 | 4 | 15 | 9 | 63 | 0 | 60.0% | 4.20 | 7.00 | 56 | 2 | 2 | 0 | 0 | 148 |
| 37 | Nick ChubbHouston Texans·#21 | 15 | 34 | 175 | 5.15 | 1 | 127 | 12 | 1 | 10 | 7 | 61 | 0 | 70.0% | 6.10 | 8.71 | 48 | 0 | 0 | 0 | 0 | 109 |
| 38 | Brashard SmithKansas City Chiefs·#24 | 16 | 11 | 27 | 2.45 | 0 | 55 | 3 | 0 | 11 | 7 | 61 | 0 | 63.6% | 5.55 | 8.71 | 60 | 2 | 2 | 0 | 1 | 51 |
| 39 | Isiah PachecoKansas City Chiefs·#10 | 13 | 41 | 152 | 3.71 | 1 | 84 | 17 | 0 | 12 | 8 | 50 | 0 | 66.7% | 4.17 | 6.25 | 50 | 2 | 0 | 0 | 0 | 162 |
| 40 | Rhamondre StevensonNew England Patriots·#38 | 14 | 38 | 237 | 6.24 | 3 | 147 | 15 | 3 | 8 | 7 | 49 | 0 | 87.5% | 6.12 | 7.00 | 42 | 2 | 2 | 0 | 1 | 143 |
| 41 | Justice HillBaltimore Ravens·#43 | 10 | 8 | 18 | 2.25 | 0 | 19 | 1 | 0 | 10 | 9 | 48 | 1 | 90.0% | 4.80 | 5.33 | 64 | 1 | 1 | 1 | 0 | 57 |
| 42 | Jeremy McNicholsWashington Commanders·#26 | 17 | 11 | 98 | 8.91 | 1 | 91 | 5 | 1 | 8 | 8 | 48 | 0 | 100.0% | 6.00 | 6.00 | 66 | 2 | 2 | 0 | 0 | 62 |
| 43 | Ameer AbdullahIndianapolis Colts·#26 | 12 | 4 | 17 | 4.25 | 1 | 12 | 2 | 1 | 6 | 6 | 47 | 0 | 100.0% | 7.83 | 7.83 | 37 | 0 | 0 | 0 | 0 | 28 |
| 44 | Cam SkatteboNew York Giants·#44 | 8 | 39 | 136 | 3.49 | 1 | 105 | 14 | 3 | 10 | 7 | 46 | 0 | 70.0% | 4.60 | 6.57 | 52 | 1 | 1 | 0 | 1 | 84 |
| 45 | Samaje PerineCincinnati Bengals·#34 | 14 | 33 | 170 | 5.15 | 1 | 131 | 13 | 1 | 6 | 6 | 44 | 0 | 100.0% | 7.33 | 7.33 | 58 | 0 | 0 | 0 | 1 | 93 |
| 46 | Keaton MitchellBaltimore Ravens·#34 | 12 | 25 | 150 | 6.00 | 0 | 63 | 9 | 0 | 6 | 4 | 43 | 0 | 66.7% | 7.17 | 10.75 | 50 | 0 | 0 | 0 | 1 | 51 |
| 47 | Isaiah DavisNew York Jets·#32 | 16 | 12 | 49 | 4.08 | 1 | 21 | 2 | 0 | 4 | 3 | 41 | 0 | 75.0% | 10.25 | 13.67 | 36 | 0 | 0 | 0 | 0 | 63 |
| 48 | Jerome FordCleveland Browns·#34 | 12 | 8 | 22 | 2.75 | 0 | 25 | 1 | 1 | 11 | 9 | 41 | 0 | 81.8% | 3.73 | 4.56 | 40 | 2 | 1 | 0 | 1 | 59 |
| 49 | Tyler BadieDenver Broncos·#28 | 15 | 2 | 6 | 3.00 | 0 | 14 | 1 | 0 | 10 | 8 | 40 | 0 | 80.0% | 4.00 | 5.00 | 75 | 2 | 2 | 0 | 0 | 36 |
| 50 | Quinshon JudkinsCleveland Browns·#10 | 14 | 76 | 238 | 3.13 | 2 | 161 | 22 | 3 | 13 | 10 | 40 | 0 | 76.9% | 3.08 | 4.00 | 55 | 0 | 0 | 0 | 0 | 156 |