| 1 | De'Von AchaneMiami Dolphins·#28 | 16 | 63 | 518 | 8.22 | 4 | 264 | 17 | 1 | 17 | 13 | 90 | 1 | 76.5% | 5.29 | 6.92 | 121 | 1 | 1 | 1 | 1 | 150 |
| 2 | Rhamondre StevensonNew England Patriots·#38 | 14 | 46 | 304 | 6.61 | 2 | 172 | 15 | 4 | 5 | 5 | 43 | 0 | 100.0% | 8.60 | 8.60 | 18 | 2 | 2 | 0 | 2 | 121 |
| 3 | Ty JohnsonBuffalo Bills·#26 | 16 | 11 | 71 | 6.45 | 0 | 28 | 3 | 0 | 9 | 7 | 52 | 0 | 77.8% | 5.78 | 7.43 | 76 | 1 | 0 | 0 | 0 | 57 |
| 4 | Ray DavisBuffalo Bills·#22 | 11 | 12 | 77 | 6.42 | 0 | 37 | 5 | 0 | 5 | 4 | 40 | 0 | 80.0% | 8.00 | 10.00 | 49 | 1 | 1 | 0 | 0 | 30 |
| 5 | James CookBuffalo Bills·#4 | 17 | 77 | 491 | 6.38 | 4 | 291 | 23 | 2 | 7 | 6 | 18 | 0 | 85.7% | 2.57 | 3.00 | 23 | 0 | 0 | 0 | 3 | 135 |
| 6 | Chris Rodriguez Jr.Washington Commanders·#36 | 8 | 29 | 182 | 6.28 | 0 | 116 | 7 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 58 |
| 7 | Zach CharbonnetSeattle Seahawks·#26 | 15 | 29 | 163 | 5.62 | 3 | 84 | 9 | 2 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 65 |
| 8 | Chris BrooksGreen Bay Packers·#30 | 16 | 5 | 28 | 5.60 | 0 | 18 | 1 | 0 | 4 | 4 | 32 | 0 | 100.0% | 8.00 | 8.00 | 30 | 1 | 1 | 0 | 0 | 43 |
| 9 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 65 | 346 | 5.32 | 2 | 127 | 14 | 7 | 11 | 10 | 50 | 0 | 90.9% | 4.55 | 5.00 | 75 | 1 | 1 | 0 | 1 | 163 |
| 10 | Tony PollardTennessee Titans·#20 | 17 | 70 | 370 | 5.29 | 1 | 196 | 13 | 0 | 7 | 5 | 33 | 0 | 71.4% | 4.71 | 6.60 | 56 | 1 | 1 | 0 | 0 | 154 |
| 11 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 72 | 377 | 5.24 | 3 | 224 | 22 | 4 | 10 | 6 | 32 | 0 | 60.0% | 3.20 | 5.33 | 26 | 3 | 2 | 0 | 1 | 179 |
| 12 | Blake CorumLos Angeles Rams·#22 | 13 | 33 | 168 | 5.09 | 1 | 88 | 12 | 6 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 83 |
| 13 | Derrick HenryBaltimore Ravens·#22 | 17 | 90 | 444 | 4.93 | 4 | 257 | 22 | 3 | 5 | 5 | 32 | 0 | 100.0% | 6.40 | 6.40 | 25 | 0 | 0 | 0 | 1 | 148 |
| 14 | Samaje PerineCincinnati Bengals·#34 | 14 | 23 | 111 | 4.83 | 0 | 82 | 10 | 2 | 6 | 6 | 39 | 0 | 100.0% | 6.50 | 6.50 | 49 | 0 | 0 | 0 | 0 | 66 |
| 15 | Kyle MonangaiChicago Bears·#25 | 16 | 42 | 199 | 4.74 | 1 | 85 | 11 | 4 | 7 | 2 | 11 | 0 | 28.6% | 1.57 | 5.50 | 6 | 0 | 0 | 0 | 0 | 103 |
| 16 | Brian RobinsonSan Francisco 49ers·#3 | 12 | 17 | 80 | 4.71 | 0 | 47 | 7 | 1 | 3 | 1 | 4 | 0 | 33.3% | 1.33 | 4.00 | 0 | 0 | 0 | 0 | 0 | 29 |
| 17 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 54 | 254 | 4.70 | 0 | 143 | 13 | 2 | 16 | 15 | 55 | 0 | 93.8% | 3.44 | 3.67 | 104 | 0 | 0 | 0 | 0 | 121 |
| 18 | Michael CarterArizona Cardinals·#22 | 8 | 25 | 117 | 4.68 | 1 | 63 | 4 | 1 | 3 | 2 | 10 | 0 | 66.7% | 3.33 | 5.00 | 8 | 0 | 0 | 0 | 0 | 66 |
| 19 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 84 | 389 | 4.63 | 1 | 227 | 17 | 2 | 27 | 19 | 165 | 2 | 70.4% | 6.11 | 8.68 | 152 | 6 | 4 | 1 | 2 | 210 |
| 20 | Brashard SmithKansas City Chiefs·#24 | 16 | 10 | 46 | 4.60 | 0 | 28 | 3 | 0 | 10 | 5 | 55 | 0 | 50.0% | 5.50 | 11.00 | 61 | 1 | 1 | 0 | 0 | 40 |
| 21 | Keaton MitchellBaltimore Ravens·#34 | 8 | 12 | 53 | 4.42 | 0 | 21 | 3 | 0 | 2 | 2 | 7 | 0 | 100.0% | 3.50 | 3.50 | 14 | 0 | 0 | 0 | 0 | 26 |
| 22 | D'Andre SwiftChicago Bears·#4 | 16 | 61 | 269 | 4.41 | 2 | 135 | 17 | 1 | 13 | 10 | 40 | 0 | 76.9% | 3.08 | 4.00 | 60 | 0 | 0 | 0 | 1 | 140 |
| 23 | Bhayshul TutenJacksonville Jaguars·#33 | 11 | 18 | 79 | 4.39 | 2 | 50 | 6 | 3 | 4 | 3 | 26 | 0 | 75.0% | 6.50 | 8.67 | 35 | 0 | 0 | 0 | 0 | 41 |
| 24 | Kareem HuntKansas City Chiefs·#29 | 17 | 29 | 127 | 4.38 | 0 | 68 | 11 | 1 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 11 | 0 | 0 | 0 | 0 | 89 |
| 25 | J.K. DobbinsDenver Broncos·#27 | 10 | 29 | 127 | 4.38 | 0 | 71 | 6 | 0 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 64 |
| 26 | Rachaad WhiteTampa Bay Buccaneers·#1 | 16 | 36 | 157 | 4.36 | 1 | 103 | 10 | 1 | 6 | 6 | 18 | 0 | 100.0% | 3.00 | 3.00 | 31 | 0 | 0 | 0 | 0 | 103 |
| 27 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 86 | 374 | 4.35 | 5 | 218 | 25 | 5 | 16 | 13 | 143 | 0 | 81.3% | 8.94 | 11.00 | 146 | 0 | 0 | 0 | 0 | 245 |
| 28 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 58 | 252 | 4.34 | 1 | 117 | 13 | 2 | 9 | 7 | 125 | 0 | 77.8% | 13.89 | 17.86 | 145 | 1 | 0 | 0 | 0 | 121 |
| 29 | RJ HarveyDenver Broncos·#12 | 16 | 38 | 164 | 4.32 | 1 | 69 | 9 | 0 | 10 | 9 | 42 | 0 | 90.0% | 4.20 | 4.67 | 58 | 1 | 1 | 0 | 1 | 103 |
| 30 | Javonte WilliamsDallas Cowboys·#33 | 16 | 87 | 375 | 4.31 | 3 | 216 | 18 | 5 | 14 | 8 | 40 | 0 | 57.1% | 2.86 | 5.00 | 52 | 2 | 1 | 0 | 2 | 193 |
| 31 | TreVeyon HendersonNew England Patriots·#32 | 17 | 43 | 185 | 4.30 | 1 | 77 | 10 | 1 | 10 | 9 | 73 | 0 | 90.0% | 7.30 | 8.11 | 70 | 1 | 1 | 0 | 0 | 100 |
| 32 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 72 | 305 | 4.24 | 2 | 182 | 16 | 3 | 28 | 21 | 137 | 2 | 75.0% | 4.89 | 6.52 | 101 | 4 | 3 | 2 | 1 | 193 |
| 33 | Sean TuckerTampa Bay Buccaneers·#44 | 10 | 18 | 76 | 4.22 | 1 | 39 | 7 | 2 | 3 | 1 | -4 | 0 | 33.3% | -1.33 | -4.00 | 3 | 2 | 1 | 0 | 0 | 39 |
| 34 | Devin SingletaryNew York Giants·#26 | 13 | 24 | 99 | 4.12 | 2 | 46 | 6 | 2 | 3 | 3 | 13 | 0 | 100.0% | 4.33 | 4.33 | 22 | 0 | 0 | 0 | 0 | 50 |
| 35 | Tyler AllgeierAtlanta Falcons·#25 | 16 | 24 | 98 | 4.08 | 2 | 41 | 7 | 1 | 2 | 2 | 8 | 0 | 100.0% | 4.00 | 4.00 | 3 | 0 | 0 | 0 | 1 | 59 |
| 36 | Alvin KamaraNew Orleans Saints·#41 | 11 | 43 | 175 | 4.07 | 0 | 97 | 6 | 1 | 9 | 7 | 40 | 0 | 77.8% | 4.44 | 5.71 | 48 | 2 | 1 | 0 | 3 | 111 |
| 37 | Chuba HubbardCarolina Panthers·#30 | 13 | 31 | 126 | 4.06 | 0 | 64 | 9 | 0 | 7 | 6 | 49 | 1 | 85.7% | 7.00 | 8.17 | 75 | 0 | 0 | 0 | 1 | 84 |
| 38 | Rico DowdleCarolina Panthers·#5 | 17 | 63 | 256 | 4.06 | 2 | 150 | 14 | 2 | 14 | 11 | 58 | 0 | 78.6% | 4.14 | 5.27 | 73 | 3 | 2 | 0 | 2 | 135 |
| 39 | Cam SkatteboNew York Giants·#44 | 8 | 21 | 83 | 3.95 | 0 | 56 | 6 | 0 | 8 | 6 | 40 | 1 | 75.0% | 5.00 | 6.67 | 35 | 1 | 1 | 1 | 0 | 60 |
| 40 | Breece HallNew York Jets·#20 | 16 | 61 | 241 | 3.95 | 0 | 130 | 16 | 1 | 11 | 9 | 64 | 0 | 81.8% | 5.82 | 7.11 | 57 | 2 | 0 | 0 | 1 | 124 |
| 41 | Jahmyr GibbsDetroit Lions·#0 | 17 | 71 | 277 | 3.90 | 4 | 184 | 16 | 7 | 20 | 18 | 152 | 1 | 90.0% | 7.60 | 8.44 | 176 | 3 | 2 | 1 | 1 | 174 |
| 42 | Josh JacobsGreen Bay Packers·#8 | 15 | 64 | 249 | 3.89 | 0 | 192 | 12 | 1 | 10 | 8 | 48 | 0 | 80.0% | 4.80 | 6.00 | 61 | 0 | 0 | 0 | 1 | 146 |
| 43 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 49 | 186 | 3.80 | 0 | 120 | 9 | 0 | 10 | 10 | 96 | 1 | 100.0% | 9.60 | 9.60 | 135 | 1 | 1 | 0 | 0 | 106 |
| 44 | Jordan MasonMinnesota Vikings·#27 | 15 | 36 | 136 | 3.78 | 0 | 70 | 12 | 0 | 2 | 2 | 12 | 0 | 100.0% | 6.00 | 6.00 | 21 | 0 | 0 | 0 | 1 | 75 |
| 45 | Chase BrownCincinnati Bengals·#30 | 17 | 72 | 270 | 3.75 | 2 | 147 | 15 | 4 | 16 | 10 | 33 | 1 | 62.5% | 2.06 | 3.30 | 46 | 1 | 1 | 1 | 0 | 171 |
| 46 | Jacory Croskey-MerrittWashington Commanders·#22 | 11 | 39 | 146 | 3.74 | 0 | 70 | 6 | 2 | 2 | 2 | 4 | 0 | 100.0% | 2.00 | 2.00 | 17 | 0 | 0 | 0 | 1 | 85 |
| 47 | Bam KnightArizona Cardinals·#20 | 9 | 27 | 101 | 3.74 | 2 | 69 | 6 | 1 | 5 | 3 | 23 | 0 | 60.0% | 4.60 | 7.67 | 22 | 1 | 1 | 0 | 1 | 72 |
| 48 | Isaiah DavisNew York Jets·#32 | 15 | 15 | 56 | 3.73 | 0 | 28 | 3 | 0 | 5 | 4 | 10 | 0 | 80.0% | 2.00 | 2.50 | 23 | 0 | 0 | 0 | 0 | 38 |
| 49 | Kimani VidalLos Angeles Chargers·#30 | 12 | 40 | 147 | 3.68 | 0 | 110 | 10 | 1 | 6 | 5 | 83 | 0 | 83.3% | 13.83 | 16.60 | 89 | 0 | 0 | 0 | 0 | 92 |
| 50 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 70 | 254 | 3.63 | 1 | 231 | 13 | 1 | 16 | 13 | 98 | 1 | 81.3% | 6.12 | 7.54 | 104 | 5 | 4 | 1 | 1 | 196 |