| 1 | James CookBuffalo Bills·#4 | 8 | 156 | 963 | 6.17 | 9 | 565 | 41 | 7 | 17 | 15 | 94 | 1 | 88.2% | 5.53 | 6.27 | 93 | 2 | 2 | 1 | 1 | 267 |
| 2 | Derrick HenryBaltimore Ravens·#22 | 8 | 150 | 950 | 6.33 | 7 | 572 | 43 | 9 | 11 | 9 | 59 | 0 | 81.8% | 5.36 | 6.56 | 51 | 0 | 0 | 0 | 1 | 251 |
| 3 | Javonte WilliamsDallas Cowboys·#33 | 8 | 118 | 546 | 4.63 | 7 | 331 | 34 | 11 | 27 | 17 | 43 | 1 | 63.0% | 1.59 | 2.53 | 67 | 9 | 5 | 1 | 3 | 354 |
| 4 | Jonathan TaylorIndianapolis Colts·#28 | 8 | 139 | 562 | 4.04 | 7 | 369 | 32 | 8 | 23 | 20 | 121 | 0 | 87.0% | 5.26 | 6.05 | 167 | 0 | 0 | 0 | 4 | 361 |
| 5 | Josh JacobsGreen Bay Packers·#8 | 8 | 112 | 436 | 3.89 | 6 | 296 | 23 | 13 | 24 | 18 | 169 | 1 | 75.0% | 7.04 | 9.39 | 182 | 3 | 2 | 1 | 2 | 250 |
| 6 | D'Andre SwiftChicago Bears·#4 | 8 | 112 | 586 | 5.23 | 6 | 296 | 34 | 9 | 24 | 17 | 169 | 1 | 70.8% | 7.04 | 9.94 | 188 | 1 | 1 | 0 | 1 | 304 |
| 7 | Blake CorumLos Angeles Rams·#22 | 9 | 82 | 488 | 5.95 | 5 | 227 | 29 | 8 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 11 | 0 | 0 | 0 | 0 | 166 |
| 8 | Christian McCaffreySan Francisco 49ers·#23 | 9 | 164 | 617 | 3.76 | 5 | 447 | 41 | 11 | 64 | 53 | 464 | 6 | 82.8% | 7.25 | 8.75 | 370 | 17 | 15 | 6 | 2 | 472 |
| 9 | Rhamondre StevensonNew England Patriots·#38 | 7 | 72 | 279 | 3.88 | 5 | 178 | 16 | 8 | 21 | 17 | 190 | 1 | 81.0% | 9.05 | 11.18 | 130 | 2 | 1 | 0 | 2 | 253 |
| 10 | Zach CharbonnetSeattle Seahawks·#26 | 9 | 104 | 394 | 3.79 | 5 | 252 | 24 | 10 | 15 | 13 | 104 | 0 | 86.7% | 6.93 | 8.00 | 89 | 1 | 1 | 0 | 0 | 248 |
| 11 | Kareem HuntKansas City Chiefs·#29 | 8 | 68 | 281 | 4.13 | 5 | 152 | 18 | 10 | 15 | 10 | 80 | 0 | 66.7% | 5.33 | 8.00 | 89 | 1 | 0 | 0 | 0 | 240 |
| 12 | Kyren WilliamsLos Angeles Rams·#23 | 9 | 137 | 654 | 4.77 | 5 | 390 | 39 | 9 | 25 | 18 | 157 | 1 | 72.0% | 6.28 | 8.72 | 81 | 3 | 3 | 1 | 2 | 378 |
| 13 | David MontgomeryDetroit Lions·#5 | 9 | 92 | 464 | 5.04 | 4 | 286 | 25 | 8 | 14 | 13 | 112 | 0 | 92.9% | 8.00 | 8.62 | 109 | 1 | 1 | 0 | 3 | 224 |
| 14 | Tyler AllgeierAtlanta Falcons·#25 | 9 | 72 | 320 | 4.44 | 4 | 153 | 24 | 5 | 7 | 6 | 38 | 0 | 85.7% | 5.43 | 6.33 | 44 | 1 | 1 | 0 | 2 | 145 |
| 15 | Saquon BarkleyPhiladelphia Eagles·#26 | 9 | 156 | 619 | 3.97 | 4 | 356 | 30 | 7 | 25 | 19 | 137 | 0 | 76.0% | 5.48 | 7.21 | 170 | 3 | 1 | 0 | 2 | 393 |
| 16 | Sean TuckerTampa Bay Buccaneers·#44 | 9 | 54 | 210 | 3.89 | 4 | 114 | 11 | 7 | 9 | 7 | 36 | 1 | 77.8% | 4.00 | 5.14 | 47 | 3 | 1 | 0 | 0 | 103 |
| 17 | Tony PollardTennessee Titans·#20 | 8 | 120 | 582 | 4.85 | 4 | 346 | 23 | 1 | 16 | 14 | 99 | 0 | 87.5% | 6.19 | 7.07 | 109 | 1 | 1 | 0 | 5 | 282 |
| 18 | Jahmyr GibbsDetroit Lions·#0 | 9 | 136 | 545 | 4.01 | 4 | 384 | 26 | 6 | 47 | 35 | 306 | 3 | 74.5% | 6.51 | 8.74 | 308 | 9 | 7 | 3 | 3 | 364 |
| 19 | Jaylen WarrenPittsburgh Steelers·#30 | 8 | 111 | 569 | 5.13 | 3 | 422 | 29 | 5 | 20 | 18 | 165 | 2 | 90.0% | 8.25 | 9.17 | 210 | 2 | 2 | 1 | 2 | 232 |
| 20 | Jacory Croskey-MerrittWashington Commanders·#22 | 9 | 93 | 418 | 4.49 | 3 | 257 | 25 | 5 | 9 | 6 | 53 | 0 | 66.7% | 5.89 | 8.83 | 63 | 1 | 1 | 0 | 2 | 198 |
| 21 | J.K. DobbinsDenver Broncos·#27 | 5 | 74 | 339 | 4.58 | 3 | 168 | 18 | 4 | 7 | 4 | 12 | 0 | 57.1% | 1.71 | 3.00 | 23 | 0 | 0 | 0 | 0 | 150 |
| 22 | Ashton JeantyLas Vegas Raiders·#2 | 8 | 124 | 443 | 3.57 | 3 | 310 | 16 | 5 | 31 | 22 | 157 | 1 | 71.0% | 5.06 | 7.14 | 176 | 2 | 1 | 0 | 0 | 310 |
| 23 | Chase BrownCincinnati Bengals·#30 | 8 | 107 | 394 | 3.68 | 3 | 271 | 19 | 6 | 37 | 31 | 183 | 3 | 83.8% | 4.95 | 5.90 | 184 | 7 | 5 | 3 | 2 | 302 |
| 24 | RJ HarveyDenver Broncos·#12 | 8 | 59 | 184 | 3.12 | 3 | 182 | 14 | 5 | 33 | 30 | 205 | 2 | 90.9% | 6.21 | 6.83 | 219 | 4 | 4 | 1 | 0 | 197 |
| 25 | Quinshon JudkinsCleveland Browns·#10 | 7 | 102 | 341 | 3.34 | 3 | 167 | 22 | 3 | 18 | 15 | 47 | 0 | 83.3% | 2.61 | 3.13 | 58 | 0 | 0 | 0 | 1 | 200 |
| 26 | Rachaad WhiteTampa Bay Buccaneers·#1 | 9 | 73 | 337 | 4.62 | 3 | 167 | 25 | 7 | 23 | 20 | 102 | 0 | 87.0% | 4.43 | 5.10 | 167 | 6 | 5 | 0 | 4 | 294 |
| 27 | Rico DowdleCarolina Panthers·#5 | 9 | 109 | 404 | 3.71 | 3 | 235 | 21 | 5 | 23 | 19 | 156 | 0 | 82.6% | 6.78 | 8.21 | 199 | 2 | 1 | 0 | 4 | 281 |
| 28 | Bhayshul TutenJacksonville Jaguars·#33 | 6 | 40 | 124 | 3.10 | 2 | 103 | 8 | 4 | 8 | 6 | 44 | 1 | 75.0% | 5.50 | 7.33 | 55 | 1 | 1 | 1 | 0 | 88 |
| 29 | Breece HallNew York Jets·#20 | 7 | 98 | 397 | 4.05 | 2 | 269 | 21 | 1 | 26 | 21 | 179 | 0 | 80.8% | 6.88 | 8.52 | 178 | 4 | 0 | 0 | 2 | 253 |
| 30 | Chris Rodriguez Jr.Washington Commanders·#36 | 7 | 57 | 276 | 4.84 | 2 | 181 | 15 | 7 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 20 | 0 | 0 | 0 | 1 | 117 |
| 31 | Devin SingletaryNew York Giants·#26 | 9 | 56 | 215 | 3.84 | 2 | 138 | 12 | 4 | 14 | 13 | 140 | 0 | 92.9% | 10.00 | 10.77 | 143 | 0 | 0 | 0 | 1 | 134 |
| 32 | Bijan RobinsonAtlanta Falcons·#7 | 9 | 150 | 762 | 5.08 | 2 | 513 | 38 | 5 | 62 | 46 | 432 | 2 | 74.2% | 6.97 | 9.39 | 465 | 8 | 6 | 2 | 4 | 448 |
| 33 | Justice HillBaltimore Ravens·#43 | 4 | 7 | 65 | 9.29 | 2 | 78 | 3 | 1 | 12 | 9 | 69 | 1 | 75.0% | 5.75 | 7.67 | 85 | 1 | 1 | 1 | 1 | 76 |
| 34 | Ollie Gordon IIMiami Dolphins·#31 | 8 | 45 | 123 | 2.73 | 2 | 86 | 16 | 3 | 5 | 4 | 23 | 1 | 80.0% | 4.60 | 5.75 | 38 | 1 | 1 | 1 | 0 | 113 |
| 35 | Kyle MonangaiChicago Bears·#25 | 9 | 105 | 511 | 4.87 | 2 | 264 | 26 | 7 | 17 | 10 | 78 | 0 | 58.8% | 4.59 | 7.80 | 98 | 2 | 1 | 0 | 0 | 261 |
| 36 | Kenneth Walker IIISeattle Seahawks·#9 | 9 | 119 | 565 | 4.75 | 2 | 289 | 30 | 4 | 22 | 18 | 179 | 0 | 81.8% | 8.14 | 9.94 | 207 | 2 | 1 | 0 | 1 | 249 |
| 37 | TreVeyon HendersonNew England Patriots·#32 | 8 | 74 | 355 | 4.80 | 2 | 139 | 14 | 5 | 13 | 10 | 69 | 0 | 76.9% | 5.31 | 6.90 | 72 | 1 | 1 | 0 | 0 | 196 |
| 38 | Omarion HamptonLos Angeles Chargers·#8 | 4 | 50 | 288 | 5.76 | 2 | 151 | 15 | 5 | 10 | 8 | 52 | 0 | 80.0% | 5.20 | 6.50 | 59 | 0 | 0 | 0 | 1 | 134 |
| 39 | Nick ChubbHouston Texans·#21 | 8 | 52 | 230 | 4.42 | 2 | 146 | 10 | 3 | 11 | 4 | -3 | 0 | 36.4% | -0.27 | -0.75 | 3 | 2 | 1 | 0 | 1 | 148 |
| 40 | Travis EtienneJacksonville Jaguars·#1 | 8 | 131 | 577 | 4.40 | 2 | 409 | 26 | 6 | 27 | 20 | 144 | 3 | 74.1% | 5.33 | 7.20 | 178 | 6 | 5 | 3 | 1 | 312 |
| 41 | Kenneth GainwellPittsburgh Steelers·#14 | 8 | 44 | 232 | 5.27 | 2 | 186 | 13 | 3 | 34 | 28 | 166 | 1 | 82.3% | 4.88 | 5.93 | 158 | 8 | 6 | 0 | 1 | 221 |
| 42 | Tyrone Tracy Jr.New York Giants·#29 | 8 | 92 | 355 | 3.86 | 1 | 209 | 20 | 2 | 22 | 14 | 121 | 0 | 63.6% | 5.50 | 8.64 | 133 | 2 | 1 | 0 | 1 | 296 |
| 43 | Ty JohnsonBuffalo Bills·#26 | 8 | 18 | 60 | 3.33 | 1 | 76 | 5 | 1 | 16 | 12 | 104 | 0 | 75.0% | 6.50 | 8.67 | 117 | 1 | 0 | 0 | 1 | 147 |
| 44 | Samaje PerineCincinnati Bengals·#34 | 7 | 38 | 136 | 3.58 | 1 | 88 | 15 | 2 | 12 | 9 | 60 | 0 | 75.0% | 5.00 | 6.67 | 67 | 0 | 0 | 0 | 3 | 135 |
| 45 | Tyjae SpearsTennessee Titans·#2 | 6 | 32 | 175 | 5.47 | 1 | 98 | 11 | 1 | 20 | 18 | 81 | 0 | 90.0% | 4.05 | 4.50 | 124 | 3 | 3 | 0 | 1 | 154 |
| 46 | De'Von AchaneMiami Dolphins·#28 | 7 | 79 | 434 | 5.49 | 1 | 275 | 15 | 1 | 39 | 31 | 192 | 3 | 79.5% | 4.92 | 6.19 | 218 | 4 | 3 | 3 | 1 | 252 |
| 47 | Emanuel WilsonGreen Bay Packers·#23 | 9 | 80 | 330 | 4.12 | 1 | 271 | 22 | 1 | 11 | 9 | 76 | 0 | 81.8% | 6.91 | 8.44 | 101 | 3 | 1 | 0 | 0 | 195 |
| 48 | Devin NealNew Orleans Saints·#24 | 5 | 41 | 151 | 3.68 | 1 | 55 | 7 | 1 | 8 | 8 | 46 | 0 | 100.0% | 5.75 | 5.75 | 57 | 1 | 1 | 0 | 0 | 133 |
| 49 | Bam KnightArizona Cardinals·#20 | 5 | 42 | 149 | 3.55 | 1 | 115 | 14 | 4 | 11 | 7 | 81 | 1 | 63.6% | 7.36 | 11.57 | 67 | 4 | 2 | 1 | 2 | 132 |
| 50 | Audric EstiméNew Orleans Saints·#30 | 3 | 38 | 168 | 4.42 | 1 | 146 | 9 | 3 | 6 | 6 | 47 | 0 | 100.0% | 7.83 | 7.83 | 38 | 0 | 0 | 0 | 1 | 101 |