| 1 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 26 | 67 | 2.58 | 0 | 102 | 1 | 0 | 29 | 23 | 201 | 1 | 79.3% | 6.93 | 8.74 | 170 | 6 | 6 | 1 | 1 | 132 |
| 2 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 13 | 44 | 3.38 | 0 | 58 | 0 | 0 | 25 | 23 | 187 | 2 | 92.0% | 7.48 | 8.13 | 177 | 3 | 3 | 1 | 1 | 93 |
| 3 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 27 | 129 | 4.78 | 0 | 79 | 4 | 0 | 23 | 16 | 184 | 0 | 69.6% | 8.00 | 11.50 | 152 | 1 | 1 | 0 | 1 | 145 |
| 4 | Jahmyr GibbsDetroit Lions·#0 | 17 | 30 | 101 | 3.37 | 0 | 58 | 2 | 0 | 29 | 24 | 181 | 2 | 82.8% | 6.24 | 7.54 | 170 | 4 | 3 | 2 | 0 | 130 |
| 5 | Josh JacobsGreen Bay Packers·#8 | 15 | 24 | 104 | 4.33 | 0 | 91 | 3 | 0 | 12 | 10 | 103 | 0 | 83.3% | 8.58 | 10.30 | 94 | 1 | 1 | 0 | 1 | 80 |
| 6 | Travis EtienneJacksonville Jaguars·#1 | 17 | 32 | 164 | 5.12 | 1 | 101 | 8 | 0 | 13 | 9 | 102 | 3 | 69.2% | 7.85 | 11.33 | 100 | 3 | 3 | 2 | 0 | 132 |
| 7 | Tyjae SpearsTennessee Titans·#2 | 13 | 6 | 23 | 3.83 | 0 | 25 | 0 | 0 | 14 | 11 | 100 | 0 | 78.6% | 7.14 | 9.09 | 108 | 2 | 2 | 0 | 0 | 55 |
| 8 | De'Von AchaneMiami Dolphins·#28 | 16 | 39 | 273 | 7.00 | 1 | 161 | 9 | 0 | 18 | 16 | 97 | 0 | 88.9% | 5.39 | 6.06 | 111 | 2 | 2 | 0 | 0 | 131 |
| 9 | TreVeyon HendersonNew England Patriots·#32 | 17 | 14 | 133 | 9.50 | 1 | 39 | 4 | 0 | 10 | 10 | 84 | 0 | 100.0% | 8.40 | 8.40 | 92 | 0 | 0 | 0 | 1 | 81 |
| 10 | RJ HarveyDenver Broncos·#12 | 17 | 20 | 95 | 4.75 | 1 | 61 | 3 | 0 | 14 | 12 | 82 | 0 | 85.7% | 5.86 | 6.83 | 94 | 0 | 0 | 0 | 0 | 91 |
| 11 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 15 | 47 | 3.13 | 0 | 36 | 1 | 0 | 14 | 12 | 79 | 0 | 85.7% | 5.64 | 6.58 | 87 | 1 | 1 | 0 | 0 | 123 |
| 12 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 37 | 140 | 3.78 | 1 | 52 | 3 | 0 | 18 | 14 | 77 | 1 | 77.8% | 4.28 | 5.50 | 111 | 3 | 2 | 1 | 1 | 130 |
| 13 | Michael CarterArizona Cardinals·#22 | 12 | 9 | 57 | 6.33 | 0 | 64 | 1 | 0 | 12 | 10 | 77 | 0 | 83.3% | 6.42 | 7.70 | 66 | 2 | 1 | 0 | 0 | 70 |
| 14 | Chase BrownCincinnati Bengals·#30 | 17 | 21 | 88 | 4.19 | 0 | 53 | 2 | 0 | 19 | 16 | 72 | 1 | 84.2% | 3.79 | 4.50 | 96 | 2 | 2 | 1 | 0 | 114 |
| 15 | Dylan SampsonCleveland Browns·#22 | 14 | 6 | 29 | 4.83 | 0 | 55 | 1 | 0 | 14 | 13 | 71 | 0 | 92.9% | 5.07 | 5.46 | 88 | 2 | 2 | 0 | 1 | 58 |
| 16 | Rico DowdleCarolina Panthers·#5 | 17 | 25 | 128 | 5.12 | 0 | 91 | 2 | 0 | 13 | 9 | 67 | 0 | 69.2% | 5.15 | 7.44 | 77 | 1 | 0 | 0 | 0 | 95 |
| 17 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 47 | 166 | 3.53 | 0 | 144 | 3 | 0 | 15 | 13 | 65 | 2 | 86.7% | 4.33 | 5.00 | 102 | 3 | 3 | 2 | 0 | 126 |
| 18 | Ty JohnsonBuffalo Bills·#26 | 15 | 3 | 14 | 4.67 | 0 | 33 | 0 | 0 | 12 | 10 | 62 | 0 | 83.3% | 5.17 | 6.20 | 89 | 2 | 1 | 0 | 0 | 35 |
| 19 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 35 | 103 | 2.94 | 0 | 73 | 3 | 0 | 8 | 8 | 57 | 0 | 100.0% | 7.12 | 7.12 | 87 | 1 | 1 | 0 | 2 | 87 |
| 20 | Breece HallNew York Jets·#20 | 16 | 30 | 109 | 3.63 | 0 | 40 | 1 | 0 | 8 | 6 | 57 | 1 | 75.0% | 7.12 | 9.50 | 67 | 1 | 0 | 0 | 0 | 99 |
| 21 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 22 | 85 | 3.86 | 0 | 88 | 3 | 0 | 12 | 10 | 56 | 0 | 83.3% | 4.67 | 5.60 | 84 | 0 | 0 | 0 | 2 | 74 |
| 22 | Brashard SmithKansas City Chiefs·#24 | 14 | 4 | 7 | 1.75 | 0 | 35 | 1 | 0 | 7 | 4 | 54 | 0 | 57.1% | 7.71 | 13.50 | 49 | 1 | 1 | 0 | 0 | 29 |
| 23 | Nick ChubbHouston Texans·#21 | 13 | 14 | 78 | 5.57 | 1 | 45 | 1 | 0 | 6 | 5 | 52 | 0 | 83.3% | 8.67 | 10.40 | 48 | 0 | 0 | 0 | 0 | 60 |
| 24 | Bam KnightArizona Cardinals·#20 | 9 | 6 | 31 | 5.17 | 0 | 19 | 1 | 0 | 9 | 7 | 52 | 0 | 77.8% | 5.78 | 7.43 | 44 | 0 | 0 | 0 | 1 | 51 |
| 25 | Alvin KamaraNew Orleans Saints·#41 | 11 | 12 | 60 | 5.00 | 0 | 57 | 2 | 0 | 9 | 8 | 49 | 0 | 88.9% | 5.44 | 6.12 | 71 | 2 | 1 | 0 | 1 | 83 |
| 26 | Tony PollardTennessee Titans·#20 | 17 | 32 | 131 | 4.09 | 0 | 89 | 4 | 0 | 10 | 9 | 46 | 0 | 90.0% | 4.60 | 5.11 | 53 | 0 | 0 | 0 | 1 | 112 |
| 27 | James CookBuffalo Bills·#4 | 16 | 16 | 77 | 4.81 | 0 | 64 | 2 | 0 | 11 | 9 | 46 | 0 | 81.8% | 4.18 | 5.11 | 46 | 0 | 0 | 0 | 0 | 82 |
| 28 | Aaron JonesMinnesota Vikings·#33 | 12 | 21 | 107 | 5.10 | 0 | 56 | 3 | 0 | 9 | 7 | 45 | 0 | 77.8% | 5.00 | 6.43 | 61 | 2 | 2 | 0 | 0 | 65 |
| 29 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 19 | 68 | 3.58 | 0 | 62 | 1 | 0 | 8 | 7 | 44 | 1 | 87.5% | 5.50 | 6.29 | 61 | 4 | 3 | 1 | 0 | 81 |
| 30 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 19 | 137 | 7.21 | 0 | 73 | 4 | 0 | 7 | 7 | 43 | 1 | 100.0% | 6.14 | 6.14 | 15 | 3 | 3 | 1 | 1 | 103 |
| 31 | Keaton MitchellBaltimore Ravens·#34 | 10 | 6 | 32 | 5.33 | 0 | 13 | 0 | 0 | 6 | 4 | 43 | 0 | 66.7% | 7.17 | 10.75 | 50 | 0 | 0 | 0 | 1 | 27 |
| 32 | Kyle MonangaiChicago Bears·#25 | 17 | 29 | 159 | 5.48 | 0 | 68 | 4 | 0 | 9 | 5 | 42 | 0 | 55.6% | 4.67 | 8.40 | 43 | 2 | 2 | 0 | 0 | 85 |
| 33 | Isaiah DavisNew York Jets·#32 | 14 | 6 | 20 | 3.33 | 0 | 18 | 0 | 0 | 3 | 3 | 41 | 0 | 100.0% | 13.67 | 13.67 | 36 | 0 | 0 | 0 | 0 | 40 |
| 34 | Chuba HubbardCarolina Panthers·#30 | 15 | 13 | 63 | 4.85 | 0 | 53 | 1 | 0 | 9 | 7 | 40 | 0 | 77.8% | 4.44 | 5.71 | 54 | 1 | 1 | 0 | 2 | 56 |
| 35 | Jeremy McNicholsWashington Commanders·#26 | 13 | 4 | 9 | 2.25 | 0 | 9 | 1 | 0 | 6 | 6 | 39 | 0 | 100.0% | 6.50 | 6.50 | 50 | 2 | 2 | 0 | 0 | 41 |
| 36 | Rachaad WhiteTampa Bay Buccaneers·#1 | 15 | 10 | 49 | 4.90 | 0 | 29 | 2 | 0 | 9 | 7 | 39 | 0 | 77.8% | 4.33 | 5.57 | 61 | 2 | 2 | 0 | 0 | 76 |
| 37 | Quinshon JudkinsCleveland Browns·#10 | 13 | 29 | 70 | 2.41 | 0 | 48 | 2 | 0 | 9 | 6 | 37 | 0 | 66.7% | 4.11 | 6.17 | 32 | 0 | 0 | 0 | 0 | 80 |
| 38 | Rhamondre StevensonNew England Patriots·#38 | 14 | 6 | 35 | 5.83 | 0 | 17 | 1 | 0 | 4 | 4 | 37 | 0 | 100.0% | 9.25 | 9.25 | 29 | 1 | 1 | 0 | 0 | 66 |
| 39 | Tyler BadieDenver Broncos·#28 | 14 | 0 | 0 | — | 0 | 7 | 0 | 0 | 7 | 6 | 37 | 0 | 85.7% | 5.29 | 6.17 | 69 | 2 | 2 | 0 | 0 | 25 |
| 40 | D'Andre SwiftChicago Bears·#4 | 16 | 27 | 141 | 5.22 | 1 | 85 | 5 | 0 | 6 | 5 | 36 | 0 | 83.3% | 6.00 | 7.20 | 55 | 0 | 0 | 0 | 1 | 95 |
| 41 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 6 | 27 | 4.50 | 0 | 30 | 1 | 0 | 6 | 5 | 36 | 0 | 83.3% | 6.00 | 7.20 | 36 | 0 | 0 | 0 | 0 | 53 |
| 42 | Jerome FordCleveland Browns·#34 | 12 | 4 | 4 | 1.00 | 0 | 10 | 0 | 0 | 6 | 5 | 31 | 0 | 83.3% | 5.17 | 6.20 | 35 | 1 | 1 | 0 | 1 | 40 |
| 43 | Audric EstiméNew Orleans Saints·#30 | 5 | 5 | 15 | 3.00 | 0 | 25 | 0 | 0 | 4 | 3 | 30 | 0 | 75.0% | 7.50 | 10.00 | 44 | 0 | 0 | 0 | 0 | 32 |
| 44 | Justice HillBaltimore Ravens·#43 | 10 | 5 | 12 | 2.40 | 0 | 13 | 0 | 0 | 6 | 5 | 29 | 1 | 83.3% | 4.83 | 5.80 | 33 | 1 | 1 | 1 | 0 | 35 |
| 45 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 25 | 93 | 3.72 | 0 | 55 | 5 | 0 | 10 | 7 | 29 | 0 | 70.0% | 2.90 | 4.14 | 42 | 0 | 0 | 0 | 1 | 101 |
| 46 | Ollie Gordon IIMiami Dolphins·#31 | 13 | 6 | 25 | 4.17 | 0 | 13 | 2 | 0 | 3 | 3 | 27 | 1 | 100.0% | 9.00 | 9.00 | 41 | 1 | 1 | 1 | 0 | 30 |
| 47 | Cam SkatteboNew York Giants·#44 | 8 | 11 | 54 | 4.91 | 0 | 35 | 2 | 0 | 6 | 4 | 25 | 0 | 66.7% | 4.17 | 6.25 | 28 | 1 | 1 | 0 | 0 | 37 |
| 48 | Devin NealNew Orleans Saints·#24 | 7 | 6 | 36 | 6.00 | 0 | 21 | 1 | 0 | 7 | 7 | 19 | 0 | 100.0% | 2.71 | 2.71 | 50 | 1 | 1 | 0 | 0 | 44 |
| 49 | Emanuel WilsonGreen Bay Packers·#23 | 16 | 11 | 42 | 3.82 | 0 | 48 | 1 | 0 | 3 | 3 | 19 | 0 | 100.0% | 6.33 | 6.33 | 26 | 1 | 1 | 0 | 0 | 42 |
| 50 | Derrick HenryBaltimore Ravens·#22 | 15 | 25 | 105 | 4.20 | 0 | 62 | 3 | 0 | 7 | 5 | 19 | 0 | 71.4% | 2.71 | 3.80 | 11 | 2 | 2 | 0 | 0 | 64 |