| 1 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 157 | 551 | 3.51 | 4 | 410 | 33 | 11 | 61 | 52 | 566 | 2 | 85.3% | 9.28 | 10.88 | 444 | 11 | 9 | 2 | 3 | 411 |
| 2 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 125 | 499 | 3.99 | 2 | 463 | 25 | 6 | 50 | 41 | 492 | 1 | 82.0% | 9.84 | 12.00 | 490 | 4 | 3 | 1 | 3 | 369 |
| 3 | Chase BrownCincinnati Bengals·#30 | 17 | 106 | 412 | 3.89 | 4 | 328 | 25 | 8 | 50 | 40 | 250 | 2 | 80.0% | 5.00 | 6.25 | 239 | 7 | 4 | 2 | 2 | 336 |
| 4 | Jahmyr GibbsDetroit Lions·#0 | 17 | 115 | 528 | 4.59 | 6 | 321 | 25 | 3 | 48 | 38 | 322 | 2 | 79.2% | 6.71 | 8.47 | 322 | 6 | 6 | 2 | 1 | 338 |
| 5 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 58 | 274 | 4.72 | 2 | 214 | 17 | 5 | 38 | 31 | 213 | 1 | 81.6% | 5.61 | 6.87 | 224 | 7 | 5 | 1 | 2 | 233 |
| 6 | De'Von AchaneMiami Dolphins·#28 | 15 | 112 | 494 | 4.41 | 4 | 381 | 28 | 4 | 35 | 29 | 201 | 1 | 82.9% | 5.74 | 6.93 | 227 | 3 | 3 | 1 | 1 | 310 |
| 7 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 122 | 388 | 3.18 | 2 | 334 | 18 | 5 | 33 | 28 | 182 | 4 | 84.8% | 5.52 | 6.50 | 246 | 4 | 4 | 3 | 0 | 322 |
| 8 | RJ HarveyDenver Broncos·#12 | 17 | 75 | 287 | 3.83 | 4 | 270 | 17 | 6 | 35 | 28 | 245 | 5 | 80.0% | 7.00 | 8.75 | 224 | 9 | 7 | 4 | 0 | 235 |
| 9 | Dylan SampsonCleveland Browns·#22 | 14 | 38 | 114 | 3.00 | 0 | 137 | 9 | 0 | 30 | 25 | 233 | 2 | 83.3% | 7.77 | 9.32 | 263 | 5 | 3 | 1 | 1 | 129 |
| 10 | Tyjae SpearsTennessee Titans·#2 | 13 | 27 | 72 | 2.67 | 2 | 74 | 4 | 2 | 28 | 24 | 107 | 0 | 85.7% | 3.82 | 4.46 | 162 | 5 | 5 | 0 | 1 | 176 |
| 11 | Tony PollardTennessee Titans·#20 | 17 | 114 | 477 | 4.18 | 4 | 290 | 28 | 4 | 25 | 22 | 123 | 0 | 88.0% | 4.92 | 5.59 | 101 | 0 | 0 | 0 | 6 | 312 |
| 12 | James CookBuffalo Bills·#4 | 16 | 162 | 688 | 4.25 | 5 | 458 | 31 | 12 | 26 | 22 | 253 | 1 | 84.6% | 9.73 | 11.50 | 224 | 1 | 1 | 0 | 1 | 325 |
| 13 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 148 | 874 | 5.91 | 10 | 561 | 42 | 10 | 24 | 21 | 136 | 1 | 87.5% | 5.67 | 6.48 | 176 | 3 | 2 | 1 | 3 | 343 |
| 14 | Michael CarterArizona Cardinals·#22 | 13 | 48 | 162 | 3.38 | 0 | 140 | 12 | 0 | 29 | 21 | 178 | 0 | 72.4% | 6.14 | 8.48 | 180 | 4 | 1 | 0 | 1 | 218 |
| 15 | Rico DowdleCarolina Panthers·#5 | 17 | 118 | 552 | 4.68 | 3 | 356 | 25 | 6 | 25 | 21 | 185 | 1 | 84.0% | 7.40 | 8.81 | 215 | 2 | 1 | 0 | 3 | 274 |
| 16 | Travis EtienneJacksonville Jaguars·#1 | 17 | 141 | 511 | 3.62 | 3 | 354 | 25 | 6 | 26 | 20 | 193 | 4 | 76.9% | 7.42 | 9.65 | 234 | 5 | 4 | 3 | 0 | 326 |
| 17 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 52 | 204 | 3.92 | 2 | 120 | 18 | 3 | 24 | 20 | 114 | 0 | 83.3% | 4.75 | 5.70 | 168 | 4 | 3 | 0 | 2 | 262 |
| 18 | Tyrone Tracy Jr.New York Giants·#29 | 14 | 89 | 441 | 4.96 | 1 | 263 | 27 | 1 | 27 | 19 | 153 | 2 | 70.4% | 5.67 | 8.05 | 150 | 3 | 3 | 2 | 3 | 248 |
| 19 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 125 | 598 | 4.78 | 4 | 346 | 35 | 6 | 25 | 18 | 167 | 2 | 72.0% | 6.68 | 9.28 | 88 | 3 | 3 | 2 | 5 | 354 |
| 20 | Javonte WilliamsDallas Cowboys·#33 | 15 | 108 | 514 | 4.76 | 4 | 334 | 27 | 8 | 25 | 18 | 54 | 2 | 72.0% | 2.16 | 3.00 | 78 | 7 | 5 | 2 | 1 | 331 |
| 21 | Jerome FordCleveland Browns·#34 | 13 | 13 | 42 | 3.23 | 0 | 49 | 3 | 0 | 23 | 18 | 44 | 0 | 78.3% | 1.91 | 2.44 | 69 | 4 | 3 | 0 | 2 | 153 |
| 22 | Breece HallNew York Jets·#20 | 16 | 113 | 533 | 4.72 | 3 | 251 | 30 | 2 | 24 | 17 | 198 | 1 | 70.8% | 8.25 | 11.65 | 173 | 5 | 1 | 0 | 2 | 319 |
| 23 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 115 | 617 | 5.37 | 3 | 324 | 30 | 3 | 20 | 17 | 125 | 0 | 85.0% | 6.25 | 7.35 | 145 | 1 | 1 | 0 | 3 | 238 |
| 24 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 103 | 504 | 4.89 | 3 | 425 | 26 | 5 | 21 | 17 | 212 | 2 | 81.0% | 10.10 | 12.47 | 259 | 4 | 3 | 1 | 4 | 220 |
| 25 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 57 | 276 | 4.84 | 3 | 146 | 13 | 7 | 17 | 16 | 104 | 0 | 94.1% | 6.12 | 6.50 | 115 | 1 | 1 | 0 | 1 | 164 |
| 26 | Chuba HubbardCarolina Panthers·#30 | 15 | 66 | 249 | 3.77 | 1 | 194 | 19 | 2 | 21 | 16 | 119 | 2 | 76.2% | 5.67 | 7.44 | 135 | 4 | 3 | 1 | 2 | 210 |
| 27 | D'Andre SwiftChicago Bears·#4 | 16 | 112 | 551 | 4.92 | 6 | 314 | 34 | 13 | 22 | 15 | 174 | 1 | 68.2% | 7.91 | 11.60 | 195 | 0 | 0 | 0 | 1 | 293 |
| 28 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 131 | 493 | 3.76 | 3 | 307 | 24 | 3 | 22 | 15 | 153 | 1 | 68.2% | 6.95 | 10.20 | 135 | 2 | 1 | 0 | 2 | 342 |
| 29 | TreVeyon HendersonNew England Patriots·#32 | 16 | 83 | 481 | 5.80 | 4 | 189 | 19 | 2 | 19 | 14 | 66 | 1 | 73.7% | 3.47 | 4.71 | 84 | 3 | 3 | 1 | 1 | 212 |
| 30 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 86 | 304 | 3.53 | 1 | 214 | 14 | 0 | 17 | 14 | 163 | 2 | 82.3% | 9.59 | 11.64 | 187 | 2 | 1 | 1 | 1 | 197 |
| 31 | Rhamondre StevensonNew England Patriots·#38 | 14 | 52 | 157 | 3.02 | 5 | 166 | 8 | 8 | 19 | 14 | 179 | 1 | 73.7% | 9.42 | 12.79 | 138 | 3 | 2 | 1 | 1 | 219 |
| 32 | Kyle MonangaiChicago Bears·#25 | 17 | 88 | 416 | 4.73 | 2 | 248 | 20 | 6 | 19 | 13 | 131 | 0 | 68.4% | 6.89 | 10.08 | 138 | 3 | 2 | 0 | 0 | 238 |
| 33 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 96 | 365 | 3.80 | 6 | 269 | 25 | 9 | 15 | 13 | 100 | 0 | 86.7% | 6.67 | 7.69 | 88 | 2 | 2 | 0 | 2 | 222 |
| 34 | Josh JacobsGreen Bay Packers·#8 | 14 | 123 | 493 | 4.01 | 11 | 350 | 30 | 14 | 19 | 13 | 113 | 0 | 68.4% | 5.95 | 8.69 | 116 | 3 | 2 | 0 | 2 | 241 |
| 35 | Cam SkatteboNew York Giants·#44 | 7 | 56 | 222 | 3.96 | 3 | 179 | 15 | 7 | 16 | 13 | 107 | 0 | 81.3% | 6.69 | 8.23 | 109 | 2 | 1 | 0 | 2 | 135 |
| 36 | Brashard SmithKansas City Chiefs·#24 | 14 | 27 | 88 | 3.26 | 0 | 99 | 3 | 1 | 17 | 13 | 94 | 0 | 76.5% | 5.53 | 7.23 | 118 | 2 | 2 | 0 | 0 | 80 |
| 37 | Isaiah DavisNew York Jets·#32 | 16 | 15 | 127 | 8.47 | 1 | 97 | 5 | 0 | 15 | 12 | 122 | 0 | 80.0% | 8.13 | 10.17 | 129 | 2 | 1 | 0 | 0 | 141 |
| 38 | Bam KnightArizona Cardinals·#20 | 9 | 35 | 112 | 3.20 | 0 | 90 | 8 | 2 | 17 | 12 | 91 | 1 | 70.6% | 5.35 | 7.58 | 79 | 5 | 3 | 1 | 2 | 120 |
| 39 | Jeremy McNicholsWashington Commanders·#26 | 17 | 23 | 95 | 4.13 | 0 | 81 | 7 | 2 | 17 | 12 | 78 | 0 | 70.6% | 4.59 | 6.50 | 83 | 1 | 1 | 0 | 2 | 146 |
| 40 | Quinshon JudkinsCleveland Browns·#10 | 13 | 104 | 414 | 3.98 | 2 | 265 | 24 | 3 | 18 | 12 | 47 | 0 | 66.7% | 2.61 | 3.92 | 43 | 0 | 0 | 0 | 0 | 188 |
| 41 | David MontgomeryDetroit Lions·#5 | 17 | 74 | 415 | 5.61 | 3 | 237 | 19 | 3 | 16 | 12 | 110 | 0 | 75.0% | 6.88 | 9.17 | 109 | 2 | 1 | 0 | 2 | 182 |
| 42 | Ty JohnsonBuffalo Bills·#26 | 17 | 25 | 81 | 3.24 | 0 | 95 | 5 | 4 | 15 | 11 | 66 | 1 | 73.3% | 4.40 | 6.00 | 94 | 2 | 1 | 1 | 1 | 154 |
| 43 | Isiah PachecoKansas City Chiefs·#10 | 13 | 57 | 233 | 4.09 | 1 | 127 | 14 | 0 | 15 | 11 | 80 | 0 | 73.3% | 5.33 | 7.27 | 77 | 2 | 1 | 0 | 0 | 191 |
| 44 | Devin NealNew Orleans Saints·#24 | 7 | 33 | 117 | 3.55 | 0 | 50 | 4 | 0 | 12 | 11 | 78 | 0 | 91.7% | 6.50 | 7.09 | 113 | 1 | 1 | 0 | 0 | 142 |
| 45 | Alvin KamaraNew Orleans Saints·#41 | 10 | 56 | 192 | 3.43 | 0 | 166 | 12 | 1 | 12 | 11 | 78 | 0 | 91.7% | 6.50 | 7.09 | 56 | 2 | 2 | 0 | 2 | 190 |
| 46 | Justice HillBaltimore Ravens·#43 | 10 | 8 | 80 | 10.00 | 2 | 86 | 2 | 1 | 14 | 11 | 102 | 0 | 78.6% | 7.29 | 9.27 | 110 | 0 | 0 | 0 | 1 | 98 |
| 47 | Ameer AbdullahIndianapolis Colts·#26 | 10 | 5 | 12 | 2.40 | 1 | 9 | 1 | 1 | 11 | 10 | 54 | 0 | 90.9% | 4.91 | 5.40 | 61 | 0 | 0 | 0 | 0 | 49 |
| 48 | Devin SingletaryNew York Giants·#26 | 16 | 61 | 228 | 3.74 | 2 | 163 | 15 | 4 | 10 | 10 | 127 | 0 | 100.0% | 12.70 | 12.70 | 122 | 2 | 2 | 0 | 0 | 163 |
| 49 | Zavier ScottMinnesota Vikings·#36 | 9 | 19 | 73 | 3.84 | 0 | 53 | 4 | 1 | 9 | 9 | 78 | 1 | 100.0% | 8.67 | 8.67 | 86 | 2 | 2 | 1 | 1 | 55 |
| 50 | Aaron JonesMinnesota Vikings·#33 | 12 | 55 | 236 | 4.29 | 0 | 147 | 13 | 0 | 14 | 8 | 77 | 1 | 57.1% | 5.50 | 9.62 | 76 | 2 | 1 | 0 | 2 | 154 |