| 1 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 72 | 305 | 4.24 | 2 | 182 | 16 | 3 | 28 | 21 | 137 | 2 | 75.0% | 4.89 | 6.52 | 101 | 4 | 3 | 2 | 1 | 193 |
| 2 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 84 | 389 | 4.63 | 1 | 227 | 17 | 2 | 27 | 19 | 165 | 2 | 70.4% | 6.11 | 8.68 | 152 | 6 | 4 | 1 | 2 | 210 |
| 3 | Jahmyr GibbsDetroit Lions·#0 | 17 | 71 | 277 | 3.90 | 4 | 184 | 16 | 7 | 20 | 18 | 152 | 1 | 90.0% | 7.60 | 8.44 | 176 | 3 | 2 | 1 | 1 | 174 |
| 4 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 54 | 254 | 4.70 | 0 | 143 | 13 | 2 | 16 | 15 | 55 | 0 | 93.8% | 3.44 | 3.67 | 104 | 0 | 0 | 0 | 0 | 121 |
| 5 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 29 | 90 | 3.10 | 2 | 57 | 6 | 3 | 16 | 14 | 62 | 1 | 87.5% | 3.88 | 4.43 | 97 | 3 | 3 | 1 | 0 | 93 |
| 6 | De'Von AchaneMiami Dolphins·#28 | 16 | 63 | 518 | 8.22 | 4 | 264 | 17 | 1 | 17 | 13 | 90 | 1 | 76.5% | 5.29 | 6.92 | 121 | 1 | 1 | 1 | 1 | 150 |
| 7 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 86 | 374 | 4.35 | 5 | 218 | 25 | 5 | 16 | 13 | 143 | 0 | 81.3% | 8.94 | 11.00 | 146 | 0 | 0 | 0 | 0 | 245 |
| 8 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 70 | 254 | 3.63 | 1 | 231 | 13 | 1 | 16 | 13 | 98 | 1 | 81.3% | 6.12 | 7.54 | 104 | 5 | 4 | 1 | 1 | 196 |
| 9 | Rico DowdleCarolina Panthers·#5 | 17 | 63 | 256 | 4.06 | 2 | 150 | 14 | 2 | 14 | 11 | 58 | 0 | 78.6% | 4.14 | 5.27 | 73 | 3 | 2 | 0 | 2 | 135 |
| 10 | Chase BrownCincinnati Bengals·#30 | 17 | 72 | 270 | 3.75 | 2 | 147 | 15 | 4 | 16 | 10 | 33 | 1 | 62.5% | 2.06 | 3.30 | 46 | 1 | 1 | 1 | 0 | 171 |
| 11 | Aaron JonesMinnesota Vikings·#33 | 12 | 48 | 170 | 3.54 | 2 | 133 | 11 | 3 | 15 | 10 | 66 | 0 | 66.7% | 4.40 | 6.60 | 87 | 2 | 1 | 0 | 0 | 101 |
| 12 | D'Andre SwiftChicago Bears·#4 | 16 | 61 | 269 | 4.41 | 2 | 135 | 17 | 1 | 13 | 10 | 40 | 0 | 76.9% | 3.08 | 4.00 | 60 | 0 | 0 | 0 | 1 | 140 |
| 13 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 65 | 346 | 5.32 | 2 | 127 | 14 | 7 | 11 | 10 | 50 | 0 | 90.9% | 4.55 | 5.00 | 75 | 1 | 1 | 0 | 1 | 163 |
| 14 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 49 | 186 | 3.80 | 0 | 120 | 9 | 0 | 10 | 10 | 96 | 1 | 100.0% | 9.60 | 9.60 | 135 | 1 | 1 | 0 | 0 | 106 |
| 15 | RJ HarveyDenver Broncos·#12 | 16 | 38 | 164 | 4.32 | 1 | 69 | 9 | 0 | 10 | 9 | 42 | 0 | 90.0% | 4.20 | 4.67 | 58 | 1 | 1 | 0 | 1 | 103 |
| 16 | TreVeyon HendersonNew England Patriots·#32 | 17 | 43 | 185 | 4.30 | 1 | 77 | 10 | 1 | 10 | 9 | 73 | 0 | 90.0% | 7.30 | 8.11 | 70 | 1 | 1 | 0 | 0 | 100 |
| 17 | Quinshon JudkinsCleveland Browns·#10 | 14 | 71 | 231 | 3.25 | 3 | 153 | 14 | 4 | 12 | 9 | 80 | 0 | 75.0% | 6.67 | 8.89 | 103 | 0 | 0 | 0 | 0 | 130 |
| 18 | Tyjae SpearsTennessee Titans·#2 | 13 | 11 | 31 | 2.82 | 0 | 46 | 3 | 0 | 9 | 9 | 47 | 0 | 100.0% | 5.22 | 5.22 | 85 | 2 | 2 | 0 | 0 | 54 |
| 19 | Breece HallNew York Jets·#20 | 16 | 61 | 241 | 3.95 | 0 | 130 | 16 | 1 | 11 | 9 | 64 | 0 | 81.8% | 5.82 | 7.11 | 57 | 2 | 0 | 0 | 1 | 124 |
| 20 | Tyrone Tracy Jr.New York Giants·#29 | 14 | 47 | 154 | 3.28 | 0 | 126 | 9 | 1 | 9 | 8 | 32 | 0 | 88.9% | 3.56 | 4.00 | 50 | 0 | 0 | 0 | 0 | 120 |
| 21 | Javonte WilliamsDallas Cowboys·#33 | 16 | 87 | 375 | 4.31 | 3 | 216 | 18 | 5 | 14 | 8 | 40 | 0 | 57.1% | 2.86 | 5.00 | 52 | 2 | 1 | 0 | 2 | 193 |
| 22 | Travis EtienneJacksonville Jaguars·#1 | 17 | 62 | 222 | 3.58 | 1 | 148 | 10 | 3 | 14 | 8 | 59 | 1 | 57.1% | 4.21 | 7.38 | 71 | 2 | 1 | 1 | 1 | 166 |
| 23 | Josh JacobsGreen Bay Packers·#8 | 15 | 64 | 249 | 3.89 | 0 | 192 | 12 | 1 | 10 | 8 | 48 | 0 | 80.0% | 4.80 | 6.00 | 61 | 0 | 0 | 0 | 1 | 146 |
| 24 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 58 | 252 | 4.34 | 1 | 117 | 13 | 2 | 9 | 7 | 125 | 0 | 77.8% | 13.89 | 17.86 | 145 | 1 | 0 | 0 | 0 | 121 |
| 25 | Ty JohnsonBuffalo Bills·#26 | 16 | 11 | 71 | 6.45 | 0 | 28 | 3 | 0 | 9 | 7 | 52 | 0 | 77.8% | 5.78 | 7.43 | 76 | 1 | 0 | 0 | 0 | 57 |
| 26 | Alvin KamaraNew Orleans Saints·#41 | 11 | 43 | 175 | 4.07 | 0 | 97 | 6 | 1 | 9 | 7 | 40 | 0 | 77.8% | 4.44 | 5.71 | 48 | 2 | 1 | 0 | 3 | 111 |
| 27 | Samaje PerineCincinnati Bengals·#34 | 14 | 23 | 111 | 4.83 | 0 | 82 | 10 | 2 | 6 | 6 | 39 | 0 | 100.0% | 6.50 | 6.50 | 49 | 0 | 0 | 0 | 0 | 66 |
| 28 | Cam SkatteboNew York Giants·#44 | 8 | 21 | 83 | 3.95 | 0 | 56 | 6 | 0 | 8 | 6 | 40 | 1 | 75.0% | 5.00 | 6.67 | 35 | 1 | 1 | 1 | 0 | 60 |
| 29 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 72 | 377 | 5.24 | 3 | 224 | 22 | 4 | 10 | 6 | 32 | 0 | 60.0% | 3.20 | 5.33 | 26 | 3 | 2 | 0 | 1 | 179 |
| 30 | James CookBuffalo Bills·#4 | 17 | 77 | 491 | 6.38 | 4 | 291 | 23 | 2 | 7 | 6 | 18 | 0 | 85.7% | 2.57 | 3.00 | 23 | 0 | 0 | 0 | 3 | 135 |
| 31 | Chuba HubbardCarolina Panthers·#30 | 13 | 31 | 126 | 4.06 | 0 | 64 | 9 | 0 | 7 | 6 | 49 | 1 | 85.7% | 7.00 | 8.17 | 75 | 0 | 0 | 0 | 1 | 84 |
| 32 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 31 | 83 | 2.68 | 0 | 78 | 7 | 0 | 7 | 6 | 31 | 1 | 85.7% | 4.43 | 5.17 | 45 | 1 | 1 | 1 | 0 | 95 |
| 33 | Rachaad WhiteTampa Bay Buccaneers·#1 | 16 | 36 | 157 | 4.36 | 1 | 103 | 10 | 1 | 6 | 6 | 18 | 0 | 100.0% | 3.00 | 3.00 | 31 | 0 | 0 | 0 | 0 | 103 |
| 34 | Kimani VidalLos Angeles Chargers·#30 | 12 | 40 | 147 | 3.68 | 0 | 110 | 10 | 1 | 6 | 5 | 83 | 0 | 83.3% | 13.83 | 16.60 | 89 | 0 | 0 | 0 | 0 | 92 |
| 35 | Brashard SmithKansas City Chiefs·#24 | 16 | 10 | 46 | 4.60 | 0 | 28 | 3 | 0 | 10 | 5 | 55 | 0 | 50.0% | 5.50 | 11.00 | 61 | 1 | 1 | 0 | 0 | 40 |
| 36 | Woody MarksHouston Texans·#27 | 16 | 47 | 160 | 3.40 | 0 | 127 | 8 | 2 | 6 | 5 | 114 | 0 | 83.3% | 19.00 | 22.80 | 117 | 0 | 0 | 0 | 0 | 105 |
| 37 | Nick ChubbHouston Texans·#21 | 15 | 34 | 115 | 3.38 | 0 | 86 | 5 | 1 | 6 | 5 | 43 | 0 | 83.3% | 7.17 | 8.60 | 44 | 0 | 0 | 0 | 0 | 86 |
| 38 | Tony PollardTennessee Titans·#20 | 17 | 70 | 370 | 5.29 | 1 | 196 | 13 | 0 | 7 | 5 | 33 | 0 | 71.4% | 4.71 | 6.60 | 56 | 1 | 1 | 0 | 0 | 154 |
| 39 | Rhamondre StevensonNew England Patriots·#38 | 14 | 46 | 304 | 6.61 | 2 | 172 | 15 | 4 | 5 | 5 | 43 | 0 | 100.0% | 8.60 | 8.60 | 18 | 2 | 2 | 0 | 2 | 121 |
| 40 | Derrick HenryBaltimore Ravens·#22 | 17 | 90 | 444 | 4.93 | 4 | 257 | 22 | 3 | 5 | 5 | 32 | 0 | 100.0% | 6.40 | 6.40 | 25 | 0 | 0 | 0 | 1 | 148 |
| 41 | Ray DavisBuffalo Bills·#22 | 11 | 12 | 77 | 6.42 | 0 | 37 | 5 | 0 | 5 | 4 | 40 | 0 | 80.0% | 8.00 | 10.00 | 49 | 1 | 1 | 0 | 0 | 30 |
| 42 | Chris BrooksGreen Bay Packers·#30 | 16 | 5 | 28 | 5.60 | 0 | 18 | 1 | 0 | 4 | 4 | 32 | 0 | 100.0% | 8.00 | 8.00 | 30 | 1 | 1 | 0 | 0 | 43 |
| 43 | Dylan SampsonCleveland Browns·#22 | 13 | 13 | 34 | 2.62 | 0 | 46 | 1 | 0 | 6 | 4 | 10 | 0 | 66.7% | 1.67 | 2.50 | 22 | 0 | 0 | 0 | 1 | 40 |
| 44 | Isiah PachecoKansas City Chiefs·#10 | 13 | 32 | 102 | 3.19 | 0 | 77 | 6 | 0 | 5 | 4 | 10 | 0 | 80.0% | 2.00 | 2.50 | 26 | 1 | 0 | 0 | 0 | 83 |
| 45 | Isaiah DavisNew York Jets·#32 | 15 | 15 | 56 | 3.73 | 0 | 28 | 3 | 0 | 5 | 4 | 10 | 0 | 80.0% | 2.00 | 2.50 | 23 | 0 | 0 | 0 | 0 | 38 |
| 46 | Emanuel WilsonGreen Bay Packers·#23 | 14 | 21 | 56 | 2.67 | 1 | 57 | 5 | 1 | 4 | 4 | 41 | 0 | 100.0% | 10.25 | 10.25 | 49 | 0 | 0 | 0 | 0 | 56 |
| 47 | Jeremy McNicholsWashington Commanders·#26 | 15 | 9 | 32 | 3.56 | 0 | 55 | 3 | 0 | 5 | 4 | 35 | 0 | 80.0% | 7.00 | 8.75 | 45 | 0 | 0 | 0 | 0 | 51 |
| 48 | Bam KnightArizona Cardinals·#20 | 9 | 27 | 101 | 3.74 | 2 | 69 | 6 | 1 | 5 | 3 | 23 | 0 | 60.0% | 4.60 | 7.67 | 22 | 1 | 1 | 0 | 1 | 72 |
| 49 | David MontgomeryDetroit Lions·#5 | 17 | 31 | 96 | 3.10 | 1 | 74 | 6 | 1 | 3 | 3 | 12 | 0 | 100.0% | 4.00 | 4.00 | 21 | 0 | 0 | 0 | 3 | 82 |
| 50 | Justice HillBaltimore Ravens·#43 | 10 | 7 | 23 | 3.29 | 0 | 16 | 2 | 0 | 4 | 3 | 22 | 1 | 75.0% | 5.50 | 7.33 | 30 | 1 | 1 | 1 | 0 | 37 |