| 1 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 125 | 480 | 3.84 | 5 | 373 | 24 | 11 | 47 | 36 | 323 | 4 | 76.6% | 6.87 | 8.97 | 365 | 13 | 9 | 3 | 3 | 349 |
| 2 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 63 | 187 | 2.97 | 5 | 196 | 18 | 9 | 47 | 38 | 294 | 3 | 80.8% | 6.26 | 7.74 | 314 | 17 | 14 | 2 | 1 | 233 |
| 3 | Jahmyr GibbsDetroit Lions·#0 | 17 | 127 | 484 | 3.81 | 11 | 313 | 32 | 10 | 46 | 40 | 293 | 5 | 87.0% | 6.37 | 7.32 | 277 | 15 | 12 | 5 | 2 | 338 |
| 4 | De'Von AchaneMiami Dolphins·#28 | 16 | 107 | 681 | 6.36 | 7 | 411 | 31 | 5 | 37 | 29 | 235 | 4 | 78.4% | 6.35 | 8.10 | 251 | 11 | 7 | 3 | 0 | 275 |
| 5 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 191 | 661 | 3.46 | 10 | 432 | 50 | 20 | 58 | 46 | 329 | 7 | 79.3% | 5.67 | 7.15 | 236 | 24 | 20 | 7 | 3 | 467 |
| 6 | Chuba HubbardCarolina Panthers·#30 | 15 | 63 | 212 | 3.37 | 1 | 184 | 15 | 2 | 27 | 20 | 161 | 3 | 74.1% | 5.96 | 8.05 | 216 | 6 | 4 | 1 | 1 | 212 |
| 7 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 100 | 481 | 4.81 | 6 | 308 | 27 | 14 | 20 | 18 | 151 | 2 | 90.0% | 7.55 | 8.39 | 197 | 5 | 4 | 1 | 3 | 218 |
| 8 | Travis EtienneJacksonville Jaguars·#1 | 17 | 134 | 562 | 4.19 | 7 | 358 | 30 | 12 | 24 | 20 | 178 | 6 | 83.3% | 7.42 | 8.90 | 193 | 10 | 8 | 5 | 1 | 315 |
| 9 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 176 | 723 | 4.11 | 16 | 386 | 49 | 24 | 22 | 17 | 163 | 2 | 77.3% | 7.41 | 9.59 | 183 | 5 | 4 | 2 | 2 | 404 |
| 10 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 63 | 220 | 3.49 | 4 | 157 | 21 | 9 | 21 | 20 | 102 | 0 | 95.2% | 4.86 | 5.10 | 182 | 10 | 9 | 0 | 3 | 261 |
| 11 | D'Andre SwiftChicago Bears·#4 | 16 | 117 | 520 | 4.44 | 9 | 341 | 38 | 14 | 19 | 15 | 107 | 0 | 79.0% | 5.63 | 7.13 | 160 | 1 | 1 | 0 | 2 | 303 |
| 12 | Chase BrownCincinnati Bengals·#30 | 17 | 106 | 404 | 3.81 | 6 | 293 | 29 | 13 | 43 | 32 | 184 | 5 | 74.4% | 4.28 | 5.75 | 157 | 11 | 8 | 5 | 1 | 323 |
| 13 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 102 | 259 | 2.54 | 2 | 246 | 16 | 10 | 27 | 23 | 110 | 4 | 85.2% | 4.07 | 4.78 | 157 | 10 | 9 | 4 | 0 | 285 |
| 14 | Brashard SmithKansas City Chiefs·#24 | 17 | 21 | 86 | 4.10 | 0 | 76 | 4 | 1 | 22 | 17 | 123 | 1 | 77.3% | 5.59 | 7.24 | 147 | 7 | 6 | 1 | 1 | 88 |
| 15 | Breece HallNew York Jets·#20 | 16 | 94 | 357 | 3.80 | 3 | 201 | 22 | 4 | 22 | 14 | 147 | 1 | 63.6% | 6.68 | 10.50 | 144 | 9 | 2 | 0 | 3 | 226 |
| 16 | Josh JacobsGreen Bay Packers·#8 | 15 | 136 | 536 | 3.94 | 13 | 382 | 36 | 20 | 17 | 15 | 135 | 1 | 88.2% | 7.94 | 9.00 | 139 | 6 | 5 | 1 | 3 | 255 |
| 17 | Rico DowdleCarolina Panthers·#5 | 17 | 106 | 419 | 3.95 | 6 | 211 | 24 | 9 | 21 | 18 | 139 | 1 | 85.7% | 6.62 | 7.72 | 137 | 5 | 3 | 0 | 3 | 247 |
| 18 | RJ HarveyDenver Broncos·#12 | 17 | 71 | 272 | 3.83 | 7 | 135 | 16 | 10 | 24 | 20 | 154 | 5 | 83.3% | 6.42 | 7.70 | 128 | 11 | 9 | 4 | 1 | 216 |
| 19 | Dylan SampsonCleveland Browns·#22 | 14 | 24 | 88 | 3.67 | 0 | 114 | 4 | 0 | 17 | 14 | 121 | 1 | 82.3% | 7.12 | 8.64 | 114 | 6 | 4 | 1 | 0 | 81 |
| 20 | Jeremy McNicholsWashington Commanders·#26 | 17 | 22 | 105 | 4.77 | 0 | 99 | 9 | 2 | 16 | 13 | 95 | 0 | 81.3% | 5.94 | 7.31 | 113 | 3 | 2 | 0 | 2 | 151 |
| 21 | Tyjae SpearsTennessee Titans·#2 | 13 | 42 | 180 | 4.29 | 2 | 100 | 12 | 2 | 19 | 18 | 90 | 0 | 94.7% | 4.74 | 5.00 | 112 | 7 | 7 | 0 | 0 | 155 |
| 22 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 56 | 172 | 3.07 | 3 | 141 | 12 | 8 | 13 | 11 | 90 | 1 | 84.6% | 6.92 | 8.18 | 111 | 2 | 2 | 1 | 2 | 151 |
| 23 | Ty JohnsonBuffalo Bills·#26 | 17 | 39 | 164 | 4.21 | 3 | 105 | 12 | 6 | 18 | 12 | 108 | 1 | 66.7% | 6.00 | 9.00 | 110 | 4 | 2 | 1 | 0 | 160 |
| 24 | Cam SkatteboNew York Giants·#44 | 8 | 46 | 163 | 3.54 | 5 | 131 | 14 | 10 | 16 | 13 | 109 | 2 | 81.3% | 6.81 | 8.38 | 104 | 4 | 3 | 2 | 2 | 115 |
| 25 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 85 | 235 | 2.76 | 1 | 165 | 12 | 0 | 12 | 11 | 81 | 2 | 91.7% | 6.75 | 7.36 | 103 | 4 | 3 | 1 | 0 | 176 |
| 26 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 107 | 332 | 3.10 | 5 | 171 | 23 | 14 | 20 | 13 | 112 | 2 | 65.0% | 5.60 | 8.62 | 101 | 8 | 5 | 1 | 2 | 291 |
| 27 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 81 | 407 | 5.02 | 2 | 223 | 22 | 2 | 23 | 17 | 101 | 2 | 73.9% | 4.39 | 5.94 | 100 | 5 | 4 | 2 | 2 | 227 |
| 28 | TreVeyon HendersonNew England Patriots·#32 | 17 | 85 | 290 | 3.41 | 5 | 138 | 20 | 8 | 17 | 14 | 87 | 1 | 82.3% | 5.12 | 6.21 | 100 | 4 | 4 | 1 | 2 | 199 |
| 29 | David MontgomeryDetroit Lions·#5 | 17 | 98 | 445 | 4.54 | 8 | 238 | 33 | 17 | 14 | 12 | 99 | 0 | 85.7% | 7.07 | 8.25 | 94 | 2 | 1 | 0 | 2 | 224 |
| 30 | James CookBuffalo Bills·#4 | 16 | 155 | 744 | 4.80 | 11 | 477 | 34 | 16 | 14 | 11 | 96 | 2 | 78.6% | 6.86 | 8.73 | 92 | 3 | 3 | 1 | 3 | 284 |
| 31 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 116 | 387 | 3.34 | 4 | 266 | 18 | 8 | 15 | 10 | 76 | 0 | 66.7% | 5.07 | 7.60 | 88 | 3 | 2 | 0 | 2 | 218 |
| 32 | Michael CarterArizona Cardinals·#22 | 13 | 42 | 134 | 3.19 | 1 | 104 | 11 | 3 | 18 | 11 | 93 | 0 | 61.1% | 5.17 | 8.45 | 87 | 7 | 4 | 0 | 1 | 191 |
| 33 | Devin NealNew Orleans Saints·#24 | 9 | 32 | 134 | 4.19 | 2 | 66 | 10 | 2 | 12 | 11 | 68 | 0 | 91.7% | 5.67 | 6.18 | 85 | 1 | 1 | 0 | 0 | 117 |
| 34 | Javonte WilliamsDallas Cowboys·#33 | 16 | 122 | 565 | 4.63 | 11 | 355 | 42 | 20 | 21 | 13 | 55 | 2 | 61.9% | 2.62 | 4.23 | 84 | 12 | 8 | 2 | 2 | 333 |
| 35 | Zavier ScottMinnesota Vikings·#36 | 9 | 14 | 47 | 3.36 | 0 | 44 | 4 | 1 | 10 | 10 | 73 | 1 | 100.0% | 7.30 | 7.30 | 83 | 3 | 3 | 1 | 1 | 44 |
| 36 | Aaron JonesMinnesota Vikings·#33 | 12 | 53 | 210 | 3.96 | 2 | 130 | 15 | 3 | 16 | 12 | 81 | 1 | 75.0% | 5.06 | 6.75 | 75 | 5 | 3 | 0 | 1 | 149 |
| 37 | Woody MarksHouston Texans·#27 | 16 | 105 | 406 | 3.87 | 2 | 293 | 28 | 9 | 19 | 12 | 62 | 3 | 63.2% | 3.26 | 5.17 | 75 | 8 | 5 | 3 | 0 | 269 |
| 38 | Alvin KamaraNew Orleans Saints·#41 | 11 | 57 | 194 | 3.40 | 1 | 162 | 12 | 2 | 22 | 18 | 82 | 0 | 81.8% | 3.73 | 4.56 | 75 | 5 | 4 | 0 | 3 | 211 |
| 39 | Chris BrooksGreen Bay Packers·#30 | 16 | 14 | 43 | 3.07 | 0 | 44 | 2 | 0 | 10 | 7 | 60 | 0 | 70.0% | 6.00 | 8.57 | 73 | 3 | 1 | 0 | 0 | 91 |
| 40 | Tyler BadieDenver Broncos·#28 | 15 | 4 | 11 | 2.75 | 0 | 12 | 1 | 1 | 14 | 7 | 53 | 0 | 50.0% | 3.79 | 7.57 | 73 | 4 | 3 | 0 | 0 | 74 |
| 41 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 133 | 651 | 4.89 | 10 | 367 | 44 | 18 | 24 | 19 | 156 | 3 | 79.2% | 6.50 | 8.21 | 73 | 10 | 8 | 3 | 5 | 376 |
| 42 | Rhamondre StevensonNew England Patriots·#38 | 14 | 65 | 284 | 4.37 | 7 | 170 | 17 | 12 | 18 | 14 | 105 | 2 | 77.8% | 5.83 | 7.50 | 66 | 6 | 5 | 1 | 3 | 234 |
| 43 | Kareem HuntKansas City Chiefs·#29 | 17 | 83 | 249 | 3.00 | 8 | 146 | 34 | 15 | 12 | 8 | 65 | 1 | 66.7% | 5.42 | 8.12 | 64 | 4 | 2 | 1 | 1 | 241 |
| 44 | Derrick HenryBaltimore Ravens·#22 | 17 | 151 | 686 | 4.54 | 16 | 357 | 40 | 27 | 12 | 9 | 81 | 0 | 75.0% | 6.75 | 9.00 | 63 | 2 | 2 | 0 | 1 | 256 |
| 45 | Jerome FordCleveland Browns·#34 | 12 | 18 | 54 | 3.00 | 0 | 55 | 3 | 3 | 16 | 14 | 34 | 0 | 87.5% | 2.12 | 2.43 | 61 | 6 | 5 | 0 | 1 | 135 |
| 46 | Devin SingletaryNew York Giants·#26 | 15 | 71 | 290 | 4.08 | 5 | 157 | 23 | 10 | 9 | 9 | 70 | 0 | 100.0% | 7.78 | 7.78 | 60 | 2 | 2 | 0 | 1 | 164 |
| 47 | Bam KnightArizona Cardinals·#20 | 9 | 45 | 147 | 3.27 | 4 | 80 | 14 | 8 | 16 | 11 | 70 | 1 | 68.8% | 4.38 | 6.36 | 60 | 6 | 4 | 1 | 1 | 122 |
| 48 | Kimani VidalLos Angeles Chargers·#30 | 12 | 77 | 265 | 3.44 | 2 | 163 | 20 | 7 | 13 | 9 | 43 | 1 | 69.2% | 3.31 | 4.78 | 58 | 6 | 3 | 1 | 0 | 214 |
| 49 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 87 | 315 | 3.62 | 8 | 201 | 26 | 10 | 9 | 9 | 49 | 0 | 100.0% | 5.44 | 5.44 | 58 | 1 | 1 | 0 | 1 | 167 |
| 50 | Tony PollardTennessee Titans·#20 | 17 | 92 | 400 | 4.35 | 4 | 220 | 23 | 4 | 13 | 10 | 41 | 0 | 76.9% | 3.15 | 4.10 | 56 | 1 | 1 | 0 | 3 | 236 |