| 1 | Rhamondre StevensonNew England Patriots·#38 | 14 | 38 | 32 | 347 | 2 | 84.2% | 9.13 | 10.84 | 263 | 6 | 5 | 1 | 4 | 481 |
| 2 | Terrell JenningsNew England Patriots·#26 | 5 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 7 | 0 | 0 | 0 | 0 | 30 |
| 3 | Najee HarrisLos Angeles Chargers·#22 | 3 | 3 | 3 | 25 | 0 | 100.0% | 8.33 | 8.33 | 15 | 0 | 0 | 0 | 0 | 39 |
| 4 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 35 | 30 | 282 | 3 | 85.7% | 8.06 | 9.40 | 360 | 4 | 3 | 1 | 1 | 401 |
| 5 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 4 | 3 | 32 | 0 | 75.0% | 8.00 | 10.67 | 39 | 1 | 1 | 0 | 0 | 114 |
| 6 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 103 | 79 | 820 | 4 | 76.7% | 7.96 | 10.38 | 857 | 13 | 9 | 3 | 6 | 804 |
| 7 | Devin SingletaryNew York Giants·#26 | 17 | 19 | 18 | 151 | 0 | 94.7% | 7.95 | 8.39 | 162 | 2 | 2 | 0 | 1 | 279 |
| 8 | Audric EstiméNew Orleans Saints·#30 | 5 | 13 | 12 | 103 | 0 | 92.3% | 7.92 | 8.58 | 108 | 0 | 0 | 0 | 1 | 163 |
| 9 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 36 | 31 | 282 | 0 | 86.1% | 7.83 | 9.10 | 339 | 3 | 2 | 0 | 5 | 451 |
| 10 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 4 | 3 | 30 | 0 | 75.0% | 7.50 | 10.00 | 26 | 1 | 0 | 0 | 2 | 237 |
| 11 | George HolaniSeattle Seahawks·#36 | 4 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 16 | 0 | 0 | 0 | 1 | 34 |
| 12 | Derrick HenryBaltimore Ravens·#22 | 17 | 20 | 15 | 150 | 0 | 75.0% | 7.50 | 10.00 | 135 | 2 | 2 | 0 | 4 | 528 |
| 13 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 45 | 40 | 333 | 2 | 88.9% | 7.40 | 8.32 | 439 | 5 | 4 | 1 | 4 | 462 |
| 14 | Breece HallNew York Jets·#20 | 16 | 48 | 36 | 350 | 1 | 75.0% | 7.29 | 9.72 | 321 | 9 | 2 | 0 | 4 | 581 |
| 15 | James CookBuffalo Bills·#4 | 17 | 40 | 33 | 291 | 2 | 82.5% | 7.28 | 8.82 | 272 | 3 | 3 | 1 | 5 | 594 |
| 16 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 127 | 102 | 904 | 7 | 80.3% | 7.12 | 8.86 | 700 | 24 | 20 | 7 | 6 | 877 |
| 17 | AJ DillonPhiladelphia Eagles·#29 | 7 | 3 | 3 | 21 | 0 | 100.0% | 7.00 | 7.00 | 9 | 1 | 1 | 0 | 1 | 37 |
| 18 | Ty JohnsonBuffalo Bills·#26 | 17 | 33 | 24 | 231 | 2 | 72.7% | 7.00 | 9.62 | 269 | 4 | 2 | 1 | 1 | 299 |
| 19 | Trayveon WilliamsCleveland Browns·#38 | 4 | 8 | 7 | 55 | 0 | 87.5% | 6.88 | 7.86 | 82 | 2 | 2 | 0 | 0 | 60 |
| 20 | Dylan SampsonCleveland Browns·#22 | 15 | 40 | 33 | 271 | 2 | 82.5% | 6.78 | 8.21 | 318 | 6 | 4 | 1 | 2 | 224 |
| 21 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 56 | 46 | 378 | 2 | 82.1% | 6.75 | 8.22 | 434 | 5 | 4 | 2 | 5 | 823 |
| 22 | David MontgomeryDetroit Lions·#5 | 17 | 29 | 24 | 192 | 0 | 82.8% | 6.62 | 8.00 | 199 | 2 | 1 | 0 | 5 | 388 |
| 23 | Zavier ScottMinnesota Vikings·#36 | 9 | 15 | 14 | 98 | 1 | 93.3% | 6.53 | 7.00 | 105 | 3 | 3 | 1 | 1 | 97 |
| 24 | Jahmyr GibbsDetroit Lions·#0 | 17 | 94 | 77 | 613 | 5 | 81.9% | 6.52 | 7.96 | 612 | 15 | 12 | 5 | 3 | 689 |
| 25 | Isaiah DavisNew York Jets·#32 | 16 | 29 | 21 | 188 | 0 | 72.4% | 6.48 | 8.95 | 189 | 2 | 1 | 0 | 2 | 260 |
| 26 | Cam SkatteboNew York Giants·#44 | 8 | 32 | 24 | 207 | 2 | 75.0% | 6.47 | 8.62 | 209 | 4 | 3 | 2 | 2 | 257 |
| 27 | Josh JacobsGreen Bay Packers·#8 | 15 | 44 | 36 | 282 | 1 | 81.8% | 6.41 | 7.83 | 304 | 6 | 5 | 1 | 5 | 512 |
| 28 | Justice HillBaltimore Ravens·#43 | 10 | 27 | 21 | 169 | 1 | 77.8% | 6.26 | 8.05 | 184 | 1 | 1 | 1 | 2 | 190 |
| 29 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 16 | 14 | 99 | 0 | 87.5% | 6.19 | 7.07 | 120 | 1 | 1 | 0 | 2 | 284 |
| 30 | Rasheen AliBaltimore Ravens·#26 | 10 | 11 | 9 | 68 | 1 | 81.8% | 6.18 | 7.56 | 83 | 1 | 1 | 0 | 3 | 101 |
| 31 | Kimani VidalLos Angeles Chargers·#30 | 13 | 22 | 16 | 136 | 1 | 72.7% | 6.18 | 8.50 | 170 | 6 | 3 | 1 | 0 | 452 |
| 32 | RJ HarveyDenver Broncos·#12 | 17 | 58 | 47 | 356 | 5 | 81.0% | 6.14 | 7.57 | 360 | 11 | 9 | 4 | 1 | 448 |
| 33 | Ray DavisBuffalo Bills·#22 | 17 | 14 | 10 | 86 | 2 | 71.4% | 6.14 | 8.60 | 99 | 5 | 4 | 2 | 0 | 135 |
| 34 | Jeremy McNicholsWashington Commanders·#26 | 17 | 32 | 25 | 196 | 0 | 78.1% | 6.12 | 7.84 | 222 | 3 | 2 | 0 | 2 | 287 |
| 35 | Rico DowdleCarolina Panthers·#5 | 17 | 49 | 39 | 297 | 1 | 79.6% | 6.06 | 7.62 | 350 | 5 | 3 | 0 | 6 | 539 |
| 36 | D'Andre SwiftChicago Bears·#4 | 16 | 48 | 34 | 290 | 1 | 70.8% | 6.04 | 8.53 | 348 | 1 | 1 | 0 | 4 | 589 |
| 37 | Kendre MillerNew Orleans Saints·#5 | 7 | 5 | 5 | 30 | 0 | 100.0% | 6.00 | 6.00 | 35 | 0 | 0 | 0 | 1 | 102 |
| 38 | Evan HullNew Orleans Saints·#34 | 6 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 1 | 66 |
| 39 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 24 | 20 | 144 | 0 | 83.3% | 6.00 | 7.20 | 123 | 3 | 3 | 0 | 4 | 444 |
| 40 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 48 | 36 | 288 | 2 | 75.0% | 6.00 | 8.00 | 314 | 5 | 4 | 2 | 3 | 515 |
| 41 | Kareem HuntKansas City Chiefs·#29 | 17 | 24 | 18 | 143 | 1 | 75.0% | 5.96 | 7.94 | 153 | 4 | 2 | 1 | 1 | 490 |
| 42 | Michael CarterArizona Cardinals·#22 | 13 | 45 | 33 | 267 | 0 | 73.3% | 5.93 | 8.09 | 257 | 7 | 4 | 0 | 1 | 374 |
| 43 | Dare OgunbowaleHouston Texans·#33 | 16 | 13 | 10 | 76 | 0 | 76.9% | 5.85 | 7.60 | 56 | 3 | 2 | 0 | 2 | 124 |
| 44 | Raheem MostertLas Vegas Raiders·#31 | 12 | 12 | 12 | 70 | 0 | 100.0% | 5.83 | 5.83 | 86 | 1 | 1 | 0 | 1 | 119 |
| 45 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 17 | 16 | 99 | 0 | 94.1% | 5.82 | 6.19 | 105 | 1 | 1 | 0 | 0 | 77 |
| 46 | Woody MarksHouston Texans·#27 | 16 | 36 | 24 | 208 | 3 | 66.7% | 5.78 | 8.67 | 223 | 8 | 5 | 3 | 0 | 528 |
| 47 | De'Von AchaneMiami Dolphins·#28 | 16 | 84 | 67 | 481 | 4 | 79.8% | 5.73 | 7.18 | 545 | 11 | 7 | 3 | 3 | 644 |
| 48 | Chuba HubbardCarolina Panthers·#30 | 15 | 39 | 30 | 223 | 3 | 76.9% | 5.72 | 7.43 | 291 | 6 | 4 | 1 | 3 | 404 |
| 49 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 85 | 73 | 486 | 3 | 85.9% | 5.72 | 6.66 | 528 | 17 | 14 | 2 | 2 | 473 |
| 50 | Braelon AllenNew York Jets·#0 | 4 | 3 | 2 | 17 | 0 | 66.7% | 5.67 | 8.50 | 9 | 2 | 1 | 0 | 1 | 46 |