| 1 | Devin SingletaryNew York Giants·#26 | 16 | 61 | 228 | 3.74 | 2 | 163 | 15 | 4 | 10 | 10 | 127 | 0 | 100.0% | 12.70 | 12.70 | 122 | 2 | 2 | 0 | 0 | 163 |
| 2 | Audric EstiméNew Orleans Saints·#30 | 5 | 32 | 165 | 5.16 | 1 | 148 | 10 | 1 | 6 | 6 | 64 | 0 | 100.0% | 10.67 | 10.67 | 76 | 0 | 0 | 0 | 1 | 98 |
| 3 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 103 | 504 | 4.89 | 3 | 425 | 26 | 5 | 21 | 17 | 212 | 2 | 81.0% | 10.10 | 12.47 | 259 | 4 | 3 | 1 | 4 | 220 |
| 4 | Raheem MostertLas Vegas Raiders·#31 | 12 | 16 | 86 | 5.38 | 0 | 69 | 3 | 0 | 4 | 4 | 40 | 0 | 100.0% | 10.00 | 10.00 | 39 | 0 | 0 | 0 | 1 | 68 |
| 5 | Chris Rodriguez Jr.Washington Commanders·#36 | 12 | 56 | 208 | 3.71 | 3 | 149 | 12 | 6 | 3 | 3 | 30 | 0 | 100.0% | 10.00 | 10.00 | 26 | 0 | 0 | 0 | 1 | 115 |
| 6 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 125 | 499 | 3.99 | 2 | 463 | 25 | 6 | 50 | 41 | 492 | 1 | 82.0% | 9.84 | 12.00 | 490 | 4 | 3 | 1 | 3 | 369 |
| 7 | James CookBuffalo Bills·#4 | 16 | 162 | 688 | 4.25 | 5 | 458 | 31 | 12 | 26 | 22 | 253 | 1 | 84.6% | 9.73 | 11.50 | 224 | 1 | 1 | 0 | 1 | 325 |
| 8 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 86 | 304 | 3.53 | 1 | 214 | 14 | 0 | 17 | 14 | 163 | 2 | 82.3% | 9.59 | 11.64 | 187 | 2 | 1 | 1 | 1 | 197 |
| 9 | Kendre MillerNew Orleans Saints·#5 | 6 | 27 | 109 | 4.04 | 0 | 94 | 4 | 0 | 2 | 2 | 19 | 0 | 100.0% | 9.50 | 9.50 | 17 | 0 | 0 | 0 | 1 | 51 |
| 10 | Rhamondre StevensonNew England Patriots·#38 | 14 | 52 | 157 | 3.02 | 5 | 166 | 8 | 8 | 19 | 14 | 179 | 1 | 73.7% | 9.42 | 12.79 | 138 | 3 | 2 | 1 | 1 | 219 |
| 11 | Derrick HenryBaltimore Ravens·#22 | 17 | 150 | 794 | 5.29 | 7 | 450 | 38 | 13 | 11 | 8 | 103 | 0 | 72.7% | 9.36 | 12.88 | 94 | 1 | 1 | 0 | 3 | 262 |
| 12 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 157 | 551 | 3.51 | 4 | 410 | 33 | 11 | 61 | 52 | 566 | 2 | 85.3% | 9.28 | 10.88 | 444 | 11 | 9 | 2 | 3 | 411 |
| 13 | Tahj BrooksCincinnati Bengals·#25 | 6 | 13 | 35 | 2.69 | 0 | 25 | 1 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 11 | 0 | 0 | 0 | 0 | 28 |
| 14 | Kaleb JohnsonPittsburgh Steelers·#20 | 8 | 19 | 44 | 2.32 | 0 | 35 | 2 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 14 | 0 | 0 | 0 | 0 | 32 |
| 15 | Zavier ScottMinnesota Vikings·#36 | 9 | 19 | 73 | 3.84 | 0 | 53 | 4 | 1 | 9 | 9 | 78 | 1 | 100.0% | 8.67 | 8.67 | 86 | 2 | 2 | 1 | 1 | 55 |
| 16 | Breece HallNew York Jets·#20 | 16 | 113 | 533 | 4.72 | 3 | 251 | 30 | 2 | 24 | 17 | 198 | 1 | 70.8% | 8.25 | 11.65 | 173 | 5 | 1 | 0 | 2 | 319 |
| 17 | Isaiah DavisNew York Jets·#32 | 16 | 15 | 127 | 8.47 | 1 | 97 | 5 | 0 | 15 | 12 | 122 | 0 | 80.0% | 8.13 | 10.17 | 129 | 2 | 1 | 0 | 0 | 141 |
| 18 | D'Andre SwiftChicago Bears·#4 | 16 | 112 | 551 | 4.92 | 6 | 314 | 34 | 13 | 22 | 15 | 174 | 1 | 68.2% | 7.91 | 11.60 | 195 | 0 | 0 | 0 | 1 | 293 |
| 19 | Dylan SampsonCleveland Browns·#22 | 14 | 38 | 114 | 3.00 | 0 | 137 | 9 | 0 | 30 | 25 | 233 | 2 | 83.3% | 7.77 | 9.32 | 263 | 5 | 3 | 1 | 1 | 129 |
| 20 | Austin EkelerWashington Commanders·#30 | 2 | 5 | 9 | 1.80 | 0 | 13 | 1 | 0 | 2 | 1 | 15 | 0 | 50.0% | 7.50 | 15.00 | 22 | 0 | 0 | 0 | 0 | 30 |
| 21 | George HolaniSeattle Seahawks·#36 | 3 | 18 | 57 | 3.17 | 0 | 52 | 4 | 0 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 16 | 0 | 0 | 0 | 1 | 27 |
| 22 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 90 | 326 | 3.62 | 4 | 239 | 20 | 7 | 8 | 6 | 60 | 0 | 75.0% | 7.50 | 10.00 | 84 | 0 | 0 | 0 | 1 | 162 |
| 23 | Travis EtienneJacksonville Jaguars·#1 | 17 | 141 | 511 | 3.62 | 3 | 354 | 25 | 6 | 26 | 20 | 193 | 4 | 76.9% | 7.42 | 9.65 | 234 | 5 | 4 | 3 | 0 | 326 |
| 24 | Rico DowdleCarolina Panthers·#5 | 17 | 118 | 552 | 4.68 | 3 | 356 | 25 | 6 | 25 | 21 | 185 | 1 | 84.0% | 7.40 | 8.81 | 215 | 2 | 1 | 0 | 3 | 274 |
| 25 | Justice HillBaltimore Ravens·#43 | 10 | 8 | 80 | 10.00 | 2 | 86 | 2 | 1 | 14 | 11 | 102 | 0 | 78.6% | 7.29 | 9.27 | 110 | 0 | 0 | 0 | 1 | 98 |
| 26 | RJ HarveyDenver Broncos·#12 | 17 | 75 | 287 | 3.83 | 4 | 270 | 17 | 6 | 35 | 28 | 245 | 5 | 80.0% | 7.00 | 8.75 | 224 | 9 | 7 | 4 | 0 | 235 |
| 27 | Raheim SandersCleveland Browns·#35 | 3 | 17 | 71 | 4.18 | 0 | 61 | 5 | 2 | 2 | 2 | 14 | 0 | 100.0% | 7.00 | 7.00 | 5 | 0 | 0 | 0 | 0 | 28 |
| 28 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 131 | 493 | 3.76 | 3 | 307 | 24 | 3 | 22 | 15 | 153 | 1 | 68.2% | 6.95 | 10.20 | 135 | 2 | 1 | 0 | 2 | 342 |
| 29 | Kyle MonangaiChicago Bears·#25 | 17 | 88 | 416 | 4.73 | 2 | 248 | 20 | 6 | 19 | 13 | 131 | 0 | 68.4% | 6.89 | 10.08 | 138 | 3 | 2 | 0 | 0 | 238 |
| 30 | David MontgomeryDetroit Lions·#5 | 17 | 74 | 415 | 5.61 | 3 | 237 | 19 | 3 | 16 | 12 | 110 | 0 | 75.0% | 6.88 | 9.17 | 109 | 2 | 1 | 0 | 2 | 182 |
| 31 | Jahmyr GibbsDetroit Lions·#0 | 17 | 115 | 528 | 4.59 | 6 | 321 | 25 | 3 | 48 | 38 | 322 | 2 | 79.2% | 6.71 | 8.47 | 322 | 6 | 6 | 2 | 1 | 338 |
| 32 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 71 | 306 | 4.31 | 1 | 239 | 19 | 3 | 10 | 8 | 67 | 0 | 80.0% | 6.70 | 8.38 | 74 | 2 | 0 | 0 | 0 | 163 |
| 33 | Cam SkatteboNew York Giants·#44 | 7 | 56 | 222 | 3.96 | 3 | 179 | 15 | 7 | 16 | 13 | 107 | 0 | 81.3% | 6.69 | 8.23 | 109 | 2 | 1 | 0 | 2 | 135 |
| 34 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 125 | 598 | 4.78 | 4 | 346 | 35 | 6 | 25 | 18 | 167 | 2 | 72.0% | 6.68 | 9.28 | 88 | 3 | 3 | 2 | 5 | 354 |
| 35 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 96 | 365 | 3.80 | 6 | 269 | 25 | 9 | 15 | 13 | 100 | 0 | 86.7% | 6.67 | 7.69 | 88 | 2 | 2 | 0 | 2 | 222 |
| 36 | Jacory Croskey-MerrittWashington Commanders·#22 | 16 | 95 | 465 | 4.89 | 3 | 334 | 21 | 7 | 8 | 5 | 52 | 0 | 62.5% | 6.50 | 10.40 | 49 | 1 | 1 | 0 | 2 | 192 |
| 37 | Alvin KamaraNew Orleans Saints·#41 | 10 | 56 | 192 | 3.43 | 0 | 166 | 12 | 1 | 12 | 11 | 78 | 0 | 91.7% | 6.50 | 7.09 | 56 | 2 | 2 | 0 | 2 | 190 |
| 38 | Devin NealNew Orleans Saints·#24 | 7 | 33 | 117 | 3.55 | 0 | 50 | 4 | 0 | 12 | 11 | 78 | 0 | 91.7% | 6.50 | 7.09 | 113 | 1 | 1 | 0 | 0 | 142 |
| 39 | Tyler BadieDenver Broncos·#28 | 15 | 5 | 20 | 4.00 | 0 | 38 | 0 | 0 | 8 | 6 | 52 | 0 | 75.0% | 6.50 | 8.67 | 85 | 2 | 2 | 0 | 0 | 75 |
| 40 | Jawhar JordanHouston Texans·#26 | 3 | 20 | 116 | 5.80 | 0 | 91 | 5 | 1 | 6 | 6 | 38 | 0 | 100.0% | 6.33 | 6.33 | 40 | 0 | 0 | 0 | 0 | 34 |
| 41 | Ray DavisBuffalo Bills·#22 | 15 | 41 | 180 | 4.39 | 0 | 127 | 10 | 2 | 7 | 5 | 44 | 1 | 71.4% | 6.29 | 8.80 | 48 | 3 | 2 | 1 | 0 | 85 |
| 42 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 115 | 617 | 5.37 | 3 | 324 | 30 | 3 | 20 | 17 | 125 | 0 | 85.0% | 6.25 | 7.35 | 145 | 1 | 1 | 0 | 3 | 238 |
| 43 | Sean TuckerTampa Bay Buccaneers·#44 | 13 | 45 | 139 | 3.09 | 4 | 78 | 11 | 6 | 6 | 5 | 37 | 1 | 83.3% | 6.17 | 7.40 | 40 | 1 | 0 | 0 | 0 | 81 |
| 44 | Michael CarterArizona Cardinals·#22 | 13 | 48 | 162 | 3.38 | 0 | 140 | 12 | 0 | 29 | 21 | 178 | 0 | 72.4% | 6.14 | 8.48 | 180 | 4 | 1 | 0 | 1 | 218 |
| 45 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 57 | 276 | 4.84 | 3 | 146 | 13 | 7 | 17 | 16 | 104 | 0 | 94.1% | 6.12 | 6.50 | 115 | 1 | 1 | 0 | 1 | 164 |
| 46 | Josh JacobsGreen Bay Packers·#8 | 14 | 123 | 493 | 4.01 | 11 | 350 | 30 | 14 | 19 | 13 | 113 | 0 | 68.4% | 5.95 | 8.69 | 116 | 3 | 2 | 0 | 2 | 241 |
| 47 | Emari DemercadoArizona Cardinals·#31 | 9 | 24 | 228 | 9.50 | 0 | 95 | 5 | 0 | 10 | 8 | 58 | 1 | 80.0% | 5.80 | 7.25 | 40 | 3 | 2 | 1 | 1 | 92 |
| 48 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 18 | 74 | 4.11 | 1 | 39 | 3 | 1 | 4 | 2 | 23 | 0 | 50.0% | 5.75 | 11.50 | 30 | 0 | 0 | 0 | 1 | 40 |
| 49 | De'Von AchaneMiami Dolphins·#28 | 15 | 112 | 494 | 4.41 | 4 | 381 | 28 | 4 | 35 | 29 | 201 | 1 | 82.9% | 5.74 | 6.93 | 227 | 3 | 3 | 1 | 1 | 310 |
| 50 | Tyrone Tracy Jr.New York Giants·#29 | 14 | 89 | 441 | 4.96 | 1 | 263 | 27 | 1 | 27 | 19 | 153 | 2 | 70.4% | 5.67 | 8.05 | 150 | 3 | 3 | 2 | 3 | 248 |