| 1 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 76 | 581 | 7.64 | 4 | 398 | 22 | 3 | 26 | 19 | 163 | 1 | 73.1% | 6.27 | 8.58 | 215 | 3 | 2 | 1 | 1 | 218 |
| 2 | James CookBuffalo Bills·#4 | 16 | 69 | 433 | 6.28 | 3 | 271 | 15 | 2 | 7 | 5 | 20 | 1 | 71.4% | 2.86 | 4.00 | 25 | 2 | 2 | 1 | 1 | 134 |
| 3 | Chase BrownCincinnati Bengals·#30 | 17 | 54 | 337 | 6.24 | 0 | 239 | 12 | 1 | 22 | 19 | 156 | 2 | 86.4% | 7.09 | 8.21 | 142 | 3 | 3 | 2 | 2 | 178 |
| 4 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 73 | 331 | 4.53 | 1 | 233 | 13 | 3 | 24 | 14 | 69 | 0 | 58.3% | 2.88 | 4.93 | 102 | 1 | 1 | 0 | 0 | 190 |
| 5 | Travis EtienneJacksonville Jaguars·#1 | 17 | 50 | 356 | 7.12 | 3 | 214 | 14 | 1 | 12 | 8 | 40 | 1 | 66.7% | 3.33 | 5.00 | 34 | 3 | 3 | 1 | 0 | 139 |
| 6 | Derrick HenryBaltimore Ravens·#22 | 16 | 67 | 357 | 5.33 | 5 | 209 | 20 | 11 | 4 | 2 | 15 | 0 | 50.0% | 3.75 | 7.50 | 16 | 1 | 1 | 0 | 0 | 118 |
| 7 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 81 | 336 | 4.15 | 4 | 199 | 23 | 6 | 36 | 27 | 179 | 3 | 75.0% | 4.97 | 6.63 | 130 | 9 | 8 | 3 | 2 | 266 |
| 8 | Jahmyr GibbsDetroit Lions·#0 | 17 | 56 | 349 | 6.23 | 2 | 181 | 15 | 0 | 26 | 21 | 139 | 2 | 80.8% | 5.35 | 6.62 | 114 | 6 | 4 | 2 | 1 | 176 |
| 9 | Kyren WilliamsLos Angeles Rams·#23 | 16 | 60 | 276 | 4.60 | 3 | 179 | 18 | 8 | 13 | 10 | 73 | 1 | 76.9% | 5.62 | 7.30 | 41 | 2 | 1 | 1 | 0 | 193 |
| 10 | De'Von AchaneMiami Dolphins·#28 | 16 | 60 | 316 | 5.27 | 0 | 172 | 10 | 0 | 32 | 25 | 190 | 2 | 78.1% | 5.94 | 7.60 | 197 | 7 | 3 | 1 | 1 | 181 |
| 11 | Tony PollardTennessee Titans·#20 | 17 | 57 | 232 | 4.07 | 0 | 162 | 7 | 0 | 9 | 6 | 50 | 0 | 66.7% | 5.56 | 8.33 | 46 | 0 | 0 | 0 | 3 | 149 |
| 12 | D'Andre SwiftChicago Bears·#4 | 16 | 48 | 260 | 5.42 | 1 | 157 | 12 | 0 | 13 | 9 | 76 | 0 | 69.2% | 5.85 | 8.44 | 93 | 1 | 1 | 0 | 2 | 154 |
| 13 | Javonte WilliamsDallas Cowboys·#33 | 15 | 46 | 248 | 5.39 | 4 | 152 | 19 | 6 | 11 | 8 | 32 | 0 | 72.7% | 2.91 | 4.00 | 61 | 3 | 2 | 0 | 1 | 172 |
| 14 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 72 | 260 | 3.61 | 2 | 152 | 12 | 4 | 18 | 12 | 70 | 1 | 66.7% | 3.89 | 5.83 | 86 | 5 | 3 | 1 | 0 | 186 |
| 15 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 55 | 190 | 3.45 | 3 | 150 | 16 | 7 | 8 | 6 | 42 | 0 | 75.0% | 5.25 | 7.00 | 35 | 0 | 0 | 0 | 2 | 149 |
| 16 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 79 | 295 | 3.73 | 2 | 149 | 16 | 9 | 16 | 12 | 99 | 1 | 75.0% | 6.19 | 8.25 | 112 | 2 | 2 | 1 | 2 | 225 |
| 17 | Woody MarksHouston Texans·#27 | 15 | 52 | 231 | 4.44 | 1 | 144 | 19 | 4 | 17 | 11 | 30 | 1 | 64.7% | 1.76 | 2.73 | 42 | 3 | 2 | 1 | 0 | 172 |
| 18 | Rico DowdleCarolina Panthers·#5 | 16 | 50 | 257 | 5.14 | 1 | 134 | 15 | 1 | 10 | 7 | 54 | 0 | 70.0% | 5.40 | 7.71 | 62 | 0 | 0 | 0 | 1 | 125 |
| 19 | Breece HallNew York Jets·#20 | 16 | 68 | 274 | 4.03 | 1 | 130 | 10 | 1 | 13 | 10 | 88 | 0 | 76.9% | 6.77 | 8.80 | 91 | 2 | 1 | 0 | 1 | 138 |
| 20 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 33 | 156 | 4.73 | 1 | 127 | 9 | 1 | 11 | 10 | 57 | 0 | 90.9% | 5.18 | 5.70 | 85 | 0 | 0 | 0 | 1 | 87 |
| 21 | Tyrone Tracy Jr.New York Giants·#29 | 14 | 37 | 138 | 3.73 | 1 | 127 | 6 | 0 | 11 | 8 | 97 | 0 | 72.7% | 8.82 | 12.12 | 112 | 2 | 1 | 0 | 0 | 135 |
| 22 | Kareem HuntKansas City Chiefs·#29 | 17 | 43 | 200 | 4.65 | 1 | 126 | 18 | 2 | 10 | 10 | 79 | 0 | 100.0% | 7.90 | 7.90 | 89 | 0 | 0 | 0 | 0 | 139 |
| 23 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 27 | 173 | 6.41 | 1 | 125 | 11 | 1 | 31 | 28 | 211 | 1 | 90.3% | 6.81 | 7.54 | 207 | 7 | 6 | 0 | 0 | 147 |
| 24 | David MontgomeryDetroit Lions·#5 | 17 | 54 | 207 | 3.83 | 4 | 123 | 17 | 13 | 10 | 9 | 70 | 0 | 90.0% | 7.00 | 7.78 | 69 | 0 | 0 | 0 | 0 | 124 |
| 25 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 54 | 200 | 3.70 | 3 | 123 | 13 | 7 | 8 | 8 | 66 | 0 | 100.0% | 8.25 | 8.25 | 76 | 1 | 1 | 0 | 0 | 121 |
| 26 | Quinshon JudkinsCleveland Browns·#10 | 14 | 56 | 184 | 3.29 | 2 | 119 | 13 | 5 | 6 | 5 | 44 | 0 | 83.3% | 7.33 | 8.80 | 48 | 1 | 1 | 0 | 1 | 107 |
| 27 | Josh JacobsGreen Bay Packers·#8 | 15 | 47 | 187 | 3.98 | 2 | 116 | 14 | 5 | 15 | 15 | 121 | 1 | 100.0% | 8.07 | 8.07 | 127 | 3 | 3 | 1 | 2 | 123 |
| 28 | Tyjae SpearsTennessee Titans·#2 | 13 | 34 | 180 | 5.29 | 0 | 116 | 9 | 0 | 13 | 12 | 110 | 0 | 92.3% | 8.46 | 9.17 | 114 | 0 | 0 | 0 | 1 | 117 |
| 29 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 45 | 211 | 4.69 | 1 | 104 | 12 | 5 | 15 | 14 | 86 | 0 | 93.3% | 5.73 | 6.14 | 130 | 6 | 6 | 0 | 2 | 154 |
| 30 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 44 | 140 | 3.18 | 1 | 103 | 5 | 3 | 7 | 7 | 32 | 0 | 100.0% | 4.57 | 4.57 | 49 | 1 | 1 | 0 | 2 | 90 |
| 31 | TreVeyon HendersonNew England Patriots·#32 | 17 | 52 | 236 | 4.54 | 4 | 101 | 15 | 5 | 13 | 12 | 82 | 0 | 92.3% | 6.31 | 6.83 | 90 | 0 | 0 | 0 | 1 | 144 |
| 32 | Jacory Croskey-MerrittWashington Commanders·#22 | 14 | 41 | 194 | 4.73 | 5 | 94 | 14 | 4 | 3 | 2 | 12 | 0 | 66.7% | 4.00 | 6.00 | 11 | 0 | 0 | 0 | 0 | 94 |
| 33 | Chuba HubbardCarolina Panthers·#30 | 15 | 38 | 136 | 3.58 | 0 | 94 | 3 | 0 | 11 | 8 | 55 | 0 | 72.7% | 5.00 | 6.88 | 81 | 2 | 1 | 0 | 0 | 110 |
| 34 | Jaylen WrightMiami Dolphins·#5 | 8 | 24 | 125 | 5.21 | 0 | 92 | 5 | 2 | 2 | 1 | 13 | 0 | 50.0% | 6.50 | 13.00 | 15 | 0 | 0 | 0 | 1 | 34 |
| 35 | Jordan MasonMinnesota Vikings·#27 | 15 | 42 | 160 | 3.81 | 2 | 91 | 10 | 2 | 6 | 6 | 15 | 0 | 100.0% | 2.50 | 2.50 | 37 | 1 | 1 | 0 | 0 | 103 |
| 36 | Jeremy McNicholsWashington Commanders·#26 | 15 | 10 | 99 | 9.90 | 1 | 89 | 3 | 0 | 9 | 9 | 83 | 0 | 100.0% | 9.22 | 9.22 | 94 | 1 | 1 | 0 | 0 | 82 |
| 37 | Alvin KamaraNew Orleans Saints·#41 | 10 | 32 | 104 | 3.25 | 1 | 87 | 4 | 0 | 18 | 15 | 94 | 0 | 83.3% | 5.22 | 6.27 | 98 | 1 | 1 | 0 | 1 | 128 |
| 38 | Isiah PachecoKansas City Chiefs·#10 | 13 | 29 | 127 | 4.38 | 0 | 87 | 7 | 0 | 6 | 4 | 11 | 1 | 66.7% | 1.83 | 2.75 | 18 | 1 | 1 | 1 | 0 | 117 |
| 39 | Cam SkatteboNew York Giants·#44 | 8 | 25 | 107 | 4.28 | 2 | 79 | 6 | 3 | 8 | 5 | 60 | 1 | 62.5% | 7.50 | 12.00 | 65 | 1 | 1 | 1 | 0 | 59 |
| 40 | Kimani VidalLos Angeles Chargers·#30 | 11 | 32 | 120 | 3.75 | 1 | 77 | 11 | 3 | 5 | 4 | 27 | 0 | 80.0% | 5.40 | 6.75 | 47 | 1 | 0 | 0 | 0 | 133 |
| 41 | Blake CorumLos Angeles Rams·#22 | 14 | 36 | 182 | 5.06 | 1 | 75 | 12 | 2 | 3 | 2 | -11 | 0 | 66.7% | -3.67 | -5.50 | 2 | 0 | 0 | 0 | 1 | 78 |
| 42 | Aaron JonesMinnesota Vikings·#33 | 12 | 29 | 142 | 4.90 | 0 | 73 | 5 | 0 | 12 | 10 | 56 | 0 | 83.3% | 4.67 | 5.60 | 64 | 1 | 1 | 0 | 1 | 103 |
| 43 | Emanuel WilsonGreen Bay Packers·#23 | 15 | 29 | 102 | 3.52 | 1 | 71 | 6 | 0 | 3 | 2 | -6 | 0 | 66.7% | -2.00 | -3.00 | 6 | 0 | 0 | 0 | 0 | 68 |
| 44 | Kyle MonangaiChicago Bears·#25 | 16 | 39 | 157 | 4.03 | 2 | 69 | 11 | 2 | 4 | 3 | 22 | 0 | 75.0% | 5.50 | 7.33 | 18 | 0 | 0 | 0 | 0 | 107 |
| 45 | Rhamondre StevensonNew England Patriots·#38 | 14 | 33 | 144 | 4.36 | 0 | 64 | 6 | 0 | 14 | 13 | 125 | 1 | 92.9% | 8.93 | 9.62 | 107 | 1 | 1 | 0 | 1 | 141 |
| 46 | Nick ChubbHouston Texans·#21 | 14 | 25 | 95 | 3.80 | 1 | 63 | 4 | 3 | 8 | 3 | -3 | 0 | 37.5% | -0.38 | -1.00 | 8 | 2 | 1 | 0 | 0 | 79 |
| 47 | Devin SingletaryNew York Giants·#26 | 15 | 32 | 103 | 3.22 | 1 | 61 | 7 | 4 | 5 | 4 | 15 | 0 | 80.0% | 3.00 | 3.75 | 15 | 0 | 0 | 0 | 1 | 62 |
| 48 | J.K. DobbinsDenver Broncos·#27 | 10 | 27 | 102 | 3.78 | 0 | 60 | 5 | 5 | 6 | 4 | 22 | 0 | 66.7% | 3.67 | 5.50 | 22 | 0 | 0 | 0 | 1 | 82 |
| 49 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 38 | 98 | 2.58 | 0 | 57 | 4 | 0 | 8 | 6 | 23 | 0 | 75.0% | 2.88 | 3.83 | 38 | 1 | 1 | 0 | 0 | 98 |
| 50 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 22 | 105 | 4.77 | 2 | 56 | 4 | 3 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 6 | 0 | 0 | 0 | 0 | 43 |