| 1 | Hunter HenryNew England Patriots·#85 | 15 | 40 | 28 | 393 | 3 | 70.0% | 9.82 | 14.04 | 212 | 278 | 1.1 | 12 | 7 | 2 | 36 | 161 | 30 | 14 | 18 | 1 | 254 |
| 2 | Tyler WarrenIndianapolis Colts·#84 | 13 | 42 | 32 | 290 | 1 | 76.2% | 6.90 | 9.06 | 211 | 118 | 0.6 | 6 | 3 | 1 | 31 | 141 | 29 | 8 | 14 | 1 | 212 |
| 3 | Brenton StrangeJacksonville Jaguars·#85 | 11 | 27 | 19 | 192 | 1 | 70.4% | 7.11 | 10.11 | 80 | 156 | 0.9 | 3 | 0 | 0 | 27 | 110 | 18 | 3 | 9 | 1 | 178 |
| 4 | Dalton SchultzHouston Texans·#86 | 14 | 44 | 34 | 301 | 2 | 77.3% | 6.84 | 8.85 | 125 | 245 | 1.1 | 5 | 2 | 2 | 25 | 151 | 29 | 1 | 14 | 0 | 238 |
| 5 | Dallas GoedertPhiladelphia Eagles·#88 | 13 | 34 | 26 | 237 | 5 | 76.5% | 6.97 | 9.12 | 128 | 160 | 0.9 | 8 | 6 | 5 | 23 | 110 | 22 | 6 | 13 | 0 | 202 |
| 6 | Kyle PittsAtlanta Falcons·#8 | 12 | 31 | 23 | 223 | 1 | 74.2% | 7.19 | 9.70 | 104 | 204 | 1.2 | 4 | 3 | 1 | 21 | 107 | 22 | 2 | 13 | 1 | 175 |
| 7 | George KittleSan Francisco 49ers·#85 | 7 | 34 | 27 | 322 | 3 | 79.4% | 9.47 | 11.93 | 154 | 203 | 1.5 | 5 | 4 | 2 | 19 | 98 | 26 | 0 | 20 | 2 | 147 |
| 8 | T.J. HockensonMinnesota Vikings·#87 | 8 | 14 | 11 | 90 | 2 | 78.6% | 6.43 | 8.18 | 27 | 88 | 1.0 | 4 | 4 | 2 | 17 | 46 | 11 | 4 | 7 | 1 | 92 |
| 9 | Tyler HigbeeLos Angeles Rams·#89 | 10 | 19 | 12 | 153 | 2 | 63.2% | 8.05 | 12.75 | 95 | 16 | 0.2 | 4 | 3 | 1 | 17 | 61 | 14 | 2 | 8 | 0 | 95 |
| 10 | Trey McBrideArizona Cardinals·#85 | 9 | 30 | 22 | 230 | 2 | 73.3% | 7.67 | 10.45 | 86 | 222 | 1.7 | 5 | 2 | 2 | 16 | 89 | 21 | 3 | 13 | 1 | 143 |
| 11 | AJ BarnerSeattle Seahawks·#88 | 14 | 25 | 17 | 221 | 1 | 68.0% | 8.84 | 13.00 | 134 | 131 | 0.7 | 5 | 2 | 1 | 15 | 107 | 16 | 4 | 7 | 3 | 184 |
| 12 | Mark AndrewsBaltimore Ravens·#89 | 13 | 22 | 14 | 123 | 2 | 63.6% | 5.59 | 8.79 | 33 | 158 | 1.3 | 7 | 4 | 2 | 15 | 72 | 18 | 2 | 6 | 1 | 125 |
| 13 | Noah FantCincinnati Bengals·#86 | 8 | 11 | 8 | 95 | 1 | 72.7% | 8.64 | 11.88 | 81 | 18 | 0.5 | 3 | 1 | 1 | 15 | 44 | 8 | 2 | 5 | 0 | 68 |
| 14 | Mike GesickiCincinnati Bengals·#88 | 8 | 10 | 8 | 117 | 2 | 80.0% | 11.70 | 14.62 | 10 | 107 | 2.4 | 3 | 2 | 2 | 14 | 35 | 8 | 3 | 8 | 0 | 51 |
| 15 | John FitzPatrickGreen Bay Packers·#86 | 12 | 6 | 5 | 35 | 1 | 83.3% | 5.83 | 7.00 | 32 | 9 | 0.1 | 2 | 1 | 1 | 13 | 37 | 2 | 2 | 3 | 0 | 64 |
| 16 | Theo JohnsonNew York Giants·#84 | 8 | 19 | 12 | 188 | 3 | 63.2% | 9.89 | 15.67 | 73 | 178 | 1.4 | 5 | 3 | 2 | 12 | 79 | 15 | 1 | 8 | 1 | 125 |
| 17 | Jake FergusonDallas Cowboys·#87 | 9 | 24 | 20 | 93 | 4 | 83.3% | 3.88 | 4.65 | 68 | 49 | 0.4 | 8 | 6 | 4 | 12 | 70 | 14 | 1 | 7 | 0 | 95 |
| 18 | Evan EngramDenver Broncos·#1 | 13 | 25 | 18 | 153 | 0 | 72.0% | 6.12 | 8.50 | 98 | 123 | 1.0 | 4 | 2 | 0 | 12 | 89 | 14 | 2 | 7 | 0 | 128 |
| 19 | Adam TrautmanDenver Broncos·#82 | 14 | 7 | 6 | 58 | 1 | 85.7% | 8.29 | 9.67 | 41 | 21 | 0.2 | 1 | 1 | 1 | 12 | 67 | 6 | 1 | 4 | 0 | 109 |
| 20 | Dalton KincaidBuffalo Bills·#86 | 8 | 17 | 12 | 165 | 1 | 70.6% | 9.71 | 13.75 | 83 | 139 | 1.9 | 1 | 0 | 0 | 12 | 51 | 13 | 2 | 7 | 0 | 81 |
| 21 | Colby ParkinsonLos Angeles Rams·#84 | 12 | 21 | 17 | 158 | 6 | 81.0% | 7.52 | 9.29 | 110 | 75 | 0.6 | 11 | 10 | 6 | 11 | 89 | 13 | 3 | 13 | 2 | 121 |
| 22 | Cade OttonTampa Bay Buccaneers·#88 | 12 | 23 | 15 | 163 | 0 | 65.2% | 7.09 | 10.87 | 112 | 118 | 0.7 | 2 | 1 | 0 | 11 | 87 | 12 | 3 | 7 | 1 | 163 |
| 23 | Greg DulcichMiami Dolphins·#85 | 7 | 12 | 8 | 111 | 1 | 66.7% | 9.25 | 13.88 | 78 | 25 | 0.5 | 3 | 2 | 1 | 11 | 37 | 10 | 1 | 6 | 1 | 56 |
| 24 | Daniel BellingerNew York Giants·#82 | 10 | 7 | 5 | 61 | 0 | 71.4% | 8.71 | 12.20 | 29 | 61 | 0.5 | 2 | 1 | 0 | 11 | 74 | 5 | 1 | 2 | 1 | 118 |
| 25 | Darren WallerMiami Dolphins·#83 | 6 | 14 | 9 | 104 | 3 | 64.3% | 7.43 | 11.56 | 26 | 130 | 2.3 | 4 | 3 | 3 | 11 | 43 | 13 | 2 | 8 | 0 | 75 |
| 26 | Elijah ArroyoSeattle Seahawks·#18 | 10 | 15 | 9 | 110 | 1 | 60.0% | 7.33 | 12.22 | 52 | 88 | 1.1 | 4 | 1 | 0 | 10 | 54 | 12 | 0 | 3 | 3 | 82 |
| 27 | Mo Alie-CoxIndianapolis Colts·#81 | 12 | 7 | 6 | 60 | 0 | 85.7% | 8.57 | 10.00 | 39 | 20 | 0.3 | 1 | 1 | 0 | 10 | 43 | 5 | 5 | 2 | 0 | 73 |
| 28 | Travis KelceKansas City Chiefs·#87 | 11 | 17 | 16 | 140 | 1 | 94.1% | 8.24 | 8.75 | 64 | 79 | 0.6 | 2 | 2 | 1 | 10 | 90 | 14 | 1 | 9 | 1 | 132 |
| 29 | Oronde Gadsden IILos Angeles Chargers·#86 | 10 | 17 | 16 | 210 | 0 | 94.1% | 12.35 | 13.12 | 80 | 130 | 1.4 | 2 | 2 | 0 | 10 | 59 | 15 | 0 | 9 | 3 | 106 |
| 30 | Jake TongesSan Francisco 49ers·#88 | 8 | 9 | 7 | 54 | 0 | 77.8% | 6.00 | 7.71 | 35 | 22 | 0.5 | 1 | 0 | 0 | 10 | 53 | 4 | 2 | 5 | 0 | 67 |
| 31 | Drew SampleCincinnati Bengals·#89 | 9 | 2 | 2 | 4 | 0 | 100.0% | 2.00 | 2.00 | 9 | -5 | -0.1 | 0 | 0 | 0 | 9 | 47 | 1 | 0 | 0 | 0 | 71 |
| 32 | Pat FreiermuthPittsburgh Steelers·#88 | 15 | 17 | 13 | 117 | 0 | 76.5% | 6.88 | 9.00 | 99 | 66 | 0.6 | 2 | 1 | 0 | 9 | 71 | 8 | 3 | 5 | 0 | 116 |
| 33 | Sam LaPortaDetroit Lions·#87 | 7 | 17 | 15 | 179 | 0 | 88.2% | 10.53 | 11.93 | 107 | 84 | 0.7 | 1 | 1 | 0 | 9 | 87 | 11 | 1 | 8 | 1 | 122 |
| 34 | Chig OkonkwoTennessee Titans·#85 | 7 | 10 | 5 | 61 | 1 | 50.0% | 6.10 | 12.20 | 64 | -4 | 0.5 | 2 | 1 | 0 | 9 | 26 | 4 | 5 | 1 | 1 | 50 |
| 35 | Andrew OgletreeIndianapolis Colts·#85 | 8 | 2 | 1 | 4 | 1 | 50.0% | 2.00 | 4.00 | 0 | 9 | 0.2 | 1 | 1 | 1 | 9 | 23 | 2 | 3 | 1 | 0 | 40 |
| 36 | Cade StoverHouston Texans·#87 | 8 | 9 | 6 | 40 | 0 | 66.7% | 4.44 | 6.67 | 27 | 15 | 0.4 | 2 | 2 | 0 | 9 | 29 | 8 | 1 | 3 | 0 | 43 |
| 37 | Charlie WoernerAtlanta Falcons·#89 | 12 | 3 | 3 | 24 | 0 | 100.0% | 8.00 | 8.00 | 21 | 3 | 0.0 | 0 | 0 | 0 | 9 | 59 | 1 | 1 | 1 | 1 | 84 |
| 38 | Luke MusgraveGreen Bay Packers·#88 | 11 | 15 | 11 | 148 | 0 | 73.3% | 9.87 | 13.45 | 33 | 164 | 2.3 | 0 | 0 | 0 | 9 | 35 | 14 | 1 | 7 | 0 | 71 |
| 39 | Harold Fannin Jr.Cleveland Browns·#44 | 8 | 16 | 11 | 145 | 1 | 68.8% | 9.06 | 13.18 | 78 | 93 | 1.4 | 0 | 0 | 0 | 9 | 35 | 8 | 1 | 6 | 1 | 65 |
| 40 | Terrance FergusonLos Angeles Rams·#18 | 10 | 11 | 4 | 117 | 1 | 36.4% | 10.64 | 29.25 | 30 | 216 | 3.3 | 1 | 0 | 0 | 8 | 37 | 11 | 1 | 4 | 0 | 67 |
| 41 | Colston LovelandChicago Bears·#84 | 11 | 25 | 17 | 179 | 0 | 68.0% | 7.16 | 10.53 | 63 | 167 | 1.6 | 4 | 1 | 0 | 8 | 64 | 19 | 5 | 9 | 0 | 123 |
| 42 | Isaiah LikelyBaltimore Ravens·#80 | 11 | 7 | 7 | 129 | 0 | 100.0% | 18.43 | 18.43 | 63 | 66 | 0.9 | 1 | 1 | 0 | 8 | 44 | 5 | 0 | 4 | 2 | 73 |
| 43 | Jonnu SmithPittsburgh Steelers·#81 | 15 | 19 | 11 | 86 | 0 | 57.9% | 4.53 | 7.82 | 67 | 95 | 0.7 | 0 | 0 | 0 | 8 | 74 | 10 | 2 | 5 | 1 | 127 |
| 44 | Luke FarrellSan Francisco 49ers·#89 | 11 | 4 | 3 | 28 | 0 | 75.0% | 7.00 | 9.33 | 11 | 24 | 0.5 | 0 | 0 | 0 | 7 | 35 | 3 | 2 | 1 | 2 | 52 |
| 45 | Payne DurhamTampa Bay Buccaneers·#87 | 11 | 3 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 11 | 0.5 | 1 | 0 | 0 | 7 | 17 | 2 | 3 | 0 | 0 | 33 |
| 46 | Grant CalcaterraPhiladelphia Eagles·#81 | 11 | 6 | 5 | 40 | 0 | 83.3% | 6.67 | 8.00 | 19 | 24 | 0.3 | 0 | 0 | 0 | 7 | 41 | 5 | 5 | 2 | 0 | 68 |
| 47 | Josh OliverMinnesota Vikings·#84 | 8 | 5 | 5 | 60 | 1 | 100.0% | 12.00 | 12.00 | 38 | 22 | 0.5 | 1 | 1 | 1 | 7 | 24 | 4 | 2 | 4 | 0 | 43 |
| 48 | Austin HooperNew England Patriots·#81 | 14 | 11 | 10 | 106 | 0 | 90.9% | 9.64 | 10.60 | 43 | 63 | 0.6 | 2 | 1 | 0 | 7 | 72 | 6 | 2 | 4 | 0 | 116 |
| 49 | Davis AllenLos Angeles Rams·#87 | 14 | 13 | 9 | 84 | 1 | 69.2% | 6.46 | 9.33 | 56 | 65 | 0.8 | 3 | 2 | 1 | 7 | 64 | 8 | 2 | 3 | 1 | 85 |
| 50 | Ben SimsMinnesota Vikings·#89 | 6 | 5 | 2 | 21 | 0 | 40.0% | 4.20 | 10.50 | 0 | 69 | 2.5 | 1 | 0 | 0 | 6 | 16 | 4 | 1 | 1 | 1 | 28 |