| 1 | Jahmyr GibbsDetroit Lions·#0 | 17 | 18 | 76 | 4.22 | 0 | 39 | 1 | 0 | 23 | 18 | 162 | 2 | 78.3% | 7.04 | 9.00 | 138 | 3 | 2 | 2 | 0 | 88 |
| 2 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 10 | 35 | 3.50 | 0 | 49 | 0 | 0 | 18 | 17 | 165 | 1 | 94.4% | 9.17 | 9.71 | 137 | 2 | 2 | 0 | 1 | 71 |
| 3 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 17 | 54 | 3.18 | 0 | 62 | 1 | 0 | 16 | 14 | 116 | 0 | 87.5% | 7.25 | 8.29 | 87 | 2 | 2 | 0 | 1 | 84 |
| 4 | De'Von AchaneMiami Dolphins·#28 | 16 | 30 | 176 | 5.87 | 0 | 89 | 6 | 0 | 13 | 12 | 78 | 0 | 92.3% | 6.00 | 6.50 | 90 | 1 | 1 | 0 | 0 | 93 |
| 5 | Dylan SampsonCleveland Browns·#22 | 14 | 4 | 22 | 5.50 | 0 | 50 | 1 | 0 | 12 | 12 | 71 | 0 | 100.0% | 5.92 | 5.92 | 82 | 2 | 2 | 0 | 1 | 43 |
| 6 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 10 | 42 | 4.20 | 0 | 29 | 1 | 0 | 14 | 11 | 121 | 0 | 78.6% | 8.64 | 11.00 | 114 | 0 | 0 | 0 | 0 | 96 |
| 7 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 22 | 120 | 5.45 | 1 | 35 | 3 | 0 | 13 | 11 | 61 | 0 | 84.6% | 4.69 | 5.55 | 101 | 1 | 0 | 0 | 1 | 91 |
| 8 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 10 | 33 | 3.30 | 0 | 22 | 0 | 0 | 9 | 9 | 62 | 0 | 100.0% | 6.89 | 6.89 | 59 | 1 | 1 | 0 | 0 | 85 |
| 9 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 18 | 74 | 4.11 | 0 | 73 | 3 | 0 | 11 | 9 | 49 | 0 | 81.8% | 4.45 | 5.44 | 76 | 0 | 0 | 0 | 1 | 59 |
| 10 | Chase BrownCincinnati Bengals·#30 | 17 | 13 | 65 | 5.00 | 0 | 37 | 1 | 0 | 11 | 9 | 33 | 0 | 81.8% | 3.00 | 3.67 | 44 | 0 | 0 | 0 | 0 | 75 |
| 11 | Tyjae SpearsTennessee Titans·#2 | 12 | 6 | 23 | 3.83 | 0 | 22 | 0 | 0 | 12 | 9 | 57 | 0 | 75.0% | 4.75 | 6.33 | 58 | 2 | 2 | 0 | 0 | 41 |
| 12 | RJ HarveyDenver Broncos·#12 | 17 | 13 | 82 | 6.31 | 1 | 47 | 3 | 0 | 11 | 9 | 65 | 0 | 81.8% | 5.91 | 7.22 | 78 | 0 | 0 | 0 | 0 | 68 |
| 13 | TreVeyon HendersonNew England Patriots·#32 | 16 | 4 | 21 | 5.25 | 0 | 19 | 1 | 0 | 9 | 9 | 72 | 0 | 100.0% | 8.00 | 8.00 | 78 | 0 | 0 | 0 | 0 | 53 |
| 14 | Josh JacobsGreen Bay Packers·#8 | 14 | 13 | 61 | 4.69 | 0 | 62 | 1 | 0 | 9 | 8 | 94 | 0 | 88.9% | 10.44 | 11.75 | 79 | 1 | 1 | 0 | 1 | 51 |
| 15 | Michael CarterArizona Cardinals·#22 | 12 | 8 | 57 | 7.12 | 0 | 62 | 1 | 0 | 9 | 8 | 75 | 0 | 88.9% | 8.33 | 9.38 | 63 | 1 | 1 | 0 | 0 | 53 |
| 16 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 36 | 165 | 4.58 | 0 | 116 | 3 | 0 | 9 | 7 | 35 | 0 | 77.8% | 3.89 | 5.00 | 57 | 1 | 1 | 0 | 0 | 98 |
| 17 | Ty JohnsonBuffalo Bills·#26 | 15 | 3 | 14 | 4.67 | 0 | 25 | 0 | 0 | 8 | 7 | 41 | 0 | 87.5% | 5.12 | 5.86 | 54 | 2 | 1 | 0 | 0 | 27 |
| 18 | Alvin KamaraNew Orleans Saints·#41 | 11 | 7 | 34 | 4.86 | 0 | 34 | 0 | 0 | 8 | 7 | 53 | 0 | 87.5% | 6.62 | 7.57 | 69 | 1 | 0 | 0 | 0 | 49 |
| 19 | James CookBuffalo Bills·#4 | 15 | 8 | 35 | 4.38 | 0 | 31 | 1 | 0 | 8 | 7 | 37 | 0 | 87.5% | 4.62 | 5.29 | 36 | 0 | 0 | 0 | 0 | 50 |
| 20 | Travis EtienneJacksonville Jaguars·#1 | 17 | 26 | 143 | 5.50 | 1 | 79 | 6 | 0 | 10 | 6 | 74 | 2 | 60.0% | 7.40 | 12.33 | 78 | 1 | 1 | 1 | 0 | 94 |
| 21 | Rico DowdleCarolina Panthers·#5 | 16 | 19 | 95 | 5.00 | 0 | 63 | 1 | 0 | 9 | 6 | 49 | 0 | 66.7% | 5.44 | 8.17 | 57 | 1 | 0 | 0 | 0 | 58 |
| 22 | Chuba HubbardCarolina Panthers·#30 | 14 | 8 | 38 | 4.75 | 0 | 41 | 0 | 0 | 8 | 6 | 39 | 0 | 75.0% | 4.88 | 6.50 | 47 | 0 | 0 | 0 | 2 | 42 |
| 23 | Javonte WilliamsDallas Cowboys·#33 | 14 | 19 | 104 | 5.47 | 0 | 65 | 2 | 0 | 7 | 5 | 6 | 0 | 71.4% | 0.86 | 1.20 | 12 | 2 | 1 | 0 | 0 | 72 |
| 24 | Breece HallNew York Jets·#20 | 15 | 19 | 59 | 3.11 | 0 | 31 | 0 | 0 | 7 | 5 | 52 | 1 | 71.4% | 7.43 | 10.40 | 63 | 1 | 0 | 0 | 0 | 74 |
| 25 | Devin NealNew Orleans Saints·#24 | 6 | 3 | 6 | 2.00 | 0 | 10 | 0 | 0 | 5 | 5 | 13 | 0 | 100.0% | 2.60 | 2.60 | 36 | 0 | 0 | 0 | 0 | 32 |
| 26 | D'Andre SwiftChicago Bears·#4 | 16 | 19 | 103 | 5.42 | 1 | 57 | 3 | 0 | 6 | 5 | 36 | 0 | 83.3% | 6.00 | 7.20 | 55 | 0 | 0 | 0 | 1 | 73 |
| 27 | Tyrone Tracy Jr.New York Giants·#29 | 13 | 14 | 34 | 2.43 | 0 | 32 | 1 | 0 | 7 | 5 | 24 | 0 | 71.4% | 3.43 | 4.80 | 33 | 0 | 0 | 0 | 1 | 69 |
| 28 | Tony PollardTennessee Titans·#20 | 17 | 21 | 84 | 4.00 | 0 | 62 | 1 | 0 | 5 | 5 | 32 | 0 | 100.0% | 6.40 | 6.40 | 36 | 0 | 0 | 0 | 0 | 68 |
| 29 | Justice HillBaltimore Ravens·#43 | 10 | 2 | 2 | 1.00 | 0 | 10 | 0 | 0 | 6 | 5 | 29 | 1 | 83.3% | 4.83 | 5.80 | 33 | 1 | 1 | 1 | 0 | 26 |
| 30 | Bam KnightArizona Cardinals·#20 | 9 | 3 | 25 | 8.33 | 0 | 11 | 1 | 0 | 7 | 5 | 29 | 0 | 71.4% | 4.14 | 5.80 | 22 | 0 | 0 | 0 | 1 | 39 |
| 31 | Rachaad WhiteTampa Bay Buccaneers·#1 | 15 | 7 | 40 | 5.71 | 0 | 18 | 2 | 0 | 6 | 5 | 33 | 0 | 83.3% | 5.50 | 6.60 | 45 | 1 | 1 | 0 | 0 | 53 |
| 32 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 27 | 75 | 2.78 | 0 | 58 | 1 | 0 | 5 | 5 | 42 | 0 | 100.0% | 8.40 | 8.40 | 61 | 0 | 0 | 0 | 1 | 59 |
| 33 | Jerome FordCleveland Browns·#34 | 12 | 3 | 3 | 1.00 | 0 | 10 | 0 | 0 | 6 | 5 | 31 | 0 | 83.3% | 5.17 | 6.20 | 35 | 1 | 1 | 0 | 1 | 32 |
| 34 | Woody MarksHouston Texans·#27 | 16 | 20 | 85 | 4.25 | 0 | 55 | 1 | 0 | 8 | 4 | 11 | 0 | 50.0% | 1.38 | 2.75 | 23 | 2 | 1 | 0 | 0 | 81 |
| 35 | Jordan MasonMinnesota Vikings·#27 | 15 | 12 | 61 | 5.08 | 0 | 27 | 2 | 0 | 4 | 4 | 9 | 0 | 100.0% | 2.25 | 2.25 | 23 | 1 | 1 | 0 | 1 | 43 |
| 36 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 14 | 52 | 3.71 | 0 | 40 | 0 | 0 | 5 | 4 | 14 | 0 | 80.0% | 2.80 | 3.50 | 23 | 3 | 2 | 0 | 0 | 50 |
| 37 | Isiah PachecoKansas City Chiefs·#10 | 13 | 5 | 17 | 3.40 | 0 | 7 | 0 | 0 | 4 | 4 | 13 | 0 | 100.0% | 3.25 | 3.25 | 20 | 0 | 0 | 0 | 0 | 52 |
| 38 | Jeremy McNicholsWashington Commanders·#26 | 12 | 2 | -2 | -1.00 | 0 | 2 | 0 | 0 | 4 | 4 | 35 | 0 | 100.0% | 8.75 | 8.75 | 47 | 1 | 1 | 0 | 0 | 29 |
| 39 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 13 | 95 | 7.31 | 0 | 51 | 2 | 0 | 4 | 4 | 28 | 0 | 100.0% | 7.00 | 7.00 | 10 | 1 | 1 | 0 | 1 | 78 |
| 40 | Aaron JonesMinnesota Vikings·#33 | 12 | 16 | 82 | 5.12 | 0 | 39 | 2 | 0 | 5 | 3 | 26 | 0 | 60.0% | 5.20 | 8.67 | 39 | 1 | 1 | 0 | 0 | 40 |
| 41 | Derrick HenryBaltimore Ravens·#22 | 14 | 12 | 62 | 5.17 | 0 | 30 | 1 | 0 | 5 | 3 | 11 | 0 | 60.0% | 2.20 | 3.67 | 8 | 2 | 2 | 0 | 0 | 39 |
| 42 | David MontgomeryDetroit Lions·#5 | 15 | 13 | 152 | 11.69 | 1 | 122 | 3 | 0 | 3 | 3 | 3 | 0 | 100.0% | 1.00 | 1.00 | 9 | 0 | 0 | 0 | 0 | 39 |
| 43 | Kimani VidalLos Angeles Chargers·#30 | 11 | 8 | 40 | 5.00 | 0 | 17 | 1 | 0 | 4 | 3 | 10 | 0 | 75.0% | 2.50 | 3.33 | 22 | 1 | 0 | 0 | 0 | 53 |
| 44 | Rhamondre StevensonNew England Patriots·#38 | 14 | 4 | 32 | 8.00 | 0 | 13 | 1 | 0 | 3 | 3 | 14 | 0 | 100.0% | 4.67 | 4.67 | 8 | 1 | 1 | 0 | 0 | 48 |
| 45 | Kyle MonangaiChicago Bears·#25 | 17 | 22 | 139 | 6.32 | 0 | 54 | 4 | 0 | 6 | 3 | 11 | 0 | 50.0% | 1.83 | 3.67 | 7 | 1 | 1 | 0 | 0 | 67 |
| 46 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 5 | 24 | 4.80 | 0 | 23 | 1 | 0 | 3 | 3 | 30 | 0 | 100.0% | 10.00 | 10.00 | 23 | 0 | 0 | 0 | 0 | 39 |
| 47 | Blake CorumLos Angeles Rams·#22 | 16 | 9 | 59 | 6.56 | 0 | 22 | 3 | 0 | 4 | 2 | 8 | 0 | 50.0% | 2.00 | 4.00 | 17 | 0 | 0 | 0 | 0 | 29 |
| 48 | Devin SingletaryNew York Giants·#26 | 14 | 11 | 49 | 4.45 | 0 | 33 | 1 | 0 | 2 | 2 | 9 | 0 | 100.0% | 4.50 | 4.50 | 16 | 0 | 0 | 0 | 0 | 28 |
| 49 | Tyler AllgeierAtlanta Falcons·#25 | 14 | 8 | 39 | 4.88 | 0 | 14 | 2 | 0 | 3 | 2 | 10 | 0 | 66.7% | 3.33 | 5.00 | 10 | 0 | 0 | 0 | 0 | 25 |
| 50 | Isaiah DavisNew York Jets·#32 | 13 | 5 | 19 | 3.80 | 0 | 15 | 0 | 0 | 2 | 2 | 31 | 0 | 100.0% | 15.50 | 15.50 | 32 | 0 | 0 | 0 | 0 | 33 |