| 1 | Justice HillBaltimore Ravens·#43 | 10 | 12 | 83 | 6.92 | 1 | 99 | 1 | 0 | 21 | 17 | 157 | 1 | 81.0% | 7.48 | 9.24 | 169 | 1 | 1 | 1 | 1 | 128 |
| 2 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 38 | 258 | 6.79 | 0 | 158 | 10 | 0 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 9 | 1 | 1 | 0 | 0 | 77 |
| 3 | Isaiah DavisNew York Jets·#32 | 16 | 28 | 185 | 6.61 | 0 | 145 | 4 | 0 | 26 | 20 | 180 | 0 | 76.9% | 6.92 | 9.00 | 183 | 1 | 1 | 0 | 1 | 190 |
| 4 | Miles SandersDallas Cowboys·#24 | 4 | 15 | 97 | 6.47 | 0 | 60 | 2 | 0 | 7 | 7 | 27 | 0 | 100.0% | 3.86 | 3.86 | 43 | 1 | 1 | 0 | 1 | 47 |
| 5 | Trey BensonArizona Cardinals·#33 | 4 | 24 | 149 | 6.21 | 0 | 134 | 3 | 0 | 12 | 10 | 41 | 0 | 83.3% | 3.42 | 4.10 | 53 | 1 | 1 | 0 | 1 | 91 |
| 6 | De'Von AchaneMiami Dolphins·#28 | 16 | 185 | 1,132 | 6.12 | 7 | 710 | 33 | 0 | 66 | 53 | 374 | 2 | 80.3% | 5.67 | 7.06 | 467 | 8 | 5 | 2 | 2 | 494 |
| 7 | Derrick HenryBaltimore Ravens·#22 | 17 | 195 | 1,159 | 5.94 | 5 | 649 | 31 | 0 | 19 | 15 | 150 | 0 | 79.0% | 7.89 | 10.00 | 135 | 2 | 2 | 0 | 3 | 373 |
| 8 | TreVeyon HendersonNew England Patriots·#32 | 17 | 124 | 720 | 5.81 | 6 | 288 | 18 | 0 | 34 | 29 | 192 | 0 | 85.3% | 5.65 | 6.62 | 218 | 1 | 1 | 0 | 2 | 343 |
| 9 | Samaje PerineCincinnati Bengals·#34 | 15 | 47 | 272 | 5.79 | 1 | 166 | 9 | 0 | 14 | 10 | 45 | 0 | 71.4% | 3.21 | 4.50 | 65 | 1 | 1 | 0 | 1 | 202 |
| 10 | Blake CorumLos Angeles Rams·#22 | 17 | 97 | 557 | 5.74 | 2 | 252 | 18 | 0 | 12 | 7 | 23 | 0 | 58.3% | 1.92 | 3.29 | 30 | 1 | 0 | 0 | 1 | 204 |
| 11 | J.K. DobbinsDenver Broncos·#27 | 10 | 104 | 597 | 5.74 | 1 | 320 | 16 | 0 | 13 | 11 | 42 | 0 | 84.6% | 3.23 | 3.82 | 56 | 0 | 0 | 0 | 1 | 226 |
| 12 | Javonte WilliamsDallas Cowboys·#33 | 16 | 169 | 927 | 5.49 | 1 | 582 | 21 | 0 | 35 | 28 | 114 | 0 | 80.0% | 3.26 | 4.07 | 174 | 6 | 4 | 0 | 3 | 475 |
| 13 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 157 | 861 | 5.48 | 2 | 492 | 23 | 0 | 35 | 28 | 197 | 3 | 80.0% | 5.63 | 7.04 | 125 | 5 | 5 | 3 | 5 | 478 |
| 14 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 208 | 1,140 | 5.48 | 2 | 841 | 28 | 0 | 80 | 61 | 633 | 1 | 76.3% | 7.91 | 10.38 | 673 | 7 | 5 | 1 | 5 | 594 |
| 15 | David MontgomeryDetroit Lions·#5 | 17 | 107 | 577 | 5.39 | 3 | 350 | 17 | 0 | 27 | 22 | 179 | 0 | 81.5% | 6.63 | 8.14 | 191 | 2 | 1 | 0 | 3 | 270 |
| 16 | Jordan MasonMinnesota Vikings·#27 | 16 | 110 | 586 | 5.33 | 0 | 340 | 18 | 0 | 14 | 12 | 36 | 0 | 85.7% | 2.57 | 3.00 | 82 | 1 | 1 | 0 | 1 | 269 |
| 17 | Najee HarrisLos Angeles Chargers·#22 | 3 | 10 | 53 | 5.30 | 0 | 37 | 0 | 0 | 3 | 3 | 25 | 0 | 100.0% | 8.33 | 8.33 | 15 | 0 | 0 | 0 | 0 | 25 |
| 18 | Ray DavisBuffalo Bills·#22 | 15 | 42 | 221 | 5.26 | 0 | 128 | 9 | 0 | 7 | 4 | 31 | 0 | 57.1% | 4.43 | 7.75 | 34 | 1 | 1 | 0 | 0 | 93 |
| 19 | Trevor EtienneCarolina Panthers·#23 | 11 | 17 | 89 | 5.24 | 0 | 49 | 5 | 0 | 2 | 2 | 6 | 0 | 100.0% | 3.00 | 3.00 | 8 | 0 | 0 | 0 | 0 | 29 |
| 20 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 26 | 135 | 5.19 | 0 | 56 | 3 | 0 | 4 | 3 | 18 | 0 | 75.0% | 4.50 | 6.00 | 31 | 0 | 0 | 0 | 0 | 53 |
| 21 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 136 | 702 | 5.16 | 1 | 511 | 17 | 0 | 36 | 32 | 259 | 0 | 88.9% | 7.19 | 8.09 | 368 | 4 | 3 | 0 | 3 | 330 |
| 22 | D'Andre SwiftChicago Bears·#4 | 16 | 148 | 759 | 5.13 | 3 | 437 | 21 | 0 | 36 | 27 | 181 | 0 | 75.0% | 5.03 | 6.70 | 238 | 1 | 1 | 0 | 3 | 413 |
| 23 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 67 | 344 | 5.13 | 1 | 226 | 9 | 0 | 3 | 3 | 30 | 0 | 100.0% | 10.00 | 10.00 | 26 | 0 | 0 | 0 | 1 | 157 |
| 24 | James CookBuffalo Bills·#4 | 17 | 224 | 1,145 | 5.11 | 2 | 623 | 31 | 0 | 33 | 28 | 174 | 1 | 84.8% | 5.27 | 6.21 | 153 | 2 | 2 | 0 | 3 | 431 |
| 25 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 74 | 378 | 5.11 | 1 | 219 | 9 | 0 | 30 | 27 | 130 | 0 | 90.0% | 4.33 | 4.81 | 172 | 1 | 1 | 0 | 2 | 237 |
| 26 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 201 | 1,025 | 5.10 | 4 | 610 | 22 | 0 | 50 | 41 | 318 | 2 | 82.0% | 6.36 | 7.76 | 362 | 4 | 4 | 2 | 2 | 585 |
| 27 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 117 | 593 | 5.07 | 2 | 387 | 13 | 0 | 10 | 7 | 64 | 0 | 70.0% | 6.40 | 9.14 | 62 | 1 | 1 | 0 | 2 | 272 |
| 28 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 166 | 840 | 5.06 | 2 | 418 | 29 | 0 | 29 | 26 | 238 | 0 | 89.7% | 8.21 | 9.15 | 295 | 2 | 1 | 0 | 3 | 353 |
| 29 | Audric EstiméNew Orleans Saints·#30 | 5 | 28 | 140 | 5.00 | 1 | 152 | 2 | 0 | 11 | 10 | 79 | 0 | 90.9% | 7.18 | 7.90 | 100 | 0 | 0 | 0 | 1 | 115 |
| 30 | Raheim SandersCleveland Browns·#35 | 3 | 12 | 60 | 5.00 | 0 | 50 | 1 | 0 | 4 | 3 | 21 | 0 | 75.0% | 5.25 | 7.00 | 14 | 0 | 0 | 0 | 0 | 32 |
| 31 | Breece HallNew York Jets·#20 | 16 | 166 | 824 | 4.96 | 2 | 381 | 22 | 0 | 38 | 31 | 313 | 1 | 81.6% | 8.24 | 10.10 | 304 | 6 | 1 | 0 | 2 | 417 |
| 32 | Kyle MonangaiChicago Bears·#25 | 17 | 120 | 594 | 4.95 | 1 | 301 | 14 | 0 | 24 | 14 | 143 | 0 | 58.3% | 5.96 | 10.21 | 149 | 3 | 2 | 0 | 0 | 329 |
| 33 | Cam SkatteboNew York Giants·#44 | 8 | 63 | 311 | 4.94 | 1 | 232 | 9 | 0 | 23 | 18 | 174 | 2 | 78.3% | 7.57 | 9.67 | 175 | 3 | 3 | 2 | 2 | 168 |
| 34 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 72 | 356 | 4.94 | 0 | 271 | 11 | 0 | 64 | 55 | 380 | 2 | 85.9% | 5.94 | 6.91 | 384 | 12 | 10 | 1 | 1 | 341 |
| 35 | Jawhar JordanHouston Texans·#26 | 4 | 35 | 173 | 4.94 | 0 | 106 | 6 | 0 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 40 | 0 | 0 | 0 | 0 | 60 |
| 36 | AJ DillonPhiladelphia Eagles·#29 | 6 | 9 | 44 | 4.89 | 0 | 29 | 1 | 0 | 2 | 2 | 18 | 0 | 100.0% | 9.00 | 9.00 | 9 | 0 | 0 | 0 | 1 | 29 |
| 37 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 64 | 312 | 4.88 | 1 | 149 | 8 | 0 | 10 | 6 | 17 | 0 | 60.0% | 1.70 | 2.83 | 23 | 2 | 1 | 0 | 0 | 119 |
| 38 | Rico DowdleCarolina Panthers·#5 | 17 | 173 | 823 | 4.76 | 0 | 473 | 22 | 0 | 39 | 30 | 257 | 1 | 76.9% | 6.59 | 8.57 | 282 | 4 | 2 | 0 | 6 | 391 |
| 39 | Rasheen AliBaltimore Ravens·#26 | 9 | 4 | 19 | 4.75 | 0 | 37 | 0 | 0 | 10 | 9 | 68 | 1 | 90.0% | 6.80 | 7.56 | 83 | 1 | 1 | 0 | 3 | 66 |
| 40 | Malik DavisDallas Cowboys·#43 | 9 | 35 | 166 | 4.74 | 0 | 74 | 3 | 0 | 5 | 2 | 16 | 0 | 40.0% | 3.20 | 8.00 | 6 | 0 | 0 | 0 | 1 | 102 |
| 41 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 91 | 431 | 4.74 | 1 | 250 | 12 | 0 | 39 | 35 | 175 | 0 | 89.7% | 4.49 | 5.00 | 281 | 8 | 7 | 0 | 3 | 375 |
| 42 | Chase BrownCincinnati Bengals·#30 | 17 | 168 | 794 | 4.73 | 1 | 560 | 21 | 0 | 66 | 56 | 343 | 3 | 84.8% | 5.20 | 6.12 | 340 | 7 | 6 | 3 | 3 | 515 |
| 43 | Jahmyr GibbsDetroit Lions·#0 | 17 | 167 | 785 | 4.70 | 5 | 413 | 19 | 0 | 77 | 63 | 483 | 2 | 81.8% | 6.27 | 7.67 | 480 | 10 | 8 | 2 | 2 | 500 |
| 44 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 52 | 244 | 4.69 | 1 | 132 | 6 | 0 | 9 | 7 | 6 | 0 | 77.8% | 0.67 | 0.86 | 28 | 2 | 1 | 0 | 0 | 110 |
| 45 | Travis EtienneJacksonville Jaguars·#1 | 17 | 183 | 850 | 4.64 | 4 | 568 | 25 | 0 | 39 | 29 | 243 | 5 | 74.4% | 6.23 | 8.38 | 276 | 7 | 6 | 4 | 1 | 474 |
| 46 | Kareem HuntKansas City Chiefs·#29 | 17 | 85 | 390 | 4.59 | 0 | 249 | 7 | 0 | 18 | 13 | 92 | 0 | 72.2% | 5.11 | 7.08 | 104 | 2 | 1 | 0 | 1 | 316 |
| 47 | Jaylen WrightMiami Dolphins·#5 | 9 | 49 | 225 | 4.59 | 0 | 180 | 6 | 0 | 5 | 3 | 40 | 0 | 60.0% | 8.00 | 13.33 | 47 | 0 | 0 | 0 | 1 | 80 |
| 48 | Tony PollardTennessee Titans·#20 | 17 | 189 | 862 | 4.56 | 1 | 521 | 22 | 0 | 32 | 26 | 160 | 0 | 81.3% | 5.00 | 6.15 | 174 | 1 | 1 | 0 | 6 | 477 |
| 49 | Ty JohnsonBuffalo Bills·#26 | 17 | 25 | 111 | 4.44 | 0 | 102 | 0 | 0 | 23 | 16 | 114 | 0 | 69.6% | 4.96 | 7.12 | 146 | 3 | 1 | 0 | 0 | 188 |
| 50 | Nick ChubbHouston Texans·#21 | 15 | 90 | 400 | 4.44 | 2 | 247 | 5 | 0 | 19 | 12 | 63 | 0 | 63.2% | 3.32 | 5.25 | 63 | 2 | 1 | 0 | 0 | 232 |